ORCID Profile
0000-0002-2585-7559
Current Organisations
Northwest A and F University
,
First Affiliated Hospital of Xi'an Jiaotong University
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Publisher: Springer Science and Business Media LLC
Date: 31-01-2015
DOI: 10.1186/S11671-015-0752-3
Abstract: Human-like collagen (HLC)-coated monodispersed superparamagnetic Fe 3 O 4 nanoparticles have been successfully prepared to investigate its effect on heat induction property and cell toxicity. After coating of HLC, the s le shows a faster rate of temperature increase under an alternating magnetic field although it has a reduced saturation magnetization. This is most probably a result of the effective heat conduction and good colloid stability due to the high charge of HLC on the surface. In addition, compared with Fe 3 O 4 nanoparticles before coating with HLC, HLC-coated Fe 3 O 4 nanoparticles do not induce notable cytotoxic effect at higher concentration which indicates that HLC-coated Fe 3 O 4 nanoparticles has improved biocompatibility. Our results clearly show that Fe 3 O 4 nanoparticles after coating with HLC not only possess effective heat induction for cancer treatment but also have improved biocompatibility for biomedicine applications.
Publisher: American Chemical Society (ACS)
Date: 06-04-2017
Abstract: Large-scale synthesis of monodisperse ultrasmall metal ferrite nanoparticles as well as understanding the correlations between chemical composition and MR signal enhancement is critical for developing next-generation, ultrasensitive T
Publisher: Wiley
Date: 14-06-2016
Abstract: Uniform wüstite Fe0.6 Mn0.4 O nanoflowers have been successfully developed as an innovative theranostic agent with T1 -T2 dual-mode magnetic resonance imaging (MRI), for diagnostic applications and therapeutic interventions via magnetic hyperthermia. Unlike their antiferromagnetic bulk counterpart, the obtained Fe0.6 Mn0.4 O nanoflowers show unique room-temperature ferromagnetic behavior, probably due to the presence of an exchange coupling effect. Combined with the flower-like morphology, ferromagnetic Fe0.6 Mn0.4 O nanoflowers are demonstrated to possess dual-modal MRI sensitivity, with longitudinal relaxivity r1 and transverse relaxivity r2 as high as 4.9 and 61.2 mm(-1) s(-1) [Fe]+[Mn], respectively. Further in vivo MRI carried out on the mouse orthotopic glioma model revealed gliomas are clearly delineated in both T1 - and T2 -weighted MR images, after administration of the Fe0.6 Mn0.4 O nanoflowers. In addition, the Fe0.6 Mn0.4 O nanoflowers also exhibit excellent magnetic induction heating effects. Both in vitro and in vivo magnetic hyperthermia experimentation has demonstrated that magnetic hyperthermia by using the innovative Fe0.6 Mn0.4 O nanoflowers can induce MCF-7 breast cancer cell apoptosis and a complete tumor regression without appreciable side effects. The results have demonstrated that the innovative Fe0.6 Mn0.4 O nanoflowers can be a new magnetic theranostic platform for in vivo T1 -T2 dual-mode MRI and magnetic thermotherapy, thereby achieving a one-stop diagnosis cum effective therapeutic modality in cancer management.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C7TB03129G
Abstract: Monodispersed 4 nm Gd-doped iron oxide nanoparticles (GdIONPs) were fabricated, and were as T 1 -weighted contrast agents to confirm the feasibility of non-invasively quantify and monitor IONPs in vivo based on MRI longitudinal relaxation times.
Publisher: Wiley
Date: 24-01-2014
Publisher: Elsevier BV
Date: 04-2015
Publisher: AIP Publishing
Date: 13-12-2012
DOI: 10.1063/1.3684963
Abstract: Magnetite nanoring with vortex domain structure may form stable magnetic colloid for biomedical applications due to its weak magnetic interaction without superparamagnetic (SPM) limitation. In the present study, we perform three-dimensional (3 D) Landau-Liftshitz-Gilbert (LLG) micromagnetics simulation for magnetite nanorings. The ground state phase diagram and stable vortex area (SVA) as a function of outer diameter (Dout), thickness (T), and inner to outer diameter ratios (β) within 100 nm are obtained. The influence of notch, eccentricity, and crystallographic orientation are taken carefully into consideration. In the SVA, the vortex state is not only the ground state but also the remanence state after in-plane is fully magnetized. In particular, the results suggest that a 20 nm inter-rings distance for a typical magnetite nanoring (Dout = 70 nm, T = 50 nm, and β = 0.6) can achieve the stable colloid based on vortex domain structure. Furthermore, these simulation results have been confirmed experimentally and demonstrated by using phosphorylated-mPEG modified magnetite nanorings. The optimization of magnetite nanorings from both simulation and experiments in this work pave the way to achieve such novel and stable vortex domain based magnetic suspension for various biomedical applications.
Publisher: Royal Society of Chemistry (RSC)
Date: 2012
DOI: 10.1039/C2JM30472D
Publisher: Elsevier BV
Date: 12-2013
Publisher: Springer Science and Business Media LLC
Date: 15-09-2015
Publisher: American Chemical Society (ACS)
Date: 25-02-2019
Location: China
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