ORCID Profile
0000-0002-6638-2422
Current Organisation
University of Queensland
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Publisher: Springer International Publishing
Date: 2017
Publisher: IEEE
Date: 03-2016
Publisher: Frontiers Media SA
Date: 17-04-2018
Publisher: ACM
Date: 28-11-2017
Publisher: ACM
Date: 27-11-2017
Publisher: IEEE
Date: 03-2012
Publisher: IEEE
Date: 10-2017
Publisher: IEEE
Date: 09-2017
Publisher: Elsevier BV
Date: 04-2016
Publisher: Springer Science and Business Media LLC
Date: 13-03-2020
DOI: 10.1038/S41467-020-15058-6
Abstract: Predicting drug-induced liver injury in a preclinical setting remains challenging, as cultured primary human hepatocytes (PHHs), pluripotent stem cell-derived hepatocyte-like cells (HLCs), and hepatoma cells exhibit poor drug biotransformation capacity. We here demonstrate that hepatic functionality depends more on cellular metabolism and extracellular nutrients than on developmental regulators. Specifically, we demonstrate that increasing extracellular amino acids beyond the nutritional need of HLCs and HepG2 cells induces glucose independence, mitochondrial function, and the acquisition of a transcriptional profile that is closer to PHHs. Moreover, we show that these high levels of amino acids are sufficient to drive HLC and HepG2 drug biotransformation and liver-toxin sensitivity to levels similar to those in PHHs. In conclusion, we provide data indicating that extracellular nutrient levels represent a major determinant of cellular maturity and can be utilized to guide stem cell differentiation to the hepatic lineage.
Publisher: Intellect
Date: 12-2019
DOI: 10.1386/VCR_00006_1
Abstract: Abstract This research explores the development of a novel method and apparatus for creating spherical panoramas enhanced with high dynamic range (HDR) for high fidelity Virtual Reality 360 degree (VR360) user experiences. A VR360 interactive panorama presentation using spherical panoramas can provide virtual interactivity and wider viewing coverage with three degrees of freedom, users can look around in multiple directions within the VR360 experiences, gaining the sense of being in control of their own engagement. This degree of freedom is facilitated by the use of mobile displays or head-mount-devices. However, in terms of image reproduction, the exposure range can be a major difficulty in reproducing a high contrast real-world scene. Imaging variables caused by difficulties and obstacles can occur during the production process of spherical panorama facilitated with HDR. This may result in inaccurate image reproduction for location-based subjects, which will in turn result in a poor VR360 user experience. In this article we describe a HDR spherical panorama reproduction approach (workflow and best practice) which can shorten the production processes, and reduce imaging variables, and technical obstacles and issues to a minimum. This leads to improved photographic image reproduction with fewer visual abnormalities for VR360 experiences, which can be adaptable into a wide range of interactive design applications. We describe the process in detail and also report on a user study that shows the proposed approach creates images which viewers prefer, on the whole, to those created using more complicated HDR methods, or to those created without the use of HDR at all.
Publisher: ACM
Date: 05-04-2018
Publisher: IEEE
Date: 03-2010
Publisher: IEEE
Date: 10-2009
Publisher: IEEE
Date: 06-2017
Publisher: ACM
Date: 09-03-2012
Publisher: IEEE
Date: 03-2016
Publisher: IEEE
Date: 03-2016
Publisher: IEEE
Date: 11-2012
Publisher: Elsevier BV
Date: 10-2014
Publisher: IEEE
Date: 03-2010
Publisher: IEEE
Date: 09-2017
Publisher: IEEE
Date: 09-2016
Publisher: ACM
Date: 22-11-2010
Publisher: ACM
Date: 19-04-2023
Publisher: IEEE
Date: 10-2010
Publisher: IEEE
Date: 10-2017
Publisher: MDPI AG
Date: 09-12-2020
DOI: 10.3390/INFORMATICS7040055
Abstract: Hyperscanning is a technique which simultaneously records the neural activity of two or more people. This is done using one of several neuroimaging methods, such as electroencephalography (EEG), functional magnetic resonance imaging (fMRI), and functional near-infrared spectroscopy (fNIRS). The use of hyperscanning has seen a dramatic rise in recent years to monitor social interactions between two or more people. Similarly, there has been an increase in the use of virtual reality (VR) for collaboration, and an increase in the frequency of social interactions being carried out in virtual environments (VE). In light of this, it is important to understand how interactions function within VEs, and how they can be enhanced to improve their quality in a VE. In this paper, we present some of the work that has been undertaken in the field of social neuroscience, with a special emphasis on hyperscanning. We also cover the literature detailing the work that has been carried out in the human–computer interaction domain that addresses remote collaboration. Finally, we present a way forward where these two research domains can be combined to explore how monitoring the neural activity of a group of participants in VE could enhance collaboration among them.
Publisher: ACM
Date: 28-08-2012
Publisher: IEEE
Date: 06-2017
Publisher: ACM
Date: 02-05-2017
No related grants have been discovered for Arindam Dey.