ORCID Profile
0000-0002-3072-2229
Current Organisations
University of Western Australia
,
University of Queensland
,
Liverpool School of Tropical Medicine
,
Curtin University
,
Australasian College of Health Service Management
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Publications
The changing epidemiology of invasive pneumococcal disease in aboriginal and non-aboriginal western Australians from 1997 through 2007 and emergence of nonvaccine serotypes
Publisher: Oxford University Press (OUP)
Date: 06-2010
DOI: 10.1086/652440
Abstract: BACKGROUND. In 2001, Australia introduced a unique 7-valent pneumococcal conjugate vaccine (7vPCV) 2-, 4-, and 6-month schedule with a 23-valent pneumococcal polysaccharide vaccine (23vPPV) booster for Aboriginal children, and in 2005, 7vPCV alone in a 2-, 4-, and 6-month schedule for non-Aboriginal children. Aboriginal adults are offered 23vPPV but coverage is poor. We investigated trends in invasive pneumococcal disease (IPD) in Western Australia (WA). METHODS. Enhanced IPD surveillance has been ongoing since 1996. We calculated IPD incidence rates for Aboriginal and non-Aboriginal Australians before and after introduction of 7vPCV. RESULTS. A total of 1792 cases occurred during the period 1997-2007 the IPD incidence rate was 47 cases per 100,000 population per year among Aboriginal people and 7 cases per 100,000 population per year in non-Aboriginal people. After introduction of 7vPCV, IPD rates among Aboriginal children decreased by 46% for those 30% in non-Aboriginal people 50 years of age but increased among Aboriginal adults (eg, from 59.1 to 109.6 cases per 100,000 population per year among those 30-49 years of age). Although IPD due to 7vPCV serotypes decreased in all age groups, IPD incidence due to non-7vPCV serotypes increased, and it almost doubled among Aboriginal adults 30-49 years of age (from 48.3 to 97.0 cases per 100,000 population per year). Among non-Aboriginal children, 37% of IPD is now due to serotype 19A. CONCLUSIONS. IPD incidence rates have decreased markedly among children and non-Aboriginal adults with a 3-dose infant 7vPCV schedule. However, IPD due to non-7vPCV serotypes has increased and is of particular concern among young Aboriginal adults, for whom an intensive 23vPPV c aign is needed. An immunization register covering all age groups should be established.
Clinical and Radiological Predictors of Outcome for Murray Valley Encephalitis
Publisher: American Society of Tropical Medicine and Hygiene
Date: 06-03-2013
18-FDG PET/ CT Scan in the Diagnosis and Follow-up of Chronic Q fever Aortic Valve Endocarditis
Publisher: Elsevier BV
Date: 02-2016
DOI: 10.1016/J.HLC.2015.09.007
Abstract: Chronic Q fever endocarditis is a rare but important infection associated with risk of morbidity and mortality. Echocardiography rarely visualises the vegetative lesion. We describe the first Australian report of chronic Q fever aortic valve endocarditis confirmed with the use of 18 -FDG PET/ CT scan. Following valvular replacement, the patient had ongoing high serological titres despite active treatment and he was managed with yearly serial PET/ CT scan to confirm the absence of active infection. The utility of serial PET /CT scan imaging as a follow-up management strategy has not been described in the literature previously and should be investigated further.
Blastocystis hominis infection
Publisher: Elsevier BV
Date: 07-1996
DOI: 10.1016/S0140-6736(05)65587-0
Abstract: Physical activity has been documented to influence several aspects of physical and mental health. Growing evidence shows that physical activity can improve attention. Less is known about how symptoms of inattention and hyperactivity / impulsivity in childhood are associated with physical activity in adolescence. We aimed to explore this relationship further. We used a cohort of 3949 Swedish children (1884 boys and 2065 girls) with data collected at ages 9 (or 12) and 15. We investigated the influence of symptoms of inattention and hyperactivity / impulsivity in childhood - age 9/12 (inattention and hyperactivity/impulsivity separately) on self-rated physical activity at age 15, using multiple logistic regression models. We considered potential confounders such as sex, parental education level, physical activity in childhood and neurodevelopmental comorbidity. A cluster robust sandwich estimator was applied to adjust the standard errors for the nested twin data when computing the regression models. Symptoms of inattention in childhood (9/12) predicted less physical activity in adolescence (age 15) (OR = 0.83 CI = 0.78-0.89), whereas the opposite was true for hyperactivity/impulsivity (OR = 1.08 CI = 1.02-1.10). These associations still remained when taking possible confounders into account including neurodevelopmental and neurodevelopmental related comorbidity. These findings support the importance of helping children and adolescents with inattention symptoms to engage in physical activity in suitable settings.
Erratum: A laboratory medicine best practices systematic review and meta-analysis of nucleic acid amplification tests (NAATs) and algorithms including NAATs for the diagnosis of clostridioides (clostridium) difficile in adults (Clin Microbiol Rev, (2019) 32(3), e00032-18, 10.1128/CMR.00032-18)
Publisher: American Society for Microbiology
Date: 18-09-2019
DOI: 10.1128/CMR.00128-19
Vitamin T overdose?: examining the phenomenon of widespread use of the broad spectrum antimicrobial piperacillin/tazobactam
Publisher: Wiley
Date: 09-2016
DOI: 10.1111/IMJ.13185
A Laboratory Medicine Best Practices Systematic Review and Meta-analysis of Nucleic Acid Amplification Tests (NAATs) and Algorithms Including NAATs for the Diagnosis of Clostridioides
Publisher: American Society for Microbiology
Date: 19-06-2019
DOI: 10.1128/CMR.00032-18
Abstract: The evidence base for the optimal laboratory diagnosis of Clostridioides ( Clostridium ) difficile in adults is currently unresolved due to the uncertain performance characteristics and various combinations of tests. This systematic review evaluates the diagnostic accuracy of laboratory testing algorithms that include nucleic acid lification tests (NAATs) to detect the presence of C. difficile .
Building employability capabilities in data science students: An interdisciplinary, industry‐focused approach
Publisher: Wiley
Date: 25-06-2021
DOI: 10.1111/TEST.12272
Abstract: In the contemporary workplace, data scientists who are capable of interdisciplinary collaboration are in high demand. Universities need to provide data science students with a plethora of learning opportunities that involve collaboration in interdisciplinary contexts and engagement with industry partners. Curtin University and Lab Tests Online Australasia (LTO AU ) collaborated to provide an interdisciplinary, industry‐focused learning experience for data science students. Upon completing the project, students reported improved understanding of the range of applications for data science skills. The experience delivered opportunities for greater self‐awareness and highlighted the importance of teamwork, decision‐making and leadership skills. This chapter presents Interdisciplinary Project‐based Work‐Integrated Learning (IPjWIL), an educational approach that equips data science students with the necessary skills to navigate the future world of work. The results of the pilot project described demonstrate how interdisciplinary, industry‐focused learning experiences enhance the capabilities of data science students, thereby augmenting employability.
Methicillin-resistant Staphylococcus aureus in the Australian community: An evolving epidemic
Publisher: AMPCo
Date: 04-2006
DOI: 10.5694/J.1326-5377.2006.TB00287.X
Abstract: To describe antimicrobial resistance and molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) isolated in community settings in Australia. Survey of S. aureus isolates collected prospectively Australia-wide between July 2004 and February 2005 results were compared with those of similar surveys conducted in 2000 and 2002. Up to 100 consecutive, unique clinical isolates of S. aureus from outpatient settings were collected at each of 22 teaching hospital and five private laboratories from cities in all Australian states and territories. They were characterised by antimicrobial susceptibilities (by agar dilution methods), coagulase gene typing, pulsed-field gel electrophoresis, multilocus sequence typing, SCCmec typing and polymerase chain reaction tests for Panton-Valentine leukocidin (PVL) gene. 2652 S. aureus isolates were collected, of which 395 (14.9%) were MRSA. The number of community-associated MRSA (CA-MRSA) isolates rose from 4.7% (118/2498) of S. aureus isolates in 2000 to 7.3% (194/2652) in 2004 (P = 0.001). Of the three major CA-MRSA strains, WA-1 constituted 45/257 (18%) of MRSA in 2000 and 64/395 (16%) in 2004 (P = 0.89), while the Queensland (QLD) strain increased from 13/257 (5%) to 58/395 (15%) (P = 0.0004), and the south-west Pacific (SWP) strain decreased from 33/257 (13%) to 26/395 (7%) (P = 0.01). PVL genes were detected in 90/195 (46%) of CA-MRSA strains, including 5/64 (8%) of WA-1, 56/58 (97%) of QLD, and 25/26 (96%) of SWP strains. Among health care-associated MRSA strains, all AUS-2 and AUS-3 isolates were multidrug-resistant, and UK EMRSA-15 isolates were resistant to ciprofloxacin and erythromycin (50%) or to ciprofloxacin alone (44%). Almost all (98%) of CA-MRSA strains were non-multiresistant. Community-onset MRSA continues to spread throughout Australia. The hypervirulence determinant PVL is often found in two of the most common CA-MRSA strains. The rapid changes in prevalence emphasise the importance of ongoing surveillance.
Fluconazole for cryptococcal cellulitis
Publisher: Oxford University Press (OUP)
Date: 06-1993
Cerebral histoplasmosis in an Australian patient with systemic lupus erythematosus
Publisher: AMPCo
Date: 08-1998
DOI: 10.5694/J.1326-5377.1998.TB140222.X
Abstract: A 39-year-old woman with systemic lupus erythematosus suffered a prolonged neurological illness associated with very low levels of glucose in her cerebrospinal fluid (CSF). Six months later, and after numerous CSF investigations, Histoplasma capsulatum was cultured. To our knowledge, this is the first report of cerebral histoplasmosis in Australia in a patient who is not HIV positive.
An open label, randomised, crossover, comparative study of infusion site tolerability in healthy volunteers. IV fleroxacin versus IV ciprofloxacin
Publisher: Springer Science and Business Media LLC
Date: 10-1996
Gram-negative meningitis and chronic constipation: An unusual presentation of caudal regression syndrome
Publisher: Oxford University Press (OUP)
Date: 09-1993
Abstract: Congenital malformations may present as meningitis caused by enteric organisms, but this is extremely rare and occurs almost exclusively in the paediatric population. We report an unusual case of a young man with chronic constipation presenting with spontaneous Gram-negative meningitis due to an underlying congenital spinal malformation known as the caudal regression syndrome.
Related Organisations
Liverpool School Of Tropical Medicine
Location: United Kingdom of Great Britain and Northern Ireland
Australasian College Of Health Service Management
Location: Australia
Related Funding Activities
West Australian SMART Application Of Blood Culture Initiative (WASABI): Improving The Management Of Patients With Serious Infection And Reducing Low Value Care
Start Date: 2020
End Date: 2023
Funder: Department of Health, Government of Western Australia
View Funded Activity