ORCID Profile
0000-0002-4418-3713
Current Organisation
GGD Amsterdam
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Publisher: Mary Ann Liebert Inc
Date: 07-2016
Publisher: Wiley
Date: 2017
Publisher: Center for Open Science
Date: 12-12-2022
Abstract: Effective science communication is challenging when scientific messages are informed by a continually updating evidence base and must often compete against misinformation. We argue for the need for a new programme of science communication as collective intelligence—a collaborative approach, supported by technology. This would have four key advantages over the typical model where scientists communicate as in iduals: scientific messages would be informed by (1) a wider base of aggregated knowledge, (2) contributions from a erse scientific community, (3) participatory input from stakeholders, and (4) better responsiveness to ongoing changes in the state of knowledge.
Publisher: Oxford University Press (OUP)
Date: 15-09-2016
Abstract: Data on pediatric second-line antiretroviral treatment (ART) outcomes are scarce, but essential to evaluate second-line and design third-line regimens. Children ≤12 years switching to second-line ART containing a protease inhibitor (PI) in Uganda were followed for 24 months. Viral load (VL) was determined at switch to second-line and every 6 months thereafter genotypic resistance testing was done if VL ≥ 1000 cps/ml. 60 children were included in the analysis all had ≥1 drug resistance mutations at switch. Twelve children (20.0%) experienced treatment failure no PI mutations were detected. Sub-optimal adherence and underweight were associated with treatment failure. No PI mutations occurred in children failing second-line ART, which is reassuring as pediatric third-line is not routinely available in these settings. Poor adherence rather than HIV drug resistance is likely to be the main mechanism for treatment failure and should receive close attention in children on second-line ART.
Publisher: Oxford University Press (OUP)
Date: 08-07-2015
DOI: 10.1093/CID/CIV556
Location: Netherlands
Location: United Kingdom of Great Britain and Northern Ireland
Location: Netherlands
No related grants have been discovered for Tamara Sonia Boender.