ORCID Profile
0000-0002-8460-0841
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Publisher: Elsevier BV
Date: 2017
DOI: 10.1016/J.JMBBM.2016.08.008
Abstract: In this study, injection molding of three poly lactic acid (PLA) based bone screws was simulated and optimized through minimizing the shrinkage and warpage of the bone screws. The optimization was carried out by investigating the process factors such as coolant temperature, mold temperature, melt temperature, packing time, injection time, and packing pressure. A response surface methodology (RSM), based on the central composite design (CCD), was used to determine the effects of the process factors on the PLA based bone screws. Upon applying the method of maximizing the desirability function, optimization of the factors gave the lowest warpage and shrinkage for nanocomposite PLA bone screw (PLA9). Moreover, PLA9 has the greatest desirability among the selected materials for bone screw injection molding. Meanwhile, a finite element analysis (FE analysis) was also performed to determine the force values and concentration points which cause yielding of the screws under certain conditions. The Von-Mises stress distribution showed that PLA9 screw is more resistant against the highest loads as compared to the other ones. Finally, according to the results of injection molding simulations, the design of experiments (DOE) and structural analysis, PLA9 screw is recommended as the best candidate for the production of biomedical materials among all the three types of screws.
Publisher: Elsevier BV
Date: 05-2018
DOI: 10.1016/J.JMBBM.2018.02.025
Abstract: In this study, injection molding process of ultrahigh molecular weight polyethylene (UHMWPE) reinforced with nano-hydroxyapatite (nHA) was simulated and optimized through minimizing the shrinkage and warpage of the hip liners as an essential part of a hip prosthesis. Fractional factorial design (FFD) was applied to the design of the experiment, modeling, and optimizing the shrinkage and warpage of UHMWPE/nHA composite liners. The Analysis of variance (ANOVA) was applied to find the importance of operative parameters and their effects. In this experiment, seven input parameters were surveyed, including mold temperature (A), melt temperature (B), injection time (C), packing time (D), packing pressure (E), coolant temperature (F), and type of liner (G). Two models were capable of predicting warpage and volumetric shrinkage (%) in different conditions with R
Publisher: Wiley
Date: 12-10-2018
DOI: 10.1002/PC.25126
Publisher: Elsevier BV
Date: 03-2018
DOI: 10.1016/J.EJPS.2017.12.008
Abstract: Brain tumor is a lethal, fast growing cancer and a difficult case for treatment. Receptor-mediated endocytosis has been recognized as one of the most effective methods for drug delivery to brain tissue by overcoming obstacles associated with conventional therapeutics. In this work, a targeted theranostic drug delivery system (DDS) was prepared based on gold‑iron oxide nanocomposites (Fe
Publisher: Elsevier BV
Date: 2017
DOI: 10.1016/J.CARBPOL.2016.08.037
Abstract: In this study, an optimized interface-modified ternary blend with antibacterial activity based on polylactic acid/starch oly ε-caprolactone (PLASCL20), mixed with nano hydroxyapatite (nHA) via melt blending. This method results in a homogeneous nanocomposite blend in which the addition of 3% nHA improves the overall properties such as hydrolytic degradation, hydrophilicity, antibacterial activity and the drug release comparing to PLASCL20. Moreover, the simultaneous use of nHA and encapsulated triclosan (LATC30) compensated the negative effect of triclosan through increasing the possible cell attachment. According to the contact angle results, nHA was thermodynamically driven into the interface of PLA and PCL/Starch phases. The addition of 3% nHA showed a good adjustment between the hydrolytic degradation and the release profile, therefore, their electrospun microfibers demonstrated an improved fibroblast (L929) cell attachment. The aforementioned nanocomposite blend is a suitable antibacterial candidate for many medical applications with minimum side effects due to the controlled release of triclosan.
Location: Iran (Islamic Republic of)
Location: Iran (Islamic Republic of)
No related grants have been discovered for Hamid Rashedi.