ORCID Profile
0000-0001-7759-0465
Current Organisation
University of Adelaide
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Publisher: Wiley
Date: 20-04-2018
Abstract: The cis-α isomer of [Ru(bb
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7OB00724H
Abstract: The relatively non-toxic family of cucurbit[n]uril, Q[n], have shown considerable potential in vitro as drug delivery agents, with only a few ex les of pharmacokinetic (PK) studies for drug⊂Q[n]. Drug-free Q[n] PK studies are the next step in determining the pharmacological applicability in their drug delivery potential. The results for the first PK and bio-distribution of drug-free
Publisher: Elsevier BV
Date: 04-2018
Publisher: Wiley
Date: 27-07-2022
Publisher: Wiley
Date: 21-11-2017
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C7DT04595F
Abstract: The strained complexes cis -β-[Ru(phen′)(bb 7 )] 2+ isomerise to the corresponding cis -α isomers, with cis -α-[Ru(Me 4 phen)(bb 7 )] 2+ showing good antibacterial activity.
Publisher: American Chemical Society (ACS)
Date: 25-02-2019
DOI: 10.1021/JACS.8B12280
Abstract: Herein we report the separation of the three stereoisomers of the DNA light-switch compound [{Ru(bpy)
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D2CC05827H
Abstract: A tetranuclear Ru dye for selective staining of extracellular vesicles for studies of in vitro blood–brain barrier permeability.
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C6MB00753H
Abstract: Condensation studies of chromosomal DNA in E. coli with a tetranuclear ruthenium complex are carried out and images obtained with wide-field fluorescence microscopy. Remarkably different condensate morphologies resulted, depending upon the treatment protocol. The occurrence of condensed nucleoid spirals in live bacteria provides evidence for the transertion hypothesis.
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9DT03221E
Abstract: Linear and non-linear tetranuclear ruthenium(ii) complexes containing the bridging ligand bis[4(4'-methyl-2,2'-bipyridyl)]-1,7-heptane have been synthesised and their biological properties examined. The minimum inhibitory concentrations (MIC) and the minimum bactericidal concentrations (MBC) of the ruthenium(ii) complexes were determined against six strains of bacteria: Gram-positive Staphylococcus aureus (S. aureus) and methicillin-resistant S. aureus (MRSA) and the Gram-negative Escherichia coli (E. coli) strains MG1655, APEC, UPEC and Pseudomonas aeruginosa (P. aeruginosa). The results showed that both tetranuclear complexes had significant antimicrobial activity, with the non-linear (branched) species (Rubb
Publisher: Wiley
Date: 14-06-2022
Abstract: A series of ligands containing a 1,4‐disubstituted 1,2,3‐triazole unit have been used for the formation of triple‐stranded dinuclear Ru(II) complexes. In contrast to the previously reported complexes of labile metals, the use of inert Ru(II) enabled stereoisomeric mixtures of triple‐stranded diruthenium(II) complexes to be accessed. The chromatographic resolution of the enantiomers of a reported helicate containing a more rigid 1,4‐xylyl spacer was carried out on cellulose. The ligand spacer was modified and as the flexibility increased the production of isomeric mixtures was detected the mesocate and helicate forms were separated when an n ‐propyl spacer was used. This pair of diastereomers was found to exhibit photoconversion, a unique observation for Ru(II) compounds of this type. Partial separation via chromatographic resolution was achieved for compounds containing an n ‐butyl spacer, and the presence of a mesocate/helicate pair confirmed.
No related grants have been discovered for Richard Keene.