ORCID Profile
0000-0002-0949-3222
Current Organisations
Universidade de São Paulo
,
Universidade Estadual de Campinas
,
Universidade Federal de São Carlos
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Publisher: Georg Thieme Verlag KG
Date: 31-01-2022
Abstract: The present article presents a literature review concerning the microbiota of breast milk and the influence of epigenetics in the susceptibility to COVID-19. A literature review. Breastfeeding transfers microbiota, nutrients, erse white blood cells, prebiotics, hormones, and antibodies to the baby, which provide short- and long-term immunological protection against several infectious, gastrointestinal, and respiratory illnesses. The little evidence available shows that breast milk very rarely carries the SARS-CoV-2 virus, and even in those cases, it has been discarded as the source of contagion. The reviewed studies show evidence of a beneficial effect of breastfeeding and highlights its importance on the current pandemic due to the immune reinforcement that it provides. Breastfed in iduals showed better clinical response due to the influence on the microbiota and to the nutritional and immune contribution provided by breast milk, compared with those who were not breastfed.
Publisher: Georg Thieme Verlag KG
Date: 26-03-2018
Abstract: Introduction Previous findings from a pragmatic trial suggest that usual care compared with usual care plus in idualised homeopathy is not a feasible design to address homeopathic interventions for asthma. Objective The main purpose of this article was to investigate the feasibility of the randomised withdrawal design as a strategy to assess the effectiveness of a standardised clinical–pharmaceutical homeopathic protocol (Organon.modus) on perennial asthma in adolescents. Methods Randomised withdrawal, double-blind, parallel, placebo-controlled, 12-week study. Patients: 12 to 17 years old adolescents, with the diagnosis of perennial asthma, using inhalatory beclomethasone (plus fenoterol for wheezing episodes), who achieved 3 months of well-controlled asthma, after a variable period of in idualised homeopathic treatment according to Organon.modus protocol. Setting: a secondary care medical specialist centre. Intervention: continuation with the in idualised homeopathic medicine or with indistinguishable placebo during 12 weeks of beclomethasone step-down. Primary outcome: number of days of well-controlled asthma. Secondary measures: number of days of fenoterol use, number of visits to an emergency service (without hospitalisation) and percentage of patients excluded due to an exacerbation characterising a partly controlled asthma. Tolerability was assessed by Adverse Events, registered at every visit. Results Nineteen patients were randomised to continue treatment with homeopathy and 21 with placebo. Effectiveness measures for the homeopathy and placebo groups respectively were median number of days of good clinical control: 84 versus 30 (p = 0.18) median number of days of fenoterol use per patient: 3 versus 5 (p = 0.41) visits to an emergency room: 1 versus 6 (p = 0.35) percentage of exclusion due to partly controlled asthma: 36.8% versus 71.4% (p = 0.05). Few Adverse Events were reported. Conclusions This pilot study supports the feasibility of the double-blind randomised withdrawal design in studies investigating homeopathy on teenage asthma, when performed by specialists following a standardised clinical–pharmaceutical homeopathic protocol. Clinical Trial Registration RBR-6XTS8Z.
Publisher: Informa UK Limited
Date: 20-04-2021
DOI: 10.1080/09638288.2021.1913650
Abstract: The purpose of this study was to perform a cross-cultural adaptation of the Functional Mobility Scale (FMS) to Brazilian Portuguese and analyse its construct validity and intra-rater reliability in a s le of caregivers of children and adolescents with spina bifida (SB). The cross-cultural adaptation followed five stages: two forward translations, synthesis, back-translation, committee review and pre-testing ( Caregivers reported no difficulties with completing the FMS in Brazilian Portuguese. Construct validity tests showed positive correlations between the distances of 5 m (house), 50 m (school) and 500 m (community) in the FMS and the classifications of Hoffer (τ = 0.84 τ = 0.90 τ = 0.68 The FMS in Brazilian Portuguese showed acceptable intra-rater reliability and construct validity when used to measure the mobility level of patients with SB. We recommend its use in clinical practice and research.Implications for RehabilitationA valid and reliable instrument for assessing the mobility of patients with SB A cross-cultural and adapted FMS in Brazilian Portuguese An instrument for therapeutic and functional approaches outside the clinicalsetting The FMS in the Brazilian Portuguese online version shows mistranslations.
Publisher: Elsevier BV
Date: 06-2022
DOI: 10.1016/J.MIDW.2022.103332
Abstract: To explore the maternal and neonatal factors associated with premature birth and low birth weight in an Ecuadorian tertiary hospital. Cross-sectional study. The Calderón General Teaching Hospital (CGTH). Maternal and delivery characteristics were obtained from medical records. All live births from April 2017 to October 2020 were considered as the source population. The study included 13,407 reported births. The proportion of low birth weight neonates was 12.4%. The frequencies of neonates with gestational ages of less than 34 and from 34 to 37 weeks were 1.8% and 8.8%, respectively. According to INTERGROWTH-21st standards, 14% and 5.5% of the neonates were classified as small- ( 90th centile), respectively. A higher proportion of low birth weight was observed among newborns of illiterate mothers, younger mothers, and with gestational hypertension. The proportion of small-for-gestational-age infants was lower among younger mothers, while large-for-gestational-age infants were more frequent among older mothers. Maternal obesity (proportion ratio [PR] 2.80, 95%CI 1.69 - 4.64), and gestational diabetes (PR 3.24, 95%CI 2.12 - 4.96) were associated with an increased percentage of large-for-gestational-age births. The proportion of low birth weight in Calderón General Teaching Hospital is large compared to those found in studies conducted in Latin America, and the preterm birth rate is close to that estimated in less developed countries. Despite the advances in maternal and child health observed in Ecuador, the present study shows that interventions are still needed in this population.
No related grants have been discovered for Edson Zangiacomi Martinez.