ORCID Profile
0000-0003-2345-5940
Current Organisations
University of Oulu
,
University of Queensland
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In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Environmental and Occupational Health and Safety | Forensic Chemistry | Environmental Monitoring | Public Health and Health Services
Public Health (excl. Specific Population Health) not elsewhere classified | Substance Abuse |
Publisher: Elsevier BV
Date: 02-2018
DOI: 10.1016/J.ENVINT.2017.11.019
Abstract: There is growing concern around the use of organophosphate esters (OPEs) due to their suspected reproductive toxicity, carcinogenicity, and neurotoxicity. OPEs are used as flame retardants and plasticizers, and due to their extensive application in consumer products, are found globally in the indoor environment. Early life exposure to OPEs is an important risk factor for children's health, but poorly understood. To study age and sex trends of OPE exposures in infants and young children, we collected, pooled, and analysed urine s les from children aged 0-5years from Queensland, Australia for 9 parent OPEs and 11 metabolites. In idual urine s les (n=400) were stratified by age and sex, and combined into 20 pools. Three in idual breast milk s les were also analysed to provide a preliminary estimate on the contribution of breast milk to the intake of OPEs. Bis(1-chloroisopropyl) phosphate (BCIPP), 1-hydroxy-2-propyl bis(1-chloro-2-propyl) phosphate (BCIPHIPP), bis(1,3-dichloroisopropyl) phosphate (BDCIPP), dibutyl phosphate (DBP), diphenyl phosphate (DPHP), bis(2-butoxyethyl) phosphate (BBOEP), bis(2-butoxyethyl) 3-hydroxyl-2-butoxyethyl phosphate (3OH-TBOEP), and bis(2-butoxyethyl) hydroxyethyl phosphate (BBOEHEP) were detected in all urine s les, followed by bis(methylphenyl) phosphate (80%), and bis(2-ethylhexyl) phosphate (BEHP, 20%), and bis(2-chloroethyl) phosphate (BCEP, 15%). Concentrations of tris(2-chloroethyl) phosphate (TCEP), BCEP, tris(2-ethylhexyl) phosphate (TEHP), and DBP decreased with age, while bis(methylphenyl) phosphate (BMPP) increased with age. Significantly higher concentrations of DPHP (p=0.039), and significantly lower concentrations of TEHP (p=0.006) were found in female s les compared to males. The estimated daily intakes (EDIs) via breastfeeding, were 4.6, 26 and 76ng/kg/day for TCEP, TBP and TEHP, respectively, and were higher than that via air and dust, suggesting higher exposure through consumption of breast milk.
Publisher: Elsevier BV
Date: 09-2019
DOI: 10.1016/J.ENVRES.2019.108532
Abstract: This study aimed to assess pesticide concentration and composition trends associated with age and sex in Australian infants and toddlers. In idual urine s les (n = 400) were collected in 2014/5 from Queensland infants and toddlers aged 0-5 y and composited into 20 pools of 20 in idual s les by age (of 5 strata) and sex. Nineteen biomarkers including organophosphate and pyrethroid pesticide metabolites, herbicides and metabolites, and an insect repellent, DEET, were measured. In total, seven organophosphate pesticide metabolites, three pyrethroid metabolites and one herbicide metabolite were detectable in >50% of the s le pools. A significant increase of concentrations of dimethyl phosphate, dimethyl dithiophosphate, diethyl thiophosphate (DETP), 3,5,6-trichloro-2-pyridinol (TCPY), 4-nitrophenol and 3-phenoxybenzoic acid with age was observed (with the p value of <0.0001 to 0.034). This suggested that exposure increases following weaning or as a result of increased dietary intake and mobility/activity. Significant age trends remained after adjustment for body weight and urine flow for DETP and TCPY (p = 0.029 and 0.016 respectively). The level of estimated "worst-case scenario" daily intake of chlorpyrifos from these pooled s les ranged from 0.40 to 1.8 μg/kg-day, which was below the Australian Acceptable Daily Intake guideline (3 μg/kg-day). This study presents the first dataset of age trends in concentrations of these pesticides for infants and toddlers and contributed to new understanding of exposure pathways and potential risks.
Publisher: Elsevier BV
Date: 11-2019
DOI: 10.1016/J.ENVRES.2019.108613
Abstract: Environmental and behavioural factors assessed via an online questionnaire were compared to insecticide metabolite concentrations in urine collected from 61 children from South East Queensland, Australia. Metabolite concentrations (μg/L urine) were transformed using the natural logarithm prior to regression analysis and adjusted for age and creatinine. A significant dietary association was reported for vegetable intake and 3-phenoxybenzoic acid (3-PBA) (β: 1.47 for top quartile of intake versus bottom quartile of intake 95% CI: 0.36, 2.57). Intake of vegetables and fruit were also positively associated with sum non-specific organophosphate metabolites (ƩnsOP). ƩnsOP concentrations were lower when fruits and vegetables were always or almost always washed prior to cooking or eating (β: -0.69 95% CI: -1.25, -0.12). In multivariable modelling 3-PBA concentrations were also associated with hand-washing frequency (β: 1.69 95% CI: 0.76, 2.61 for 3 day), presence of a dog in the home (β: 0.73 95% CI: 0.07, 1.38), frequency of pest-spray use in the summer months (β: 0.88 95% CI: 0.22, 1.54 weekly versus less than weekly) and season (β: 0.88 95% CI: 0.32, 1.44 for spring/summer versus winter/autumn). This is the first study in Australia to report dietary, behavioural and environmental factors associated with biomarkers of insecticide exposure in young children.
Publisher: Elsevier BV
Date: 04-2018
DOI: 10.1016/J.ENVINT.2018.01.010
Abstract: Perfluoroalkyl acids (PFAAs) have been suspected to act as endocrine disruptors and adversely affect human reproductive health. We aimed to investigate the association between PFAAs in blood and semen, explore a potential link between PFAAs exposure and semen quality in the population of the Pearl River Delta (PRD) region in China, one of the "world factories". The monitoring results demonstrated that the population (103 male participants) from the PRD region in this study had higher PFAAs levels in blood and semen than some other areas in China. PFOS was found at the highest mean concentrations of 118.16 ng/mL in blood and 5.31 ng/mL in semen among the nine PFAAs. Significant associations were found between concentrations of several analytes in blood and semen, including Σ
Publisher: Elsevier BV
Date: 2020
Publisher: Elsevier BV
Date: 03-2017
DOI: 10.1016/J.TALANTA.2016.10.108
Abstract: Flame retardants are associated to numerous adverse health effects, can accumulate in humans and have been used intensively worldwide. Recently, dust has been identified as a major human exposure route for flame retardants. The aim of this study was to develop a multi-residue method using a two-step SPE purification. It enabled us to effectively limit co-extracted matrix/interferets and therefore a simultaneous analysis of brominated and organophosphate flame retardants for indoor dust was achieved. The optimized method was validated according to standard protocol and achieved good accuracy and reproducibility (percent error ranged from -29% to 28%). Standard Reference Material (SRM) for dust was also analysed, and good agreement was found with reported brominated and organophosphate flame retardants (OPFRs) concentrations. The applicability of the validated method was demonstrated by the analysis of ten indoor dust s les from ten Australian homes. Overall 89% of the analytes were detected in these s les. The average concentrations of ∑OPFRs and ∑PBDEs in those s les were 41 and 3.6μg/g, respectively. Tris(2-butoxyethyl) phosphate and tris(2-chloroisopropyl) phosphate were the most abundant OPFRs, accounting for 57-92% ∑OPFRs, while decabromodiphenyl ether dominated the Polybrominated diphenyl ethers (PBDE) congeners contributing between 71-94% to the ∑PBDEs.
Publisher: Springer Science and Business Media LLC
Date: 29-10-2019
DOI: 10.1007/S10653-019-00448-7
Abstract: PM
Publisher: Elsevier BV
Date: 09-2019
DOI: 10.1016/J.SCITOTENV.2019.05.170
Abstract: Chlorinated paraffins (CPs) are a group of polychlorinated n-alkanes with high production volumes. Until now, there are only limited data on the levels of CPs in the environment, especially in the indoor environment. In this study, dust s les were collected from 44 indoor environments, including 27 private houses, 10 offices, and 7 vehicles. Short-, medium-, and long-chain CPs were detected in all dust s les. The median concentration of ∑CPs (C
Publisher: Elsevier BV
Date: 03-2021
Publisher: Elsevier
Date: 2019
Publisher: Elsevier BV
Date: 03-2015
DOI: 10.1016/J.JES.2015.05.022
Abstract: Polyurethane foam (PUF) passive s lers were deployed and tree bark s les were collected at 15 sites across western China in 2013, and the organochlorine pesticide (OCP) concentrations in the s les were determined. Dichlorodiphenyltrichloroethane and its degradation products (collectively called DDTs), hexachlorocyclohexanes (HCHs), and hexachlorobenzene (HCB) were the dominant OCPs in the PUF s les and tree bark s les. The mean DDTs, HCHs and HCB concentrations were 33, 22 and 18ng/s le in the PUF s les, and 428, 74, and 43ng/(g lipid weight (lw)) in the tree bark, respectively. The OCP concentrations in the air, calculated using PUF-air and tree-bark-air partitioning models, were of the same order of magnitude. Both s le types showed that relatively fresh inputs of DDT and HCHs to the environment have occurred in western China. Meanwhile, PUF passive s lers were compared with the use of tree bark s les as passive s lers. The OCP compositions in the PUF and tree bark s les were different. Only the relatively stable OCPs (such as HCB, β-HCH and p,p'-dichlorodiphenyldichloro-ethylene (DDE)) were consistent in the PUF and tree bark s les.
Publisher: Wiley
Date: 28-05-2014
DOI: 10.1002/ETC.2621
Abstract: Willow tree bark s les from urban and rural sites in Inner Mongolia, Ningxia Province, and Gansu Province, in the Yellow River basin, were analyzed for polybrominated diphenyl ethers (PBDEs), dechlorane plus (DP), and dioxin-like polychlorinated biphenyls (DL-PCBs) to compare their relative levels in air in these areas (i.e., treating bark as a passive air s ler). No difference was found between the pollutant concentrations in Salix matsudana and Salix babylonica bark s les. The mean concentrations of the total PBDEs, DP, and total DL-PCBs were 13000 ± 6400, 46 ± 44, and 26 ± 17 pg/g dry weight, respectively, with urban s les containing much higher concentrations (19000 ± 5700 pg/g, 51 ± 27 pg/g, and 37 ± 29 pg/g dry wt in PBDEs, DP, and DL-PCBs, respectively) than rural s les (10000 ± 5200 pg/g, 45 ± 53 pg/g, 22 ± 9 pg/g dry wt). A strong positive correlation between PBDEs and DP was found in all of the s les (r=0.712, p=0.006), but correlations between PCBs and the other pollutants were only found in the rural s les. The total DL-PCB concentration in the tree bark correlated with population density.
Publisher: University of Queensland Library
Date: 2019
DOI: 10.14264/UQL.2019.87
Publisher: Elsevier BV
Date: 11-2019
DOI: 10.1016/J.SCITOTENV.2019.133588
Abstract: Paired indoor air and floor dust s les were collected from residential houses and offices (n = 28) in two Australian cities in 2015. For the air s les, a modified passive air s ler (PAS) was used to collect semi-volatile organic compounds (SVOCs) in gaseous phase and airborne particles simultaneously. S ling rates (R) of the PAS for gaseous SVOCs ranged from 0.69 to 3.4 m
Publisher: Elsevier BV
Date: 10-2012
Publisher: Elsevier BV
Date: 07-2018
DOI: 10.1016/J.ENVRES.2018.02.040
Abstract: In recent years, the production and usage volumes of organophosphate flame retardants (OPFRs) has increased substantially. Certain OPFRs are suspected reproductive toxins, carcinogenic, and neurotoxic. Insufficient information is available on human exposure pathways to these chemicals, particularly in Australia. We aim to assess the association between OPFR concentrations in the urine of children to environmental and behavioural risk factors. Concentrations of eight OPFRs and eleven metabolites were measured in the urine of 51 children, aged 3-29 months, in Southeast Queensland, Australia and compared to their behavioural and environmental risk factor data obtained by an online questionnaire. Of the 11 OPFR metabolites analysed, 55% were frequently detected in the majority (> 80%) of s les. The most frequently detected metabolite was bis(1,3-dichloroisopropyl) phosphate (BDCIPP) (detected in 100% of s les), followed by 1-hydroxy-2-propyl bis(1-chloro-2-propyl) phosphate (BCIPHIPP) (96%), diphenyl phosphate (DPHP) (94%) and bis(1-chloroisopropyl) phosphate (BCIPP) (86%). In multivariable modelling, age was positively associated with concentrations of bis(2-butoxyethyl) phosphate (BBOEP) and negatively associated with concentrations of BCIPP and BCIPHIPP. Other non-age related factors, including vacuuming frequency, hand-washing frequency and presence and number of some electrical appliances in the home were also associated with concentrations of OPFR metabolites.
Publisher: Elsevier BV
Date: 03-2014
Publisher: Elsevier BV
Date: 02-2021
Publisher: American Chemical Society (ACS)
Date: 17-08-2022
Abstract: A semiquantitative high-resolution mass spectrometry method was developed and applied to assess the occurrence of bromo-/chloro paraffins (BCPs) and olefins (BCOs) in the environment. More than 400 possible BCPs and BCO congener groups were detected in dust, air, and sewage sludge s les collected from Australia. Median chain analytes with the number of halogen atoms <7 (C
Publisher: Wiley
Date: 05-11-2016
DOI: 10.1002/PPP.1922
Publisher: MDPI AG
Date: 07-06-2018
DOI: 10.3390/EN11061491
Publisher: Elsevier BV
Date: 02-2018
DOI: 10.1016/J.CHEMOSPHERE.2017.11.107
Abstract: 2, 2', 4, 4'-tetrabromodiphenyl ether (BDE-47), an extensively used brominated flame retardant (BFR), is frequently detected in biotic environments. To date, studies have reported that BDE-47 induces hepatotoxicity, reproductive toxicity, and neurotoxicity in vitro. However, little is known regarding BDE-47 metabolites-mediated cell toxicity in relevant human cell models. The cytotoxic effects of BDE-47 and its eight metabolites on hepatoblastoma cell line-HepG2 cells were investigated in this study. We found that BDE-47 and all its metabolites inhibited cell viability in both a dose- and time-dependent manner. For BDE-47 and its debromination products (BDE-28 and BDE-7), they had less severe effects on cell viability when the cells were pretreated with lower dose of the same compound, however, no significant difference was observed in control, suggesting that low concentrations have an adaptation effect on HepG2 cells. BDE-47 and its metabolites also induce changes in ROS generation, SOD and GSH activity, cell cycle regulation, DNA damage and cell apoptosis, indicating that the toxicity mechanisms of BDE-47 and its degradation products are mediated by oxidative stress, DNA damage and cell cycle dysregulation. Moreover, brominated phenol products (2,4-DBP and 4-BP) posed the highest toxic effects on HepG2, followed by hydroxylated products (6-OH-BDE-47, 5-OH-BDE-47, 2-OH-BDE-28, and 4-OH-BDE-17), and BDE-47 and its debromination products were comparatively less toxic to HepG2 cells. Taken together, these results demonstrate the hepatotoxic potential of BDE-47 and its metabolites.
Publisher: Springer Science and Business Media LLC
Date: 11-12-2018
DOI: 10.1038/S41467-018-07557-4
Abstract: Degradation of near-surface permafrost can pose a serious threat to the utilization of natural resources, and to the sustainable development of Arctic communities. Here we identify at unprecedentedly high spatial resolution infrastructure hazard areas in the Northern Hemisphere’s permafrost regions under projected climatic changes and quantify fundamental engineering structures at risk by 2050. We show that nearly four million people and 70% of current infrastructure in the permafrost domain are in areas with high potential for thaw of near-surface permafrost. Our results demonstrate that one-third of pan-Arctic infrastructure and 45% of the hydrocarbon extraction fields in the Russian Arctic are in regions where thaw-related ground instability can cause severe damage to the built environment. Alarmingly, these figures are not reduced substantially even if the climate change targets of the Paris Agreement are reached.
Publisher: American Chemical Society (ACS)
Date: 10-10-2018
Abstract: There were several studies that measured organophosphate esters (OPEs) in foods to assess the dietary intake of OPEs but none has measured OPE metabolites (mOPEs) in the same s les. In this study, we measured the concentrations of OPEs and mOPEs in 87 food s les and in five tap water s les collected in Queensland, Australia belonging to eight food groups. Tris(2-chloroisopropyl) phosphate (TCIPP) (detection frequency (DF), 77%) and tributyl phosphate (TBP) (DF, 71%), were the most frequently detected OPEs, while dibutyl phosphate (DBP) (DF, 84%) and diphenyl phosphate (DPhP) (DF, 86%) were the most frequently detected mOPEs. Vegetables had the highest concentrations of both ∑
Publisher: American Chemical Society (ACS)
Date: 29-07-2020
Publisher: Elsevier BV
Date: 04-2018
DOI: 10.1016/J.ENVPOL.2017.12.017
Abstract: Concentrations of nine organophosphate flame retardants (OPFRs) and eight polybrominated diphenyl ethers (PBDEs) were measured in s les of indoor dust (n = 85) and air (n = 45) from Australian houses, offices, hotels, and transportation (buses, trains, and aircraft). All target compounds were detected in indoor dust and air s les. Median ∑
Publisher: Elsevier BV
Date: 04-2020
Publisher: American Chemical Society (ACS)
Date: 29-09-2023
Publisher: Wiley
Date: 24-03-2016
DOI: 10.1002/ETC.3287
Abstract: Tree bark s les were collected from 15 sites across western China in 2013, and the polybrominated diphenyl ether (PBDE) and new polybrominated flame retardant (NBFR) concentrations in the s les were determined. The mean total PBDE concentration was 51.8 ng/g lipid weight, which was 85.2% to 99.4% lower than in Chinese eastern coastal areas and the E‐waste recycling areas. The dominant PBDE congener was BDE209, and its mean concentration was 49 ng/g lipid weight. The mean 2,3,5,6‐tetrabromo‐ p ‐xylene, pentabromobenzene, pentabromotoluene, and hexabromobenzene concentrations were 0.61 ng/g, 0.97 ng/g, 0.68 ng/g, and 0.68 ng/g lw, respectively. The PBDE and NBFR concentrations in the air at the s ling sites were estimated from the concentrations in the tree bark s les. The estimated mean total PBDE and total NBFR concentrations in air were 58.5 pg/m 3 and 2.76 pg/m 3 , respectively. The sources of NBFR emissions were found to be different from the sources of PBDE emissions, as no relationship was found between the NBFR and PBDE concentrations, and it appeared that sources of measured hexabromobenzene, pentabromobenzene, and pentabromotoluene in tree bark in western China include industrial activity related to the aluminum industry. Environ Toxicol Chem 2016 :1364–1370. © 2015 SETAC
Publisher: Elsevier BV
Date: 06-2016
DOI: 10.1016/J.CHEMOSPHERE.2016.03.089
Abstract: Organohalogen compound concentrations in paired air and bark s les from the Yellow River region were determined. Overall, the organohalogen compound concentrations were higher in the s les from the lower than from the upper Yellow River region. The polybrominated diphenyl ether, polychlorinated biphenyl, and organochlorine pesticide concentrations were 310-5200, 0.92-3.8, and 120-6700 pg m(-3), respectively, in the air s les and 29,000-190,0000, 220-1400, and 49,000-220,0000 pg g(-1) lipid weight, respectively, in the bark s les. The concentrations in the air s les were significantly positively correlated with the concentrations in the bark s les. Constant B, related to the partitioning of a contaminant between the gas and particle phases in the air, was calculated for each compound. This was the first time constant B was simultaneously been determined for a range of different organohalogen compounds. An air-tree bark exchange model was calibrated and verified. The exchange coefficients (K(BA)) that were determined were compared with the model results, and the optimum K(OA) values for use in the model were found to be 10(9)-10(16). The compound of interest needed to be detected in more than 50% of the s les for the model results to be valid.
Start Date: 04-2022
End Date: 04-2025
Amount: $296,579.00
Funder: Australian Research Council
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