ORCID Profile
0000-0002-8584-1591
Current Organisation
Dalian University of Technology
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Publisher: Elsevier BV
Date: 09-2018
Publisher: Elsevier BV
Date: 02-2021
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8CC08061E
Abstract: We report a ratiometric luminescence probe for sensing and imaging of mitochondrial ONOO − based on a ruthenium( ii ) complex–cyanine energy transfer scaffold.
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9DT04614C
Abstract: We report the design, synthesis, and characterization of a responsive Ru( ii ) complex probe for background-free time-gated luminescence detection of bisulfite.
Publisher: American Chemical Society (ACS)
Date: 29-03-2019
DOI: 10.1021/JACS.8B13898
Abstract: Biomedical investigations reveal that excessive formaldehyde generation is possibly a critical factor for tissue cancerization, cancer progression, and metastasis. Responsive molecular probes that can detect lysosomal formaldehyde in live cells and tumors and monitor drug-triggered formaldehyde scavenging contribute potentially to future cancer diagnosis and treatment monitoring. Herein, a novel "dual-key-and-lock" strategy-based ruthenium(II) complex probe, Ru-FA, is reported as an effective tool for formaldehyde detection in vitro and in vivo. Ru-FA shows weak luminescence due to photon-induced electron transfer (PET) process from Ru(II) center to electron withdrawing group 2,4-dinitrobenzene (DNB). Triggered by the specific reaction with formaldehyde (first "key") in an acidic microenvironment (second "key"), DNB is cleaved from Ru-FA, affording an emissive Ru(II) complex derivative, Ru-NR. Spectrometric analysis including steady-state and time-gated luminescence indicates that Ru-FA is favorable to be used as the probe for quantification of formaldehyde in human sera and mouse organs. Ru-FA is biocompatible and cell membrane permeable. Together with its smart "dual-key-and-lock" response to formaldehyde, luminescence imaging of lysosomal formaldehyde in live cells, visualization of tumor-derived endogenous formaldehyde, and monitoring of formaldehyde scavenging in mice were achieved, followed by the successful demonstration on detection of formaldehyde in tumors and other organs. These in vivo and in vitro detection confirm not only the excessive formaldehyde generation in tumors, but also the efficient drug administration to scavenge formaldehyde, demonstrating the potential application of Ru-FA in cancer diagnosis and treatment monitoring through lysosomal formaldehyde detection.
No related grants have been discovered for Bo SONG.