ORCID Profile
0000-0002-5789-2068
Current Organisation
Dublin City University
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Publisher: Frontiers Media SA
Date: 04-03-2021
DOI: 10.3389/FCLIM.2021.638805
Abstract: Since the adoption of the Paris Agreement in 2015, spurred by the 2018 IPCC Special Report on Global Warming of 1.5°C, net zero emission targets have emerged as a new organizing principle of climate policy. In this context, climate policymakers and stakeholders have been shifting their attention to carbon dioxide removal (CDR) as an inevitable component of net zero targets. The importance of CDR would increase further if countries and other entities set net-negative emissions targets. The scientific literature on CDR governance and policy is still rather scarce, with empirical case studies and comparisons largely missing. Based on an analytical framework that draws on the multi-level perspective of sociotechnical transitions as well as existing work on CDR governance, we gathered and assessed empirical material until early 2021 from 9 Organization for Economic Co-operation and Development (OECD) cases: the European Union and three of its Member States (Ireland, Germany, and Sweden), Norway, the United Kingdom, Australia, New Zealand, and the United States. Based on a synthesis of differences and commonalities, we propose a tripartite conceptual typology of the varieties of CDR policymaking: (1) incremental modification of existing national policy mixes, (2) early integration of CDR policy that treats emission reductions and removals as fungible, and (3) proactive CDR policy entrepreneurship with support for niche development. Although these types do not necessarily cover all dimensions relevant for CDR policy and are based on a limited set of cases, the conceptual typology might spur future comparative work as well as more fine-grained case-studies on established and emerging CDR policies.
Publisher: Springer Science and Business Media LLC
Date: 12-2015
Publisher: Elsevier BV
Date: 11-2014
DOI: 10.1016/J.TAAP.2014.09.011
Abstract: Blood uric acid has been recognized as a putative marker for cardiovascular diseases (CVDs). CVDs are the major causes of arsenic-related morbidity and mortality. However, the association of arsenic exposure with plasma uric acid (PUA) levels in relation to CVDs has not yet been explored. This study for the first time demonstrated the associations of arsenic exposure with PUA levels and its relationship with hypertension. A total of 483 subjects, 322 from arsenic-endemic and 161 from non-endemic areas in Bangladesh were recruited as study subjects. Arsenic concentrations in the drinking water, hair and nails of the study subjects were measured by inductively coupled plasma mass spectroscopy. PUA levels were measured using a colorimetric method. We found that PUA levels were significantly (p<0.001) higher in males and females living in arsenic-endemic areas than those in non-endemic area. Arsenic exposure (water, hair and nail arsenic) levels showed significant positive correlations with PUA levels. In multiple regression analyses, arsenic exposure levels were found to be the most significant contributors on PUA levels among the other variables that included age, body mass index, blood urea nitrogen, and smoking. There were dose-response relationships between arsenic exposure and PUA levels. Furthermore, diastolic and systolic blood pressure showed significant positive correlations with PUA levels. Finally, the average PUA levels were significantly higher in the hypertensive group than those in the normotensive group in both males and females living in arsenic-endemic areas. These results suggest that arsenic exposure-related elevation of PUA levels may be implicated in arsenic-induced CVDs.
Publisher: OMICS Publishing Group
Date: 2015
Publisher: Springer Science and Business Media LLC
Date: 27-10-2017
DOI: 10.1007/S12011-016-0883-0
Abstract: Arsenic (As) toxicity has caused an environmental tragedy affecting millions of people in the world. Little is known about the toxic effects of As on neurobehavioral and biochemical changes in vivo. Along this line of metal toxicity, co-exposure of lead (Pb) could aggravate the situation in the host. The present study was designed to explore the combined effects of As and Pb on behavioral changes like anxiety, spatial memory and learning impairment, and blood indices related to organ dysfunction. Exposure of mice to As (10 mg/kg body weight), Pb (10 mg/kg body weight), and As + Pb via drinking water significantly decreased the time spent exploring the open arms while it increased the time spent in the closed arms compared to control mice in the elevated plus maze. The mean latency time of the control group to find the platform decreased significantly during the learning for 7 days compared to all three treated groups in the Morris water maze test, and the As-exposed group spent significantly less time in the desired quadrant as compared to the control group in the probe trial. Both metals posed an anxiety-like behavior and deficits in spatial memory and learning, and also altered blood indices related to liver and kidney dysfunction, and a combined exposure of these metals inhibited the in idual accumulation of As and Pb. Taken together, these data suggest that As has more toxic effects on neurobehavioral and biochemical changes than Pb, and there may be antagonism in the effects and accumulation between these two toxicants.
No related grants have been discovered for Barry McMullin.