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ORCID Profile
Orcid icon. 0000-0001-9552-0807

Current Organisations
University of Ferrara , University of Southampton , Universita' degli Studi di FERRARA

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Publications

Publication

Antidiuretic effect of desmopressin chimera agglomerates by nasal administration in rats

Publisher: Elsevier BV

Date: 2013

DOI: 10.1016/J.IJPHARM.2012.09.049

Abstract: In the present study, a nasal powder of the antidiuretic peptide desmopressin (DDAVP) formulated as chimera agglomerates was studied to improve drug bioavailability and provide a flexible drug product. Firstly, DDAVP was spray-dried along with mannitol and lecithin to produce primary microparticles capable of instantaneous dissolution in water. The chimera agglomerates were spontaneously formed by mechanically vibrating the microparticles on two stacked sieves. Agglomerate formation and strength were favored by the presence of lecithin. Drug content and dissolution rate remained unmodified after agglomeration. However, owing to the agglomerate larger size, powder flowability was greatly improved in comparison with the original microparticles, allowing accurate powder dosing into the nasal delivery device. DDAVP in vitro permeation across excised rabbit nasal mucosa from the agglomerates was significantly higher than that obtained from a commercial liquid nasal spray. In rats, intranasal DDAVP agglomerates allowed for efficient administration with almost 80% of the loaded powder emitted from the device into the animal nose. The administration of DDAVP agglomerates induced a significant reduction in urine production. Moreover, the antidiuretic effect of agglomerates did not significantly differ from the one induced by an intravenous injection of DDAVP at a ten-fold lower dose.

Related Organisations

Organisation

University Of Ferrara

Location: Italy

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Organisation

University Of Southampton

Location: United Kingdom of Great Britain and Northern Ireland

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Organisation

Università Degli Studi Di Ferrara

Location: Italy

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Organisation

Università Degli Studi D Ferrara

Location: Italy

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Organisation

Universita' Degli Studi Di FERRARA

Location: Italy

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Eidgenössische Technische Hochschule Zürich

Location: Switzerland

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Related Funding Activities

No related grants have been discovered for Claudio Nastruzzi.

Claudio Nastruzzi

Researcher

Related Links

Publications

Antidiuretic effect of desmopressin chimera agglomerates by nasal administration in rats

Related Organisations

University Of Ferrara

University Of Southampton

Università Degli Studi Di Ferrara

Università Degli Studi D Ferrara

Universita' Degli Studi Di FERRARA

Eidgenössische Technische Hochschule Zürich

Related Funding Activities

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