ORCID Profile
0000-0001-9278-230X
Current Organisations
Imperial College London
,
Amgen Ltd
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: Springer Science and Business Media LLC
Date: 20-04-2008
DOI: 10.1038/NATURE06882
Publisher: Springer Science and Business Media LLC
Date: 16-06-2021
Publisher: American Chemical Society (ACS)
Date: 08-03-2006
DOI: 10.1021/AC0517085
Publisher: Royal Society of Chemistry (RSC)
Date: 2012
DOI: 10.1039/C1AY05427A
Publisher: MDPI AG
Date: 04-12-2020
Abstract: Background: Overweight and obesity amongst women of reproductive age are increasingly common in developed economies and are shown to adversely affect birth outcomes and both childhood and adulthood health risks in the offspring. Metabolic profiling in conditions of overweight and obesity in pregnancy could potentially be applied to elucidate the molecular basis of the adverse effects of gestational weight gain (GWG) and postpartum weight loss (WL) on future risks for cardiovascular disease (CVD) and other chronic diseases. Methods: Biofluid s les were collected from 114 ethnically erse pregnant women with body mass index (BMI) between 25 and 40 kg/m2 from Chicago (US), as part of a randomized lifestyle intervention trial (Maternal Offspring Metabolics: Family Intervention Trial NCT01631747). At 15 weeks, 35 weeks of gestation, and at 1 year postpartum, the blood plasma lipidome and metabolic profile of urine s les were analyzed by liquid chromatography mass spectrometry (LC-MS) and 1H nuclear magnetic resonance spectroscopy (1H NMR) respectively. Results: Urinary 4-deoxyerythronic acid and 4-deoxythreonic acid were found to be positively correlated to BMI. Seventeen plasma lipids were found to be associated with GWG and 16 lipids were found to be associated with WL, which included phosphatidylinositols (PI), phosphatidylcholines (PC), lysophospholipids (lyso-), sphingomyelins (SM) and ether phosphatidylcholine (PC-O). Three phospholipids found to be positively associated with GWG all contained palmitate side-chains, and amongst the 14 lipids that were negatively associated with GWG, seven were PC-O. Six of eight lipids found to be negatively associated with WL contained an 18:2 fatty acid side-chain. Conclusions: Maternal obesity was associated with characteristic urine and plasma metabolic phenotypes, and phospholipid profile was found to be associated with both GWG and postpartum WL in metabolically healthy pregnant women with overweight/obesity. Postpartum WL may be linked to the reduction in the intake of linoleic acid/conjugated linoleic acid food sources in our study population.
Publisher: American Chemical Society (ACS)
Date: 27-06-2008
DOI: 10.1021/AC800859X
Publisher: American Chemical Society (ACS)
Date: 10-02-2022
DOI: 10.1021/ACS.JPROTEOME.1C00851
Abstract: Trimethylamine (TMA) and its
Publisher: Elsevier BV
Date: 08-2010
Publisher: Springer Science and Business Media LLC
Date: 22-06-2020
Publisher: Copernicus GmbH
Date: 05-06-2019
Abstract: Abstract. The Atmospheric Pollution and Human Health in a Chinese Megacity (APHH-Beijing) programme is an international collaborative project focusing on understanding the sources, processes and health effects of air pollution in the Beijing megacity. APHH-Beijing brings together leading China and UK research groups, state-of-the-art infrastructure and air quality models to work on four research themes: (1) sources and emissions of air pollutants (2) atmospheric processes affecting urban air pollution (3) air pollution exposure and health impacts and (4) interventions and solutions. Themes 1 and 2 are closely integrated and support Theme 3, while Themes 1–3 provide scientific data for Theme 4 to develop cost-effective air pollution mitigation solutions. This paper provides an introduction to (i) the rationale of the APHH-Beijing programme and (ii) the measurement and modelling activities performed as part of it. In addition, this paper introduces the meteorology and air quality conditions during two joint intensive field c aigns – a core integration activity in APHH-Beijing. The coordinated c aigns provided observations of the atmospheric chemistry and physics at two sites: (i) the Institute of Atmospheric Physics in central Beijing and (ii) Pinggu in rural Beijing during 10 November–10 December 2016 (winter) and 21 May–22 June 2017 (summer). The c aigns were complemented by numerical modelling and automatic air quality and low-cost sensor observations in the Beijing megacity. In summary, the paper provides background information on the APHH-Beijing programme and sets the scene for more focused papers addressing specific aspects, processes and effects of air pollution in Beijing.
Publisher: American Chemical Society (ACS)
Date: 05-09-2018
Publisher: Springer Science and Business Media LLC
Date: 22-12-2016
DOI: 10.1038/HR.2016.164
Publisher: American Chemical Society (ACS)
Date: 02-11-2010
DOI: 10.1021/PR100798R
Publisher: Springer Science and Business Media LLC
Date: 21-11-2013
DOI: 10.1038/JHH.2013.115
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 12-2013
DOI: 10.1161/HYPERTENSIONAHA.113.01810
Abstract: Black compared with non-Hispanic white Americans have higher systolic and diastolic blood pressure and rates of prehypertension/hypertension. Reasons for these adverse findings remain obscure. Analyses here focused on relations of foods/nutrients/urinary metabolites and higher black blood pressure for 369 black compared with 1190 non-Hispanic white Americans aged 40 to 59 years from 8 population s les. Multiple linear regression, standardized data from four 24-hour dietary recalls per person, two 24-hour urine collections, and 8 blood pressure measurements were used to quantitate the role of foods, nutrients, and metabolites in higher black blood pressure. Compared with non-Hispanic white Americans, blacks’ average systolic/diastolic pressure was higher by 4.7/3.4 mm Hg (men) and 9.0/4.8 mm Hg (women). Control for higher body mass index of black women reduced excess black systolic/diastolic pressure to 6.8/3.8 mm Hg. Lesser intake of vegetables, fruits, grains, vegetable protein, glutamic acid, starch, fiber, minerals, and potassium, and higher intake of processed meats, pork, eggs, and sugar-sweetened beverages, along with higher cholesterol and higher Na/K ratio, related to in higher black blood pressure. Control for 11 nutrient and 10 non-nutrient correlates reduced higher black systolic/diastolic pressure to 2.3/2.3 mm Hg (52% and 33% reduction in men) and to 5.3/2.8 mm Hg (21% and 27% reduction in women). Control for foods/urinary metabolites had little further influence on higher black blood pressure. Less favorable multiple nutrient intake by blacks than non-Hispanic white Americans accounted, at least in part, for higher black blood pressure. Improved dietary patterns can contribute to prevention/control of more adverse black blood pressure levels.
Publisher: Elsevier BV
Date: 02-2020
DOI: 10.1093/AJCN/NQZ293
Publisher: American Chemical Society (ACS)
Date: 27-02-2007
DOI: 10.1021/AC062305N
Publisher: Springer Science and Business Media LLC
Date: 17-07-2020
Publisher: American Chemical Society (ACS)
Date: 11-08-2010
DOI: 10.1021/PR1003449
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5AY00850F
Abstract: An automated nESI-HRMS method for targeted quantitative analysis and global metabolic profiling of urine s les.
Publisher: Elsevier BV
Date: 07-2022
DOI: 10.1093/AJCN/NQAC067
Publisher: Oxford University Press (OUP)
Date: 05-01-2012
DOI: 10.1093/AJE/KWR292
Publisher: Elsevier BV
Date: 09-2010
Publisher: American Association for the Advancement of Science (AAAS)
Date: 29-04-2015
DOI: 10.1126/SCITRANSLMED.AAA5680
Abstract: In a large-scale population-based metabolic phenotyping study, erse sets of urinary metabolites, including gut microbial co-metabolites, were reproducibly associated with human adiposity.
Publisher: MDPI AG
Date: 03-04-2023
Abstract: Demographic and clinical factors influence the metabolome. The discovery and validation of disease biomarkers are often challenged by potential confounding effects from such factors. To address this challenge, we investigated the magnitude of the correlation between serum and urine metabolites and demographic and clinical parameters in a well-characterized observational cohort of 444 post-menopausal women participating in the Women’s Health Initiative (WHI). Using LC-MS and lipidomics, we measured 157 aqueous metabolites and 756 lipid species across 13 lipid classes in serum, along with 195 metabolites detected by GC-MS and NMR in urine and evaluated their correlations with 29 potential disease risk factors, including demographic, dietary and lifestyle factors, and medication use. After controlling for multiple testing (FDR 0.01), we found that log-transformed metabolites were mainly associated with age, BMI, alcohol intake, race, s le storage time (urine only), and dietary supplement use. Statistically significant correlations were in the absolute range of 0.2–0.6, with the majority falling below 0.4. Incorporation of important potential confounding factors in metabolite and disease association analyses may lead to improved statistical power as well as reduced false discovery rates in a variety of data analysis settings.
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Queenie Chan.