ORCID Profile
0000-0001-8790-4915
Current Organisations
Hasanuddin University Hospital
,
Rumah Sakit Dr Wahidin
,
Universitas Hasanuddin Fakultas Kedokteran
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Publications
Development of Nutrition Education Module during Pregnancy and Evaluation Effectively Increase the Daily Energy Intake, Mid-Upper Arm Circumference, and Body Weight of Adolescent Pregnant Women
Publisher: Scientific Foundation SPIROSKI
Date: 10-03-2022
Abstract: BACKGROUND: The nutritional status and health of pregnant women are determinants of perinatal growth and the welfare of neonates. Therefore, efforts to prevent fetal growth disorders start from the time of pregnancy, one of which is through increasing knowledge of pregnant women. AIM: This study aims to produce educational media products in the form of modules and measures their effectiveness on daily energy intake, mid-upper arm circumference (MUAC), and weight of pregnant women. METHODS: The research method uses the stages of Research and Development. The module development stages consist of product analysis, initial product development, expert test validation (materials and media), small s le trials, and large s le trials. The large s le trial used a quasi-experimental. RESULTS: After receiving education through the module, pregnant women’s daily energy intake increased by 3629.6 kcal, MUAC increased by 2.55 cm, and body weight increased by 7.47 kg, with a significance p 0.05. CONCLUSION: The pregnancy nutrition module is effective in increasing pregnant women’s daily energy intake, MUAC size, and weight. Further research was conducted using the nutrition module during pregnancy as a medium of education on the family approach to increasing pregnant women’s nutritional intake through family and community support.
A cautionary note to hepatitis B e antigen (HBeAg)-negative test results in pregnant women in an area prevalent of HBeAg-negative chronic hepatitis B.
Publisher: Wiley
Date: 14-09-2022
DOI: 10.1002/JMV.28125
Abstract: Maternal hepatitis B e Antigen (HBeAg) positivity poses a risk for hepatitis B virus (HBV) mother-to-child transmission (MTCT). In resource-constrained settings, HBeAg testing is recommended as an alternative to HBV DNA testing to establish antiviral prophylaxis eligibility. Nevertheless, the high prevalence of HBeAg-negative chronic hepatitis B (e-CHB) in many countries should not be overlooked. We studied HBV characteristics and explored the potential MTCT risk among HBeAg-negative/HBsAg-positive expectant mothers in an area prevalent of e-CHB. Among 1,348 pregnant mothers screened for HBV infection, 81 (6.0%) were HBsAg-positive. These women were examined for HBeAg, HBV DNA, and cord blood HBV DNA. Sixteen (19.8%) of the HBsAg-positive mothers were HBeAg-positive, whereas 65 (80.2%) were HBeAg-negative, including eight inactive carriers (HBsAg <100 IU/mL, HBV DNA ≤2,000 IU/mL, and ALT 200,000 IU/mL), which is associated with a high MTCT risk and therefore qualifies them for antiviral prophylaxis. This pilot study provides a cautionary note to the interpretation of negative HBeAg test results when determining eligibility for MTCT antiviral prophylaxis in situations with limited resources and in regions where e-CHB is prevalent. This article is protected by copyright. All rights reserved.
Association of Toll-Like Receptor 2 (TLR2) Expression in Placenta and Intrauterine Exposure to Hepatitis B Virus
Publisher: Hindawi Limited
Date: 13-07-2022
DOI: 10.1155/2022/4838376
Abstract: Introduction. The placenta is a specialized organ that only performs during pregnancy and serves as an immunological barrier in preventing pathogens to reach the fetus. It has been known that toll-like receptors (TLRs) on the placenta respond to antigens, such as zymosan, lipopolysaccharide, and other viral infections. This study analyzes the distribution of TLR2 protein and hepatitis B DNA virus (HBV DNA) virus identification to gain an understanding of hepatitis B viral transmission from the mother to child. Methods. We performed enzyme-linked immunoadsorbent assay of HBeAg, HBsAg titer, Anti-HBs, and Anti-HBc to 59 HBsAg-positive pregnant women and identified HBV DNA using nested PCR in their cord blood during delivery for evidence of exposure to HBV DNA. The expression of TLR2 protein in the placenta was performed using immunohistochemistry analysis. Results. Intrauterine exposure to the hepatitis B virus occurred in 69.5% of all pregnant women who were HbsAg positive. TLR2 expression was predominantly identified in syncytiotrophoblast and cytotrophoblast cells with the highest score in mothers aged 20–35 years (75%), multigravida (58.3%), and mothers with term pregnancies (70.8%). Statistical analysis results showed that placental TLR2 expression did not indicate any association with hepatitis B virus DNA identified in cord blood with a p value of 0.730 and an OR of 0.650 (95% CI 0.173–2.440). Conclusion. TLR2 expression is not associated with intrauterine exposure of hepatitis B virus.
Related Organisations
The Geneva Foundation For Medical Education And Research
Location: Switzerland
Related Funding Activities
No related grants have been discovered for Maisuri Chalid.