ORCID Profile
0000-0003-0831-3717
Current Organisations
Texas A & M University
,
Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: Elsevier BV
Date: 2010
Publisher: Wiley
Date: 28-03-2014
DOI: 10.1002/ESP.3558
Publisher: Elsevier BV
Date: 02-2015
DOI: 10.1016/J.SCITOTENV.2014.11.016
Abstract: Anthropogenically enhanced delivery of sediments and other land-based sources of pollution represent well-recognized threats to nearshore coral reef communities worldwide. Land cover change is commonly used as a proxy to document human-induced alterations to sediment and pollutant delivery rates to coral reef bearing waters. In this article, land cover change was assessed for a 69-km(2) watershed in Puerto Rico between 1936 and 2004 by aerial photograph interpretation. Forests and sugar cane fields predominated from 1936 through the late 1970s, but while cropland dipped to negligible levels by 2004, net forest cover doubled and built-up areas increased tenfold. The watershed-scale land cover changes documented here mimicked those of the entire Puerto Rican landmass. Sediment yield predictions that rely on the sort of land cover changes reported here inevitably result in declining trends, but anecdotal and scientific evidence in the study watershed and throughout Puerto Rico suggests that sediment and pollutant loading rates still remain high and at potentially threatening levels. The simultaneous reduction in living coral cover that accompanied reforestation and urbanization patterns since the 1970s in our study region is discussed here within the context of the following non-mutually exclusive potential explanations: (a) the inability of land cover change-based assessments to discern spatially-focused, yet highly influential sources of sediment (b) the potentially secondary role of cropland and forest cover changes in influencing nearshore coral reef conditions relative to other types of stressors like those related to climate change and (c) the potentially dominant role that urban development may have had in altering marine water quality to the extent of reducing live coral cover. Since identification of the causes for coral reef degradation has proven elusive here and elsewhere, we infer that coral reef management may only be effective when numerous land- and marine-based stressors are simultaneously mitigated.
Publisher: Hindawi Limited
Date: 27-10-2021
DOI: 10.1155/2021/7007933
Abstract: Gastric cancer is a highly malignant tumor with poor survival rate. Ferroptosis, a newly defined regulated cell death, is closely related to several tumors. Introduction of ferroptosis is promising for cancer treatments. However, the predictive role of ferroptosis in GC remains elusive. In this study, we screened the ferroptosis-related genes which were differentially expressed between normal and GC tissues. Then, based on these differentially expressed genes (DEGs), the least absolute shrinkage and selection operator (LASSO) and multivariate Cox regressions were applied to construct the 10-gene prognostic signature (SP1, MYB, ALDH3A2, KEAP1, AIFM2, ITGB4, TGFBR1, MAP1LC3B, NOX4, and ZFP36) in TCGA training dataset. Based on the median risk score, all GC patients in TCGA training dataset and GSE84437 testing dataset were classified into a high- or low-risk group. GC patients in the low-risk group showed significantly higher survival possibilities than those in the high-risk group ( P 0.001 ). Combined with the clinical characteristics, the risk score was proven as an independent factor for predicting the OS of GC patients. Besides, the GC patients in the high- or low-risk group showed significantly different GO and KEGG functional enrichments, somatic mutation, fractions of immune cells, and immunotherapy response. Then, the expression levels of these genes in signature were further verified in the GC cell lines and our own GC s les (30-paired tumor/normal tissues). Furthermore, the effects of ferroptosis inducer Erastin on these 10 ferroptosis-related genes in GC cell lines were also explored in our study. In conclusion, our study constructed a prognostic signature of 10 ferroptosis-related genes, which could well predict the prognosis and immunotherapy for GC patients.
Location: United States of America
Location: China
Location: United States of America
Location: United States of America
No related grants have been discovered for Carlos Ramos-Scharron.