ORCID Profile
0000-0001-9432-9509
Current Organisation
Royal Brisbane and Women's Hospital
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Publisher: Korean Society for Sexual Medicine and Andrology
Date: 2021
DOI: 10.5534/WJMH.190166
Publisher: Springer Science and Business Media LLC
Date: 12-09-2021
Publisher: Springer Science and Business Media LLC
Date: 17-03-2022
DOI: 10.1007/S00259-022-05756-2
Abstract: The prognostic value of PSMA intensity on PSMA PET/CT due to underlying biology and subsequent clinical implications is an emerging topic of interest. We sought to investigate whether primary tumour PSMA PET intensity contributes to pre- and post-operative prediction of oncological outcomes following radical prostatectomy. We performed a retrospective cohort study of 848 men who underwent all of multiparametric MRI (mpMRI), transperineal prostate biopsy, and 68 Ga-PSMA PET/CT prior to radical prostatectomy. PSMA intensity, quantified as maximum standard uptake value (SUVmax), and other clinical variables were considered relative to post-operative biochemical recurrence-free survival (BRFS) using Cox regression and Kaplan–Meier analysis. After a median follow-up of 41 months, 219 events occurred the estimated 3-year BRFS was 79% and the 5-year BRFS was 70%. Increasing PSMA intensity was associated with less favourable BRFS overall (Log rank p 0.001), and within subgroups of Gleason score category (Log rank p 0.03). PSMA intensity was significantly associated with shorter time to biochemical recurrence, after adjusting for pre-operative (HR per 5-unit SUVmax increase = 1.15) and post-operative (HR per 5-unit SUVmax increase = 1.10) parameters. These results in a large series of patients confirm PSMA intensity to be a novel, independent prognostic factor for BRFS.
Publisher: Springer Science and Business Media LLC
Date: 22-07-2021
Publisher: Wiley
Date: 17-06-2020
DOI: 10.1111/BJU.15098
Publisher: Canadian Urological Association Journal
Date: 27-10-2020
DOI: 10.5489/CUAJ.6725
Publisher: Springer Science and Business Media LLC
Date: 19-09-2018
DOI: 10.1007/S00259-018-4160-7
Abstract: Positron emission tomography (PET) for prostate-specific membrane antigen (PSMA) represents a promising method for prostate cancer diagnosis and staging. Comparisons of PSMA-based tumour characterisation to multiparametric MRI (mpMRI) are limited, hence this study sought to compare the diagnostic accuracy of A retrospective cohort study of consecutive patients who underwent pre-operative mpMRI and Fifty-eight patients (median age 65.5 years, median PSA 7.35 ng/mL) underwent RP, resulting in a high-risk cohort (≥pT3 69%). Sensitivities for identification of index lesion, bilateral and multifocal disease were 90%, 21%, 19% for mpMRI and 93%, 42%, 34% for
Publisher: American Medical Association (AMA)
Date: 20-12-2006
Abstract: Immune suppression after organ transplantation is associated with a markedly increased risk of nonmelanoma skin cancer and a few virus-associated cancers. Although it is generally accepted that other cancers do not occur at increased rates, there have been few long-term population-based cohort studies performed. To compare the incidence of cancer in patients receiving immune suppression after kidney transplantation with incidence in the same population in 2 periods before receipt of immune suppression: during dialysis and during end-stage kidney disease before renal replacement therapy (RRT). A population-based cohort study of 28,855 patients with end-stage kidney disease who received RRT, with 273,407 person-years of follow-up. Incident cancers (1982-2003) were ascertained by record linkage between the Australia and New Zealand Dialysis and Transplant Registry and the Australian National Cancer Statistics Clearing House. Standardized incidence ratios (SIRs) of cancer, using age-specific, sex-specific, calendar year-specific, and state/territory-specific population cancer incidence rates. The overall incidence of cancer, excluding nonmelanoma skin cancer and those cancers known to frequently cause end-stage kidney disease, was markedly increased after transplantation (n = 1236 SIR, 3.27 95% confidence interval [CI], 3.09-3.46). In contrast, cancer incidence was only slightly increased during dialysis (n = 870 SIR, 1.35 95% CI, 1.27-1.45) and before RRT (n = 689 SIR, 1.16 95% CI, 1.08-1.25). After transplantation, cancer occurred at significantly increased incidence at 25 sites, and risk exceeded 3-fold at 18 of these sites. Most of these cancers were of known or suspected viral etiology. Kidney transplantation is associated with a marked increase in cancer risk at a wide variety of sites. Because SIRs for most types of cancer were not increased before transplantation, immune suppression may be responsible for the increased risk. These data suggest a broader than previously appreciated role of the interaction between the immune system and common viral infections in the etiology of cancer.
Publisher: Elsevier BV
Date: 11-2021
No related grants have been discovered for Andrew Morton.