ORCID Profile
0000-0001-7972-5634
Current Organisation
University of Basel
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Publisher: Cold Spring Harbor Laboratory
Date: 17-10-2023
Publisher: Elsevier BV
Date: 2019
Publisher: Cold Spring Harbor Laboratory
Date: 15-09-2019
DOI: 10.1101/763359
Abstract: Exposure to even moderately bright, short-wavelength light in the evening can strongly suppress the production of melatonin and can delay our circadian rhythm. These effects are mediated by the retinohypothalamic pathway, connecting a subset of retinal ganglion cells to the circadian pacemaker in the suprachiasmatic nucleus (SCN) in the brain. These retinal ganglion cells directly express the photosensitive protein melanopsin, rendering them intrinsically photosensitive (ipRGCs). But ipRGCs also receive input from the classical photoreceptors — the cones and rods. Here, we examined whether the short-wavelength-sensitive (S) cones contribute to circadian photoreception by using lights which differed exclusively in the amount of S cone excitation by almost two orders of magnitude (ratio 1:83), but not in the excitation of long-wavelength-sensitive (L) and medium-wavelength-sensitive (M) cones, rods, and melanopsin. We find no evidence for a role of S cones in the acute alerting and melatonin supressing response to evening light exposure, pointing to an exclusive role of melanopsin in driving circadian responses.
Publisher: SAGE Publications
Date: 13-02-2023
DOI: 10.1177/14771535221147140
Abstract: This article describes the development of a device to investigate the non-visual responses to light: The Light-Dosimeter (lido). Its multidisciplinary team followed a user-centred approach throughout the project, that is, their design decisions focused on researchers’ and participants’ needs. Together with custom-made mountings and the software Lido Studio, the lidos provide researchers with a holistic solution to record participants’ light exposure in the near-corneal plane in laboratory settings and under real-world conditions. Validation measurements with commercial equipment were deemed satisfying, as was the combining with data from other devices. The handling of the lidos and mountings and the use of the software Lido Studio during the trial period by various researchers and participants were successful. Despite some limitations, the lidos can help advance research on the non-visual responses to light over the coming years.
Publisher: Open Science Framework
Date: 2020
Publisher: Elsevier BV
Date: 12-2019
Publisher: Springer Science and Business Media LLC
Date: 30-06-2022
Publisher: Cold Spring Harbor Laboratory
Date: 04-04-2019
DOI: 10.1101/596957
Abstract: Optical filters and tints manipulating short-wavelength light (so-called “blue-blocking” or “blue-attenuating”) are used as a remedy for a range of ocular, retinal, neurological and psychiatric disorders. In many cases, the only available quantification of the optical effects of a given optical filter is the spectral transmittance, which specifies the amount of light transmitted as a function of wavelength. Here, we propose a novel physiologically relevant and retinally referenced framework for quantifying the visual and non-visual effects of these filters, incorporating the attenuation of luminance (luminance factor), the attenuation of melanopsin activation (melanopsin factor), the shift in colour, and the reduction of the colour gamut (gamut factor). We examined a novel data base of optical transmittance filters (n=120) which were digitally extracted from a variety of sources and find a large ersity in the alteration of visual and non-visual properties. We suggest that future studies and examinations of the physiological effects of optical filters quantify the visual and non-visual effects of the filters beyond the spectral transmittance, which will eventually aid in developing a mechanistic understanding of how different filters affect physiology.
Publisher: International Commission on Illumination, CIE
Date: 06-12-2021
Abstract: Research on the non-visual responses to light under real-world conditions has been hindered by the lack of suitable measuring devices. Here, we present a novel, portable and miniaturised light-dosimeter attached to a spectacle frame, taking measurements in the near-corneal plane. The recorded data is processed with the help of the custom-made software package Lido Studio. In addition to commonly used metrics such as illuminance and correlated colour temperature (CCT), it also provides metrics standardised in CIE S 026:2018. Data can be analysed directly in Lido Studio or exported as a PDF report or a comma-separated values (CSV) file for further in-depth time-series analyses. The Federal Institute of Metrology (METAS) optics laboratory (Bern-Wabern, Switzerland) assessed the light-dosimeter’s spectral and geometric properties. Subsequentially, the team at the Centre for Chronobiology (Basel, Switzerland) confirmed that measurements performed with a light-dosimeter were comparable to those from a commercial spectroradiometer.
Publisher: Bundesanstalt für Arbeitsschutz und Arbeitsmedizin
Date: 2022
Publisher: Wiley
Date: 11-2019
DOI: 10.1111/OPO.12648
Abstract: Optical filters and tints manipulating short‐wavelength light (sometimes called ‘blue‐blocking’ or ‘blue‐attenuating’ filters) are used in the management of a range of ocular, retinal, neurological and psychiatric disorders. In many cases, the only available quantification of the optical effects of a given optical filter is the spectral transmittance, which specifies the amount of light transmitted as a function of wavelength. We propose a novel physiologically relevant and retinally referenced framework for quantifying the visual and non‐visual effects of these filters, incorporating the attenuation of luminance ( luminous transmittance ), the attenuation of melanopsin activation ( melanopsin transmittance ), the colour shift , and the reduction of the colour gamut ( gamut reduction ). Using these criteria, we examined a novel database of spectral transmittance functions of optical filters ( n = 121) which were digitally extracted from a variety of sources. We find a large ersity in the alteration of visual and non‐visual properties. The spectral transmittance properties of the examined filters vary widely, in terms of shapes and cut‐off wavelengths. All filters show relatively more melanopsin attenuation than luminance attenuation (lower melanopsin transmittance than luminous transmittance). Across the data set, we find that melanopsin transmittance and luminous transmittance are correlated. We suggest that future studies and examinations of the physiological effects of optical filters quantify the visual and non‐visual effects of the filters beyond the spectral transmittance, which will eventually aid in developing a mechanistic understanding of how different filters affect physiology. We strongly discourage comparing the downstream effects of different filters on, e.g. sleep or circadian responses, without considering their effects on the retinal stimulus.
No related grants have been discovered for Rafael Lazar.