ORCID Profile
0000-0001-7859-7909
Current Organisations
Luxembourg Institute of Health Department of Infection and Immunity
,
MEMO Therapeutics
,
University Hospital of Basel
,
Chalmers University of Technology
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Publications
Stability study of quinoxaline and pyrido pyrazine based co-polymers for solar cell applications
Publisher: Elsevier BV
Date: 11-2014
Electron Microscopy of Organic Solar Cells Thermally Stabilized with Fullerene Nucleating Agents
Publisher: Oxford University Press (OUP)
Date: 08-2014
Glutathione-dependent redox balance characterizes the distinct metabolic properties of follicular and marginal zone B cells
Publisher: Springer Science and Business Media LLC
Date: 04-04-2022
DOI: 10.1038/S41467-022-29426-X
Abstract: The metabolic principles underlying the differences between follicular and marginal zone B cells (FoB and MZB, respectively) are not well understood. Here we show, by studying mice with B cell-specific ablation of the catalytic subunit of glutamate cysteine ligase ( Gclc ), that glutathione synthesis affects homeostasis and differentiation of MZB to a larger extent than FoB, while glutathione-dependent redox control contributes to the metabolic dependencies of FoB. Specifically, Gclc ablation in FoB induces metabolic features of wild-type MZB such as increased ATP levels, glucose metabolism, mTOR activation, and protein synthesis. Furthermore, Gclc -deficient FoB have a block in the mitochondrial electron transport chain (ETC) due to diminished complex I and II activity and thereby accumulate the tricarboxylic acid cycle metabolite succinate. Finally, Gclc deficiency h ers FoB activation and antibody responses in vitro and in vivo, and induces susceptibility to viral infections. Our results thus suggest that Gclc is required to ensure the development of MZB, the mitochondrial ETC integrity in FoB, and the efficacy of antiviral humoral immunity.
The Influence of Alkoxy Substitutions on the Properties of Diketopyrrolopyrrole-Phenyl Copolymers for Solar Cells
Publisher: MDPI AG
Date: 22-07-2013
DOI: 10.3390/MA6073022
Enhanced thermal stability of a polymer solar cell blend induced by electron beam irradiation in the transmission electron microscope
Publisher: Elsevier BV
Date: 05-2017
DOI: 10.1016/J.ULTRAMIC.2017.03.013
Abstract: We show by in situ microscopy that the effects of electron beam irradiation during transmission electron microscopy can be used to lock microstructural features and enhance the structural thermal stability of a nanostructured polymer:fullerene blend. Polymer:fullerene bulk-heterojunction thin films show great promise for use as active layers in organic solar cells but their low thermal stability is a hindrance. Lack of thermal stability complicates manufacturing and influences the lifetime of devices. To investigate how electron irradiation affects the thermal stability of polymer:fullerene films, a model bulk-heterojunction film based on a thiophene-quinoxaline copolymer and a fullerene derivative was heat-treated in-situ in a transmission electron microscope. In areas of the film that exposed to the electron beam the nanostructure of the film remained stable, while the nanostructure in areas not exposed to the electron beam underwent large phase separation and nucleation of fullerene crystals. UV-vis spectroscopy shows that the polymer:fullerene films are stable for electron doses up to 2000kGy.
Influence of synthetic pathway, molecular weight and side chains on properties of indacenodithiophene-benzothiadiazole copolymers made by direct arylation polycondensation
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1TC00043H
Abstract: Poly(indacenodithiophene- alt -benzothiadiazole) with different side chains and molecular weight is made using two different pathways in which all C–C coupling steps are achieved by C–H activation, and the products are comprehensively investigated.
Fullerene mixtures enhance the thermal stability of a non-crystalline polymer solar cell blend
Publisher: AIP Publishing
Date: 14-04-2014
DOI: 10.1063/1.4870997
Abstract: Printing of polymer:fullerene solar cells at high speed requires annealing at temperatures up to 140 °C. However, bulk-heterojunction blends that comprise a non-crystalline donor polymer often suffer from insufficient thermal stability and hence rapidly coarsen upon annealing above the glass transition temperature of the blend. In addition, micrometer-sized fullerene crystals grow, which are detrimental for the solar cell performance. In this manuscript, we present a strategy to limit fullerene crystallization, which is based on the use of fullerene mixtures of the two most common derivatives, PC61BM and PC71BM, as the acceptor material. Blends of this fullerene mixture and a non-crystalline thiophene-quinoxaline copolymer display considerably enhanced thermal stability and largely retain their photovoltaic performance upon annealing at elevated temperatures as high as 170 °C.
Role of Ultrafast Torsional Relaxation in the Emission from Polythiophene Aggregates
Publisher: American Chemical Society (ACS)
Date: 07-12-2010
DOI: 10.1021/JZ101026G
Organogels from Diketopyrrolopyrrole Copolymer Ionene/Polythiophene Blends Exhibit Ground-State Single Electron Transfer in the Solid State
Publisher: American Chemical Society (ACS)
Date: 08-06-2022
Correction to “A New Tetracyclic Lactam Building Block for Thick, Broad-Bandgap Photovoltaics”
Publisher: American Chemical Society (ACS)
Date: 06-01-2015
DOI: 10.1021/JA512173J
Diffusion-Limited Crystallization: A Rationale for the Thermal Stability of Non-Fullerene Solar Cells
Publisher: American Chemical Society (ACS)
Date: 07-06-2019
Abstract: Organic solar cells are thought to suffer from poor thermal stability of the active layer nanostructure, a common belief that is based on the extensive work that has been carried out on fullerene-based systems. We show that a widely studied non-fullerene acceptor, the indacenodithienothiophene-based acceptor ITIC, crystallizes in a profoundly different way as compared to fullerenes. Although fullerenes are frozen below the glass-transition temperature T
Facile Monitoring of Fullerene Crystallization in Polymer Solar Cell Blends by UV–vis Spectroscopy
Publisher: Wiley
Date: 05-02-2014
A New Tetracyclic Lactam Building Block for Thick, Broad-Bandgap Photovoltaics
Publisher: American Chemical Society (ACS)
Date: 06-08-2014
DOI: 10.1021/JA5051692
Abstract: A new tetracyclic lactam building block for polymer semiconductors is reported that was designed to combine the many favorable properties that larger fused and/or amide-containing building blocks can induce, including improved solid-state packing, high charge carrier mobility, and improved charge separation. Copolymerization with thiophene resulted in a semicrystalline conjugated polymer, PTNT, with a broad bandgap of 2.2 eV. Grazing incidence wide-angle X-ray scattering of PTNT thin films revealed a strong tendency for face-on π-stacking of the polymer backbone, which was retained in PTNT:fullerene blends. Corresponding solar cells featured a high open-circuit voltage of 0.9 V, a fill factor around 0.6, and a power conversion efficiency as high as 5% for >200 nm thick active layers, regardless of variations in blend stoichiometry and nanostructure. Moreover, efficiencies of >4% could be retained when thick active layers of ∼400 nm were employed. Overall, these values are the highest reported for a conjugated polymer with such a broad bandgap and are unprecedented in materials for tandem and particularly ternary blend photovoltaics. Hence, the newly developed tetracyclic lactam unit has significant potential as a conjugated building block in future organic electronic materials.
Tailored Side-Chain Architecture of Benzil Voltage Stabilizers for Enhanced Dielectric Strength of Cross-Linked Polyethylene
Publisher: Wiley
Date: 09-06-2014
DOI: 10.1002/POLB.23523
Sub-glass transition annealing enhances polymer solar cell performance
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C3TA14165A
Impact of Oligoether Side-Chain Length on the Thermoelectric Properties of a Polar Polythiophene
Publisher: American Chemical Society (ACS)
Date: 14-09-2023
One‐Step Macroscopic Alignment of Conjugated Polymer Systems by Epitaxial Crystallization during Spin‐Coating
Publisher: Wiley
Date: 03-01-2013
A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation
Publisher: Cold Spring Harbor Laboratory
Date: 07-07-2023
DOI: 10.1101/2023.07.06.547932
Abstract: Although the intestinal tract is a major site of reactive oxygen species (ROS) generation, the mechanisms by which antioxidant defense in gut T cells contribute to intestinal homeostasis are currently unknown. Here we show, using T cell-specific ablation of the catalytic subunit of glutamate cysteine ligase ( Gclc ), that the ensuing loss of glutathione (GSH) impairs the production of gut-protective IL-22 by Th17 cells within the lamina propria. Although Gclc ablation does not affect T cell cytokine secretion in the gut of mice at steady-state, infection with C. rodentium increases ROS, inhibits mitochondrial gene expression and mitochondrial function in Gclc -deficient Th17 cells. These mitochondrial deficits affect the PI3K/AKT/mTOR pathway, leading to reduced phosphorylation of the translation repressor 4E-BP1. As a consequence, the initiation of translation is restricted, resulting in decreased protein synthesis of IL-22. Loss of IL-22 results in poor bacterial clearance, enhanced intestinal damage, and high mortality. ROS-scavenging, reconstitution of IL-22 expression or IL-22 supplementation in vivo prevent the appearance of these pathologies. Our results demonstrate the existence of a previously unappreciated role for Th17 cell-intrinsic GSH coupling to promote mitochondrial function, IL-22 translation and signaling. These data reveal an axis that is essential for maintaining the integrity of the intestinal barrier and protecting it from damage caused by gastrointestinal infection. - GSH-regulated Th17 cell-derived IL-22, but not IL-17 is required to maintain intestinal barrier integrity and to revent lethality following C. rodentium infection. - GCLC expression in IBD patients correlates positively with expression of genes related to gut integrity. - Gclc -deficient Th17 cells accumulate mitochondrial ROS, which is linked to impaired mitochondrial function, ysregulated PI3K/AKT/mTOR signaling and impaired translation of IL-22. - ROS-scavenging, IL-22 reconstitution or T cell-specific expression of IL-22 in Gclc -deficient T cells rescues utant mice from the lethal infection outcome in vivo .
Thermoelectric plastics: from design to synthesis, processing and structure–property relationships
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6CS00149A
Abstract: Thermoelectric plastics are a class of polymer-based materials that combine the ability to directly convert heat to electricity, and vice versa , with ease of processing.
Nano-pathways: Bridging the divide between water-processable nanoparticulate and bulk heterojunction organic photovoltaics
Publisher: Elsevier BV
Date: 2016
Mapping fullerene crystallization in a photovoltaic blend: an electron tomography study
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5NR00443H
Abstract: Transmission electron tomography is used to study the vertical distribution of fullerene crystals in a polymer solar cell blend.
Structure–property relationships of oligothiophene–isoindigo polymers for efficient bulk-heterojunction solar cells
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C3EE42989J
High electron affinity: a guiding criterion for voltage stabilizer design
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C4TA04956J
Abstract: A high electron affinity is found to correlate with the ability of voltage-stabilizer additives to improve the dielectric strength of cross-linked polyethylene, which is a highly desirable for high-voltage insulation materials.
Visualisation of individual dopants in a conjugated polymer: sub-nanometre 3D spatial distribution and correlation with electrical properties
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D2NR03554E
Abstract: The 3D sub-nanometre distribution of in idual dopant species in organic semiconductors determines the electrical properties. The distribution and cluster shape have been determined by electron tomography and shown to depend on dopant concentration.
Synthesis, thin-film morphology, and comparative study of bulk and bilayer heterojunction organic photovoltaic devices using soluble diketopyrrolopyrrole molecules
Publisher: Royal Society of Chemistry (RSC)
Date: 2011
DOI: 10.1039/C1EE01544C
Isothermal Crystallization Kinetics and Time–Temperature–Transformation of the Conjugated Polymer: Poly(3-(2′-ethyl)hexylthiophene)
Publisher: American Chemical Society (ACS)
Date: 27-06-2017
Solar Energy Storage by Molecular Norbornadiene–Quadricyclane Photoswitches: Polymer Film Devices
Publisher: Wiley
Date: 25-04-2019
Thermally Activated in Situ Doping Enables Solid-State Processing of Conducting Polymers
Publisher: American Chemical Society (ACS)
Date: 02-04-2019
Two-in-one: cathode modification and improved solar cell blend stability through addition of modified fullerenes
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C5TA06420A
Abstract: Addition of customised fullerenes to a polymer : fullerene bulk-heterojunction blend significantly increases the efficiency and the thermal stability after annealing at 140 °C.
Polar Side Chains Enhance Processability, Electrical Conductivity, and Thermal Stability of a Molecularly p‐Doped Polythiophene
Publisher: Wiley
Date: 24-04-2017
Abstract: Molecular doping of organic semiconductors is critical for optimizing a range of optoelectronic devices such as field-effect transistors, solar cells, and thermoelectric generators. However, many dopant:polymer pairs suffer from poor solubility in common organic solvents, which leads to a suboptimal solid-state nanostructure and hence low electrical conductivity. A further drawback is the poor thermal stability through sublimation of the dopant. The use of oligo ethylene glycol side chains is demonstrated to significantly improve the processability of the conjugated polymer p(g
Double Doping of a Low-Ionization-Energy Polythiophene with a Molybdenum Dithiolene Complex
Publisher: American Chemical Society (ACS)
Date: 13-06-2022
Neat C60:C70 buckminsterfullerene mixtures enhance polymer solar cell performance
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C4TA02515F
Abstract: Ternary blends of C 60 , C 70 and a thiophene–quinoxaline copolymer (TQ1) can be readily processed from solution. A solar cell efficiency of 3.6% is achieved with a 2 : 1 : 1 TQ1:C 60 :C 70 mixture, accompanied by a high internal quantum efficiency of 75%.
Highly stable doping of a polar polythiophene through co-processing with sulfonic acids and bistriflimide
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8TC01593G
Abstract: Upon doping with sulfonic acids and bistriflimide the polar polythiophene p(g 4 2T-T) exhibits a maximum conductivity of 120 S cm −1 and can be hot-pressed into self-standing, flexible films.
Conformational Disorder Enhances Solubility and Photovoltaic Performance of a Thiophene–Quinoxaline Copolymer
Publisher: Wiley
Date: 25-02-2013
Nucleation-limited fullerene crystallisation in a polymer–fullerene bulk-heterojunction blend
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3TA11018D
Hexanary blends: a strategy towards thermally stable organic photovoltaics
Publisher: Springer Science and Business Media LLC
Date: 08-2023
DOI: 10.1038/S41467-023-39830-6
Abstract: Non-fullerene based organic solar cells display a high initial power conversion efficiency but continue to suffer from poor thermal stability, especially in case of devices with thick active layers. Mixing of five structurally similar acceptors with similar electron affinities, and blending with a donor polymer is explored, yielding devices with a power conversion efficiency of up to 17.6%. The hexanary device performance is unaffected by thermal annealing of the bulk-heterojunction active layer for at least 23 days at 130 °C in the dark and an inert atmosphere. Moreover, hexanary blends offer a high degree of thermal stability for an active layer thickness of up to 390 nm, which is advantageous for high-throughput processing of organic solar cells. Here, a generic strategy based on multi-component acceptor mixtures is presented that permits to considerably improve the thermal stability of non-fullerene based devices and thus paves the way for large-area organic solar cells.
Pyruvate dehydrogenase fuels a critical citrate pool that is essential for Th17 cell effector functions
Publisher: Elsevier BV
Date: 03-2023
Lateral Phase Separation Gradients in Spin‐Coated Thin Films of High‐Performance Polymer:Fullerene Photovoltaic Blends
Publisher: Wiley
Date: 20-06-2011
Fullerene Nucleating Agents: A Route Towards Thermally Stable Photovoltaic Blends
Publisher: Wiley
Date: 04-03-2014
Two-photon absorption of polyfluorene aggregates stabilized by insulin amyloid fibrils
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5RA08302H
Abstract: We report on the photophysical and optical properties of a polyfluorene derivative (PFO) and its binding to the amyloid-forming protein insulin.
New quinoxaline and pyridopyrazine-based polymers for solution-processable photovoltaics
Publisher: Elsevier BV
Date: 10-2012
All-Organic Textile Thermoelectrics with Carbon-Nanotube-Coated n-Type Yarns
Publisher: American Chemical Society (ACS)
Date: 11-06-2018
Mechanically Adaptive Mixed Ionic-Electronic Conductors Based on a Polar Polythiophene Reinforced with Cellulose Nanofibrils
Publisher: American Chemical Society (ACS)
Date: 06-2023
Enhanced Electrical Conductivity of Molecularly p-Doped Poly(3-hexylthiophene) through Understanding the Correlation with Solid-State Order
Publisher: American Chemical Society (ACS)
Date: 11-10-2017
A New Application Area for Fullerenes: Voltage Stabilizers for Power Cable Insulation
Publisher: Wiley
Date: 12-12-2015
Abstract: Fullerenes are shown to be efficient voltage-stabilizers for polyethylene, i.e., additives that increase the dielectric strength of the insulation material. Such compounds are highly sought-after because their use in power-cable insulation may considerably enhance the transmission efficiency of tomorrow's power grids. On a molal basis, fullerenes are the most efficient voltage stabilizers reported to date.
Comparison of selenophene and thienothiophene incorporation into pentacyclic lactam-based conjugated polymers for organic solar cells
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5PY01245G
Abstract: In this work, we compare the effect of incorporating selenophene versus thienothiophene spacers into pentacyclic lactam-based conjugated polymers for organic solar cells.
Related Organisations
Luxembourg Institute Of Health Department Of Infection And Immunity
Location: Luxembourg
University Of Cambridge
Location: United Kingdom of Great Britain and Northern Ireland
Related Funding Activities
No related grants have been discovered for Christian Müller.