ORCID Profile
0000-0002-6341-7677
Current Organisation
University of Queensland
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Analytical spectrometry | Nanomaterials | Nanotechnology | Functional materials
Publisher: Wiley
Date: 05-03-2014
Abstract: A unique combined pore approach to the sensitive detection of human insulin is developed. Through a systematic study to understand the impact of pore size and surface chemistry of nanoporous materials on their enrichment and purification performance, the advantages of selected porous materials are integrated to enhance detection sensitivity in a unified two-step process. In the first purification step, a rationally designed large pore material (ca. 100 nm in diameter) is chosen to repel the interferences from nontarget molecules. In the second enrichment step, a hydrophobically modified mesoporous material with a pore size of 5 nm is selected to enrich insulin molecules. A low detection limit of 0.05 ng mL(-1) in artificial urine is achieved by this advanced approach, similar to most antibody-based analysis protocols. This designer approach is efficient and low cost, and thus has great potential in the sensitive detection of biomolecules in complex biological systems.
Publisher: Wiley
Date: 28-01-2012
DOI: 10.1002/JBM.B.32662
Abstract: Periodontal regeneration is defined as regeneration of the tooth-supporting tissues including cementum, periodontal ligament, and alveolar bone. Guided tissue regeneration (GTR) has been demonstrated to be an effective technique to achieve periodontal regeneration. In the GTR procedures, various kinds of membranes play important roles. Chitosan, a deacetylated derivative of chitin, is biocompatible, biodegradable, and antimicrobial. It acts as hydrating agent and possesses tissue healing and osteoinducing effect. Chitosan can be easily processed into membranes, gels, nanofibers, beads, nanoparticles, scaffolds, and sponges forms and can be used in drug delivery systems. Here, we review the bioproperties of chitosan and report the progress of application of chitosan as membranes in GTR and guided bone regeneration (GBR), which indicates that chitosan could be a good substrate candidate as the materials for the GTR/GBR membranes.
Publisher: Wiley
Date: 29-05-2018
Publisher: Springer Science and Business Media LLC
Date: 04-2017
DOI: 10.1007/S10103-017-2197-7
Abstract: The purpose of this in vitro study was to investigate the efficacy of micro-Raman spectroscopy on detecting mineral content change during the demineralization and de/remineralization cycling process. The enamel s les (n = 55) were randomly ided into three groups and separately treated with demineralization solution (n = 20), de/remineralization cycling solution (n = 30), and distilled water (n = 5). Micro-Raman spectroscopy, microhardness (MHS), and the released calcium ions concentration were performed before and after treatment, respectively. A one-way analysis of variance (ANOVA) with a post hoc Tukey test was used to analyze the results. The Spearman correlation coefficients among the parameters of Raman relative intensity decrease (RRI
Publisher: Elsevier BV
Date: 08-2021
Publisher: Frontiers Media SA
Date: 05-2019
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3NR04194H
Abstract: Mass spectrometry (MS) based analyses have received intense research interest in a series of rapidly developing disciplines. Although current MS techniques have enjoyed great successes, several key challenges still remain in practical applications, especially for the detection of biomolecules in biological systems. The use of nanomaterials in MS based analysis provides a promising approach due to their unique physical and chemical properties. In this review, nanomaterials with different compositions and nanostructures employed in MS applications are summarised and classified by their functions. Such an integrated and wide reaching review will provide a comprehensive handbook to researchers with various backgrounds working in this exciting interdisciplinary area.
Publisher: American Chemical Society (ACS)
Date: 03-05-2021
Publisher: American Chemical Society (ACS)
Date: 29-01-2020
Publisher: Wiley
Date: 02-02-2021
Publisher: Wiley
Date: 07-10-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C4NR00633J
Abstract: A novel combo-pore approach has been designed for the programmable purification, minimisation of s le complexity, enrichment and sensitive detection of peptides in bios les.
Publisher: Springer Science and Business Media LLC
Date: 23-04-2020
Publisher: Springer International Publishing
Date: 11-2021
Publisher: MDPI AG
Date: 21-06-2022
DOI: 10.3390/BIOENGINEERING9070266
Abstract: Lateral flow assays (LFAs) have attracted much attention as rapid and affordable point-of-care devices for medical diagnostics. The global SARS-CoV-2 pandemic has further highlighted the importance of LFAs. Many efforts have been made to enhance the sensitivity of LFAs. In recent years, silica nanomaterials have been used to either lify the signal of label materials or provide stability, resulting in better detection performance. In this review, the recent progress of silica-nanomaterial-assisted LFAs is summarized. The impact of the structure of silica nanomaterials on LFA performance, the challenges and prospects in this research area are also discussed.
Publisher: SPIE-Intl Soc Optical Eng
Date: 2012
Publisher: American Chemical Society (ACS)
Date: 19-03-2019
Abstract: Thiolated dendritic mesoporous silica nanoparticles (T-DMSNs) with ultrahigh density of thiol groups (284.6 ± 9 μmol g
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9NR08467C
Abstract: Deoxyribonuclease I (DNase I) was loaded and delivered by silver-doped mesoporous silica nanoparticles (MSN-Ag) for biofilm treatments.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8RA02072H
Abstract: Microsphere based drug delivery systems show great advantages for tissue engineering.
Publisher: American Chemical Society (ACS)
Date: 25-08-2021
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5CC04458H
Abstract: A mesoporous material modified with insulin-binding-aptamers and –CH 3 is applied in s le pre-treatment to enhance the limit-of-detection of ELISA 30-fold.
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7NJ00713B
Abstract: Dendritic mesoporous silica–titania nanospheres (DMSTN) show remarkable performance as a photocatalyst and an adsorbent for photochromic methylene green (MG) dye.
Publisher: CSIRO Publishing
Date: 2016
DOI: 10.1071/CH16443
Abstract: A macroporous TiO2 monolith-entrapped pipette-tip was developed through a binder-free packing method for convenient phosphorylated peptide enrichment. A detection limit of 1 ng mL–1 for phosphorylated peptide is achieved, showing a better enrichment efficiency compared with the commercial pure TiO2-embedded NuTip.
Publisher: MDPI AG
Date: 26-10-2022
DOI: 10.3390/PHARMACEUTICS14112302
Abstract: Micro-ribonucleic acid (miRNA)-based therapies show advantages for bone regeneration but need efficient intracellular delivery methods. Inorganic nanoparticles such as mesoporous bioactive glass nanoparticles (MBGN) and mesoporous silica nanoparticles (MSN) have received growing interest in the intracellular delivery of nucleic acids. This study explores the capacity of MBGN and MSN for delivering miRNA to bone marrow mesenchymal stem cells (BMSC) for bone regenerative purposes, with a focus on comparing the two in terms of cell viability, transfection efficiency, and osteogenic actions. Spherical MBGN and MSN with a particle size of ~200 nm and small-sized mesopores were prepared using the sol-gel method, and then the surface was modified with polyethyleneimine for miRNA loading and delivery. The results showed miRNA can be loaded into both nanoparticles within 2 h and was released sustainedly for up to 3 days. Confocal laser scanning microscopy and flow cytometry analysis indicated a high transfection efficiency ( %) of both nanoparticles without statistical difference. Compared with MSN, MBGN showed stronger activation of alkaline phosphatase and activation of osteocalcin genes. This translated to a greater osteogenic effect of MBGN on BMSC, with Alizarin red staining showing greater mineralization compared with the MSN group. These findings show the potential for MBGN to be used in bone tissue engineering.
Publisher: Springer Science and Business Media LLC
Date: 23-10-2021
Publisher: Wiley
Date: 10-2015
Abstract: A new type of monodispersed mesoporous silica nanoparticles with a core-cone structure (MSN-CC) has been synthesized. The large cone-shaped pores are formed by silica lamellae closely packed encircling a spherical core, showing a structure similar to the flower dahlia. MSN-CC has a large pore size of 45 nm and a high pore volume of 2.59 cm(3) g(-1). MSN-CC demonstrates a high loading capacity of large proteins and successfully delivers active β-galactosidase into cells, showing their potential as efficient nanocarriers for the cellular delivery of proteins with large molecular weights.
Publisher: MDPI AG
Date: 22-03-2023
DOI: 10.3390/PHARMACEUTICS15031017
Abstract: Bone regeneration is a comprehensive process that involves different stages, and various growth factors (GFs) play crucial roles in the entire process. GFs are currently widely used in clinical settings to promote bone repair however, the direct application of GFs is often limited by their fast degradation and short local residual time. Additionally, GFs are expensive, and their use may carry risks of ectopic osteogenesis and potential tumor formation. Nanomaterials have recently shown great promise in delivering GFs for bone regeneration, as they can protect fragile GFs and control their release. Moreover, functional nanomaterials can directly activate endogenous GFs, modulating the regeneration process. This review provides a summary of the latest advances in using nanomaterials to deliver exogenous GFs and activate endogenous GFs to promote bone regeneration. We also discuss the potential for synergistic applications of nanomaterials and GFs in bone regeneration, along with the challenges and future directions that need to be addressed.
Publisher: American Chemical Society (ACS)
Date: 11-09-2017
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0SC02803G
Abstract: The nano-enabled post-translational modification assisted strategy for effective cancer immunotherapy.
Publisher: American Chemical Society (ACS)
Date: 12-04-2018
DOI: 10.1021/ACS.LANGMUIR.8B00377
Abstract: The insulin immobilization behaviors of silica vesicles (SV) before and after modification with hydrophobic alkyl -C
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9EN01123D
Abstract: Silica nanoadsorbents with a gradient of sulfur content with higher density at the external part enable effective decontamination of mercury.
Publisher: Elsevier BV
Date: 03-2022
DOI: 10.1016/J.BIOS.2021.113892
Abstract: Incorporating quantum dots (QDs) into dendritic mesoporous silica nanoparticles (DMSNs) for signal lification of label materials represents an efficient strategy to improve the performance of lateral flow immunoassays (LFIAs). In this work, it is found that the CdSe/ZnS QD's size matters for balancing their loading amount and quantum yields (QYs) in the DMSNs-QDs based label materials and ultimately determining the performance of LFIA. The impacts of three CdSe/ZnS QDs with diameters of 9.1, 10.5 and 11.7 nm on CdSe/ZnS QDs incorporation and LFIA applications are studied. The increase of CdSe/ZnS QDs size from 9.1 to 11.7 nm results in a decrease in CdSe/ZnS QDs loading amount and an increase in QYs of incorporated CdSe/ZnS QDs. This trade-off leads to an optimized CdSe/ZnS QDs size of 10.5 nm, which exhibits the best LFIA performance due to the balanced QDs loading (2.26 g g
Publisher: Springer International Publishing
Date: 2021
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6TB01023G
Publisher: Wiley
Date: 06-08-2018
Abstract: Immunosuppressive tumors generally exhibit poor response to immune checkpoint blockade based cancer immunotherapy. Rationally designed hybrid nanoreactors are now presented that have integrated functions as Fenton catalysts and glutathione depletion agents for lifying the immunogenic cell death and activating immune cells. A simple physical mixture of nanoreactors and chemodrugs in combination with immune checkpoint blockades show synergistically and concurrently enhanced chemo-immunotherapy efficacy, inhibiting the growth of both treated primary immunosuppressive tumors and untreated distant tumors. The off-the-shelf strategy uses tumor antigens generated in situ and avoids cargo loading, and is thus a substantial advance in personalized nanomedicine for clinical translation.
Publisher: Wiley
Date: 24-09-2019
Abstract: Osteoarthritis (OA) is a common joint degenerative disease that causes pain, joint damage, and dysfunction. External hyaluronic acid (HA) supplement is a common method for the management of osteoarthritis which requires multi-injections. It is demonstrated that biodegradable mesoporous silica nanoparticles successfully deliver an enzyme, hyaluronan synthase type 2 (HAS2), into synoviocytes from the temporomandibular joint (TMJ) and generate endogenous HA with high molecular weights. In a rat TMJ osteoarthritis inflammation model, this strategy promotes endogenous HA production and inhibits the synovial inflammation of OA for more than 3 weeks with one-shot administration. Such nanotherapy also helps repairing the bone defects in a rat OA bone defect model.
Start Date: 2024
End Date: 12-2026
Amount: $445,437.00
Funder: Australian Research Council
View Funded Activity