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0000-0003-4279-3443
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University of Wollongong
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Applied Ethics | Bioethics (human and animal) | Ethical Use of New Technology (e.g. Nanotechnology, Biotechnology) | Environmental Philosophy
Publisher: Research Square Platform LLC
Date: 16-06-2022
DOI: 10.21203/RS.3.RS-1745613/V1
Abstract: Background Refugee and migrant women are at higher risk of childbirth complications and generally poorer pregnancy outcomes. They also report lower satisfaction with pregnancy care because of language barriers, perceived negative attitudes among service providers, and a lack of understanding of refugee and migrant women’s needs. This study juxtaposes health policy expectations in New South Wales (NSW), Australia on pregnancy and maternity care and cultural responsiveness and the experiences of maternal healthcare providers in their day-to-day work with refugee and migrant women. Methods This study used a qualitative framework method. Sixteen maternal health service providers who work with refugee and migrant women were recruited from two local health districts in New South Wales, Australia and interviewed (November 2019 to August 2020) about their experiences and the challenges they faced. In addition, a systematic search was conducted for policy documents related to the provision of maternal health care to refugee and migrant women on a state and federal level. Five policies were included in the analysis. The framework method matrix allowed for a comparison of providers’ experiences with the policy expectations. Results Framework analysis revealed structural barriers to culturally responsive service provision and the differential impacts of implementation gaps that impede appropriate care resulting in moral distress. Rather than being the programmatic outcome of well-resourced policies, the enactment of cultural responsiveness in the settings studied relied primarily on the intuitions and personal responses of in idual service providers such as nurses and social workers. Conclusion Authentic culturally responsive care requires healthcare organisations to do more than provide staff training. To better promote service user and staff satisfaction and wellbeing, organisations need to embed structures to respond to the needs of refugee and migrant communities in the maternal health sector and beyond.
Publisher: Public Library of Science (PLoS)
Date: 30-10-2019
Publisher: Elsevier BV
Date: 12-2022
Publisher: MDPI AG
Date: 15-01-2023
DOI: 10.3390/BUILDINGS13010245
Abstract: In this study, the preliminary serviceability performance of cross-laminated timber (CLT) panels constructed from fibre-managed Eucalyptus nitens (E. nitens) was investigated via bending and vibration tests. Linear four-point bending tests were performed to determine the stiffness and deflection of all CLT panels under serviceability loads. The dynamic response of CLT panels was tested using a basketball and an accelerometer. The fundamental natural frequencies of all tested panels were above the minimum frequency limit (8 Hz) when extrapolated to spans of up to 4.4 m. The configurations of E. nitens CLT panels were based on different modulus of elasticity (MOE) values for each board. Using higher MOE timber boards as the top and bottom layers can significantly increase the serviceability performance of both bending and vibration tests. The same experiments were carried out on two CLT panels made of strength class C24 Spruce-Pine-Fir to compare the serviceability performance of E. nitens CLT. The results demonstrated that E. nitens is a reliable resource for CLT manufacturing, and exhibits better serviceability performance compared to Spruce CLT. This provides more sustainable options for a species traditionally destined for pulp.
Publisher: Wiley
Date: 22-02-2023
DOI: 10.1111/HEX.13734
Abstract: Transvaginal mesh (mesh) surgeries have been used to treat stress urinary incontinence (incontinence) and/or pelvic organ prolapse (prolapse). In Australia, as in many other countries, the harms caused by mesh eventually prompted in idual and collective attempts to achieve redress. The rise of mesh surgery as a procedure, the experience of mesh‐affected women and the formal inquiries and legal actions that followed all occurred in social, cultural and discursive contexts. One strategy to understand these contexts is to track how the mesh and key actors in the mesh stories have been portrayed in mass media sources. We conducted a media analysis of the most highly read Australian newspapers and online news media platforms, focusing on how mesh and the interaction of stakeholders in mesh stories were presented to the Australian public. We searched systematically in the top 10 most‐read print and online media outlets in Australia. We included all articles that mentioned mesh, from the date of first use of mesh in Australia to the date of our final search (1996–2021). After early scant media reporting focusing on the benefits of mesh procedures, major Australian medicolegal processes created a hook to shift reporting about mesh. The news media then played a significant role in redressing women's experienced epistemic injustice, including by lifying previously ignored evidence of harm. This created an opportunity for previously unreported suffering to be revealed to powerful actors, in settings beyond the immediate control and epistemic authority of healthcare stakeholders, validating women's testimony and creating new hermeneutic resources for understanding mesh. Over time, media reports show healthcare stakeholders responding sympathetically to these new understandings in public discourse, contrasting with their statements in earlier media coverage. We argue that mass media reporting, in synergy with medicolegal actions and the Australian Senate Inquiry, appears to have provided women with greater epistemic justice, giving their testimony privileged epistemic status such that it was considered by powerful actors. Although medical reporting is not recognised in the hierarchy of evidence embedded in the medical knowledge system, in this case, media reporting appears to have contributed to shaping medical knowledge in significant ways. We used publicly available data, print and online media outlets, for our analysis. Therefore, this manuscript does not contain the direct contribution of patients, service users, caregivers, people with lived experience or members of the public.
Publisher: SAGE Publications
Date: 19-08-2016
Abstract: General practitioners have implicitly been given responsibility for guiding men’s decisions about prostate-specific antigen–based screening for prostate cancer, but patients’ expectations of the bounds of this responsibility remain unclear. We sought to explore how well-informed members of the public allocate responsibilities in prostate-specific antigen screening decision-making. In 2014, we convened two Community juries in Sydney, Australia, to address questions related to the content and timing of information provision and respective roles of patients and general practitioners in screening decisions. Participants in the first jury were of mixed gender and of all ages (n = 15) the participants in the second jury were all male and of screening age (n = 12). Both juries were presented with balanced factual evidence on the harms and benefits of prostate-specific antigen screening and expert perspectives on ethico-legal aspects of consent in medical practice. In their deliberations, jurors agreed that general practitioners should take responsibility for informing men of the options, risks and benefits of prostate-specific antigen testing, but arrived at different positions on whether or not general practitioners should also guide screening decisions. Jurors also disagreed on how much and when general practitioners should provide detailed information about biopsies and treatments. These responses suggest that for prostate-specific antigen testing, there is a public expectation that both the allocation of responsibility between general practitioners and their male patients, and the level of information provided will be tailored to in idual men. In the presence of expert uncertainty, a well-informed public may have reason to embrace or resist shared decision-making processes.
Publisher: Springer Science and Business Media LLC
Date: 13-09-2019
Publisher: Elsevier BV
Date: 11-2022
Publisher: Springer Science and Business Media LLC
Date: 08-03-2008
Publisher: Springer Science and Business Media LLC
Date: 26-07-2022
DOI: 10.1186/S12992-022-00850-4
Abstract: The emergence of SARS-CoV-2 and the subsequent COVID-19 pandemic has resulted in significant global impact. However, COVID-19 is just one of several high-impact infectious diseases that emerged from wildlife and are linked to the human relationship with nature. The rate of emergence of new zoonoses (diseases of animal origin) is increasing, driven by human-induced environmental changes that threaten bio ersity on a global scale. This increase is directly linked to environmental drivers including bio ersity loss, climate change and unsustainable resource extraction. Australia is a bio ersity hotspot and is subject to sustained and significant environmental change, increasing the risk of it being a location for pandemic origin. Moreover, the global integration of markets means that consumption trends in Australia contributes to the risk of disease spill-over in our regional neighbours in Asia-Pacific, and beyond. Despite the clear causal link between anthropogenic pressures on the environment and increasing pandemic risks, Australia’s response to the COVID-19 pandemic, like most of the world, has centred largely on public health strategies, with a clear focus on reactive management. Yet, the span of expertise and evidence relevant to the governance of pandemic risk management is much wider than public health and epidemiology. It involves animal/wildlife health, biosecurity, conservation sciences, social sciences, behavioural psychology, law, policy and economic analyses to name just a few. The authors are a team of multidisciplinary practitioners and researchers who have worked together to analyse, synthesise, and harmonise the links between pandemic risk management approaches and issues in different disciplines to provide a holistic overview of current practice, and conclude the need for reform in Australia. We discuss the adoption of a comprehensive and interdisciplinary ‘One Health’ approach to pandemic risk management in Australia. A key goal of the One Health approach is to be proactive in countering threats of emerging infectious diseases and zoonoses through a recognition of the interdependence between human, animal, and environmental health. Developing ways to implement a One Health approach to pandemic prevention would not only reduce the risk of future pandemics emerging in or entering Australia, but also provide a model for prevention strategies around the world.
Publisher: BMJ
Date: 11-03-2022
DOI: 10.1136/ANNRHEUMDIS-2021-222083
Abstract: Factors predicting axial spondyloarthritis (axSpA) among first-degree relatives (FDRs) of ankylosing spondylitis (AS) patients need to be defined. We investigated the predictive value of the probands’ HLA-B27 and radiographic sacroiliitis status on disease occurrence among their FDR. We also assessed the predictive value of features of the clinical history, including chronic inflammatory back pain (CIBP) and acute anterior uveitis (AAU), among the FDR and how they can be used to improve classification and diagnosis of axSpA. In 1985, we studied 363 AS probands and 806 FDR who underwent rheumatologic examination, completed questionnaires, provided blood s les for HLA-typing and underwent radiography of sacroiliac joints. At follow-up in 2018–2019, 125 patients and 360 FDR were available for study, and completed a postal questionnaire about axSpA features. FDRs were asked to report whether after 1985 they had been diagnosed by Swiss rheumatologists as having axSpA. Among HLA-B27(+) FDR, axSpA occurred in 25.4%–26.3%, independent of the radiographic sacroiliitis status of the proband. AAU occurred in 13/34 (38.2%) FDR with axSpA vs 29/251 (11.6%) FDR without axSpA (p = 0.00004, OR=4.74 95% CI 2.15 to 10.47). The presence of CIBP at baseline did not predict later occurrence of axSpA but combining CIBP and pain/discomfort at the thoracic spine and at anterior (ventral) chest wall ever, assessed at follow-up in 2018–2019, provided 83.1% sensitivity and 87.2% specificity for current axSpA. Occurrence of AAU among FDR of axSpA probands should prompt screening for axSpA. Moreover, co-occurrence of CIBP and pain/discomfort in the thoracic spine and at anterior chest wall as a three-question tool may further enhance clinical suspicion of axSpA among these FDR.
Publisher: Springer Science and Business Media LLC
Date: 22-08-2017
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 08-2004
DOI: 10.1109/TKDE.2004.29
Publisher: MDPI AG
Date: 21-02-2019
DOI: 10.3390/F10020194
Abstract: The use of fast-growing plantation eucalypt (i.e., pulpwood eucalypt) in the construction of high-value structural products has received special attention from the timber industry in Australia and worldwide. There is still, however, a significant lack of knowledge regarding the physical and mechanical properties of the lumber from such plantation resources as they are mainly being managed to produce woodchips. In this study, the physical and mechanical properties of lumber from a 16-year-old pulpwood Eucalyptus nitens H.Deane & Maiden resource from the northeast of Tasmania, Australia was evaluated. The tests were conducted on 318 small wood s les obtained from different logs harvested from the study site. The tested mechanical properties included bending modulus of elasticity (10,377.7 MPa) and modulus of rupture (53 MPa), shear strength parallel (5.5 MPa) and perpendicular to the grain (8.5 MPa), compressive strength parallel (42.8 MPa) and perpendicular to the grain (4.1 MPa), tensile strength perpendicular to the grain (3.4 MPa), impact bending (23.6 J/cm2), cleavage (1.6 kN) and Janka hardness (23.2 MPa). Simple linear regression models were developed using density and moisture content to predict the mechanical properties. The variations in the moisture content after conventional kiln drying within randomly selected s les in each test treatment were not high enough to significantly influence the mechanical properties. A relatively high variation in the density values was observed that showed significant correlations with the changes in the mechanical properties. The presence of knots increased the shear strength both parallel and perpendicular to the grain and significantly decreased the tensile strength of the lumber. The results of this study created a profile of material properties for the pulpwood E. nitens lumber that can be used for numerical modelling of any potential structural product from such a plantation resource.
Publisher: Wiley
Date: 13-07-2023
DOI: 10.1111/BIOE.13202
Abstract: In the past decade, numerous ethical frameworks have been developed to support public health decision‐making in challenging areas. Before the COVID‐19 pandemic began, members of the authorship team were involved in research programmes, in which the development of ethical frameworks was planned, to guide (a) the use of new technologies for emerging infectious disease surveillance and (b) the allocation of scarce supplies of pandemic influenza vaccine. However, as the pandemic evolved, significant practical challenges emerged that led to our questioning the value of these frameworks. We now believe that a normative instrument, such as a framework, cannot adequately or reliably provide the ethical guidance that needs to be incorporated into public health decision‐making during natural disasters or infectious disease emergencies. Recently it has been suggested that there are potentially more dynamic, flexible, and effective ways to navigate decisions involving complex considerations entailed in policies and practices during a public health emergency. In this paper, we first outline the key functions of a public health ethics framework, before describing why we believe it would not be fit for purpose during a crisis. We end by considering whether proposed alternative methods to promote ethical public health decision‐making goals have the potential to meet these objectives.
Publisher: Springer Science and Business Media LLC
Date: 18-07-2023
Publisher: BMJ
Date: 05-2022
DOI: 10.1136/RMDOPEN-2022-002302
Abstract: Axial spondyloarthritis (axSpA) comprises both radiographic and non-radiographic disease. However, the paucity of specific objective measures for the disease and current classification criteria showing suboptimal specificity contribute to disease heterogeneity observed in clinical practice and research. We used a historical cohort of patients with axSpA to assess sources of heterogeneity. The study involved 363 axSpA probands recruited from membership of the Swiss Ankylosing Spondylitis Patient Society. Participants underwent examination by a rheumatologist, completed questionnaires and provided blood s les for HLA typing. Patients underwent radiography of sacroiliac joints and were categorised according to the New York (NY) criteria (ankylosing spondylitis (AS) or non-radiographic axSpA (nr-axSpA)) and HLA-B27 status. Genetic characterisation by single nucleotide polymorphism microarray was performed and AS polygenic risk scores (PRS) were calculated. Considerable heterogeneity was observed. The male to female ratio for AS (NY+) was 3:1, but 1:1 for nr-axSpA. For HLA-27(+) AS, the ratio was 2.5:1, but nearly 1:1 for HLA-B27(−) disease. Women with nr-axSpA had strikingly lower mean PRS and lower HLA-B27 prevalence than men with nr-axSpA or NY(+) male and female patients with AS. PRS was able to distinguish male but not female patients with nr-axSpA from related healthy first-degree relatives. Radiographic sacroiliitis was strongly associated with HLA-B27, especially in men. Women clinically diagnosed with axSpA but without radiographic sacroiliitis as a group have a disease that is distinct from AS by the modified New York criteria overall and from nr-axSpA in men. Given the high degree of heterogeneity, stratified or adjusted analysis of effectiveness studies is indicated, taking genetics, sex and radiographic damage (sacroiliitis) into account.
Publisher: Wiley
Date: 12-03-2019
DOI: 10.1111/HEX.12880
Publisher: Oxford University Press (OUP)
Date: 1992
Publisher: Elsevier BV
Date: 06-1996
Publisher: Springer Science and Business Media LLC
Date: 12-2013
Publisher: BMJ
Date: 30-01-2019
DOI: 10.1136/BMJ.L351
Publisher: Public Library of Science (PLoS)
Date: 14-01-2022
DOI: 10.1371/JOURNAL.PONE.0261917
Abstract: Social and behavioural drivers of inappropriate antibiotic use contribute to antimicrobial resistance (AMR). Recent reports indicate the Australian community consumes more than twice the defined daily doses (DDD) of antibiotics per 1000 population than in Sweden, and about 20% more than in the United Kingdom (UK). We compare measures of public knowledge, attitudes and practices (KAP) surrounding AMR in Australia, the UK and Sweden against the policy approaches taken in these settings to address inappropriate antibiotic use. National antimicrobial stewardship policies in Australia, Sweden, and the UK were reviewed, supplemented by empirical studies of their effectiveness. We searched PubMed, EMBASE, PsycINFO, Web of Science and CINAHL databases for primary studies of the general public’s KAP around antibiotic use and AMR in each setting (January 1 2011 until July 30 2021). Where feasible, we meta-analysed data on the proportion of participants agreeing with identical or very similar survey questions, using a random effects model. Policies in Sweden enact tighter control of community antibiotic use reducing antibiotic use through public awareness raising is not a priority. Policies in the UK and Australia are more reliant on practitioner and public education to encourage appropriate antibiotic use. 26 KAP were included in the review and 16 were meta-analysable. KAP respondents in Australia and the UK are consistently more likely to report beliefs and behaviours that are not aligned with appropriate antibiotic use, compared to participants in similar studies conducted in Sweden. Interactions between public knowledge, attitudes and their impacts on behaviours surrounding community use of antibiotics are complex and contingent. Despite a greater focus on raising public awareness in Australia and the UK, neither antibiotic consumption nor community knowledge and attitudes are changing significantly. Clearly public education c aigns can contribute to mitigating AMR. However, the relative success of policy approaches taken in Sweden suggests that practice level interventions may also be required to activate prescribers and the communities they serve to make substantive reductions in inappropriate antibiotic use.
Publisher: BMJ
Date: 04-10-2011
DOI: 10.1136/MEDETHICS-2011-100086
Abstract: Since the 1990s, glycated haemoglobin (HbA1C) has been the gold standard for monitoring glycaemic control in people diagnosed as having either type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM). Discussions are underway about diagnosing diabetes mellitus on the basis of HbA1C titres and using HbA1C tests to screen for T2DM. These discussions have focused on the relative benefits for in idual patients, with some attention directed towards reduced costs to healthcare systems and benefits to society. We argue that there are strong ethical reasons for adopting HbA1C-based diagnosis and T2DM screening that have not yet been articulated. The rationale includes the differential impact of HbA1C-based diabetic testing on disadvantaged groups, and what we are beginning to learn about HbA1C vis-à-vis population health. Although it is arguable that screening must primarily benefit the in idual, using HbA1C to diagnose and screen for T2DM may promote a more just distribution of health resources and lead to advances in investigating, monitoring and tackling the social determinants of health.
Publisher: Informa UK Limited
Date: 14-05-2009
Publisher: Elsevier BV
Date: 2022
DOI: 10.2139/SSRN.4129747
Publisher: Public Library of Science (PLoS)
Date: 10-10-2019
Publisher: Elsevier BV
Date: 02-2021
Publisher: Springer Berlin Heidelberg
Date: 2006
DOI: 10.1007/11871842_50
Publisher: Springer Berlin Heidelberg
Date: 2003
Publisher: Cambridge University Press (CUP)
Date: 25-07-2019
DOI: 10.1017/S136898001900185X
Abstract: There is an urgent need to identify and develop cross-sectoral policies which promote and support a healthy, safe and sustainable food system. To help shape the political agenda, a critical first step is a shared definition of such a system among policy makers across relevant sectors. The aim of the present study was to determine how Australian policy actors define, and contribute to, a healthy, safe and sustainable food system. A Delphi survey, consisting of two rounds, was conducted. Participants were asked how they define, and contribute to, a healthy, safe and sustainable food system (Round 1) and indicate their level of agreement with summary statements (Round 2). This was an online Delphi survey conducted in Australia. Twenty-nine and fourteen multisectoral and multilevel policy makers completed Round 1 and Round 2, respectively. The definition included food processing regulation, environmentally friendly food production and access to nutritious food. All agreed that it was important for them to improve access and supply of healthy food and ensure healthy planning principles are applied. There were cross-sectoral differences in definitions and contributions however, critical consensus was achieved. The study contributes to the definition of key elements of a cross-sectoral food and nutrition policy to meet today’s environmental, health, social and economic challenges however, further research using a more representative multisectoral s le is warranted.
Publisher: Elsevier BV
Date: 04-2017
DOI: 10.1016/J.SOCSCIMED.2017.03.003
Abstract: Citizens'/community juries [CJs] engage members of the public in policy decision-making processes. CJs can be employed to develop policy responses to health problems that require the consideration of both community values and scientific evidence. Based on the principles of deliberative democracy, recent reviews indicate that findings from CJs have successfully been used to influence health policy decision-making. Despite this evidence of success, there appears to be a gap between the goals of health researchers who organize CJs and the needs of policy actors and decision makers. Drawing on our experiences working with CJs and recent research on CJ methods, we describe a synopsis of the current state of the art organized around four key questions, and informed by insights from deliberative theory and critical policy studies. Our intention is to stimulate further discussion as to the types of health policy questions that can be usefully addressed through public deliberation, and provide guidance on the methodological and political dimensions that need to be considered in deciding whether a CJ is an appropriate approach for informing a policy decision-making process.
Publisher: Informa UK Limited
Date: 09-2011
Publisher: BMJ
Date: 08-07-2016
DOI: 10.1136/MEDETHICS-2015-102928
Abstract: Overdiagnosis is an emerging problem in health policy and practice: we address its definition and ethical implications. We argue that the definition of overdiagnosis should be expressed at the level of populations. Consider a condition prevalent in a population, customarily labelled with diagnosis A. We propose that overdiagnosis is occurring in respect of that condition in that population when (1) the condition is being identified and labelled with diagnosis A in that population (consequent interventions may also be offered) (2) this identification and labelling would be accepted as correct in a relevant professional community but (3) the resulting label and/or intervention carries an unfavourable balance between benefits and harms. We identify challenges in determining and weighting relevant harms, then propose three central ethical considerations in overdiagnosis: the extent of harm done, whether harm is avoidable and whether the primary goal of the actor/s concerned is to benefit themselves or the patient, citizen or society. This distinguishes predatory (avoidable, self-benefiting), misdirected (avoidable, other-benefiting) and tragic (unavoidable, other-benefiting) overdiagnosis the degree of harm moderates the justifiability of each type. We end with four normative challenges: (1) methods for adjudicating between professional standards and identifying relevant harms and benefits should be procedurally just (2) in iduals, organisations and states are differently responsible for addressing overdiagnosis (3) overdiagnosis is a matter for distributive justice: the burdens of both overdiagnosis and its prevention could fall on the least-well-off and (4) communicating about overdiagnosis risks harming those unaware that they may have been overdiagnosed. These challenges will need to be addressed as the field develops.
Publisher: BMJ
Date: 16-02-2019
DOI: 10.1136/MEDETHICS-2018-105043
Abstract: Emerging infectious diseases (EIDs) remain a significant and dynamic threat to the health of in iduals and the well-being of communities across the globe. Over the last decade, in response to these threats, increasing scientific consensus has mobilised in support of a One Health (OH) approach so that OH is now widely regarded as the most effective way of addressing EID outbreaks and risks. Given the scientific focus on OH, there is growing interest in the philosophical and ethical dimensions of this approach, and a nascent OH literature is developing in the humanities. One of the key issues raised in this literature concerns ethical frameworks and whether OH merits the development of its very own ethical framework. In this paper, we argue that although the OH approach does not demand a new ethical framework (and that advocates of OH can coherently adhere to this approach while deploying existing ethical frameworks), an OH approach does furnish the theoretical resources to support a novel ethical framework, and there are benefits to developing one that may be lost in its absence. We begin by briefly explaining what an OH approach to the threats posed by EIDs entails before outlining two different ways of construing ethical frameworks. We then show that although on one account of ethical frameworks there is no need for OH to generate its own, there may be advantages for its advocates in doing so.
Publisher: SAGE Publications
Date: 03-2011
Publisher: MDPI AG
Date: 02-09-2017
DOI: 10.3390/ANI7090068
Publisher: Informa UK Limited
Date: 04-2015
Publisher: SAGE Publications
Date: 03-2000
DOI: 10.2190/N0VV-0P48-XJ9G-F8WV
Abstract: It is widely agreed that learning to program is difficult. Program visualization tools make visible aspects of program execution which are often hidden from the user. While several program visualization tools aimed at novice programmers have been developed over the past decade there is little empirical evidence showing that novices actually benefit from their use [1]. In this article we describe a “Glass-box Interpreter” called Bradman. An experiment is presented which tests the efficacy of Bradman in assisting novice programmers learn programming concepts. We show that students that used the glass-box interpreter achieved greater understanding of some programming concepts than those without access. We also give evidence that the student's ability to assimilate new concepts was enhanced by exposure to the glass-box interpreter. This is experimental confirmation that such tools are beneficial in helping novices learn programming.
Publisher: MDPI AG
Date: 10-11-2020
DOI: 10.3390/F11111189
Abstract: Thermo-hydro mechanical (THM) treatments and thermo-treatments are used to improve the properties of wood species and enhance their uses without the application of chemicals. This work investigates and compares the effects of THM treatments on three timber species from Tasmania, Australia plantation fibre-grown shining gum (Eucalyptus nitens H. Deane and Maiden), plantation saw-log radiata pine (Pinus radiata D. Don) and native-grown saw-log timber of the common name Tasmanian oak (which can be any of E. regnans F. Muell, E. obliqua L’Hér and E. delegatensis L’Hér). Thin lamellae were compressed by means of THM treatment from 8 mm to a target final thickness of 5 mm to investigate the suitability for using THM-treated lamellas in engineered wood products. The springback, mass loss, set-recovery after soaking, dimensional changes, mechanical properties, and Brinell hardness were used to evaluate the effects of the treatment on the properties of the species. The results show a marked increase in density for all three species, with the largest increase presented by E. nitens (+53%) and the smallest by Tasmanian oak (+41%). E. nitens displayed improvements both in stiffness and strength, while stiffness decreased in P. radiata s les and strength in Tasmanian oak s les. E. nitens also displayed the largest improvement in hardness (+94%) with respect to untreated s les. P. radiata presented the largest springback whilst having the least mass loss. E. nitens and Tasmanian oak showed similar dimensional changes, whilst P. radiata timber had the largest thickness swelling and set-recovery due to the high water absorption (99%). This study reported the effects of THM treatments in less-known and commercially important timber species, demonstrating that the wood properties of a fibre-grown timber can be improved through the treatments, potentially increasing the utilisation of E. nitens for structural and higher quality timber applications.
Publisher: MDPI AG
Date: 13-10-2022
Abstract: The 2019–2020 Australian bushfires followed by the COVID-19 pandemic brought the significant mental health implications of working in healthcare to the fore. The importance of appropriate support services to ensure the resilience and recovery of healthcare workers has been highlighted. In response to healthcare staff experiences during the bushfires, the SEED Wellness Program was created in 2020 in the Illawarra Shoalhaven Local Health District in New South Wales, Australia. SEED used a participant-led design to engage healthcare staff in workplace-based restorative activities. Guided by practice theory, this study aimed to identify and describe SEED wellness practices that supported healthcare staff. Thirty-three healthcare workers participated in focus groups or in idual interviews between June 2021 and March 2022. The analysis involved inductive thematic in idual and collective exploration of SEED practices, including co-analysis with participants. Eight core practices that supported participants’ wellbeing were identified, including responsive and compassionate leading, engaging staff at every stage of the recovery process, creating a sense of connection with others, and collective caring. The study found that workplace wellness initiatives are optimised when they are place-based and grounded in local knowledge, needs, and resources incorporating a collective and supportive team approach. Moreover, to ensure engagement in, and sustainability of these initiatives, both bottom-up and top-down commitment is required.
Publisher: Oxford University Press (OUP)
Date: 03-02-2010
DOI: 10.1093/BIOINFORMATICS/BTQ043
Abstract: Motivation: The caspase family of cysteine proteases play essential roles in key biological processes such as programmed cell death, differentiation, proliferation, necrosis and inflammation. The complete repertoire of caspase substrates remains to be fully characterized. Accordingly, systematic computational screening studies of caspase substrate cleavage sites may provide insight into the substrate specificity of caspases and further facilitating the discovery of putative novel substrates. Results: In this article we develop an approach (termed Cascleave) to predict both classical (i.e. following a P1 Asp) and non-typical caspase cleavage sites. When using local sequence-derived profiles, Cascleave successfully predicted 82.2% of the known substrate cleavage sites, with a Matthews correlation coefficient (MCC) of 0.667. We found that prediction performance could be further improved by incorporating information such as predicted solvent accessibility and whether a cleavage sequence lies in a region that is most likely natively unstructured. Novel bi-profile Bayesian signatures were found to significantly improve the prediction performance and yielded the best performance with an overall accuracy of 87.6% and a MCC of 0.747, which is higher accuracy than published methods that essentially rely on amino acid sequence alone. It is anticipated that Cascleave will be a powerful tool for predicting novel substrate cleavage sites of caspases and shedding new insights on the unknown caspase-substrate interactivity relationship. Availability: sunflower.kuicr.kyoto-u.ac.jp/∼sjn/Cascleave/ Contact: jiangning.song@med.monash.edu.au takutsu@kuicr.kyoto-u.ac.jp james whisstock@med.monash.edu.au Supplementary information: Supplementary data are available at Bioinformatics online.
Publisher: Springer Science and Business Media LLC
Date: 24-07-2020
DOI: 10.1038/S41598-020-69316-0
Abstract: Community perspectives are rarely sought or integrated into dog management policy and practice. Dog management in remote communities in Australia has focused on reducing the number of dogs, which is often implemented by visiting veterinarians, despite widely-held opinions that fly-in-fly-out services provide only temporary solutions. We conducted participatory research in a group of remote communities in northern Australia to explore how dog-related problems arise and are managed, and explain their impacts from a One Health perspective. Over the course of a year, 53 residents from a range of backgrounds contributed through in-depth interviews with key community service providers, and informal semi-structured discussions with community residents. Free-roaming dogs have broader impacts on canine and human health than previously documented. Dog-keeping norms that enable free-roaming can enhance human and dog wellbeing and intra-family connectivity. This can also cause disengagement and conflict with other residents, leading to resentment and occasionally violence towards dogs. Dog-related problems are underpinned by constraints associated with remote-living, governance and differing sociocultural norms. Focusing on dog population reduction detracts from the welfare benefits and sociocultural value of free-roaming dogs and undermines community-determined management that can overcome constraints to support local values and co-promote canine and human wellbeing.
Publisher: Springer Science and Business Media LLC
Date: 12-2015
Publisher: Elsevier BV
Date: 12-2009
DOI: 10.1016/J.ENDEAVOUR.2009.09.004
Abstract: Orthopaedists have long found hip fractures to be a significant source of clinical uncertainty and professional disagreement. For much of the nineteenth century, surgeons were happy to follow Sir Astley Cooper's directive to 'treat the patient and let the fracture go'. Most sufferers were elderly, near the end of their lives and at significant risk from morbid complications. This palliative posture was further justified by a substantial corpus of medical evidence. Any attempt at therapeutic innovation was unwarranted because clinical experience, post-mortem studies and animal experiments indicated that fractures within the hip joint never healed. Yet as there were isolated cases of intra-capsular healing, surgeons such as Nicholas Senn began to contest this evidence. To his consternation, as he tried to demonstrate the possibility of restorative treatments, Senn found the fundamental problem with hip fractures was that the empiricism of current clinical methods created and perpetuated their own therapeutic justifications.
Publisher: Wiley
Date: 28-05-2017
DOI: 10.1111/AVJ.12590
Abstract: To determine what veterinary students in Australia and New Zealand consider important competences in companion animal welfare and ethics (AWE) required on their first day of practice, and to explore how their priorities relate to gender and stage of study. Undergraduate students at all veterinary schools in Australia and New Zealand were sent an online survey. A subset of questions required participants to rank the importance of preselected AWE topics pertaining to companion animals. Data were analysed to determine differences in the way students of different gender or academic stage prioritised each of these AWE topics. Of 3220 currently enrolled students, 851 participated in the survey: 79% were female, 17% male, 4% unspecified. Ranking of the AWE topics, from highest to lowest importance, was: neutering, companion animal husbandry, euthanasia, behaviour and training, animal breeding, over-servicing in relation to animal needs and cosmetic surgery. Female students consistently ranked competency in AWE issues surrounding neutering more highly than male students (P = 0.006). Students in senior years of study ranked the importance of competency in animal abuse/hoarding (P = 0.048), shelter medicine (P = 0.012) and animal breeding (P = 0.002) less highly than those in junior years. Australasian veterinary students placed more importance on competency in AWE issues associated with clinical practice (such as neutering and euthanasia) than on professional behaviours (such as over-servicing and animal breeding). However, we consider that emphasis should still be placed on developing graduate competency in the latter categories to reflect growing societal concerns about companion animal over-supply and inappropriate professional conduct.
Publisher: Oxford University Press (OUP)
Date: 13-03-2019
Publisher: BMJ
Date: 04-03-2015
DOI: 10.1136/BMJ.H869
Publisher: Elsevier BV
Date: 05-2021
Publisher: BMJ Publishing Group Ltd
Date: 12-2019
Publisher: Elsevier BV
Date: 10-2020
Publisher: BMJ
Date: 07-2022
DOI: 10.1136/RMDOPEN-2022-002208
Abstract: The lifetime recurrence rate (RR) of axial spondyloarthritis (axSpA) among first-degree relatives (FDR) and the effect of proband’s gender, HLA-B27 and radiographic status is unclear. Our 35-year-follow-up family study has enabled these issues to be addressed. In 1985, 363 ankylosing spondylitis (AS) probands (members of the Swiss AS Patient Society) and 806 FDR recruited into the study, completed questionnaires regarding axSpA manifestations, underwent a physical examination and most also underwent pelvic radiography and HLA-B27 typing. At follow-up in 2018–2019, of the former participants whose current addresses could be retrieved, 162 had died and 485 (125 patients with AS plus 360 FDR) completed a postal questionnaire. At follow-up, 48 of 177 HLA-B27(+) FDR had developed axSpA, an RR of 27.1% (95% CI 20.6% to 33.7%). 27/148 (18.2%) children of AS probands (modified New York (mNY) criteria) were affected versus 2/50 (4.0%) children of non-radiographic axSpA probands (p=0.0138, OR=5.36 95% CI 1.23 to 23.40). Children of female probands were more often affected (12/22 54.5%) than of male probands (15/78 19.2%) (p=0.0003 OR=4.89 95% CI 1.96 to 12.23). This increased risk applies equally to sons and daughters. The lifetime RR of axSpA for HLA-B27(+) FDR is substantial (27.1%), and disease severity (as defined by radiographic sacroiliitis by the mNY criteria) is an additional risk factor. Affected mothers pass on the disease significantly more often to their offspring than do affected fathers. These findings may lead to better assessment of lifetime risk for axSpA in the offspring. Moreover, investigation of this gender effect may uncover additional putative disease susceptibility factors.
Publisher: Oxford University Press (OUP)
Date: 14-06-2022
Abstract: During disasters, the behaviour of pet owners and of pets themselves may compromise the ability of emergency responders to perform their duties safely. Furthermore, pet loss can have deleterious effects on personal and community recovery. To explore these issues and their implications for health promotion and disaster management practice, we conducted semi-structured interviews with 27 emergency responders in Australia, where disaster policy embraces shared responsibility yet does not acknowledge pets. We found that responders commit to being responsible for protecting human lives, especially members of their teams. Frontline emergency responders did not regard pets as their responsibility, yet decisions made with tragic consequences for pets exacted an emotional toll. Emergency managers consider community education as a pivotal strategy to support building people's capacity to reduce their own risk in disasters. While important, we question whether this is sufficient given that human life is lived in more-than-human contexts. Reformulating the parameters of the Ottawa Charter for Health Promotion as 'One Health Promotion' may help to account for the intermeshed lives of people and pets, while acknowledging human priority in public policy and programming. To acknowledge the influence of people's pets in disaster responses and recovery, we recommend five overlapping spheres of action: (i) integrate pets into disaster management practice and policy (ii) create pet-friendly environments and related policies (iii) engage community action in disaster management planning (iv) develop personal skills by engaging owners in capacity building and (v) reorient health and emergency services toward a more-than-human approach.
Publisher: American Public Health Association
Date: 2012
Abstract: Public health arguments for collecting hemoglobin A1c (HbA1c) data, particularly in clinical settings, should be reframed to place more emphasis on nonmedical determinants of population health. We compare in idual- with population-level interpretations of HbA1c titers. This comparison reveals that public health researchers need to pay close attention to diagnostic tests and their uses, including rhetorical uses. We also synthesize historical and current evidence to map out 2 possible scenarios for the future. In the first scenario, prevention efforts emphasize primary care and focus almost entirely downstream. The second scenario anticipates downstream interventions but also upstream interventions targeting environments. Our analysis adapts actor–network theory to strategic planning and forecasting in public health.
Publisher: MDPI AG
Date: 19-10-2021
DOI: 10.3390/JCM10204798
Abstract: An effective but balanced cellular and inflammatory immune response may limit the severity of coronavirus disease (COVID-19), whereas uncontrolled inflammation leads to disease progression. Older age is associated with higher risk of COVID-19 and a worse outcome, but the underlying immunological mechanisms for this age-related difference are not clear. We investigated the impact of age on viral replication, inflammation, and innate and adaptive cellular immune responses in 205 hospitalized COVID-19 patients. During the early symptomatic phase of COVID-19, we found that patients above 65 years had significantly higher viral load, higher levels of proinflammatory markers, and inadequate mobilization and activation of monocytes, dendritic cells, natural killer cells, and CD8 T cells compared to those below 65 years. Our study points toward age-related deficiencies in the innate immune cellular response to SARS-CoV-2 as a potential cause of poorly controlled viral replication and inflammation during the early symptom phase and subsequent disease progression.
Publisher: Elsevier BV
Date: 09-2018
DOI: 10.1016/J.SOCSCIMED.2018.07.006
Abstract: Australia is currently canine rabies free however, the spread of rabies in eastern Indonesia poses an increasing risk to northern Australia. Domestic dogs are numerous in East Arnhem Land (EAL) and the Northern Peninsular Area (NPA), usually unrestrained and living in close relationships with humans. The response to any rabies outbreak on Australian territory will focus on dog vaccination, controlling dog movements and depopulation. A One Health approach to zoonotic disease control should seek to co-promote human and animal health, whilst also seeking to accommodate the preferences of affected communities. We report on 5 collaborative workshops and 28 semi-structured interviews conducted between January 2017 and June 2018 with: (i) EAL and NPA community members (ii) Indigenous Rangers in EAL and NPA and (iii) residents of Cairns, the local regional centre. Storyboard methodologies were used to work with participants and explore what rabies response measures they thought were justified or unacceptable, why they held these views, and what other steps they believed needed to be taken. Key findings include that the capacity of the NPA and EAL communities to contribute/adapt to a biosecurity response is limited by structural disadvantage including poor infrastructure (such as lockable premises and intact fences) and appropriate information, dominant cultural norms and food security concerns. Dogs and dingoes can have great cultural and social importance key interventions might be accommodated within cultural beliefs and long-standing norms of dog management if sufficient effort is made to adapt interventions to local contexts and community preferences. Adopting such a 'strengths-based' approach mandates that the communities at greatest risk need help to prepare for and develop strategies to manage a biosecurity response to a rabies incursion. This would include listening to in idual and community concerns and attending to the educational and infrastructural needs for supporting different groups to respond appropriately.
Publisher: Research Square Platform LLC
Date: 09-09-2023
Publisher: BMJ
Date: 07-09-2023
Publisher: Informa UK Limited
Date: 03-05-2020
Publisher: Springer Science and Business Media LLC
Date: 11-06-2021
Publisher: Elsevier BV
Date: 04-2013
Publisher: Springer Science and Business Media LLC
Date: 2003
Publisher: Elsevier BV
Date: 10-2020
Publisher: Oxford University Press (OUP)
Date: 25-11-2022
DOI: 10.1093/PHE/PHAC029
Abstract: The One Health approach to antimicrobial resistance (AMR) requires stakeholders to contribute to cross-sectoral efforts to improve antimicrobial stewardship (AMS). One Health AMR policy implementation is challenging in livestock farming because of the infrastructural role of antibiotics in production systems. Mitigating AMR may require the development of more stringent stewardship obligations and the future limitation of established entitlements. Drawing on Amatai Etzioni’s compliance theory, regulatory analyses and qualitative studies with stakeholder groups we examine the structural and socio-cultural dimension of antibiotic use and AMS compliance in Australian beef and dairy production. We found a disconnect between how antibiotic use is conceptualised by farmers and the way in which AMS policies construe agricultural AMR risks. Under the umbrella of food safety standards and national-level prescribing restrictions, farmers and veterinarians interact around antibiotic use with different operating logics and compliance mechanisms. These parallel regimes service distinct and sometimes competing common goods of food security and antibiotic preservation. Further reforms to mitigate AMR need to account for the value orientations of different groups and the embeddedness of the constraints imposed by existing systems. Advocacy for greater AMR precaution in agriculture should acknowledge and compensate for erosions in competing common goods and the cost of proposed interventions.
Publisher: Elsevier BV
Date: 08-2017
DOI: 10.1016/J.SOCSCIMED.2017.06.036
Abstract: Dog-bites and rabies are neglected problems worldwide, notwithstanding recent efforts to raise awareness and to consolidate preventive action. As problems, dog-bites and rabies are entangled with one another, and both align with the concept of One Health. This concept emphasizes interdependence between humans and non-human species in complex socio-ecological systems. Despite intuitive appeal, One Health applications and critiques remain under-developed with respect to social science and social justice. In this article, we report on an ethnographic case-study of policies on dog bites and rabies, with a focus on Calgary, Alberta, Canada, which is widely recognized as a leader in animal-control policies. The fieldwork took place between 2013 and 2016. Our analysis suggests that current policies on rabies prevention may come at the expense of a 'bigger picture' for One Health. In that 'bigger picture,' support is needed to enhance coordination between animal-control and public-health policies. Such coordination has direct relevance for the well-being of children, not least Indigenous children.
Publisher: Elsevier BV
Date: 2018
DOI: 10.1016/J.SOCSCIMED.2017.11.006
Abstract: In this qualitative study implemented in November 2016, we elicited narratives about fictional rabies incursions from key employees (n = 16) of the National Agriculture and Quarantine Inspection Authority in Papua New Guinea (PNG) to explore the potential circumstances and routes of entry of a rabies-infected dog, and direct rabies preparedness. Although PNG is rabies free, proximity to rabies-endemic Indonesia poses a risk of introduction and it is expected that an outbreak in PNG would have devastating human health impacts consistent with other countries with similarly low human development indices and abundant free-roaming dogs. Participants used their local and professional knowledge to create plausible narratives in response to contextual, but fictitious, newspaper stories. An ethnographic content analysis was used to extract themes and interpret the narratives. Themes were assessed in the context of their potential influence on rabies preparedness in PNG against the social and political background of PNG and relevant, published literature. Consistent themes included the ubiquity of trade and the complexity of routes between Indonesia and PNG. Dog ownership seemed pragmatic - actors in the narratives readily and rationally involved dogs in transactions in response to trade, exchange or gifting opportunities. Consequently, dogs changed ownership frequently. The findings of this study have important implications for rabies preparedness in PNG there is potential for wide geographic dissemination of rabies in dogs before outbreak detection. However, common patterns of travel - trade of dogs via Papuan towns and use of traditional trade routes - do provide opportunity for targeted surveillance and response in the event of an incursion.
Publisher: MDPI AG
Date: 14-07-2018
Abstract: Veterinarians are in a strong position of social influence on animal-related issues. Hence, veterinary schools have an opportunity to raise animal health and welfare standards by improving veterinary students’ animal welfare and ethics (AWE) education, including that related to animals used for scientific purposes. A survey of 818 students in the early, mid, and senior stages of their courses at all eight veterinary schools across Australia and New Zealand was undertaken on their first day of practice (or Day One Competences) to explore how veterinary students viewed the importance of their competence in the management of welfare and ethical decision-making relating to animals kept for scientific purposes. From highest to lowest, the rankings they assigned were: Animal Ethics Committee (AEC) Procedures or Requirements 3Rs (Replacement, Refinement and Reduction) Humane Endpoints Euthanasia “What Is a Research Animal?” and Conscientious Objections. Female students rated Conscientious Objections, Humane Endpoints, and Euthanasia significantly higher than male students did across the three stages of study. The score patterns for these three variates showed a trend for the male students to be more likely to score these topics as extremely important as they advanced through the course, but female students’ scores tended to decline slightly or stay relatively stable. No gender differences emerged for the three variates: 3Rs (Replacement, Refinement and Reduction) AEC Procedures or Requirements and “What Is a Research Animal?”. This study demonstrates that understandings of the regulatory and normative frameworks are considered most important in animal welfare and ethics competence in veterinary students. To the authors’ knowledge, this is the first study to investigate what importance veterinary students place on their competence regarding animals kept for scientific purposes.
Publisher: Cambridge University Press (CUP)
Date: 17-10-2019
Publisher: Informa UK Limited
Date: 11-2020
Publisher: MDPI AG
Date: 12-07-2018
Abstract: The importance of animal welfare and ethics (AWE) within the veterinary education should reflect community concerns and expectations about AWE, and the professional demands of veterinary accreditation on the first day of practice (or ‘Day One’ competences). Currently, much interest and debate surrounds the treatment of production animals, particularly around live export. To explore the attitudes to AWE of veterinary students in Australia and New Zealand, a survey was undertaken to (i) understand what students consider important AWE topics for initial production animal competence and (ii) ascertain how these priorities correlated with gender, area of intended practice and stage-of-study. The results from 575 veterinary students showed that all students ranked strategies to address painful husbandry procedures as the most important issues on their first day in production animal practice. Additionally, it was found that the importance students assigned to an understanding of human–animal interactions declined as they progressed through the veterinary course. In contrast, the importance of an understanding of euthanasia issues for production animals increased for male students as they progressed through the course, and remained consistently high in females. Females also gave higher ranking to the importance of understanding production animal stress associated with transport, and ranked strategies to address painful husbandry procedures more important than did males. These findings should help the development of AWE teaching resources that address students’ attitudes and competence and that can be delivered when students are most receptive.
Publisher: BMJ Publishing Group Ltd
Date: 08-2018
Publisher: American College of Physicians
Date: 04-12-2018
DOI: 10.7326/L18-0517
Publisher: American College of Physicians
Date: 04-12-2018
DOI: 10.7326/L18-0515
Publisher: Elsevier BV
Date: 03-2022
Publisher: Elsevier BV
Date: 05-2019
DOI: 10.1016/J.SOCSCIMED.2019.03.013
Abstract: There is increasing scientific consensus that a One Health approach (acknowledging links between human, animal and environmental health) is the most effective way of responding to emerging infectious disease (EID) threats. However, reviews of past EID events show that successful implementation of control strategies hinge on alignment with public values. Given the limited evidence about public values in this area, we sought to understand public preferences for attributes associated with One Health strategies for EID prevention and control, using a discrete choice experiment (DCE). The DCE was conducted in 2016 using an online panel of Australian respondents aged over 18. Participants were presented with 18 pairs of scenarios describing One Health strategies and outcomes, and asked to select their preferred one. Scenarios were described by nine attributes with varying levels: personal autonomy, economic development, environmental health, community cohesion, free trade and travel, zoonotic risk, mortality, animal welfare and food security. Respondents were broadly representative of the Australian population (n = 1999, mean age 45.3 years (range 18-89) 50.7% male). The public preferred scenarios in which in idual freedoms are not restricted for the greater good unemployment is low the environment is healthy there is good community cohesion travel, imports and exports are tightly controlled there is lower mortality and incidence of disease and where animal welfare and food security are protected. Although lower morbidity and mortality were preferable, respondents were willing to accept extra cases of severe disease and deaths to avoid reductions in some attributes. However, a mixed logit model indicated significant heterogeneity. A latent class analysis suggested wide variability across respondent classes in the valuation of attributes, and the trade-offs respondents were willing to accept. Therefore, a single approach to managing EID using One Health is unlikely to be acceptable to all community members.
Publisher: Elsevier BV
Date: 2020
DOI: 10.1016/J.HEALTHPOL.2019.11.009
Abstract: The World Health Organization's End TB Strategy aims to eliminate tuberculosis (TB) by 2050. Low-burden countries such as Australia are targeted for early elimination (2035), which will require an increase in the intensity and scope of case finding and treatment of people with latent TB infection (LTBI). Because 80 % of TB disease in Australia occurs in metropolitan Sydney (New South Wales) and Melbourne (Victoria), the commitment to move towards elimination has major implications for TB programs in these jurisdictions. We report on a case study analysis that compares and contrasts key attributes of each of these healthcare organizations. Such analysis has important implications for all countries seeking to implement international agreements within local health structures. Differences in the organizational structure, culture and systems of care in NSW and Victoria may facilitate or create barriers to changes in organizational system functions, especially the way in which TB prevention and LTBI treatment is delivered. Ratification of global health treaties and the development of national strategies, alone, is insufficient for realizing the promised outcomes. Even in high income countries, global health agendas such as TB elimination can be complicated by differences in local system structure and funding. As the timelines tighten towards 2035, more work must be done to identify the organizational conditions and service models that will facilitate progress towards TB elimination.
Publisher: Springer Science and Business Media LLC
Date: 05-09-2020
DOI: 10.1186/S41479-020-00072-5
Abstract: Tuberculosis (TB) is the leading infectious cause of human mortality and is responsible for nearly 2 million deaths every year. It is often regarded as a ‘silent killer’ because it predominantly affects the poor and marginalized, and disease outbreaks occur in ‘slow motion’ compared to Ebola or coronavirus 2 (COVID-19). In low incidence countries, TB is predominantly an imported disease and TB control in migrants is pivotal for countries to progress towards TB elimination in accordance with the World Health Organisations (WHO’s) End TB strategy. This review provides a brief overview of the different screening approaches and surveillance processes that are in place in low TB incidence countries. It also includes a detailed discussion of the ethical issues related to TB screening of migrants in these settings and the different interests that need to be balanced. Given recognition that a holistic approach that recognizes and respects basic human rights is required to end TB, the review considers the complexities that require consideration in low-incidence countries that are aiming for TB elimination.
Publisher: Springer Science and Business Media LLC
Date: 2005
Publisher: MDPI AG
Date: 23-11-2021
DOI: 10.3390/ANTIBIOTICS10121432
Abstract: Educating the public about antimicrobial resistance (AMR) is considered a key part of an optimal public health response. In both media depictions and policy discourses around health risks, how a problem is framed underpins public awareness and understanding, while also guiding opinions on what actions can and should be taken. Using a mixed methods approach we analyse newspaper content in Australia and the United Kingdom (UK) from 2011 to 2020 to track how causes, consequences and solutions to AMR are represented in countries with different policy approaches. Analyses demonstrate greater variability in the frames used in UK newspapers reflecting large hospital and community outbreaks and a sustained period of policy reform mid-decade. Newspapers in Australia focus more on AMR causes and consequences, highlighting the importance of scientific discovery, whereas UK coverage has greater discussion of the social and economic drivers of AMR and their associated solutions. Variations in the trends of different frames around AMR in UK newspapers indicate greater levels of public deliberation and debate around immediate and actionable solutions whereas AMR has not had the same health and political impacts in Australia resulting in a media framing that potentially encourages greater public complacency about the issue.
Publisher: Elsevier BV
Date: 12-1992
Publisher: Springer Science and Business Media LLC
Date: 02-09-2009
Publisher: Springer Science and Business Media LLC
Date: 2000
Publisher: Springer Science and Business Media LLC
Date: 17-01-2023
DOI: 10.1186/S12913-023-09066-7
Abstract: Refugee and migrant women are at higher risk of childbirth complications and generally poorer pregnancy outcomes. They also report lower satisfaction with pregnancy care because of language barriers, perceived negative attitudes among service providers, and a lack of understanding of refugee and migrant women’s needs. This study juxtaposes health policy expectations in New South Wales (NSW), Australia on pregnancy and maternity care and cultural responsiveness and the experiences of maternal healthcare providers in their day-to-day work with refugee and migrant women from non-English speaking backgrounds. This study used a qualitative framework method to allow for a comparison of providers’ experiences with the policy expectations. Sixteen maternal health service providers who work with refugee and migrant women were recruited from two local health districts in New South Wales, Australia and interviewed (November 2019 to August 2020) about their experiences and the challenges they faced. In addition, a systematic search was conducted for policy documents related to the provision of maternal health care to refugee and migrant women on a state and federal level and five policies were included in the analysis. Framework analysis revealed structural barriers to culturally responsive service provision and the differential impacts of implementation gaps that impede appropriate care resulting in moral distress. Rather than being the programmatic outcome of well-resourced policies, the enactment of cultural responsiveness in the settings studied relied primarily on the intuitions and personal responses of in idual service providers such as nurses and social workers. Authentic culturally responsive care requires healthcare organisations to do more than provide staff training. To better promote service user and staff satisfaction and wellbeing, organisations need to embed structures to respond to the needs of refugee and migrant communities in the maternal health sector and beyond.
Publisher: Informa UK Limited
Date: 11-05-2017
DOI: 10.1080/10888705.2017.1322515
Abstract: During a disaster, people may make evacuation decisions based on their companion animal's welfare, therefore exposing themselves, their companion animals, and emergency responders to increased risk for injury or death. The loss and suffering of companion animals in disasters causes deep distress, diminishing people's capacity to rebuild their lives. This scoping review presents scholarly research studies and reviews relating to people and their companion animals in the context of disasters, with an aim of informing researchers, policymakers, and practitioners and providing direction for future research. Using the Arksey and O'Malley framework, articles in scholarly journals from 2004 to 2014 are discussed. Analysis included 38 articles: 20 research studies, 12 reviews, and 6 editorials. Findings revealed 2 central themes: companion animals as a risk factor to human health and safety and companion animals being "at risk" themselves. An emerging theme was "responsibility": Who is responsible for companion animals in disasters and how? Understanding the implications of human-nonhuman animal relationships for disaster response and having a broader public consensus on what is owed to animals at times of emergency are important to community preparedness and resilience.
Publisher: SAGE Publications
Date: 19-12-2007
Abstract: At the beginning of the twentieth century, human and veterinary surgeons faced the challenge of a medical marketplace transformed by technology. The socioeconomic value ascribed to their patients was changing, reflecting the increasing mechanization of industry and the decreasing dependence of society on nonhuman animals for labor. In human medicine, concern for the economic consequences of fractures “pathologized” any significant level of posttherapeutic disability, a productivist perspective contrary to the traditional corpus of medical values. In contrast, veterinarians adapted to the mechanization of horsepower by shifting their primary professional interest to companion animals a type of patient generally valued for the unique emotional attachment of the owner and not their productive capacity. The economic rationalization of human fracture care and the “sentimental” transformation of veterinary orthopedic expertise indicate how these specialists utilized increasingly convergent rhetorical arguments to justify the application of innovative fracture care technologies to their human and animal patients.
Publisher: Elsevier BV
Date: 10-2018
Publisher: American Association of Zoo Veterinarians
Date: 23-09-2019
DOI: 10.1638/2017-0014
Publisher: Public Library of Science (PLoS)
Date: 31-12-2018
Publisher: Public Library of Science (PLoS)
Date: 17-09-2009
Publisher: BMJ
Date: 11-2020
DOI: 10.1136/BMJOPEN-2020-041592
Abstract: As governments attempt to navigate a path out of COVID-19 restrictions, robust evidence is essential to inform requirements for public acceptance of technologically enhanced communicable disease surveillance systems. We examined the value of core surveillance system attributes to the Australian public, before and during the early stages of the current pandemic. A discrete choice experiment was conducted in Australia with a representative group of respondents, before and after the WHO declared COVID-19 a Public Health Emergency of International Concern. We identified and investigated the relative importance of seven attributes associated with technologically enhanced disease surveillance: respect for personal autonomy privacy/confidentiality data certainty/confidence data security infectious disease mortality prevention infectious disease morbidity prevention and attribution of (causal) responsibility. Specifically, we explored how the onset of the COVID-19 outbreak influenced participant responses. 2008 Australians (general public) completed the experiment: 793 before COVID-19 outbreak onset (mean age 45.9 years, 50.2% male) and 1215 after onset (mean age 47.2 years, 49% male). All seven attributes significantly influenced respondents’ preferences for communicable disease surveillance systems. After onset, participants demonstrated greater preference for a surveillance system that could prevent a higher number of illnesses and deaths, and were less concerned about their personal autonomy. However, they also increased their preference for a system with high data security. Public acceptance of technology-based communicable disease surveillance is situation dependent. During an epidemic, there is likely to be greater tolerance of technologically enhanced disease surveillance systems that result in restrictions on personal activity if such systems can prevent high morbidity and mortality. However, this acceptance of lower personal autonomy comes with an increased requirement to ensure data security. These findings merit further research as the pandemic unfolds and strategies are put in place that enable in iduals and societies to live with SARS-CoV-2 endemicity.
Publisher: Wiley
Date: 12-05-2022
DOI: 10.1111/HEX.13511
Abstract: Communities with high levels of vaccine rejection present unique challenges to vaccine‐preventable disease outbreak management. We sought perspectives of nonvaccinating parents to inform public health responses in such communities. Nineteen purposively s led nonvaccinating Australian parents participated in one of seven online dialogue groups. We asked what they thought parents, school principals and public health professionals should do in a hypothetical school measles outbreak and used a framework approach to data analysis. Parents' views were grounded in strong beliefs in parental responsibility and the belief that vaccines are not effective, thus unvaccinated children do not therefore pose a threat. They then reasoned that the forced exclusion of unvaccinated children from school in a measles outbreak was disproportionate to the risk they pose, and their child's right to education should not be overridden. Nonvaccinating parents judged that all parents should keep sick children at home regardless of disease or vaccination status that school principals should communicate directly with parents and avoid using social media that public health professionals should provide information to parents so they can decide for themselves about excluding their children from school that public health responses should avoid accidental identification of unvaccinated children and that mainstream media should be avoided as a communication tool. Nonvaccinating parents do not always agree with current Australian approaches to measles outbreak management. Their perspectives can inform approaches to outbreak responses in communities with high levels of vaccine rejection. We sought input from in iduals who did and did not vaccinate on study design in its early phases. In idual conversations were used deliberately as we felt the group advisory situation may have felt less safe for nonvaccinating parents, given the isive and often hostile nature of the topic.
Publisher: BMJ
Date: 31-01-2017
DOI: 10.1136/MEDETHICS-2016-103424
Abstract: Tuberculosis (TB) remains a leading cause of morbidity and mortality worldwide, and the burdens of this disease continue to track prior disadvantage. In order to galvanise a coordinated global response, WHO has recently launched the
Publisher: BMJ
Date: 03-2018
DOI: 10.1136/BMJOPEN-2017-020439
Abstract: To explore and compare the knowledge, attitudes and experiences of doctors, dentists and veterinarians (as prescribers) in relation to antibiotic use and antibiotic resistance (AbR), and to consider the implications of these for policy-making that support a One Health approach. A cross-sectional survey conducted online. Doctors, dentists and veterinarians practising in primary, secondary or tertiary care in Australia. 547 doctors, 380 dentists and 403 veterinarians completed the survey. Prescribers’ knowledge, attitudes and perceptions of AbR, the extent to which a range of factors are perceived as barriers to appropriate prescribing practices, and perceived helpfulness of potential strategies to improve antibiotic prescribing in practice. There was substantial agreement across prescriber groups that action on AbR is required by multiple sectors and stakeholders. However, prescribers externalised responsibility to some extent by seeing the roles of others as more important than their own in relation to AbR. There were common and context-specific barriers to optimal prescribing across the prescriber groups. Prescriber groups generally perceived restrictive policies as unhelpful to supporting appropriate prescribing in their practice. The results have implications for implementing a One Health approach that involves doctors, dentists and veterinarians as key players to tackling the crisis of AbR. The findings are that (1) prescribers understand and are likely receptive to a One Health policy approach to AbR, (2) policy development should be sensitive to barriers that are specific to in idual prescriber groups and (3) the development and introduction of interventions that might be perceived as reducing prescriber autonomy will need to be carefully designed and implemented.
Publisher: Wiley
Date: 06-1989
Publisher: Springer Science and Business Media LLC
Date: 1999
Publisher: Springer Science and Business Media LLC
Date: 28-06-2022
DOI: 10.1186/S13756-022-01128-5
Abstract: Antimicrobial resistance (AMR) is a problem in residential aged care facilities (RACF). There is a gap in our understanding of how psychosocial barriers such as risk perceptions shape staff attitudes towards antimicrobial stewardship (AMS). We sought to ascertain the attitudinal domains that have been identified to be of importance to AMS in RACF and comment on how they have been measured empirically. Our aim was to consolidate what is known regarding staff attitudes and perceptions in order to inform future stewardship. We searched PsycINFO, PsycARTICLES, CINAHL Plus, MEDLINE, PubMed, Web of Science, Cochrane, and Scopus databases for primary studies of healthcare workers attitudes to AMS in RACF (1990-February 2021). 14 Studies were included in the review, within which 10 domains were identified: attitudes towards antimicrobial prescribing guidelines educational interventions self-confidence regarding clinical assessment and prescribing awareness of AMR as a problem and stewardship as a priority self-efficacy perception of role perception of risk team culture and resident/family members expectations. 46 measures were developed across the 14 studies to measure the 10 domains. The variability in the attitudinal domains and how these domains were measured was large. Only 13% included psychometric data regarding reliability and/or internal consistency. Attitudes are generally defined as having three evaluative bases: cognitive, behavioural, and affective. Findings from the current review suggest that the measures commonly used to capture healthcare staff attitudes to AMS do not sufficiently capture affect particularly with respect to staff’s risk perceptions, perceptions of their role, and family members’ expectations. Given that affective processes have been postulated to influence medical decision making, these findings highlight the importance of understanding how staff, especially nurses feel about implementing AMS strategies and other peoples’ (e.g. residents and their families) perceptions of stewardship. It is expected that a more nuanced understanding of RACF nurses affective experiences when applying AMS, and their perceptions of the risks entailed, will help in reducing barriers to overprescribing antibiotics.
Publisher: Informa UK Limited
Date: 04-2012
DOI: 10.4161/AUTO.19496
Publisher: Wiley
Date: 09-2014
DOI: 10.5694/MJA14.01191
Abstract: The current outbreak of Ebola virus disease in West Africa is the worst so far. The unprecedented extent of mortality and morbidity in this outbreak has followed more from imposition of neoliberal economic policies on the countries affected than from the biological virulence of Ebola virus. The lack of vaccines and medications for Ebola virus disease is evidence that markets cannot reliably supply treatments for epidemic diseases. We attribute the current difficulties in containment chiefly to the erosion or non-development of the health and medical infrastructure needed to respond effectively, as a direct result of market-privileging policies imposed in the interests of wealthy nations. These events and responses hold lessons for public health priorities in Australia.
Publisher: Elsevier BV
Date: 03-2015
DOI: 10.1016/J.SOCSCIMED.2014.05.050
Abstract: This article contributes to the literature on One Health and public health ethics by expanding the principle of solidarity. We conceptualise solidarity to encompass not only practices intended to assist other people, but also practices intended to assist non-human others, including animals, plants, or places. To illustrate how manifestations of humanist and more-than-human solidarity may selectively complement one another, or collide, recent responses to Hendra virus in Australia and Rabies virus in Canada serve as case ex les. Given that caring relationships are foundational to health promotion, people's efforts to care for non-human others are highly relevant to public health, even when these efforts conflict with edicts issued in the name of public health. In its most optimistic explication, One Health aims to attain optimal health for humans, non-human animals and their shared environments. As a field, public health ethics needs to move beyond an exclusive preoccupation with humans, so as to account for moral complexity arising from people's erse connections with places, plants, and non-human animals.
Publisher: Elsevier BV
Date: 03-2023
Publisher: Research Square Platform LLC
Date: 11-10-2023
Publisher: Wiley
Date: 10-06-2012
DOI: 10.1111/J.1467-8519.2012.01980.X
Abstract: Surgery is an increasingly common and expensive mode of medical intervention. The ethical dimensions of the surgeon-patient relationship, including respect for personal autonomy and informed consent, are much discussed but broader equity issues have not received the same attention. This paper extends the understanding of surgical ethics by considering the nature of evidence in surgery and its relationship to a just provision of healthcare for in iduals and their populations.
Publisher: Association for Computing Machinery (ACM)
Date: 2010
Abstract: Self-sufficient itemsets are those whose frequency cannot be explained solely by the frequency of either their subsets or of their supersets. We argue that itemsets that are not self-sufficient will often be of little interest to the data analyst, as their frequency should be expected once that of the itemsets on which their frequency depends is known. We present tests for statistically sound discovery of self-sufficient itemsets, and computational techniques that allow those tests to be applied as a post-processing step for any itemset discovery algorithm. We also present a measure for assessing the degree of potential interest in an itemset that complements these statistical measures.
Publisher: Elsevier BV
Date: 11-2022
DOI: 10.1016/J.JHIN.2022.07.004
Abstract: Staphylococcus aureus is associated with significant mortality and increased burden on the healthcare system. Relatively few reliable estimates are available regarding the impact of meticillin-resistant S. aureus (MRSA) infection compared with meticillin-susceptible S. aureus (MSSA) infection. To compare patients with MRSA infection and MSSA infection to identify differences in inpatient mortality, length of stay and costs of hospital services, and identify predictors of MRSA as a cause of S. aureus infection. An analytical, retrospective, longitudinal study using non-identifiable linked data on adults admitted to hospitals of a health district in Australia with a diagnosis of S. aureus infection over a 10-year period. The main outcome measure was 30-day inpatient mortality. Secondary endpoints included total overnight stays, all-cause inpatient mortality, and hospitalization costs within 1 year of index admission. Inpatient mortality at 30, 100 and 365 days was estimated to be significantly greater for patients with MRSA infection. The mean additional cost of MRSA infection when controlling for additional factors was $5988 and 4 nights of additional hospital stay per patient within 1 year of index admission. Key predictors of MRSA infection were: date of index admission higher comorbidity score greater socio-economic disadvantage admission to hospital other than via the emergency department older age and prior admission to hospital within 28 days of index admission. MRSA infection is associated with increased inpatient mortality, costs and hospital length of stay compared with MSSA infection. Efforts are required to alleviate the additional burden of MRSA infection on patients and healthcare systems.
Publisher: Mary Ann Liebert Inc
Date: 07-2021
Publisher: SAGE Publications
Date: 2022
DOI: 10.1177/20539517221108988
Abstract: Precision medicine is an emerging approach to treatment and disease prevention that relies on linkages between very large datasets of health information that is shared amongst researchers and health professionals. While studies suggest broad support for sharing precision medicine data with researchers at publicly funded institutions, there is reluctance to share health information with private industry for research and development. As the private sector is likely to play an important role in generating public benefits from precision medicine initiatives, it is important to understand what the concerns are and how they might be mitigated. This study reports outcomes of a deliberative method of citizen engagement in Singapore that asked whether sharing precision medicine data with private industry would be permissible, and if so, under what circumstances. Findings from this citizens’ jury suggest sharing with industry would be permissible under certain conditions that are set out in nine recommendations. Implications of the recommendations and their underlying assumptions for policy decision makers are discussed. This study aligns with prior international studies which found conditional acceptance for data sharing with private industry, a public benefit requirement, specific reluctance to share with insurance companies and an emphasis on accountability and transparency to demonstrate trustworthiness. However, our results differ from prior studies in that opt-in consent did not dominate the deliberations as jurors were able to set it aside as an assumed prerequisite for participation in a precision medicine programme.
Publisher: Elsevier BV
Date: 06-2022
DOI: 10.1016/J.SOCSCIMED.2022.114954
Abstract: The Apple Watch Electrocardiogram (ECG) is a digital feature that detects signs of atrial fibrillation (AFib), a heart arrhythmia that can lead to stroke. Unlike AFib detection offered in a clinical setting to patients or those at higher risk, the Apple Watch ECG is a direct-to-consumer (DTC) product marketed to the healthy as a self-performed medical test. The feature is incorporated in the design as one of many applications in a multifunctional smartwatch. The Apple Watch ECG signals the movement of consumer wearables into the domain of medical devices, and the highly contested practice of AFib screening. This article examines how this technology produces new avenues for medical overuse among people who are unlikely to gain clinical benefit, and who as active consumers become medicalised via taking part in disease-specific monitoring. Interviews with Apple Watch ECG consumers suggest their strongly trust in the Apple brand is lified by the promissory quality of screening and technical innovation. What would otherwise be a costly clinical procedure is condensed into an accessible function in a wearable device. Consequently, AFib screening loses its clinical purpose, and is instead refashioned into a component of healthy lifestyle behaviour. Repeat self-screening becomes 'bundled' with similar health monitoring practices routinised in consumer wearables. Active uptake supports a market for the product and adds to the reputation of the Apple brand such that consumers become complicit in legitimising a medical practice that has limited clinical justification.
Publisher: Springer Science and Business Media LLC
Date: 2001
Publisher: Robert E. Kennedy Library, Cal Poly
Date: 12-2011
Publisher: Informa UK Limited
Date: 10-2011
DOI: 10.1080/10888705.2011.600160
Abstract: In industrialized societies, more than 1 in 3 dogs and people currently qualify as overweight or obese. Experts in public health expect both these figures to rise. Although clinical treatment remains important, so are public perceptions and social norms. This article presents a thematic analysis of English-language mass media coverage on canine obesity from 2000 through 2009 and compares these results with a thematic analysis of articles on canine obesity in leading veterinary journals during the same time period. Drawing on Giddens's theory of structuration, this study identified articles that emphasized in idual agency, environmental structure, or both as contributors to canine obesity. Comparisons with weight-related health problems in human populations were virtually absent from the veterinary s le. Although such comparisons were almost always present in the media s le, quotations from veterinarians and other spokespeople for the welfare of nonhuman animals emphasized the agency of in idual caregivers (owners) over structural influences. Now that weight gain and obesity have been established as a pressing animal welfare problem, these results suggest a need for research and for interventions, such as media advocacy, that emphasize intersections between animal-owner agency, socioenvironmental determinants, and connections between animal welfare and human health.
Publisher: Intellect
Date: 10-2016
Abstract: In recent times the Papua New Guinea (PNG) balsa wood industry has increased in global volume and value, offering employment to a significant number of in iduals in East New Britain (ENB) Province. The PNG balsa industry previously relied on China’s renewable wind energy industry for rotor blade manufacturing, which was claimed to be the largest consumer of processed balsa from PNG. Since the Global Financial Crisis (GFC) the Chinese demand for PNG balsa has significantly reduced, resulting in a mass over-supply and under-demand for the PNG resource. A lack of design innovation has added to the current market conundrum and left many smallholders unable to sell their balsa, leading to widespread financial hardship. It has come to the attention of the Australian Centre for International Agricultural Research (ACIAR) and many stakeholders that if there are no new applications for balsa there is no point continuing to grow the resource for a market that is not consuming it. Design innovation generated through research-led industrial design practice is argued as a key element in value-adding to the PNG balsa industry and smallholder businesses. The use of research to inform the design process and generate design innovation is demonstrated through a case study as an attempt to rectify the current over-supply and under-demand.
Publisher: Informa UK Limited
Date: 03-2012
Publisher: Springer Science and Business Media LLC
Date: 2005
Publisher: Springer Science and Business Media LLC
Date: 30-11-2014
DOI: 10.1007/S11248-013-9770-Z
Abstract: Efforts to advance our understanding of neurodegenerative diseases involve the creation chimeric organisms from human neural stem cells and primate embryos--known as prenatal chimeras. The existence of potential mentally complex beings with human and non-human neural apparatus raises fundamental questions as to the ethical permissibility of chimeric research and the moral status of the creatures it creates. Even as bioethicists find fewer reasons to be troubled by most types of chimeric organisms, social attitudes towards the non-human world are often influenced by religious beliefs. In this paper scholars representing eight major religious traditions provide a brief commentary on a hypothetical case concerning the development and use of prenatal human-animal chimeric primates in medical research. These commentaries reflect the plurality and complexity within and between religious discourses of our relationships with other species. Views on the moral status and permissibility of research on neural human animal chimeras vary. The authors provide an introduction to those who seek a better understanding of how faith-based perspectives might enter into biomedical ethics and public discourse towards forms of biomedical research that involves chimeric organisms.
Publisher: Wiley
Date: 05-10-2016
DOI: 10.1111/HEX.12493
Publisher: Springer Science and Business Media LLC
Date: 02-11-2015
Publisher: Springer Science and Business Media LLC
Date: 2000
Publisher: IEEE
Date: 12-2010
DOI: 10.1109/ICDM.2010.5
Publisher: Springer Science and Business Media LLC
Date: 02-02-2016
DOI: 10.1007/S11673-015-9697-6
Abstract: With attention to the experiences, agency, and rights of tuberculosis (TB) patients, this symposium on TB and ethics brings together a range of different voices from the social sciences and humanities. To develop fresh insights and new approaches to TB care and prevention, it is important to incorporate erse perspectives from outside the strictly biomedical model. In the articles presented in this issue of the Journal of Bioethical Inquiry, clinical experience is married with historical and cultural context, ethical concerns are brought to bear on global health, and structural analyses shed light upon the lived experience of people living with TB. The relational and reciprocal dimensions of care feature strongly in these discussions, which serve as a poignant reminder that behind each of the yearly deaths from TB is a deeply personal story. No single discipline holds a monopoly on how to care for each of these people, but strong cases are made for support from mental health and social workers in addressing the kaleidoscope of needs in TB prevention. As the World Health Organization moves towards the goal of eliminating TB globally by 2050, attending to the needs of TB patients serves global interests to lower disease burden and to develop better integrated communities worldwide.
Publisher: Springer Berlin Heidelberg
Date: 2009
Publisher: Informa UK Limited
Date: 10-1990
Publisher: John Wiley & Sons, Inc
Date: 15-04-2016
Publisher: Research Square Platform LLC
Date: 27-02-2023
DOI: 10.21203/RS.3.RS-2609675/V1
Abstract: Background: Parental refusal of routine childhood vaccination remains an ethically contested area. This systematic review sought to explore and characterise the normative arguments made about parental refusal of routine vaccination, with the aim of providing researchers, practitioners, and policymakers with a synthesis of current normative literature. Methods: Nine databases covering health and ethics research were searched, and 121 publications identified for the period Jan 1998 to Mar 2022. For articles, source journals were categorised according to Australian Standard Field of Research codes, and normative content was analysed using a framework analytical approach. Results: Most of the articles were published in biomedical journals (34%), bioethics journals (21%), and journals that carry both classifications (20%). Two central questions dominated the literature: 1) Whether vaccine refusal is justifiable (which we labelled ‘refusal arguments’) and 2) Whether strategies for dealing with those who reject vaccines are justifiable (‘response arguments’). Refusal arguments relied on principlism, religious frameworks, the rights and obligations of parents, the rights of children, the medico-legal best interests of the child standard, and the potential to cause harm to others. Response arguments were broadly ided into arguments about policy, arguments about how in idual physicians should practice regarding vaccine rejectors, and both legal precedents and ethical arguments for vaccinating children against a parent’s will. Policy arguments considered the normative significance of coercion, non-medical or conscientious objections, and possible reciprocal social efforts to offset vaccine refusal. In idual physician practice arguments covered nudging and coercive practices, patient dismissal, and the ethical and professional obligations of physicians. Most of the legal precedents discussed were from the American setting, with some from the United Kingdom. Conclusions: This review provides a comprehensive picture of the scope and substance of normative arguments about vaccine refusal and responses to vaccine refusal. It can serve as a platform for future research to extend the current normative literature, better understand the role of cultural context in normative judgements about vaccination, and more comprehensively translate the nuance of ethical arguments into practice and policy.
Publisher: BMJ
Date: 06-2018
Publisher: Wiley
Date: 15-04-2020
Publisher: Springer Berlin Heidelberg
Date: 2005
DOI: 10.1007/11589990_13
Publisher: Informa UK Limited
Date: 25-09-2013
Publisher: Informa UK Limited
Date: 06-05-2016
Publisher: Springer Science and Business Media LLC
Date: 23-12-2020
Publisher: Springer Science and Business Media LLC
Date: 06-2019
Publisher: Wiley
Date: 03-04-2012
DOI: 10.1111/J.1365-2656.2012.01983.X
Abstract: 1. Breeding with kin can reduce in idual fitness through the deleterious effects of inbreeding depression. Inbreeding avoidance mechanisms are expected to have developed in most species, and especially in cooperatively breeding species where in iduals may delay dispersal until long after sexual maturity. Such potential mechanisms include sex-biased dispersal and avoidance of kin known through associative learning. 2. The investigation of inbreeding avoidance through dispersal dynamics can be enhanced by combining fine-scale population genetic structure data with detailed behavioural observations of wild populations. 3. We investigate possible inbreeding avoidance in a wild population of cooperatively breeding southern pied babblers (Turdoides bicolor). A combination of genetic, geographic and observational data is used to examine fine-scale genetic structure, dispersal (including sex-biased dispersal) and inheritance of dominance in cooperatively breeding groups. 4. Unusually, sex-bias in dispersal distance does not occur. Rather, in iduals appear to avoid inbreeding through two routes. First, through dispersal itself: although both males and females disperse locally, they move outside the range within which genetically similar in iduals are usually found, going twice as far from natal groups as from non-natal groups. Second, through avoidance of familiar group members as mates: in iduals inherit a dominant position in the natal group only when an unrelated breeding partner is present. 5. This study uses spatial genetic analyses to investigate inbreeding avoidance mechanisms in a cooperative breeder and shows that in iduals of both sexes can avoid inbreeding through a dispersal distance mechanism. While it appears that dispersal allows most in iduals to move beyond the range of closely related kin, matings may still occur between distant kin. Nevertheless, any costs of breeding with a distant relative may be outweighed by the benefits of local dispersal and the immense fitness gains available from attaining a breeding position.
Publisher: Springer Berlin Heidelberg
Date: 1990
Publisher: Informa UK Limited
Date: 14-12-2009
Publisher: Springer US
Date: 2010
Publisher: ACM
Date: 24-08-2003
Publisher: MDPI AG
Date: 03-08-2020
DOI: 10.3390/ANI10081341
Abstract: This article introduces the online One Welfare learning and teaching portal (OWP) and describes its development, use, importance and relevance to animal welfare and ethics (AWE) stakeholders. As animal welfare issues increase in importance, veterinarians must be trained to lead the science that underpins AWE discourses. The OWP is a collection of resources designed to engage and challenge veterinary science students as they become advocates for animals. It was developed collaboratively by all eight veterinary schools in Australia and New Zealand, and funded by the Australian Government Office for Learning and Teaching. Surveys to investigate the attitudes of students and educators to AWE issues in six context-specific themes based on the Australian Animal Welfare Strategy (AAWS) (companion animals animals used in research and teaching livestock roduction animals animals used for sport, recreation or display animals in the wild and aquatic animals) were administered through all participating schools. Students assigned more importance to Day One competence in knowledge of welfare concepts than did educators for the following groups: production animals, companion animals, animals in the wild, aquatic animals, animals used in research and teaching, and animals used for sport, recreation or display (all p 0.01). Agreement between educators and students was closer regarding the importance of Day One competence for euthanasia for all six context-specific themes (p 0.01–0.03). Students assigned more importance than educators to social, economic and cultural drivers of welfare outcomes in production animals (p 0.01) slaughter and preslaughter inspections in production animals (p 0.01) animal abuse and hoarding in companion animals (p 0.01) shelter medicine in companion animals (p 0.01) disaster preparedness in wildlife animals (p 0.01) pain and distress caused by fishing in aquatic animals (p 0.01) conscientious objection related to animals held for research and teaching (p 0.01) behaviour, selection and training of animals used for sport, recreation and display (p = 0.046) and educating the public around sporting animal welfare (p 0.01). Agreement between educators and students was closer for strategies to address painful husbandryprocedures in production animals (p = 0.03) behaviour and training of companion animals (p = 0.03) veterinarians’ duties to wild animals in wildlife (p = 0.02) the 3Rs in animals held for research and teaching (p = 0.03) and ownership responsibility in sporting animals (p = 0.01). This report discusses the reasons for differences among students and educators as they approach these issues. The portal is expected to gather more content as veterinary schools in other countries use its resources and users submit scenarios and discussion topics that reflect local needs.
Publisher: Oxford University PressOxford
Date: 19-05-2023
Publisher: Springer Science and Business Media LLC
Date: 29-01-2015
DOI: 10.1007/S11673-014-9595-3
Abstract: This article critically examines current responses to multi-drug resistant tuberculosis (MDR-TB) and argues that bioethics needs to be willing to engage in a more radical critique of the problem than is currently offered. In particular, we need to focus not simply on market-driven models of innovation and anti-microbial solutions to emergent and re-emergent infections such as TB. The global community also needs to address poverty and the structural factors that entrench inequalities-thus moving beyond the orthodox medical ublic health frame of reference.
Publisher: Palgrave Macmillan UK
Date: 2016
Publisher: Duke University Press
Date: 05-2018
Publisher: BMJ
Date: 09-2022
DOI: 10.1136/BMJOPEN-2022-061513
Abstract: General practitioners (GPs) and their staff have been at the frontline of the SARS-CoV-2 pandemic in Australia. However, their experiences of responding to and managing the risks of viral transmission within their facilities are poorly described. The aim of this study was to describe the experiences, and infection prevention and control (IPC) strategies adopted by general practices, including enablers of and challenges to implementation, to contribute to our understanding of the pandemic response in this critical sector. Semistructured interviews were conducted in person, by telephone or online video conferencing software, between November 2020 and August 2021. Twenty general practice personnel working in New South Wales, Australia, including nine GPs, one general practice registrar, four registered nurses, one nurse practitioner, two practice managers and two receptionists. Participants described implementing wide-ranging repertoires of IPC strategies—including telehealth, screening of patients and staff, altered clinic layouts and portable outdoor shelters, in addition to appropriate use of personal protective equipment (PPE)—to manage the demands of the SARS-CoV-2 pandemic. Strategies were proactive, influenced by the varied contexts of different practices and the needs and preferences of in idual GPs as well as responsive to local, state and national requirements, which changed frequently as the pandemic evolved. Using the ‘hierarchy of controls’ as a framework for analysis, we found that the different strategies adopted in general practice often functioned in concert with one another. Most strategies, particularly administrative and PPE controls, were subjected to human variability and so were less reliable from a human factors perspective. However, our findings highlight the creativity, resilience and resourcefulness of general practice staff in developing, implementing and adapting their IPC strategies amidst constantly changing pandemic conditions.
Publisher: EMBO
Date: 03-2022
Publisher: Springer Berlin Heidelberg
Date: 2001
Publisher: BMJ
Date: 03-2023
DOI: 10.1136/BMJGH-2022-011182
Abstract: It is common for aspects of the COVID-19 response—and other public health initiatives before it—to be described as polarised. Public health decisions emerge from an interplay of facts, norms and preferred courses of action. What counts as ‘evidence’ is erse and contestable, and disagreements over how it should be interpreted are often the product of differing choices between competing values. We propose a definition of polarisation for the context of public health expertise that acknowledges and accounts for epistemic and social values as part of evidence generation and its application to public health practice. The ‘polarised’ label should be used judiciously because the descriptor risks generating or exacerbating the problem by oversimplifying complex issues and positions and creating groups that seem dichotomous. ‘Independence’ as a one-size-fits-all answer to expert polarisation is insufficient this solution is premised on a scientistic account of the role of evidence in decision making and does not make room for the value difference that is at the heart of both polarisation and evidence-based decision making.
Publisher: Springer Science and Business Media LLC
Date: 02-07-2009
Publisher: Wiley
Date: 30-06-2018
DOI: 10.1111/HEX.12589
Publisher: Oxford University Press (OUP)
Date: 27-06-2010
DOI: 10.1093/BIOINFORMATICS/BTQ339
Abstract: Motivation: Identification of functionally equivalent genes in different species is essential to understand the evolution of biological pathways and processes. At the same time, identification of strings of conserved orthologous genes helps identify complex genomic rearrangements across different organisms. Such an insight is particularly useful, for ex le, in the transfer of experimental results between different experimental systems such as Drosophila and mammals. Results: Here, we describe the Encapsulated Gene-by-gene Matching (EGM) approach, a method that employs a graph matching strategy to identify gene orthologs and conserved gene segments. Given a pair of genomes, EGM constructs a global gene match for all genes taking into account gene context and family information. The Hungarian method for identifying the maximum weight matching in bipartite graphs is employed, where the resulting matching reveals one-to-one correspondences between nodes (genes) in a manner that maximizes the gene similarity and context. Conclusion: We tested our approach by performing several comparisons including a detailed Human versus Mouse genome mapping. We find that the algorithm is robust and sensitive in detecting orthologs and conserved gene segments. EGM can sensitively detect rearrangements within large and small chromosomal segments. The EGM tool is fully automated and easy to use compared to other more complex methods that also require extensive manual intervention and input. Availability: The EGM software, Supplementary information and other tools are available online from vbc.med.monash.edu.au/∼kmahmood/EGM Contacts: james.whisstock@monash.edu geoff.webb@monash.edu Supplementary information: Supplementary data are available at Bioinformatics online.
Publisher: Springer Science and Business Media LLC
Date: 16-06-2007
Publisher: Informa UK Limited
Date: 24-07-2013
Publisher: Elsevier BV
Date: 12-2020
Publisher: Informa UK Limited
Date: 09-2012
Publisher: MDPI AG
Date: 28-05-2021
Abstract: That dogs can live and breed as free-living animals contributes to public health risks including zoonotic transmission, dog bites, and compromising people’s sense of safety in public spaces. In Australia, free-living dog populations are comprised of domestic dogs, dingoes, and dog–dingo hybrids, and are described using various terms (for ex le, stray or community), depending on social or geographic context. Urban expansion and regional migration mean that risks associated with contact between humans and free-living dogs are increasing. Public health authorities, local governments, and community organisations have called for transdisciplinary partnerships to address dog-related health risks with a sustainable long-term approach. Values pluralism and a lack of sustained community engagement in affected areas have meant that the outcome of such efforts to date has been mixed. To identify ideas in public circulation about the impact of unrestrained and free-living dogs on human health and well-being, and understand the framework through which these animals are problematised and solutions are proposed in public discourse, we systematically examined coverage of these issues in print media. Our analyses indicate that reporting in Australian newspapers tends to frame the public health impacts of free-living dogs as problems of public order requiring direct government action to re-establish control. The public health impacts of free-living dog populations in Australia have complex causes that intersect at the nexus between human and canine behaviour, agricultural and land management practices, local bylaws, and efforts to conserve ecological systems. Placing responsibility on governments limits opportunities for greater community involvement in developing integrated One Health approaches. Better-quality evidence of the impacts of dog populations on community health and well-being, and broad community support are needed to reshape public debates on animal control, which, ultimately, will promote more effective approaches to mitigate dog-related public health risks at the human–animal–environment interface.
Publisher: University of Toronto Press Inc. (UTPress)
Date: 05-2017
Abstract: The study of animal welfare and ethics (AWE) as part of veterinary education is important due to increasing community concerns and expectations about this topic, global pressures regarding food security, and the requirements of veterinary accreditation, especially with respect to Day One Competences. To address several key questions regarding the attitudes to AWE of veterinary students in Australia and New Zealand (NZ), the authors surveyed the 2014 cohort of these students. The survey aimed (1) to reveal what AWE topics veterinary students in Australia and NZ consider important as Day One Competences, and (2) to ascertain how these priorities align with existing research on how concern for AWE relates to gender and stage of study. Students identified triage and professional ethics as the most important Day One Competences in AWE. Students ranked an understanding of triage as increasingly important as they progressed through their program. Professional ethics was rated more important by early and mid-stage students than by senior students. Understanding the development of animal welfare science and perspectives on animal welfare were rated as being of little importance to veterinary graduates as Day One Competences, and an understanding of “why animal welfare matters” declined as the students progressed through the program. Combined, these findings suggest that veterinary students consider it more important to have the necessary practical skills and knowledge to function as a veterinarian on their first day in practice.
Publisher: MDPI AG
Date: 26-06-2023
DOI: 10.3390/F14071309
Abstract: Abrasion resistance is an important property for the functional performance and serviceability of timber floors. Although hardness is the conventional criterion used in selecting species for flooring applications, it shows greater variations and restricts the use of low-density species, whereas abrasion resistance could generate a more reliable indication of a product’s surface performance. Eucalyptus nitens is a fast-grown global plantation species extensively available in Tasmania, Australia. Until recently, this material has been perceived as unsuitable for appearance applications such as flooring. This study assesses several engineered flooring prototypes comprised of E. nitens—sawlog managed and fibre-managed resources—compared to an existing market product (E. obliqua and a commercial engineered timber flooring product with UV-cured coating). Tests were performed in accordance with the EN 14354:2016, sandpaper method using Taber abraser and further modified to test flooring prototypes. The highest abrasion resistance was observed in the E. nitens veneer composite product. Fibre-managed E. nitens resulted in the greatest level of abrasion, while sawlog-managed E. nitens was comparable to native regrowth E. obliqua, a commonly used flooring species historically used in Australia. Therefore, the findings from this research suggest there are suitable flooring applications for plantation E. nitens as engineered wood products in some domestic and residential dwellings when compared to existing native products.
Publisher: Elsevier BV
Date: 11-2023
Publisher: Elsevier BV
Date: 11-2023
Publisher: AMPCo
Date: 10-2015
DOI: 10.5694/MJA15.00164
Abstract: To elicit the views of well informed community members on the ethical obligations of general practitioners regarding prostate-specific antigen (PSA) testing, and what should be required before a man undergoes a PSA test. Three community juries held at the University of Sydney over 6 months in 2014. Forty participants from New South Wales, of erse social and cultural backgrounds and with no experience of prostate cancer, recruited through public advertising: two juries of mixed gender and ages one all-male jury of PSA screening age. In contrast to Royal Australian College of General Practitioners guidelines, the three juries concluded that GPs should initiate discussions about PSA testing with asymptomatic men over 50 years of age. The mixed juries voted for GPs offering detailed information about all potential consequent benefits and harms before PSA testing, and favoured a cooling-off period before undertaking the test. The all-male jury recommended a staggered approach to providing information. They recommended that written information be available to those who wanted it, but eight of the 12 jurors thought that doctors should discuss the benefits and harms of biopsy and treatment only after a man had received an elevated PSA test result. Informed jury participants preferred that GPs actively supported in idual men in making decisions about PSA testing, and that they allowed a cooling-off period before testing. However, men of screening age argued that uncertain and detailed information should be communicated only after receiving an elevated PSA test result.
Publisher: MDPI AG
Date: 08-06-2023
DOI: 10.3390/F14061192
Abstract: The performance characteristics of finger-joints as a jointing technique for Eucalyptus nitens is crucial for their use in engineered wood products. This research evaluated the strength of the finger-jointed laminations made from fiber-managed E. nitens. A total of 237 specimens with (117 pieces) and without (120 pieces) finger-joints were sectioned from finger-jointed laminations and tested by bending, tensile, shear, and bearing tests. Bending and tensile tests were paired to identify any correlations. The mean value with finger-joints for bending and tensile were 92.1 MPa and 79.6 MPa, respectively. The presence of finger-joints reduced the strength values. Joint efficiencies in bending and tensile are 0.73 and 0.62, respectively. The distributions of bending and tensile strength were similar for the s les without finger-joints. For the s les with finger-joints, tensile strength was significantly lower than paired bending strength. Shear test results show that the short-span test is inefficient in obtaining the shear strength of fiber-managed E. nitens boards. Meanwhile, the finger-joint efficiency in the bearing is 0.86. The prediction models of lamination’s bending, tensile, and bearing strength were established by non-destructive properties as predictors. Bending strength was highly correlated to the modulus of elasticity value, while tensile and bearing strength were correlated to density. This study obtained promising results on finger-jointed boards from fiber-managed E. nitens suggesting they could be suitable for structural purposes.
Publisher: BMJ
Date: 06-05-2020
DOI: 10.1136/MEDETHICS-2020-106243
Abstract: We thank Zohar Lederman and Benjamin Capps for engaging with our paper on One Health (OH) and ethical frameworks, however we want to take issue with them on three points. First, they appear to misunderstand the distinction we appeal to between ethical theory and ethical frameworks, and so misinterpret what we are trying to achieve in our paper. Second, in spite of what they seem to imply, we agree that an OH approach can obscure differences in values, and that to progress the field there needs to be recognition of competing values and their implications for OH. Finally, we are puzzled by their interest in pursuing a deliberative process, as this seems at odds with other positions they take in their paper, and also opens up many questions that need to be addressed.
Publisher: Springer Science and Business Media LLC
Date: 20-11-2019
DOI: 10.1007/S42532-019-00038-Y
Abstract: Increasing recognition of interdependencies of the health of humans, other organisms and ecosystems, and of their importance to socio-ecological systems, necessitates application of integrative concepts such as One Health and EcoHealth. These concepts open new perspectives for research and practice but also generate confusion and ergent opinion, prompting new theories, and call for empirical clarification and evaluation. Through a semi-systematic evaluation of knowledge generation in scientific publications (comprised of literature reviews, conceptual models and analyses of communities of practice), we show how integrative concepts and approaches to health evolve and are adopted. Our findings indicate that while their contexts, goals and rationales vary, integrative concepts of health essentially arise from shared interests in living systems. Despite recent increased attention to ecological and societal aspects of health including broader sustainability issues, the focus remains anthropocentric and oriented towards biomedicine. Practices reflect and in turn transform these concepts, which together with practices also influence ways of integration. Overarching narratives vary between optimism and pessimism towards integrated health and knowledge. We conclude that there is an urgent need for better, coherent and more deeply integrative health concepts, approaches and practices to foster the well-being of humans, other animals and ecosystems. Consideration of these concepts and practices has methodological and political importance, as it will transform thinking and action on both society and nature and specifically can enrich science and practice, expanding their scope and linking them better. Transdisciplinary efforts are crucial to developing such concepts and practices to properly address the multiple facets of health and to achieve their appropriate integration for the socio-ecological systems at stake. We propose the term “transdisciplinary health” to denote the new approaches needed.
Publisher: Springer Science and Business Media LLC
Date: 04-04-2019
Publisher: BMJ
Date: 23-02-2023
Abstract: There is a growing concern about artificial intelligence (AI) applications in healthcare that can disadvantage already under-represented and marginalised groups (eg, based on gender or race). Our objectives are to canvas the range of strategies stakeholders endorse in attempting to mitigate algorithmic bias, and to consider the ethical question of responsibility for algorithmic bias. The study involves in-depth, semistructured interviews with healthcare workers, screening programme managers, consumer health representatives, regulators, data scientists and developers. Findings reveal considerable ergent views on three key issues. First, views on whether bias is a problem in healthcare AI varied, with most participants agreeing bias is a problem (which we call the bias-critical view), a small number believing the opposite (the bias-denial view), and some arguing that the benefits of AI outweigh any harms or wrongs arising from the bias problem (the bias-apologist view). Second, there was a disagreement on the strategies to mitigate bias, and who is responsible for such strategies. Finally, there were ergent views on whether to include or exclude sociocultural identifiers (eg, race, ethnicity or gender- erse identities) in the development of AI as a way to mitigate bias. Based on the views of participants, we set out responses that stakeholders might pursue, including greater interdisciplinary collaboration, tailored stakeholder engagement activities, empirical studies to understand algorithmic bias and strategies to modify dominant approaches in AI development such as the use of participatory methods, and increased ersity and inclusion in research teams and research participant recruitment and selection.
Publisher: MDPI AG
Date: 29-05-2015
DOI: 10.3390/ANI5020362
Publisher: Elsevier BV
Date: 2023
DOI: 10.1016/J.IJMEDINF.2022.104903
Abstract: Alongside the promise of improving clinical work, advances in healthcare artificial intelligence (AI) raise concerns about the risk of deskilling clinicians. This purpose of this study is to examine the issue of deskilling from the perspective of erse group of professional stakeholders with knowledge and/or experiences in the development, deployment and regulation of healthcare AI. We conducted qualitative, semi-structured interviews with 72 professionals with AI expertise and/or professional or clinical expertise who were involved in development, deployment and/or regulation of healthcare AI. Data analysis using combined constructivist grounded theory and framework approach was performed concurrently with data collection. Our analysis showed participants had erse views on three contentious issues regarding AI and deskilling. The first involved competing views about the proper extent of AI-enabled automation in healthcare work, and which clinical tasks should or should not be automated. We identified a cluster of characteristics of tasks that were considered more suitable for automation. The second involved expectations about the impact of AI on clinical skills, and whether AI-enabled automation would lead to worse or better quality of healthcare. The third tension implicitly contrasted two models of healthcare work: a human-centric model and a technology-centric model. These models assumed different values and priorities for healthcare work and its relationship to AI-enabled automation. Our study shows that a erse group of professional stakeholders involved in healthcare AI development, acquisition, deployment and regulation are attentive to the potential impact of healthcare AI on clinical skills, but have different views about the nature and valence (positive or negative) of this impact. Detailed engagement with different types of professional stakeholders allowed us to identify relevant concepts and values that could guide decisions about AI algorithm development and deployment.
Publisher: Cold Spring Harbor Laboratory
Date: 24-11-2021
DOI: 10.1101/2021.11.23.469755
Abstract: Understanding the molecular pathways driving the acute antiviral and inflammatory response to SARS-CoV-2 infection is critical for developing treatments for severe COVID-19. Here we show that in COVID-19 patients, circulating plasmacytoid dendritic cells (pDCs) decline early after symptom onset and this correlated with COVID-19 disease severity. This transient depletion coincides with decreased expression of antiviral type I IFNα and the systemic inflammatory cytokines CXCL10 and IL-6. Importantly, COVID-19 disease severity correlated with decreased pDC frequency in peripheral blood. Using an in vitro stem cell-based human pDC model, we demonstrate that pDCs directly sense SARS-CoV-2 and in response produce multiple antiviral (IFNα and IFNλ1) and inflammatory (IL-6, IL-8, CXCL10) cytokines. This immune response is sufficient to protect epithelial cells from de novo SARS-CoV-2 infection. Targeted deletion of specific sensing pathways identified TLR7-MyD88 signaling as being crucial for production of the antiviral IFNs, whereas TLR2 is responsible for the inflammatory IL-6 response. Surprisingly, we found that SARS-CoV-2 engages the neuropilin-1 receptor on pDCs to mitigate the antiviral IFNs but not the IL-6 response. These results demonstrate distinct sensing pathways used by pDCs to elicit antiviral vs. immunopathological responses to SARS-CoV-2 and suggest that targeting neuropilin-1 on pDCs may be clinically relevant for mounting TLR7-mediated antiviral protection. pDCs sense SARS-CoV-2 and elicit antiviral protection of lung epithelial cells through TLR7, while recognition of TLR2 elicits an IL-6 inflammatory response associated with immunopathology. Graphical abstract: SARS-CoV-2 is internalized by pDCs via a yet unknown endocytic mechanism. The intracellular TLR7 sensor detects viral RNA and induces a signaling cascade involving MyD88-IRAK4-TRAF6 (1) to induce CXCL10 and, via IRF7 phosphorylation and translocation, inducing type I and III Interferons (2). Once secreted, type I and III IFNs initiate autocrine and paracrine signals that induce the expression of IFN stimulated genes (ISGs), thereby facilitating an antiviral response that can protect the cell against infection. However, SARS-CoV-2, has the intrinsic property to facilitate CD304 signaling, potentially by interfering with IRF7 nuclear translocation, thereby inhibiting type I IFNα production and thus reducing the antiviral response generated by the pDC (4). Furthermore, the SARS-CoV-2 envelope (E) glycoprotein is sensed by the extracellular TLR2/6 heterodimer and this facilitates production of the inflammatory IL-6 cytokine (5). Illustration was created with BioRender.com
Publisher: Springer Science and Business Media LLC
Date: 26-10-2022
Publisher: SAGE Publications Ltd
Date: 2020
Publisher: Elsevier BV
Date: 06-2019
Publisher: Wiley
Date: 05-2012
DOI: 10.1136/VR.E3420
Publisher: Springer Science and Business Media LLC
Date: 25-04-2020
DOI: 10.1186/S12910-020-00474-6
Abstract: Outbreaks of infectious disease cause serious and costly health and social problems. Two new technologies – pathogen whole genome sequencing (WGS) and Big Data analytics – promise to improve our capacity to detect and control outbreaks earlier, saving lives and resources. However, routinely using these technologies to capture more detailed and specific personal information could be perceived as intrusive and a threat to privacy. Four community juries were convened in two demographically different Sydney municipalities and two regional cities in New South Wales, Australia (western Sydney, Wollongong, Tamworth, eastern Sydney) to elicit the views of well-informed community members on the acceptability and legitimacy of: making pathogen WGS and linked administrative data available for public health research using this information in concert with data linkage and machine learning to enhance communicable disease surveillance systems Fifty participants of erse backgrounds, mixed genders and ages were recruited by random-digit-dialling and topic-blinded social-media advertising. Each jury was presented with balanced factual evidence supporting different expert perspectives on the potential benefits and costs of technologically enhanced public health research and communicable disease surveillance and given the opportunity to question experts. Almost all jurors supported data linkage and WGS on routinely collected patient isolates for the purposes of public health research, provided standard de-identification practices were applied. However, allowing this information to be operationalised as a syndromic surveillance system was highly contentious with three juries voting in favour, and one against by narrow margins. For those in favour, support depended on several conditions related to system oversight and security being met. Those against were concerned about loss of privacy and did not trust Australian governments to run secure and effective systems. Participants across all four events strongly supported the introduction of data linkage and pathogenomics to public health research under current research governance structures. Combining pathogen WGS with event-based data surveillance systems, however, is likely to be controversial because of a lack of public trust, even when the potential public health benefits are clear. Any suggestion of private sector involvement or commercialisation of WGS or surveillance data was unanimously rejected.
Publisher: Informa UK Limited
Date: 03-04-2015
Publisher: Frontiers Media SA
Date: 18-02-2020
Publisher: Springer Science and Business Media LLC
Date: 1995
DOI: 10.1007/BF01099758
Publisher: Cold Spring Harbor Laboratory
Date: 13-06-2007
DOI: 10.1101/GR.6255407
Abstract: Over 3% of human proteins contain single amino acid repeats (repeat-containing proteins, RCPs). Many repeats (homopeptides) localize to important proteins involved in transcription, and the expansion of certain repeats, in particular poly-Q and poly-A tracts, can also lead to the development of neurological diseases. Previous studies have suggested that the homopeptide makeup is a result of the presence of G+C-rich tracts in the encoding genes and that expansion occurs via replication slippage. Here, we have performed a large-scale genomic analysis of the variation of the genes encoding RCPs in 13 species and present these data in an online database ( repeats.med.monash.edu.au/genetic_analysis/ ). This resource allows rapid comparison and analysis of RCPs, homopeptides, and their underlying genetic tracts across the eukaryotic species considered. We report three major findings. First, there is a bias for a small subset of codons being reiterated within homopeptides, and there is no G+C or A+T bias relative to the organism’s transcriptome. Second, single base pair transversions from the homocodon are unusually common and may represent a mechanism of reducing the rate of homopeptide mutations. Third, homopeptides that are conserved across different species lie within regions that are under stronger purifying selection in contrast to nonconserved homopeptides.
Publisher: Springer Science and Business Media LLC
Date: 14-04-2007
Publisher: MDPI AG
Date: 20-07-2020
DOI: 10.3390/ANI10071230
Abstract: Dingo classification and management is complicated by hybridisation with domestic dogs. Northern Australia is a relatively high-risk zone for a rabies incursion, and in the event of an incursion, Aboriginal and Torres Strait Islander peoples who reside in this region would prioritise the protection of dingoes. Therefore, the classification of dingoes in this context is important. Twelve pictures of canids with features associated with both dingoes and domestic dogs from camera traps in the Northern Peninsula Area (NPA), northern Queensland, were shown to Aboriginal and Torres Strait Islander rangers (n = 3), biosecurity officers (n = 2), environmental health workers (n = 2), and residents (n = 39) in the NPA. Nearly all pictures (10/12) were classified as dingo or domestic dog (none as hybrid) and two were inconclusive (no overall agreement). Dingoes were consistently identified as medium to large-framed dogs, with a long nose, pointed ears, narrow abdomen, a bushy or feathered tail, and smooth coats of a single base colour. Some hybrid features were acceptable, including sable coats, lack of white tail tip or feet, and curled tail. These findings are a preliminary guide for identifying canids in the NPA region for whom management might be controversial. Building on this approach via further consultation with residents is needed to inform rabies response policy. Our approach using locally acquired camera trap pictures could also be extended to other regions in which dingoes have value but their management is controversial.
Publisher: Elsevier BV
Date: 11-2021
Publisher: Informa UK Limited
Date: 04-2012
Publisher: Wiley
Date: 16-08-2022
DOI: 10.1111/AJO.13603
Abstract: Australia has recently legalised mitochondrial donation. However, key ethical and legal issues still need to be addressed. This paper maps the relevant issues and offers some suggestions for how they ought to be resolved.
Publisher: MDPI AG
Date: 12-01-2023
DOI: 10.3390/BUILDINGS13010208
Abstract: Significant volumes of plantation hardwood are available in Australia to produce value-added engineered wood products such as cross-laminated timber (CLT). To validate the possibility of utilising this available resource, the bending structural properties of plantation Eucalyptus nitens solid board and finger-jointed feedstock were measured. The studied CLT panels produced from finger-jointed lamellas were subjected to bending strength, bending stiffness, rolling shear strength in bending, and pure rolling shear tests to obtain characteristic design values. Solid and finger-jointed timber test results suggested that boards used in longitudinal lamellas have a bending strength of 36.0 MPa and a modulus of elasticity (MOE) of 13,000 MPa. Finger-jointed timber in crossed lamellas presented a declared bending strength of 25.0 MPa. CLT panels showed a bending strength of 24.0 MPa and a rolling shear strength of 2.0 MPa. The experimental results for the CLT panels evidenced that the CLT bending stiffness matches up very well with the modelled results when an MOE of 13,000 MPa is used to describe the stiffness of longitudinal boards. The results presented in this study establish a basis for the commercial use of Australian plantation hardwood CLT in structural applications such as floors and roofs in commercial and residential buildings.
Publisher: Springer Science and Business Media LLC
Date: 09-04-2021
DOI: 10.1186/S12889-021-10604-3
Abstract: Communities with low vaccination rates are at greater risk during outbreaks of vaccine preventable diseases. Most Australian parents support vaccines, but some refuse and are often judged harshly by their community, especially during an outbreak. We sought the perspectives of Australian public health experts on the key issues faced when managing a measles outbreak in an area with high anti-vaccination sentiment. A measles outbreak scenario formed the basis of a 3-round modified Delphi process to identify key practitioner concerns in relation to parents/carers who don’t follow the recommended vaccination schedule. We surveyed a range of professionals in the field: policymakers, infectious disease experts, immunisation program staff, and others involved in delivering childhood vaccinations, to identify key priorities when responding to an outbreak in a community with low vaccination coverage. Findings indicate that responses to measles outbreaks in communities with high anti-vaccination sentiment are motivated by concerns about the potential for a much larger outbreak event. The highest operational priority is to isolate infected children. The two most highly ranked practical issues are mistrust from non-vaccinating members of the local region and combatting misinformation about vaccines. Trying to change minds of such in iduals is not a priority during an outbreak, nor is vaccinating their children. Using media and social media to provide information about the outbreak and measures the public can take to limit the spread of the disease was a focus. Our findings provide a deeper understanding of the challenges faced during an outbreak and priorities for communicating with communities where there is a high level of anti-vaccination sentiment. In the context of a global pandemic, the results of this study also have implications for managing public health responses to community transmission of SARS-CoV-2, as COVID-19 vaccines becomes widely available.
Publisher: Informa UK Limited
Date: 2021
Publisher: Springer Berlin Heidelberg
Date: 1992
Publisher: JSTOR
Date: 2008
DOI: 10.2307/40111302
Publisher: Research Square Platform LLC
Date: 03-07-2023
DOI: 10.21203/RS.3.RS-3065441/V1
Abstract: Background During a pre-commissioning inspection of a new biocontainment centre, radiographers noted several structural features of quarantine rooms that could compromise staff and patient safety and the quality of X-rays, even with significant modifications to a previously developed and tested radiography protocol. Methods To evaluate the safety and effectiveness of the existing protocol in the new space, two simulated mobile x-rays were undertaken in the unit prior to commissioning. The simulations were videoed, and participants and other stakeholders collaboratively analysed video footage to identify potential problems and devise solutions. These sessions were audio-recorded, transcribed and analysed thematically. Identified problems and solutions were collated and communicated to the hospital executive, to be endorsed and actioned where possible. Results Seven healthcare workers volunteered to participate. Participants identified serious latent safety threats including: increased risks of exposure to infection, occupational injury and radiation, interference with communication, and X-ray quality. Several unforeseen but important issues, across all four areas of risk, were identified only during facilitated group reviews of video footage. Conclusions In situ simulation is increasingly used to evaluate and improve healthcare practices. This study confirmed the added value of video-reflexive methods, which provide experienced participants with a richer view of a familiar protocol, in a new setting. Video footage can be examined immediately or later, if required, and by a broader group of stakeholders with erse experience or expertise. Using video-reflexivity, clinicians were able to identify, collate and present latent safety threats to those who could endorse and implement the modifications. Trial registration: Not applicable.
Publisher: MDPI AG
Date: 15-08-2022
DOI: 10.20944/PREPRINTS202208.0262.V1
Abstract: The 2019-2020 Australian bushfires followed by the COVID-19 pandemic brought the significant mental health implications of working in healthcare to the fore. The importance of appropriate support services to ensure the resilience and recovery of healthcare workers has been highlighted. In response to healthcare staff experiences during the bushfires, the SEED Wellness Program was created in 2020 in the Illawarra Shoalhaven Local Health District, in NSW Australia. SEED used a participatory action methodology to engage and collaborate with healthcare staff teams in workplace-based restorative activities. Guided by Practice Theory, this study aimed to identify and describe SEED wellness practices that supported healthcare staff. Thirty-three healthcare workers participated in focus groups or in idual interviews between June 2021 and March 2022. The analysis involved inductive thematic in idual and collective exploration of SEED practices, including co-analysis with participants. Eight core practices that supported participants’ wellbeing were identified including responsive and compassionate leading, engaging staff at every stage of the recovery process, creating a sense of connection with others, and collective caring. The study found that workplace wellness initiatives are optimised when place-based and grounded in local knowledge, needs, and resources incorporating a collective and supportive team approach. Moreover, to ensure engagement in, and sustainability of these initiatives, both bottom-up and top-down commitment is required.
Publisher: Informa UK Limited
Date: 2013
Publisher: Springer Science and Business Media LLC
Date: 05-10-2022
DOI: 10.1007/S40271-021-00547-7
Abstract: Trans Vaginal Mesh (TVM) surgeries have been used to treat stress urine incontinency (SUI) and/or pelvic organ prolapse (POP). Systematic reviews of clinical studies of outcomes suggest that the procedures have benefited a majority of women, while noting that a small minority of women have experienced harms. To provide a more complete picture of outcomes, we conducted a systematic review of the qualitative literature to provide a comprehensive analysis of women's own accounts of their experience. We conducted a systematic review and thematic synthesis of the evidence from the international qualitative literature on women's experiences of and perspectives on TVM surgery for SUI and/or POP between 1996 and 2020. We retrieved 6587 papers from PubMed, Cochrane, CINAHL, PsycINFO, Scopus, and Sociological Abstracts. After application of inclusion and exclusion criteria and full-text review of eligible articles, five articles were included in our systematic review. Findings from included articles were organised under three main themes: women's everyday lives were transformed by TVM surgery women's expectations of and approach to their future lives and women's critiques of TVM surgery. The transformation of women's everyday lives included a struggle to obtain recognition and support for their injuries before and after corrective surgery, ongoing limitations on their social, professional and personal lives, and compounding medical and psychological trauma as a result. Women's approaches to their future lives changed because of this transformation we identified five main approaches, four were ways of accommodating change, a fifth involved being unable to accommodate life changes. Women's critiques included that TVM surgeries were overused, consent processes were poor, and surgeons' definitions of success were deficient. Women expressed concerns about the safety of TVM products and future risks of further complications and discussed multiple system failures in the health care they received. This review suggests that discounting women's experiences has caused compound trauma and skewed the clinical evidence base while harms occurred in a minority of women, we suggest they should be recognised as an ethically significant potential outcome. Approaches to TVM injury should attend to historical epistemic injustice and recognise women's agency.
Publisher: Springer Science and Business Media LLC
Date: 19-09-2007
Publisher: Cambridge University Press (CUP)
Date: 07-12-2015
DOI: 10.1017/JMO.2015.45
Abstract: The purpose of this study is to employ Koeske and Koeske’s stressor-strain-outcome model of stress to examine the extent to which strain, a central component of occupational stress, mediates the relationship between safety climate and safety-related outcomes. The relationship between safety climate, strain and safety outcomes has been relatively under tested where strain is a mediating variable. This study makes a contribution to the literature by examining the dynamics of these relationships. Questionnaires were sent to 1,800 employees of an electricity provider, with a 41.4% response rate. The hypothesized model was tested using structural equation modeling. Analysis of the hypothesized model indicated that, while safety climate had a significant direct relationship with safety-related behaviors, the model was also partially mediated by the experience of strain. Understanding the relationship between safety climate, strain and safety outcomes is important. Support for the model verifies that safety climate is mediated by strain in terms of safety outcomes. Practical implications include the need to manage safety climate through management attitudes to safety, maintaining high safety standards and communication to reduce ambiguity on safety norms.
Publisher: Springer Science and Business Media LLC
Date: 2005
Publisher: University of Toronto Press Inc. (UTPress)
Date: 2016
Abstract: Historically, the veterinary profession has understood animal welfare primarily in terms of animal health and productivity, with less recognition of animals' feelings and mental state. Veterinary students' career preferences and attitudes to animal welfare have been the focus of several international studies. As part of a survey in Australia and New Zealand, this study reports on whether veterinary students prioritize animal welfare topics or professional conduct on the first day of practice and examines links between students' career preferences and their institution, gender, and year of study. The questionnaire was designed to explore the importance that students assign to topics in animal welfare and ethics. Of the 3,320 students invited to participate in the online survey, a total of 851 students participated, representing a response rate of 25.5%. Students' preferences increased for companion-animal practice and decreased for production-animal practice as they progressed through their studies. Females ranked the importance of animal welfare topics higher than males, but the perceived importance declined for both genders in their senior years. In line with previous studies, this report highlighted two concerns: (1) the importance assigned to animal welfare declined as students progressed through their studies, and (2) males placed less importance overall on animal welfare than females. Given that veterinarians have a strong social influence on animal issues, there is an opportunity, through enhanced education in animal welfare, to improve student concern for animal welfare and in turn improve animal care and policy making by future veterinarians.
Publisher: Springer Science and Business Media LLC
Date: 27-07-2013
Publisher: Wiley
Date: 12-09-2020
DOI: 10.1111/HEX.13121
Publisher: Elsevier BV
Date: 05-2022
Publisher: BMJ
Date: 29-08-2016
DOI: 10.1136/MEDETHICS-2016-103822
Abstract: It is a privilege to have respected colleagues engage with our definition and ethical evaluation of overdiagnosis. In our response to the commentaries, we first deal with paradigmatic issues: the place of realism, the relationship between diagnostic standards and correctness and the distinction between overdiagnosis and both false-positives and medicalisation. We then discuss issues arising across the commentaries in turn. Our definition captures the range of different types of overdiagnosis, unlike a definition limited to diagnosis of harmless disease. Certain implications do flow from our definition, as noted by commentators, but we do not view them as problematic: overdiagnoses can become beneficial diagnoses as medical knowledge and practice changes over time inadequate systems of healthcare can produce tragic overdiagnosis, and the effectiveness of treatment partly determines whether overdiagnosis occurs. Complexity and uncertainty in balancing benefits and harms is unfortunate, but not a reason to avoid making a judgement (ideally one that reflects multiple perspectives). We reaffirm that overdiagnosis, for the foreseeable future, must be estimated at a population level and defend the importance of good-quality risk communication for in iduals. We acknowledge that a lot turns on the relevance of professional communities in our definition and expand our reasoning in this regard then conclude with a note on the difference between intentions and goals. We expect that it will be some time before these matters are settled and we look forward to continue debating these matters with our colleagues.
Publisher: University of Toronto Press Inc. (UTPress)
Date: 05-2019
Abstract: A veterinary anesthesia simulated environment (VASE) with clinical scenarios has been integrated into the pre-clinical curriculum at Midwestern University College of Veterinary Medicine to simulate anesthesia of a live patient within a surgical suite. Although this modality was shown to significantly improve veterinary students’ perceived preparedness to perform anesthesia on live patients, whether this would improve anesthesia competency in the actual clinical environment, described as operational performance, remained unclear. Our goal was to examine the relationship between anesthesia simulation training and student anesthesia operational performance. Anesthesia operational performance assessment of students was determined by quantifying critical event occurrences that negatively impacted patient safety during the anesthesia of 287 patients during students’ initial surgical experience in 2015 and 2016. The relationship between total numbers of critical incidents to students having anesthesia simulation training was determined through evaluation of anesthesia records from 2015 and 2016, where students did not have anesthesia simulation training or they had pre-clinical training, respectively. Results showed a significant relationship between simulation training and critical incident occurrence, with a critical incident more likely to occur during patient anesthesia for students who did not experience pre-clinical anesthesia simulation training. Of the total critical incidents that occurred in the two-year study, 88% were in patients anesthetized by students who did not have simulation training. Our findings suggest that students who were given the opportunity to participate in anesthesia-focused simulations before a live-animal anesthesia encounter demonstrated significant improvements in anesthesia operational performance and improved patient safety.
Publisher: Wiley
Date: 05-04-2011
DOI: 10.1002/WIDM.28
Abstract: Association mining has been one of the most intensively researched areas of data mining. However, direct uptake of the resulting technologies has been relatively low. This paper examines some of the reasons why the dominant paradigms in association mining have not lived up to their promise, and argues that a powerful alternative is provided by top‐ k techniques coupled with appropriate statistical and other filtering. © 2011 John Wiley & Sons, Inc. WIREs Data Mining Knowl Discov 2011 1 183–192 DOI: 10.1002/widm.28 This article is categorized under: Algorithmic Development Association Rules Algorithmic Development Statistics Technologies Association Rules
Publisher: Elsevier BV
Date: 2019
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 12-2007
Publisher: Springer Science and Business Media LLC
Date: 04-09-2015
Publisher: JSTOR
Date: 2006
DOI: 10.2307/40111535
Publisher: Oxford University Press (OUP)
Date: 22-12-2019
DOI: 10.1093/PHE/PHZ017
Abstract: A One Health approach holds great promise for attenuating the risk and burdens of emerging infectious diseases (EIDs) in both human and animal populations. Because the course and costs of EID outbreaks are difficult to predict, One Health policies must deal with scientific uncertainty, whilst addressing the political, economic and ethical dimensions of communication and intervention strategies. Drawing on the outcomes of parallel Delphi surveys conducted with policymakers in Singapore and Australia, we explore the normative dimensions of two different precautionary approaches to EID decision-making—which we call regimes of risk management and organizing uncertainty, respectively. The imperative to act cautiously can be seen as either an epistemic rule or as a decision rule, which has implications for how EID uncertainty is managed. The normative features of each regime, and their implications for One Health approaches to infectious disease risks and outbreaks, are described. As One Health attempts to move upstream to prevent rather than react to emergence of EIDs in humans, we show how the approaches to uncertainty, taken by experts and decision-makers, and their choices about the content and quality of evidence, have implications for who pays the price of precaution, and, thereby, social and global justice.
Publisher: Elsevier BV
Date: 09-2021
Publisher: Research Square Platform LLC
Date: 12-2020
DOI: 10.21203/RS.3.RS-115156/V1
Abstract: Background Communities with low vaccination rates are at greater risk during outbreaks of vaccine preventable diseases. Most Australian parents support vaccines, but some refuse and are often judged harshly by their community, especially during an outbreak. We sought the perspectives of Australian public health experts on the key issues faced when managing a measles outbreak in an area with high anti-vaccination sentiment. Methods A measles outbreak scenario formed the basis of a 3-round modified Delphi process to identify key practitioner concerns in relation to parents/carers who don’t follow the recommended vaccination schedule. We surveyed a range of professionals in the field: policymakers, infectious disease experts, immunisation program staff, and others involved in delivering childhood vaccinations, to identify key priorities when responding to an outbreak in a community with low vaccination coverage. Results Findings indicate that responses to measles outbreaks in communities with high anti-vaccination sentiment are motivated by concerns about the potential for a much larger outbreak event. The highest operational priority is to isolate infected children. The two most highly ranked practical issues are mistrust from non-vaccinating members of the local region and combatting misinformation about vaccines. Trying to change minds of such in iduals is not a priority during an outbreak, nor is vaccinating their children. Using media and social media to provide information about the outbreak and measures the public can take to limit the spread of the disease was a focus. Conclusions Our findings provide a deeper understanding of the challenges faced during an outbreak and priorities for communicating with communities where there is a high level of anti-vaccination sentiment. In the context of a global pandemic, the results of this study also have implications for managing public health responses to community transmission of SARS-CoV-2, if and when a safe and effective vaccine becomes widely available.
Publisher: Elsevier BV
Date: 04-2015
DOI: 10.1016/J.SOCSCIMED.2015.03.009
Abstract: Deliberative methods are of increasing interest to public health researchers and policymakers. We systematically searched the peer-reviewed literature to identify public health and health policy research involving deliberative methods and report how deliberative methods have been used. We applied a taxonomy developed with reference to health policy and science and technology studies literatures to distinguish how deliberative methods engage different publics: citizens (ordinary people who are unfamiliar with the issues), consumers (those with relevant personal experience e.g. of illness) and advocates (those with technical expertise or partisan interests). We searched four databases for empirical studies in English published 1996-2013. This identified 78 articles reporting on 62 distinct events from the UK, USA, Canada, Australasia, Europe, Israel, Asia and Africa. Ten different types of deliberative techniques were used to represent and capture the interests and preferences of different types of public. Citizens were typically directed to consider community interests and were treated as a resource to increase democratic legitimacy. Citizens were preferred in methodological studies (those focused on understanding the techniques). Consumers were directed to focus on personal preferences thus convened not as a source of policy decisions, but of knowledge about what those affected by the issue would accept. Advocates-who are most commonly used as expert witnesses in juries-were sometimes engaged to deliberate with consumers or citizens. This almost always occurred in projects directly linked to policy processes. This suggests health policymakers may value deliberative methods as a way of understanding disagreement between perspectives. Overall however, the 'type' of public sought was often not explicit, and their role not specified. This review provides new insight into the heterogeneity and rising popularity of deliberative methods, and indicates a need for greater clarity regarding both the constitution of publics and the relative usefulness of different deliberative techniques.
Publisher: Springer Science and Business Media LLC
Date: 02-02-2008
Publisher: Springer Science and Business Media LLC
Date: 13-04-2010
Publisher: Springer Science and Business Media LLC
Date: 04-10-2013
DOI: 10.1007/S11673-013-9478-Z
Abstract: Within the field of medical ethics, discussions related to public health have mainly concentrated on issues that are closely tied to research and practice involving technologies and professional services, including vaccination, screening, and insurance coverage. Broader determinants of population health have received less attention, although this situation is rapidly changing. Against this backdrop, our specific contribution to the literature on ethics and law vis-à-vis promoting population health is to open up the ubiquitous presence of pets within cities and towns for further discussion. An expanding body of research suggests that pet animals are deeply relevant to people's health (negatively and positively). Pet bylaws adopted by town and city councils have largely escaped notice, yet they are meaningful to consider in relation to everyday practices, social norms, and cultural values, and thus in relation to population health. Nevertheless, not least because they pivot on defining pets as private property belonging to in idual people, pet bylaws raise emotionally charged ethical issues that have yet to be tackled in any of the health research on pet ownership. The literature in moral philosophy on animals is vast, and we do not claim to advance this field here. Rather, we pragmatically seek to reconcile philosophical objections to pet ownership with both animal welfare and public health. In doing so, we foreground theorizations of personhood and property from sociocultural anthropology.
Publisher: Oxford University Press (OUP)
Date: 2011
Publisher: Oxford University Press (OUP)
Date: 02-07-2012
Abstract: Research into physical activity and human health has recently begun to attend to dog-walking. This study extends the literature on dog-walking as a health behaviour by conceptualizing dog-walking as a caring practice. It centres on qualitative interviews with 11 Canadian dog-owners. All participants resided in urban neighbourhoods identified through previous quantitative research as conducive to dog-walking. Canine characteristics, including breed and age, were found to influence people's physical activity. The health of the dog and its position in the life-course influenced patterns of dog-walking. Frequency, duration and spatial patterns of dog-walking all depended on relationships and people's capacity to tap into resources. In foregrounding networks of care, inclusive of pets and public spaces, a relational conceptualization of dog-walking as a practice of caring helps to make sense of heterogeneity in patterns of physical activity among dog-owners.
Publisher: MDPI AG
Date: 28-11-2022
DOI: 10.3390/BUILDINGS12122078
Abstract: Fibre-managed E. nitens has the potential to be used as a feedstock for engineered wood products. This resource, however, has a number of strength-reducing features that need to be removed, and the board needs to be re-joint to be useful in greater lengths for timber construction. A common jointing practice is finger jointing. The suitability of the finger jointing technique for this species is crucial to the mechanical properties of the final product. This study was conducted to explore the influence of finger jointing on the stiffness of sawn boards. A strict manufacturing process of docking and re-joining timber boards in the same location without removing strength-reducing features was conducted to compare the stiffness parameters before and after finger jointing with bending tests. A statistical analysis was conducted. The results showed that the frequency of finger joints along the board did not significantly impact the edgewise stiffness however, the average flatwise stiffness of the s les with more finger joints was improved slightly. A 10% increase in the end pressure reduced the tip gap significantly but did not influence the stiffness. The finger joint efficiency was 0.824 for the edgewise stiffness of the s les and 1.034 for flatwise stiffness of the jointed sections.
Publisher: Elsevier BV
Date: 2021
Publisher: International Union Against Tuberculosis and Lung Disease
Date: 10-2015
Abstract: Biomedical innovations are unlikely to provide effective and ethical tuberculosis (TB) control measures without complementary social science research. However, a strong interest in interdisciplinary work is often undermined by differences in language and concepts specific to each disciplinary approach. Accordingly, biological and social scientists need to learn how to communicate with each other. This article will outline key concepts relating to TB from medical anthropology and health sociology. Distilling these concepts in an introductory framework is intended to make this material accessible to researchers in laboratory, clinical and fieldwork settings, as well as to encourage more social scientists to engage with TB research among target groups critical for successful programmatic interventions. For pedagogical purposes, the relevant concepts are grouped into three categories: 1) structures and settings, which includes overarching themes such as syndemics, local biologies, medicalisation, structural violence and surveillance 2) practices and processes, encompassing gender, stigma, taboo, and victim blaming and 3) experience and enculturation, which includes illness narratives, biographical disruption and dynamic nominalism. By helping to navigate this literature, we hope to foster more cross-disciplinary conversations between qualitative and quantitative researchers. TB, a quintessential social disease, will be controlled more effectively using a multistranded research approach.
Publisher: Elsevier BV
Date: 07-2022
DOI: 10.1016/J.SOCSCIMED.2022.115094
Abstract: Recent social science scholarship has sought to understand the visible and invisible impacts of how antibiotics are entrenched as infrastructures and put to work as a proxy for higher levels of care (clinical or otherwise) within modern healthcare. Using a qualitative research design, in this paper our aim is to draw attention to less visible aspects of antimicrobial stewardship (AMS) in residential aged care and their implications for nurse-led optimization of antibiotic use in these settings. By developing an account of the perceptions, experiences and practices of staff regarding the 'on the ground' work associated with implementing and upholding AMS objectives our study extends research on attempts to dismantle antibiotic infrastructures in Australian residential aged care facilities (RACF). Drawing on a review of relevant policies, empirical data is presented from fifty-six in-depth interviews conducted in 2021 with staff at 8 different RACFs. Interview participants included managers, nurses, and senior and junior personal care assistants. Our results suggest that registered nurses in residential aged care have been tasked with promoting antibiotic optimization and assigned with AMS responsibilities without sufficient authority and resourcing. A host of hidden care work associated with AMS strategies was evident, reinforcing some staff support for empirical antibiotic prescribing as a 'safety net' in uncertain clinical cases. We argue that this hidden work occurs where AMS strategies displace the infrastructural role previously performed by antibiotics, exposing structural gaps and pressures. The inability of organisational accounting systems and the broader AMS policy agenda to capture hidden AMS workflows in RACFs has consequences for future resourcing and organisational learning in ways that mean AMS gaps may remain unaddressed. These results support findings that AMS interventions might not be easily accepted by aged care staff in view of associated burdens which are under recognised and under supported in this domain.
Publisher: Elsevier BV
Date: 04-2018
Publisher: University of Toronto Press Inc. (UTPress)
Date: 05-2019
Abstract: Animals used for sport, recreation and display are highly visible and can ide community attitudes. The study of animal welfare and ethics (AWE) as part of veterinary education is important because it is the responsibility of veterinarians to use their scientific knowledge and skills to promote animal welfare in the context of community expectations. To explore the attitudes of veterinary students in Australia and New Zealand to AWE, a survey of the current cohort was undertaken. The survey aimed to reveal how veterinary students in Australia and New Zealand rate the importance of five selected AWE topics for Day One Competences in animals used in sport, recreation and display and to establish how veterinary students’ priorities were associated with gender and stage of study. The response rate (n = 851) across the seven schools was just over 25%. Results indicated little variation on ratings for topics. The topics were ranked in the following order (most to least important): Pushing of animals to their physiologic/behavioral limits ownership/responsibility euthanasia educating the public and behavior, selection, and training for sport and recreation displays. In contrast to related studies, ratings were not associated with stage of study and there were few differences associated with gender. More females rated the pushing of animals to physiologic/behavioral limits as extremely important than did males ( p .001). The role of veterinarians in advocating for and educating the public about the welfare of animals used in sport, recreation and display merits further discussion.
Publisher: Wiley
Date: 11-06-2020
DOI: 10.1111/AVJ.12957
Publisher: Oxford University Press (OUP)
Date: 26-02-2013
DOI: 10.1093/JMP/JHT004
Abstract: The seminal 1993 article by LaFollette and Shanks "Animal Models in Biomedical Research: Some Epistemological Worries" introduced an influential taxonomy into the debate about the value of animal experimentation. The distinction they made between hypothetical and causal analog models served to highlight a concern regarding extrapolating results obtained in animal models to human subjects, which endures today. Although their taxonomy has made a significant contribution to the field, we maintain that it is flawed, and instead, we offer a new practice-oriented taxonomy of animal models as a means to allow philosophers, modelers, and other interested parties to discuss the epistemic merits and shortcomings, purpose, and predictive capacities of specific modeling practices.
Publisher: Springer Science and Business Media LLC
Date: 04-09-2009
Publisher: Springer Berlin Heidelberg
Date: 2003
Publisher: Association for Research in Vision and Ophthalmology (ARVO)
Date: 05-06-2023
DOI: 10.1167/IOVS.64.7.8
Publisher: Springer Berlin Heidelberg
Date: 1996
Publisher: MDPI AG
Date: 03-11-2022
DOI: 10.3390/BUILDINGS12111862
Abstract: Hardness is commonly used to determine the suitability of a timber species for flooring applications. In this study, Janka hardness test is conducted on sawlog managed Eucalyptus nitens and regrowth forest Eucalyptus obliqua sourced from Tasmania, Australia. Plantation E. nitens timber is currently entering the Australian market and the feasibility of using this fast grown species in value added applications such as timber flooring is advantageous. Further to testing Janka hardness on solid timber s les, a regime of engineered timber flooring prototypes consisting of plantation E. nitens top layers, veneers and solid densified E. nitens boards were developed and subjected to Janka hardness test. The results were compared against solid E. obliqua flooring and a commercially available engineered flooring product with Tasmanian Oak top layer. The results showed that Janka hardness of plantation grown E. nitens, and E. obliqua currently available in the market are lower than the values published in the literature. This indicates that the material properties of fast grown plantation timber and regrowth forest material are different to the native forest timber properties published decades earlier. Furthermore, some of the tested engineered flooring prototypes showed similar behaviour to timber flooring products currently in market, suggesting that E. nitens engineered flooring would be suitable for domestic/light commercial flooring applications despite the general conception of unsuitability due to lower densities.
Publisher: SAGE Publications
Date: 2023
DOI: 10.1177/20552076231191057
Abstract: Mammographic screening for breast cancer is an early use case for artificial intelligence (AI) in healthcare. This is an active area of research, mostly focused on the development and evaluation of in idual algorithms. A growing normative literature argues that AI systems should reflect human values, but it is unclear what this requires in specific AI implementation scenarios. Our objective was to understand women's values regarding the use of AI to read mammograms in breast cancer screening. We ran eight online discussion groups with a total of 50 women, focused on their expectations and normative judgements regarding the use of AI in breast screening. Although women were positive about the potential of breast screening AI, they argued strongly that humans must remain as central actors in breast screening systems and consistently expressed high expectations of the performance of breast screening AI. Women expected clear lines of responsibility for decision-making, to be able to contest decisions, and for AI to perform equally well for all programme participants. Women often imagined both that AI might replace radiographers and that AI implementation might allow more women to be screened: screening programmes will need to communicate carefully about these issues. To meet women's expectations, screening programmes should delay implementation until there is strong evidence that the use of AI systems improves screening performance, should ensure that human expertise and responsibility remain central in screening programmes, and should avoid using AI in ways that exacerbate inequities.
Start Date: 2011
End Date: 2013
Funder: Canadian Institutes of Health Research
View Funded ActivityStart Date: 2013
End Date: 2016
Funder: Canadian Institutes of Health Research
View Funded ActivityStart Date: 2017
End Date: 2021
Funder: National Health and Medical Research Council
View Funded ActivityStart Date: 2015
End Date: 2018
Funder: National Health and Medical Research Council
View Funded ActivityStart Date: 2012
End Date: 2015
Funder: National Health and Medical Research Council
View Funded ActivityStart Date: 2021
End Date: 2021
Funder: National Health and Medical Research Council
View Funded ActivityStart Date: 2020
End Date: 2023
Funder: National Health and Medical Research Council
View Funded ActivityStart Date: 2022
End Date: 2024
Funder: Australian Research Council
View Funded ActivityStart Date: 07-2022
End Date: 06-2025
Amount: $630,000.00
Funder: Australian Research Council
View Funded Activity