ORCID Profile
0000-0002-5140-676X
Current Organisation
Washington University in Saint Louis
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Publisher: American Association for Cancer Research (AACR)
Date: 08-2023
DOI: 10.1158/1055-9965.23814290
Abstract: Supplementary Table 6 shows the association between composite sleep score and EAC risk with deaths as competing events
Publisher: American Association for Cancer Research (AACR)
Date: 08-2023
DOI: 10.1158/1055-9965.23814311.V1
Abstract: Supplementary Figure 1 shows the s le selection process
Publisher: American Association for Cancer Research (AACR)
Date: 08-2023
DOI: 10.1158/1055-9965.23814281.V1
Abstract: Supplementary Table 9 shows the additive interaction between composite sleep score and genetic risk with EAC risk
Publisher: American Association for Cancer Research (AACR)
Date: 14-06-2023
DOI: 10.1158/1055-9965.23516042.V1
Abstract: Supplementary Table 3 shows the sensitivity analyses for the association between sleep and EAC and ESCC by excluding cancer cases diagnosed within 2 years of enrollment
Publisher: American Association for Cancer Research (AACR)
Date: 08-2023
DOI: 10.1158/1055-9965.23814305.V1
Abstract: Supplementary Table 2 shows the weights used to construct the weighted sleep score
Publisher: American Association for Cancer Research (AACR)
Date: 14-06-2023
DOI: 10.1158/1055-9965.23516048.V1
Abstract: Supplementary Table 1 shows the associations between SNPs and EAC risk
Publisher: American Association for Cancer Research (AACR)
Date: 14-06-2023
DOI: 10.1158/1055-9965.23516051.V1
Abstract: Supplementary Figure 1 shows the s le selection process
Publisher: American Association for Cancer Research (AACR)
Date: 14-06-2023
DOI: 10.1158/1055-9965.23516024.V1
Abstract: Supplementary Table 9 shows the additive interaction between composite sleep score and genetic risk with EAC risk
Publisher: American Association for Cancer Research (AACR)
Date: 14-06-2023
DOI: 10.1158/1055-9965.23516039
Abstract: Supplementary Table 4 shows the association between finer composite sleep score and EAC risk
Publisher: American Association for Cancer Research (AACR)
Date: 08-2023
DOI: 10.1158/1055-9965.23814290.V1
Abstract: Supplementary Table 6 shows the association between composite sleep score and EAC risk with deaths as competing events
Publisher: American Association for Cancer Research (AACR)
Date: 14-06-2023
DOI: 10.1158/1055-9965.23516036
Abstract: Supplementary Table 5 shows the association between weighted sleep score and EAC risk
Publisher: American Association for Cancer Research (AACR)
Date: 08-2023
DOI: 10.1158/1055-9965.C.6695939
Abstract: AbstractBackground: Risk factors contributing to more than 10-fold increase in esophageal cancer in the last 50 years remain underexplored. We aim to examine the associations of sleep behaviors with esophageal adenocarcinoma (EAC) and squamous cell carcinoma (ESCC). Methods: We prospectively assessed the associations between sleep behaviors (chronotype, duration, daytime napping, daytime sleepiness, snoring, and insomnia) and EAC and ESCC risk in 393,114 participants in the UK Biobank (2006–2016). Participants with 0, 1, and ≥2 unhealthy behaviors, including sleep or h/d, daytime napping, and usual daytime sleepiness were classified as having a good, intermediate, and poor sleep. For EAC, we also examined interactions with polygenic risk score (PRS). Cox models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI). Results: We documented 294 incident EAC and 95 ESCC. Sleep h/d (HR, 2.05 95% CI, 1.18–3.57) and sometimes daytime napping (HR, 1.36 95% CI, 1.06–1.75) were in idually associated with increased EAC risk. Compared with in iduals with good sleep, those with intermediate sleep had a 47% (HR, 1.47 95% CI, 1.13–1.91) increased EAC risk, and those with poor sleep showed an 87% (HR, 1.87 95% CI, 1.24–2.82) higher risk ( i P /i sub trend /sub 0.001). The elevated risks for EAC were similar within strata of PRS ( i P /i sub interaction /sub = 0.884). Evening chronotype was associated with elevated risk of ESCC diagnosed after 2 years of enrollment (HR, 2.79 95% CI, 1.32–5.88). Conclusions: Unhealthy sleep behaviors were associated with an increased risk of EAC, independent of genetic risk. Impact: Sleep behaviors may serve as modifiable factors for the prevention of EAC. /
Publisher: American Association for Cancer Research (AACR)
Date: 14-06-2023
DOI: 10.1158/1055-9965.23516033
Abstract: Supplementary Table 6 shows the association between composite sleep score and EAC risk with deaths as competing events
Publisher: American Association for Cancer Research (AACR)
Date: 08-2023
DOI: 10.1158/1055-9965.23814311
Abstract: Supplementary Figure 1 shows the s le selection process
Publisher: American Association for Cancer Research (AACR)
Date: 08-2023
DOI: 10.1158/1055-9965.23814299
Abstract: Supplementary Table 4 shows the association between finer composite sleep score and EAC risk
Publisher: American Association for Cancer Research (AACR)
Date: 14-06-2023
DOI: 10.1158/1055-9965.23516030.V1
Abstract: Supplementary Table 7 shows the association between composite sleep score and EAC risk by BMI group
Publisher: American Association for Cancer Research (AACR)
Date: 08-2023
DOI: 10.1158/1055-9965.23814293
Abstract: Supplementary Table 5 shows the association between weighted sleep score and EAC risk
Publisher: American Association for Cancer Research (AACR)
Date: 16-05-2023
DOI: 10.1158/1055-9965.EPI-23-0101
Abstract: Risk factors contributing to more than 10-fold increase in esophageal cancer in the last 50 years remain underexplored. We aim to examine the associations of sleep behaviors with esophageal adenocarcinoma (EAC) and squamous cell carcinoma (ESCC). We prospectively assessed the associations between sleep behaviors (chronotype, duration, daytime napping, daytime sleepiness, snoring, and insomnia) and EAC and ESCC risk in 393,114 participants in the UK Biobank (2006–2016). Participants with 0, 1, and ≥2 unhealthy behaviors, including sleep & or & h/d, daytime napping, and usual daytime sleepiness were classified as having a good, intermediate, and poor sleep. For EAC, we also examined interactions with polygenic risk score (PRS). Cox models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI). We documented 294 incident EAC and 95 ESCC. Sleep & h/d (HR, 2.05 95% CI, 1.18–3.57) and sometimes daytime napping (HR, 1.36 95% CI, 1.06–1.75) were in idually associated with increased EAC risk. Compared with in iduals with good sleep, those with intermediate sleep had a 47% (HR, 1.47 95% CI, 1.13–1.91) increased EAC risk, and those with poor sleep showed an 87% (HR, 1.87 95% CI, 1.24–2.82) higher risk (Ptrend & 0.001). The elevated risks for EAC were similar within strata of PRS (Pinteraction = 0.884). Evening chronotype was associated with elevated risk of ESCC diagnosed after 2 years of enrollment (HR, 2.79 95% CI, 1.32–5.88). Unhealthy sleep behaviors were associated with an increased risk of EAC, independent of genetic risk. Sleep behaviors may serve as modifiable factors for the prevention of EAC.
Publisher: American Association for Cancer Research (AACR)
Date: 14-06-2023
DOI: 10.1158/1055-9965.23516030
Abstract: Supplementary Table 7 shows the association between composite sleep score and EAC risk by BMI group
Publisher: American Association for Cancer Research (AACR)
Date: 14-06-2023
DOI: 10.1158/1055-9965.23516051
Abstract: Supplementary Figure 1 shows the s le selection process
Publisher: American Association for Cancer Research (AACR)
Date: 14-06-2023
DOI: 10.1158/1055-9965.23516036.V1
Abstract: Supplementary Table 5 shows the association between weighted sleep score and EAC risk
Publisher: American Association for Cancer Research (AACR)
Date: 08-2023
DOI: 10.1158/1055-9965.23814281
Abstract: Supplementary Table 9 shows the additive interaction between composite sleep score and genetic risk with EAC risk
Publisher: American Association for Cancer Research (AACR)
Date: 08-2023
DOI: 10.1158/1055-9965.23814284.V1
Abstract: Supplementary Table 8 shows the joint associations between composite sleep score and genetic risk with EAC risk
Publisher: American Association for Cancer Research (AACR)
Date: 14-06-2023
DOI: 10.1158/1055-9965.C.6695939.V1
Abstract: AbstractBackground: Risk factors contributing to more than 10-fold increase in esophageal cancer in the last 50 years remain underexplored. We aim to examine the associations of sleep behaviors with esophageal adenocarcinoma (EAC) and squamous cell carcinoma (ESCC). Methods: We prospectively assessed the associations between sleep behaviors (chronotype, duration, daytime napping, daytime sleepiness, snoring, and insomnia) and EAC and ESCC risk in 393,114 participants in the UK Biobank (2006–2016). Participants with 0, 1, and ≥2 unhealthy behaviors, including sleep or h/d, daytime napping, and usual daytime sleepiness were classified as having a good, intermediate, and poor sleep. For EAC, we also examined interactions with polygenic risk score (PRS). Cox models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI). Results: We documented 294 incident EAC and 95 ESCC. Sleep h/d (HR, 2.05 95% CI, 1.18–3.57) and sometimes daytime napping (HR, 1.36 95% CI, 1.06–1.75) were in idually associated with increased EAC risk. Compared with in iduals with good sleep, those with intermediate sleep had a 47% (HR, 1.47 95% CI, 1.13–1.91) increased EAC risk, and those with poor sleep showed an 87% (HR, 1.87 95% CI, 1.24–2.82) higher risk ( i P /i sub trend /sub 0.001). The elevated risks for EAC were similar within strata of PRS ( i P /i sub interaction /sub = 0.884). Evening chronotype was associated with elevated risk of ESCC diagnosed after 2 years of enrollment (HR, 2.79 95% CI, 1.32–5.88). Conclusions: Unhealthy sleep behaviors were associated with an increased risk of EAC, independent of genetic risk. Impact: Sleep behaviors may serve as modifiable factors for the prevention of EAC. /
Publisher: American Association for Cancer Research (AACR)
Date: 14-06-2023
DOI: 10.1158/1055-9965.23516027.V1
Abstract: Supplementary Table 8 shows the joint associations between composite sleep score and genetic risk with EAC risk
Publisher: American Association for Cancer Research (AACR)
Date: 14-06-2023
DOI: 10.1158/1055-9965.23516045.V1
Abstract: Supplementary Table 2 shows the weights used to construct the weighted sleep score
Publisher: American Association for Cancer Research (AACR)
Date: 08-2023
DOI: 10.1158/1055-9965.23814308.V1
Abstract: Supplementary Table 1 shows the associations between SNPs and EAC risk
Publisher: American Association for Cancer Research (AACR)
Date: 08-0002
DOI: 10.1158/1055-9965.23814305
Abstract: Supplementary Table 2 shows the weights used to construct the weighted sleep score
Publisher: American Association for Cancer Research (AACR)
Date: 08-2023
DOI: 10.1158/1055-9965.23814308
Abstract: Supplementary Table 1 shows the associations between SNPs and EAC risk
Publisher: American Association for Cancer Research (AACR)
Date: 08-2023
DOI: 10.1158/1055-9965.23814302.V1
Abstract: Supplementary Table 3 shows the sensitivity analyses for the association between sleep and EAC and ESCC by excluding cancer cases diagnosed within 2 years of enrollment
Publisher: American Association for Cancer Research (AACR)
Date: 08-2023
DOI: 10.1158/1055-9965.C.6695939.V2
Abstract: AbstractBackground: Risk factors contributing to more than 10-fold increase in esophageal cancer in the last 50 years remain underexplored. We aim to examine the associations of sleep behaviors with esophageal adenocarcinoma (EAC) and squamous cell carcinoma (ESCC). Methods: We prospectively assessed the associations between sleep behaviors (chronotype, duration, daytime napping, daytime sleepiness, snoring, and insomnia) and EAC and ESCC risk in 393,114 participants in the UK Biobank (2006–2016). Participants with 0, 1, and ≥2 unhealthy behaviors, including sleep or h/d, daytime napping, and usual daytime sleepiness were classified as having a good, intermediate, and poor sleep. For EAC, we also examined interactions with polygenic risk score (PRS). Cox models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI). Results: We documented 294 incident EAC and 95 ESCC. Sleep h/d (HR, 2.05 95% CI, 1.18–3.57) and sometimes daytime napping (HR, 1.36 95% CI, 1.06–1.75) were in idually associated with increased EAC risk. Compared with in iduals with good sleep, those with intermediate sleep had a 47% (HR, 1.47 95% CI, 1.13–1.91) increased EAC risk, and those with poor sleep showed an 87% (HR, 1.87 95% CI, 1.24–2.82) higher risk ( i P /i sub trend /sub 0.001). The elevated risks for EAC were similar within strata of PRS ( i P /i sub interaction /sub = 0.884). Evening chronotype was associated with elevated risk of ESCC diagnosed after 2 years of enrollment (HR, 2.79 95% CI, 1.32–5.88). Conclusions: Unhealthy sleep behaviors were associated with an increased risk of EAC, independent of genetic risk. Impact: Sleep behaviors may serve as modifiable factors for the prevention of EAC. /
Publisher: American Association for Cancer Research (AACR)
Date: 08-2023
DOI: 10.1158/1055-9965.23814302
Abstract: Supplementary Table 3 shows the sensitivity analyses for the association between sleep and EAC and ESCC by excluding cancer cases diagnosed within 2 years of enrollment
Publisher: American Association for Cancer Research (AACR)
Date: 08-2023
DOI: 10.1158/1055-9965.23814287.V1
Abstract: Supplementary Table 7 shows the association between composite sleep score and EAC risk by BMI group
Publisher: American Association for Cancer Research (AACR)
Date: 08-2023
DOI: 10.1158/1055-9965.23814293.V1
Abstract: Supplementary Table 5 shows the association between weighted sleep score and EAC risk
Publisher: American Association for Cancer Research (AACR)
Date: 14-06-2023
DOI: 10.1158/1055-9965.23516027
Abstract: Supplementary Table 8 shows the joint associations between composite sleep score and genetic risk with EAC risk
Publisher: American Association for Cancer Research (AACR)
Date: 14-06-2023
DOI: 10.1158/1055-9965.23516048
Abstract: Supplementary Table 1 shows the associations between SNPs and EAC risk
Publisher: American Association for Cancer Research (AACR)
Date: 14-06-0004
DOI: 10.1158/1055-9965.23516024
Abstract: Supplementary Table 9 shows the additive interaction between composite sleep score and genetic risk with EAC risk
Publisher: American Association for Cancer Research (AACR)
Date: 08-2023
DOI: 10.1158/1055-9965.23814287
Abstract: Supplementary Table 7 shows the association between composite sleep score and EAC risk by BMI group
Publisher: American Association for Cancer Research (AACR)
Date: 14-06-2023
DOI: 10.1158/1055-9965.23516033.V1
Abstract: Supplementary Table 6 shows the association between composite sleep score and EAC risk with deaths as competing events
Publisher: American Association for Cancer Research (AACR)
Date: 14-06-2023
DOI: 10.1158/1055-9965.23516045
Abstract: Supplementary Table 2 shows the weights used to construct the weighted sleep score
Publisher: American Association for Cancer Research (AACR)
Date: 08-2023
DOI: 10.1158/1055-9965.23814299.V1
Abstract: Supplementary Table 4 shows the association between finer composite sleep score and EAC risk
Publisher: American Association for Cancer Research (AACR)
Date: 14-06-2023
DOI: 10.1158/1055-9965.23516042
Abstract: Supplementary Table 3 shows the sensitivity analyses for the association between sleep and EAC and ESCC by excluding cancer cases diagnosed within 2 years of enrollment
Publisher: American Association for Cancer Research (AACR)
Date: 14-06-2023
DOI: 10.1158/1055-9965.23516039.V1
Abstract: Supplementary Table 4 shows the association between finer composite sleep score and EAC risk
Publisher: American Association for Cancer Research (AACR)
Date: 08-2023
DOI: 10.1158/1055-9965.23814284
Abstract: Supplementary Table 8 shows the joint associations between composite sleep score and genetic risk with EAC risk
Location: United States of America
No related grants have been discovered for Xiaoyan Wang.