ORCID Profile
0000-0003-2993-9671
Current Organisations
The University of Newcastle
,
University of Leeds
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Publisher: Yeshwantrao Chavan College of Engineering
Date: 21-10-2021
Publisher: Elsevier BV
Date: 11-2023
Publisher: Informa UK Limited
Date: 09-08-2021
Publisher: Wiley
Date: 20-01-2023
Publisher: Elsevier BV
Date: 02-2016
Publisher: Informa UK Limited
Date: 07-07-2020
Publisher: Elsevier BV
Date: 11-2023
Publisher: Springer Science and Business Media LLC
Date: 29-08-2020
Publisher: Cold Spring Harbor Laboratory
Date: 04-2021
DOI: 10.1101/2021.04.01.438050
Abstract: The MscL channel gates in response to membrane tension changes to allow the exchange of molecules through its pore. Lipid removal from transmembrane pockets leads to a MscL response. However, it is unknown whether there is correlation between the tension mediated state and the state derived by pocket delipidation in the absence of tension. Transitions between MscL states may follow a similar pathway to cover the available conformational space but may not necessarily s le the same discrete intermediates. Here, we combined pulsed-EPR and HDX-MS measurements on MscL, coupled with molecular dynamics under membrane tension, to investigate the changes associated with the distinctively derived states. Whether it is tension or pocket delipidation, we find that MscL s les a similar expanded state, which is the final step of the delipidation pathway but only an intermediate stop of the tension mediated path. Our findings hint at synergistic modes of regulation in mechanosensitive channels.
Publisher: Springer Science and Business Media LLC
Date: 25-01-2021
DOI: 10.1007/S42461-021-00378-Y
Abstract: Investigation and uptake of filtered tailings continues to grow throughout the globe. This is driven by a wide range of site-specific considerations, which include such factors as tailings characteristics (e.g., amenability to filtration), production rates, climate, water availability, cost drivers, environmental requirements, and social factors. Despite the aforementioned technological growth, the currently available filtration technology is not able to meet the needs of many operations and projects that would otherwise adopt the technology. Experience with large-scale industrial filtration shows that vacuum belt filter systems meet the needs of many modern users, exceptions being the inability to effectively dewater tailings at altitude and/or with a fine particle size distribution: a potential fatal flaw. This paper presents a case study on the utilization of the patented Viper Filtration technology on gold tailings to overcome this challenge and shares the resultant full-scale plant design, highlighting the features designed to overcome cost and scalability deterrents. This technology is a novel mechanical process which complements the vacuum pressure in dewatering the filter cake as it travels along the belt filter. This project commenced with a pilot testing program, which successfully met the objective to rigorously test, measure and record any performance improvements achieved when engaging the Viper technology. Of the two tailings products tested, gross improvements of 4.2%w/w and 5.7%w/w were achieved when compared to the conventional vacuum belt filter operation. This pilot testing facilitated measurement of operating and design data, which forms the basis of the full-scale system design and resultant equipment supply of three vibration roller assemblies for retro-fitting on the existing vacuum belt filter.
Publisher: Elsevier BV
Date: 05-2022
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Peter Robinson.