ORCID Profile
0000-0002-3492-0599
Current Organisations
faculty of medicine hasanuddin university
,
James Cook University
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Publisher: IOP Publishing
Date: 10-2019
Publisher: Maad Rayan Publishing Company
Date: 20-10-2020
DOI: 10.34172/JHP.2021.10
Abstract: Introduction: Antituberculosis drugs are associated with hepatic and renal toxicities due to drug’s radical metabolites. Kleinhovia hospita L extract possesses a potent antioxidant capacity that can be beneficial in eradication of oxidative-induced cell damage. This study aimed to evaluate the effects of K. hospita hydro-alcoholic extract on biomarkers and structure changes in liver and kidney induced by a combination of antituberculosis drugs (CAD), comprising isoniazid, rif icin, pyrazinamide and ethambutol in Wistar rats. Methods: Thirty-five male Wistar rats were assigned into one of the five groups: control, CAD, and CAD with K. hospita extract in three different doses (125, 250 and 500 mg/kg). The extract was administered three hours prior to CAD and all treatments were carried out for 28 days. Following the last day of treatment, blood s les and organs were collected for biomarker analysis and histopathological examinations. Results: Twenty-eight days of CAD treatment in rats induced marked elevation of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), serum creatinine and urea levels compared to controls. K. hospita extract at higher doses (250 mg/kg and 500 mg/kg) significantly improved ALT, urea and creatinine levels in the rats treated with CAD (P .05), although it did not significantly reduce AST. Furthermore, liver and renal tissue damages induced by CAD were restored with K. hospita extract treatment, especially at higher doses. Conclusion: Kleinhovia hospita extract treatment has the potential to protect the liver and renal damage induced by toxic doses of CAD.
Publisher: Elsevier BV
Date: 03-2020
Publisher: Elsevier BV
Date: 03-2020
Publisher: Elsevier BV
Date: 03-2020
Publisher: Elsevier BV
Date: 03-2020
Publisher: Elsevier BV
Date: 03-2020
Publisher: Springer Science and Business Media LLC
Date: 23-05-2016
Publisher: EManuscript Technologies
Date: 31-07-2018
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 10-2021
Publisher: Frontiers Media SA
Date: 20-10-2017
Publisher: Springer Science and Business Media LLC
Date: 12-2016
Publisher: SynthesisHub Advance Scientific Research
Date: 04-2020
Publisher: Hindawi Limited
Date: 29-06-2020
DOI: 10.1155/2020/3642035
Abstract: Background . Ketogenic diet has been used as supportive therapy in a range of conditions including epilepsy, diabetes mellitus, and cancer. Objective . This study aimed to investigate the effects of long-term consumption of ketogenic diet on blood gas, hematological profiles, organ functions, and superoxide dismutase level in a rat model. Materials and Methods . Fifteen male Wistar rats were ided into control ( n = 8) and ketogenic ( n = 7) groups. Controls received standard diet contained 52.20% of carbohydrates, 7.00% fat, and 15.25% protein meanwhile, the ketogenic group received a high-fat-low-carbohydrate diet which contained 5.66% of carbohydrate, 86.19% fat, and 8.15% protein. All rats were caged in idually and received 30g of either standard or high-fat-low-carbohydrate pellets. The experiment was carried out for 60 days before the blood s les were taken and analyzed to obtain blood gas, cell counts, organ biomarkers, and plasma antioxidant superoxide dismutase (SOD) levels. Results . The rats subjected to ketogenic diet experienced a marked decrease in body weight, blood sugar, and increased blood ketones ( p 0.05 ). The average blood pH was 7.36 ± 0.02 and base excess was −5.57 ± 2.39 mOsm/L, which were significantly lower than controls ( p 0.05 ). Hematological analysis showed significantly lower erythrocyte, hemoglobin, and hematocrit levels. No significant changes were found in alanine aminotransferase, aspartate aminotransferase, urea, and creatinine levels, indicating normal liver and kidney functions. Nevertheless, plasma SOD level significantly reduced with ketogenic diet. Conclusion . Long-term ketogenic diet induces metabolic acidosis, anemia, and reduced antioxidant enzyme level in rats following 60 days of consuming high-fat-low-carbohydrate diet.
No related grants have been discovered for Aryadi Arsyad.