ORCID Profile
0000-0002-6369-4746
Current Organisation
University of Oxford
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Publisher: Springer Science and Business Media LLC
Date: 30-01-2014
Publisher: Springer Science and Business Media LLC
Date: 20-07-2019
Publisher: Wiley
Date: 29-09-2020
DOI: 10.1002/ACR.24030
Abstract: To examine associations between calcaneal enthesophytes and osteoarthritis (OA) in the hands and feet, and to provide insights into the role of biomechanical and systemic processes in the development of OA. Adults ages ≥50 years who were registered with 4 general practices were mailed a Health Survey. Responders reporting foot pain within the last 12 months underwent a detailed assessment, including hand and foot radiographs. Calcaneal enthesophytes (plantar and posterior) and OA features (osteophytes and joint space narrowing) were documented. Associations between enthesophytes and hand and foot OA (including OA phenotypes and OA features at in idual joints) were explored using generalized estimating equations, adjusting for age, sex, and body mass index. Data were available from 532 participants (298 women, mean ± SD age 64.9 ± 8.4 years). Calcaneal enthesophytes were not associated with hand OA phenotypes or OA at in idual hand joints. In contrast, plantar calcaneal enthesophytes were positively associated with polyarticular foot OA (odds ratio [OR] 1.80 [95% confidence interval (95% CI) 1.02-3.17]). When in idual foot joints were examined, posterior enthesophytes were associated with talonavicular joint OA (OR 1.58 [95% CI 1.02-2.44]) and plantar enthesophytes were associated with first metatarsophalangeal joint OA (OR 0.67 [95% CI 0.49-0.98]) and navicular-cuneiform joint OA (OR 2.30 [95% CI 1.40-3.79]). Patterns of association were similar for osteophytes and joint space narrowing. Calcaneal enthesophytes are associated with foot OA but not hand OA. The pattern of association is indicative of a local, biomechanical rather than systemic bone-forming process.
Publisher: Wiley
Date: 20-04-2020
DOI: 10.1002/MSC.1472
Publisher: Oxford University Press (OUP)
Date: 02-2016
Publisher: Oxford University Press (OUP)
Date: 10-09-2018
Publisher: Wiley
Date: 25-01-2016
DOI: 10.1002/ACR.22677
Publisher: Wiley
Date: 25-11-2021
DOI: 10.1002/ACR.24823
Abstract: To identify distinct foot pain trajectories over 7 years and examine their associations with potential prognostic factors. Adults ages ≥50 years and registered with 4 general practices in North Staffordshire, UK were mailed a baseline health survey. Those reporting current or recent foot pain were invited to attend a research assessment clinic. Follow-up was by repeated postal surveys at 18, 36, 54, and 84 months. Distinct trajectories of foot pain were explored using latent class growth analysis (LCGA). Subsequently, identified trajectories were combined into most and least progressive groups, and covariate-adjusted associations with a range of prognostic factors were examined. Of 560 adults with foot pain attending baseline research clinics, 425 (76%) provided data at baseline and 2 or more follow-up time points. LCGA for foot pain severity (0-10 numerical rating scale) identified a 4-trajectory model: "mild, improving" (37%) "moderate, improving" (33%) "moderate-severe, persistent" (24%) and "severe, persistent" (6%). Compared with in iduals in more favorable (improving) pain trajectories, those in less favorable (persistent) pain trajectories were more likely to be obese, have routine/manual and intermediate occupations, have poorer physical and mental health, have catastrophizing beliefs, have greater foot-specific functional limitation, and have self-assessed hallux valgus at baseline. Four distinct trajectories of foot pain were identified over a 7-year period, with one-third of in iduals classified as having pain that is persistently moderate-severe and severe in intensity. The effect of intervening to target modifiable prognostic factors such as obesity and hallux valgus on long-term outcomes in people with foot pain requires investigation.
Publisher: Springer Science and Business Media LLC
Date: 25-01-2019
Publisher: Public Library of Science (PLoS)
Date: 30-04-2018
Publisher: Elsevier BV
Date: 12-2015
Publisher: BMJ
Date: 06-2017
Publisher: Elsevier BV
Date: 2015
Publisher: Wiley
Date: 11-05-2022
DOI: 10.1002/ACR.24582
Abstract: To compare the sensitivity of alternative case finding approaches for the identification of foot osteoarthritis ( OA ) based on the La Trobe radiographic atlas. This was a cross‐sectional study of 533 adults age ≥50 years with foot pain in the past year. Weightbearing dorsoplantar ( DP ) and lateral radiographs were taken of both feet. The La Trobe radiographic atlas was used to document the presence of osteophytes ( OPs ) and joint space narrowing ( JSN ). The prevalence of OA in each joint was documented using both views and features in combination (as recommended in the original atlas), and by using a single view ( DP or lateral only) and a single feature ( OP or JSN only). Compared to the recommended case definition based on OPs and JSN using both views, a DP ‐only view identified between 15% and 77% of OA cases, while a lateral‐only view identified between 28% and 97% of OA cases. Compared to the recommended case definition of using both features, using only OPs identified between 46% and 94% of OA cases, while using only JSN identified between 19% and 76% of OA cases. Applying the La Trobe radiographic atlas but using only 1 radiograph view ( DP or lateral) or 1 feature ( OP or JSN ) in isolation misses a substantial number of OA cases, and the sensitivity of these approaches varies considerably between different foot joints. These findings indicate that, where possible, the atlas should be administered according to the original description to avoid under‐ascertainment of radiographic foot OA .
Publisher: BMJ
Date: 19-11-2013
DOI: 10.1136/ANNRHEUMDIS-2013-203804
Abstract: To estimate the population prevalence of symptomatic radiographic osteoarthritis (OA) affecting the 1st metatarsophalangeal joint (MTPJ), 1st and 2nd cuneometatarsal joints (CMJs), navicular first cuneiform joint (NCJ) and talonavicular joint (TNJ) in community-dwelling older adults. 9334 adults aged ≥50 years registered with four general practices were mailed a health survey. Responders reporting foot pain within the last 12 months were invited to undergo weight-bearing dorso-plantar and lateral radiographs of both feet. OA at the 1st MTPJ, 1st and 2nd CMJs, NCJ and TNJ was graded using a validated atlas. Population prevalence estimates for symptomatic radiographic foot OA overall and for each joint were calculated using multiple imputation and weighted logistic regression modelling to account for missing data and non-response. 5109 health surveys were received (adjusted response 56%). Radiographs were obtained on 557 participants. Overall population prevalence of symptomatic radiographic OA was 16.7% (95% CI 15.3% to 18.0%), 1st MTPJ 7.8% (6.7% to 8.9%), 1st CMJ 3.9% (2.9% to 4.9%), 2nd CMJ 6.8% (5.7% to 7.8%), NCJ 5.2% (4.0% to 6.4%) and TNJ 5.8% (4.8% to 6.9%). With the exception of the 1st CMJ, prevalence was greater in females than males, increased with age and was higher in lower socioeconomic classes. Three-quarters of those with symptomatic radiographic OA reported disabling foot symptoms. While cautious interpretation due to non-response is warranted, our study suggests that symptomatic radiographic foot OA affects one in six older adults and the majority report associated disability. Clinicians should consider OA as a possible cause of chronic foot pain in older people.
Publisher: Wiley
Date: 31-08-2021
DOI: 10.1002/ACR.24754
Abstract: Hallux valgus is a common and disabling condition. The objective of this study was to identify factors associated with hallux valgus incidence and progression. Participants were from a population-based prospective cohort study, the Clinical Assessment Study of the Foot. All adults aged ≥50 years registered with four general practices in North Staffordshire, UK were invited to take part in a postal survey at baseline and at 7-year follow-up which included health questionnaires and self-assessment of hallux valgus using line drawings. Complete baseline and follow-up data were available for 1,482 participants (739 women and 743 men, mean [standard deviation] age 62.9 [8.1] years), of whom 450 (30.4%) had hallux valgus in at least one foot at baseline. Incident hallux valgus was identified in 207 (20.1%) participants (349 [15.4%] feet) and was associated with baseline age, poorer physical health, foot pain and wearing shoes with a very narrow toe-box shape between the age of 20 and 29 years. Hallux valgus progression was identified in 497 (33.6%) participants (719 [24.3%] feet) but was not associated with any baseline factors. Incident hallux valgus develops in one in five adults aged ≥50 years over a 7-year period and is related to age, poorer physical health, foot pain and previous use of constrictive footwear. Progression occurs in one in three adults. These findings suggest that changes in first metatarsophalangeal joint alignment may still occur beyond the age of 50 years.
Publisher: Springer Science and Business Media LLC
Date: 13-07-2015
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Trishna Rathod-Mistry.