ARDC Research Link Australia

ORCID Profile
Orcid icon. 0000-0002-9214-9317

Current Organisations
Oregon State University , Fred Hutchinson Cancer Research Center , Baylor College of Medicine: Houston, Texas, US

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Publications

Publication

A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization

Publisher: Springer Science and Business Media LLC

Date: 11-01-2021

DOI: 10.1038/S41467-020-20368-W

Abstract: Previous Mendelian randomization (MR) studies on 25-hydroxyvitamin D (25(OH)D) and cancer have typically adopted a handful of variants and found no relationship between 25(OH)D and cancer however, issues of horizontal pleiotropy cannot be reliably addressed. Using a larger set of variants associated with 25(OH)D (74 SNPs, up from 6 previously), we perform a unified MR analysis to re-evaluate the relationship between 25(OH)D and ten cancers. Our findings are broadly consistent with previous MR studies indicating no relationship, apart from ovarian cancers (OR 0.89 95% C.I: 0.82 to 0.96 per 1 SD change in 25(OH)D concentration) and basal cell carcinoma (OR 1.16 95% C.I.: 1.04 to 1.28). However, after adjustment for pigmentation related variables in a multivariable MR framework, the BCC findings were attenuated. Here we report that lower 25(OH)D is unlikely to be a causal risk factor for most cancers, with our study providing more precise confidence intervals than previously possible.

Publication

The suprachoroidal pathway: a new drug delivery route to the back of the eye

Publisher: Elsevier BV

Date: 04-2015

DOI: 10.1016/J.DRUDIS.2014.10.010

Abstract: The development of safe and convenient drug delivery strategies for treatment of posterior segment eye diseases is challenging. Although intravitreal injection has wide acceptance amongst clinicians, its use is associated with serious side-effects. Recently, the suprachoroidal space (SCS) has attracted the attention of ophthalmologists and pharmaceutical formulators as a potential site for drug administration and delivery to the posterior segment of the eye. This review highlights the major constraints of drug delivery to the posterior eye segment, key anatomical and physiological features of the SCS and drug delivery applications of this route with emphasis on microneedles along with future perspectives.