ORCID Profile
0000-0003-2220-9799
Current Organisations
University of Strasbourg
,
University of Oxford
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Publisher: Informa UK Limited
Date: 11-12-2012
Publisher: IEEE
Date: 10-2007
Publisher: Elsevier BV
Date: 09-2016
Publisher: Springer Science and Business Media LLC
Date: 12-03-2008
DOI: 10.1155/2008/374095
Publisher: Elsevier BV
Date: 09-2021
Publisher: IEEE
Date: 09-2013
Publisher: Springer Berlin Heidelberg
Date: 2009
Publisher: Elsevier BV
Date: 09-2012
Publisher: Springer Science and Business Media LLC
Date: 23-09-2016
DOI: 10.1038/SREP33322
Abstract: Scattered inflammatory cells are commonly observed in mammary gland tissue, most likely in response to normal cell turnover by proliferation and apoptosis, or as part of immunosurveillance. In contrast, lymphocytic lobulitis (LLO) is a recurrent inflammation pattern, characterized by lymphoid cells infiltrating lobular structures, that has been associated with increased familial breast cancer risk and immune responses to clinically manifest cancer. The mechanisms and pathogenic implications related to the inflammatory microenvironment in breast tissue are still poorly understood. Currently, the definition of inflammation is mainly descriptive, not allowing a clear distinction of LLO from physiological immunological responses and its role in oncogenesis remains unclear. To gain insights into the prognostic potential of inflammation, we developed an agent-based model of immune and epithelial cell interactions in breast lobular epithelium. Physiological parameters were calibrated from breast tissue s les of women who underwent reduction mammoplasty due to orthopedic or cosmetic reasons. The model allowed to investigate the impact of menstrual cycle length and hormone status on inflammatory responses to cell turnover in the breast tissue. Our findings suggested that the immunological context, defined by the immune cell density, functional orientation and spatial distribution, contains prognostic information previously not captured by conventional diagnostic approaches.
Publisher: IEEE
Date: 09-2015
Publisher: IEEE
Date: 12-2009
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 07-2009
Publisher: IEEE
Date: 07-2010
Publisher: Hogrefe Publishing Group
Date: 03-2018
DOI: 10.1024/0040-5930/A000986
Abstract: Zusammenfassung. Die medikamentöse Therapie der Herzinsuffizienz (HI) hat im Verlauf der letzten drei Dekaden grosse Fortschritte gemacht. Evidenz-basierte medikamentöse Therapien haben Überleben und Lebensqualität entscheidend verbessert. Die medikamentöse Stufentherapie der Herzinsuffizienz beginnt mit den Angiotensin-konvertierenden-Enzym Hemmern (ACEH) oder Angiotensin-Rezeptorblockern (ARB) und Betablockern, welche bei praktisch jedem Patienten mit einer Herzinsuffizienz und reduzierter Ejektionsfraktion indiziert sind. Fällt die linksventrikuläre Ejektionsfraktion unter 35 % und / oder persistieren die Symptome (NYHA II-IV) kommt zusätzlich ein Mineralokortikoidrezeptor-Antagonist (MRA) zum Einsatz. Relativ neu, aber mit überzeugenden Daten, ist die Substanzkombination Sacubitril / Valsartan. Das Erreichen der maximal verträglichen Dosis der einzelnen Medikamente ist essentiell für den Therapieerfolg. Diverse Zusatztherapien haben keinen erwiesenen Einfluss auf das Überleben, sind jedoch oft wesentlich für die Symptomfreiheit im Alltag. Wichtige Vertreter hierfür sind die Diuretika (Schleifendiuretika zeigen ein besseres Wirkungsprofil und sind den Thiaziden vorzuziehen), die Therapie eines Eisenmangels oder der Einsatz des Frequenzmodulators Ivabradin. Digoxin hat aktuell nur noch einen sehr begrenzten Stellenwert. Signifikante Rhythmusstörungen (vor allem Vorhofflimmern und ventrikuläre Arrhythmien) gehören zum klassischen Krankheitsverlauf. Neben Betablockern ist Amiodaron das Antiarrhythmikum der Wahl. Mit der frühen interventionellen Behandlung des Vorhofflimmerns mittels Pulmonalvenenablation ist gemäss neuster Daten eine Reduktion der Mortalität potentiell möglich. Neue Entwicklungen im Bereich der Antidiabetika sind bezüglich Therapieoptimierungen vielversprechend.
Publisher: Elsevier BV
Date: 11-2010
Publisher: Elsevier BV
Date: 07-2016
DOI: 10.1016/J.COMPBIOMED.2016.05.004
Abstract: Ongoing research into inflammatory conditions raises an increasing need to evaluate immune cells in histological sections in biologically relevant regions of interest (ROIs). Herein, we compare different approaches to automatically detect lobular structures in human normal breast tissue in digitized whole slide images (WSIs). This automation is required to perform objective and consistent quantitative studies on large data sets. In normal breast tissue from nine healthy patients immunohistochemically stained for different markers, we evaluated and compared three different image analysis methods to automatically detect lobular structures in WSIs: (1) a bottom-up approach using the cell-based data for subsequent tissue level classification, (2) a top-down method starting with texture classification at tissue level analysis of cell densities in specific ROIs, and (3) a direct texture classification using deep learning technology. All three methods result in comparable overall quality allowing automated detection of lobular structures with minor advantage in sensitivity (approach 3), specificity (approach 2), or processing time (approach 1). Combining the outputs of the approaches further improved the precision. Different approaches of automated ROI detection are feasible and should be selected according to the in idual needs of biomarker research. Additionally, detected ROIs could be used as a basis for quantification of immune infiltration in lobular structures.
Publisher: Elsevier BV
Date: 04-2013
Publisher: IEEE
Date: 12-2008
Publisher: Springer Berlin Heidelberg
Date: 2008
Publisher: IEEE
Date: 07-2013
Publisher: Elsevier BV
Date: 02-2010
Publisher: Springer Berlin Heidelberg
Date: 2008
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 05-2019
Publisher: Wiley
Date: 15-01-2020
DOI: 10.1111/AOR.13612
Abstract: An increasing number of mechanical assist devices, especially left ventricular assist devices (VADs), are being implanted for prolonged periods and as destination therapy. Some VAD patients require radiotherapy due to concomitant oncologic morbidities, including thoracic malignancies. This raises the potential of VAD malfunction via radiation-induced damage. So far, only case reports and small case series on radiotherapy have been published, most of them on HeartMate II (HMII, Abbott, North Chicago, IL, USA). Significantly, the effects of irradiation on the HeartMate 3 (HM3, Abbott) remain undefined, despite the presence of controller components engineered within the pump itself. We report the first case of a patient with a HM3 who successfully underwent stereotactic hypofractionated radiotherapy due to an early-stage non-small-cell lung cancer. The patient did not suffer from any complications, including toxicity or VAD malfunction. Based on this case report and on published literature, we think that performing radiotherapy after VAD implantation with the aid of a multidisciplinary team could be performed, but more in vitro studies and cases series are needed to reinforce this statement.
Publisher: Springer International Publishing
Date: 2015
Publisher: SPIE
Date: 17-09-2009
DOI: 10.1117/12.830392
Publisher: IEEE
Date: 2008
Publisher: Springer Berlin Heidelberg
Date: 2010
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Stephan Dobner.