ORCID Profile
0000-0002-4482-893X
Current Organisation
Beijing Institute of Technology
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Publisher: AIP Publishing
Date: 09-2023
DOI: 10.1063/5.0165614
Publisher: Elsevier BV
Date: 2018
Publisher: AIP Publishing
Date: 2022
DOI: 10.1063/5.0131077
Abstract: The particle focus in the channel flow refers to a randomly initialized particle finally running at an equilibrium position at the channel cross section. The binding focus is a particle focus phenomenon that comprises two adjacent particles (including one rigid and the other soft), where particles can form and share a new equilibrium position. In this study, the result suggests that migrating the rigid particle laterally can lead to a passive migration of the soft. The above phenomenon is termed external force attached binding focus (EFABF). The EFABF is modeled to be three-dimensional using the immersed boundary-lattice Boltzmann method. The inertial focus of a single particle and the binding focus of two particles are numerically confirmed to validate the model. The migrating conditions of the soft particle are mainly discussed to further investigate the conditions of EFABF. Two patterns to migrate the soft particle are observed, including rigid particle ahead and soft particle ahead. The Reynolds number of 10 is proposed, which can apply to EFABF to obtain a significant migration scope. Moreover, the mechanism of EFABF is further analyzed to gain more insight into EFABF. Finally, as its application, a label-free single-cell separation architecture is designed by replacing the soft particle with a spherical circulating tumor cell and magnetically manipulating the rigid particle. The numerical results suggest that the soft particle (cell) can be well driven to stride over streamlines and form a new equilibrium position by migrating the rigid particle, thus making the separation pathway well-controlled.
Publisher: Informa UK Limited
Date: 12-01-2022
Publisher: Elsevier BV
Date: 09-2021
Publisher: SAGE Publications
Date: 02-08-2020
Abstract: The capture of cells in a microfluidic device based on U-shaped sieves is numerically investigated by the immersed boundary-lattice Boltzmann method (IB-LBM). The effects of the width of the inlet ( h), the radius of sieves ([Formula: see text]), and the radius of posts ([Formula: see text]) on the efficiency of the device on trapping cells are studied. It is found that a narrower inlet improves the capability of the device to capture cells and promotes the uniform trapping of cells. In addition, the device is not sufficiently efficient in capturing cells when the radius [Formula: see text] is small. By increasing [Formula: see text] gradually, the cells trapped in the device are found to grow up first and then decrease. This can be explained as an optimal size of apertures between posts to induce the cells to enter the sieve, and then the cells can plug up these apertures. Finally, the effects of the post size on the cell-capturing are studied. It is found that more cells can be captured as [Formula: see text] experiences a slight increase, while the capturing efficiency will not improve if continuing to increase [Formula: see text].
Publisher: Hindawi Limited
Date: 2016
DOI: 10.1155/2016/2564584
Abstract: As a typical microfluidic cell sorting technique, the size-dependent cell sorting has attracted much interest in recent years. In this paper, a size-dependent cell sorting scheme is presented based on a controllable asymmetric pinched flow by employing an immersed boundary-lattice Boltzmann method (IB-LBM). The geometry of channels consists of 2 upstream branches, 1 transitional channel, and 4 downstream branches (D-branches). Simulations are conducted by varying inlet flow ratio, the cell size, and the ratio of flux of outlet 4 to the total flux. It is found that, after being randomly released in one upstream branch, the cells are aligned in a line close to one sidewall of the transitional channel due to the hydrodynamic forces of the asymmetric pinched flow. Cells with different sizes can be fed into different downstream D-branches just by regulating the flux of one D-branch. A principle governing D-branch choice of a cell is obtained, with which a series of numerical cases are performed to sort the cell mixture involving two, three, or four classes of diameters. Results show that, for each case, an adaptive regulating flux can be determined to sort the cell mixture effectively.
No related grants have been discovered for Yuanqing Xu.