ORCID Profile
0000-0002-0137-6355
Current Organisation
University of Western Australia
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Interdisciplinary Engineering | Fluidisation and Fluid Mechanics
Expanding Knowledge in the Physical Sciences | Expanding Knowledge in Engineering |
Publisher: AIP Publishing
Date: 08-2023
DOI: 10.1063/5.0169672
Publisher: AIP Publishing
Date: 2020
DOI: 10.1063/1.5139479
Abstract: Instantaneous and time-averaged flow separation locations for the canonical case of flow past a circular cylinder are investigated through direct numerical simulations. It is found that the instantaneous movement of the upper/lower separation point on the cylinder surface is governed by a dynamic balance between the upper/lower separating shear layer and a shear layer generated at the back of the cylinder due to wake recirculation. It is also found that flow three-dimensionality contributes to an upstream movement of the time-averaged separation point through the effect of the separating shear layer. For the three-dimensional flow, the disordered mode B flow structures developed in the separating shear layer (which is directly responsible for the flow three-dimensionality) would result in turbulent energy dissipation and, therefore, the separating shear layer is less rolled-up in the cross-flow direction, which weakens the effect of the separating shear layer in pushing the separation point downstream. The time-averaged separation angle vs the Reynolds number (θs¯−Re) relationship is not monotonic over the three-dimensional wake transition regimes of Re = 190–270 since there is a transition sequence of different wake flow patterns with different levels of flow three-dimensionality. For Re ≥ 270, on the physical basis that the increasingly disordered mode B flow becomes the sole wake flow pattern, an empirical formula is proposed for the θs¯−Re relationship, i.e., θs¯=78.8+505Re−1/2 (270 ≤ Re ≲ 105).
Publisher: Wiley
Date: 22-03-2017
DOI: 10.1002/FLD.4376
Publisher: Cambridge University Press (CUP)
Date: 06-03-2018
DOI: 10.1017/JFM.2018.104
Abstract: Three-dimensional (3-D) wake transition for flow past a square cylinder aligned with sides perpendicular and parallel to the approaching flow is investigated using direct numerical simulation. The secondary wake instability, namely a Mode A instability, occurs at a Reynolds number ( $Re$ ) of 165.7. A gradual wake transition from Mode A* (i.e. Mode A with vortex dislocations) to Mode B is observed over a range of $Re$ from 185 to 210, within which the probability of occurrence of vortex dislocations decreases monotonically with increasing $Re$ . The characteristics of the Strouhal–Reynolds number relationship are analysed. At the onset of Mode A*, a sudden drop of the 3-D Strouhal number from its two-dimensional counterpart is observed, which is due to the subcritical nature of the Mode A* instability. A continuous 3-D Strouhal–Reynolds number curve is observed over the mode swapping regime, since Mode A* and Mode B have extremely close vortex shedding frequencies and therefore only a single merged peak is observed in the frequency spectrum. The existence of hysteresis for the Mode A and Mode B wake instabilities is examined. The unconfined Mode A and Mode B wake instabilities are hysteretic and non-hysteretic, respectively. However, a spanwise confined Mode A could be non-hysteretic. It is proposed that the existence of hysteresis at a wake instability can be identified by examining the sudden/gradual variation of the 3-D flow properties at the onset of the wake instability, with sudden and gradual variations corresponding to hysteretic (subcritical) and non-hysteretic (supercritical) flows, respectively.
Publisher: Elsevier BV
Date: 02-2022
Publisher: AIP Publishing
Date: 10-2016
DOI: 10.1063/1.4964379
Abstract: A stable three-dimensional (3D) wake structure for flow past a circular cylinder has been discovered through 3D direct numerical simulations (DNS). The stable 3D wake structure occurs over a small range of Reynolds number (Re) below the critical Re for Mode A∗ (i.e., Mode A with large-scale vortex dislocations, where Mode A is the first 3D instability mode which will evolve into Mode A∗) instability. It is believed that the stable 3D wake structure discovered in this study is the stable state of Mode A wake structure inferred by Williamson [“Three-dimensional wake transition,” J. Fluid Mech. 328, 345–407 (1996)]. This confirms the wake transition sequence of 2D → A → A∗ → B suggested by Williamson. Compared with conventional Mode A structure, the stable state of Mode A structure has much weaker litude and does not evolve into large-scale vortex dislocations. The stable state of Mode A structure is triggered by small-scale spanwise disturbance introduced upstream of the cylinder, due to energy lification through convective instability of the flow. The stable state of Mode A is transient and is d ed out eventually under a transient initial disturbance condition, but is sustained throughout under a persistent disturbance condition. The emergence of the stable state of Mode A structure is correlated with both Re and the disturbance level. With the decrease of Re, the stable state of Mode A structure gradually becomes less well-defined and eventually disappears. With the decrease of the disturbance level, the stable state of Mode A structure emerges at a higher Re.
Publisher: Cambridge University Press (CUP)
Date: 05-01-2017
DOI: 10.1017/JFM.2016.810
Abstract: Two-dimensional (2D) and three-dimensional (3D) instabilities in the wake of a circular cylinder placed near to a moving wall are investigated using direct numerical simulation (DNS). The study covers a parameter space spanning a non-dimensional gap ratio ( $G^{\\ast }$ ) between 0.1 to 19.5 and Reynolds number ( $Re$ ) up to 300. Variations in the flow characteristics with $Re$ and $G^{\\ast }$ are studied, and their correlations with the hydrodynamic forces on the cylinder are investigated. It is also found that the monotonic increase of the critical $Re$ for 2D instability ( $Re_{cr2D}$ ) with decreasing $G^{\\ast }$ is influenced by variations in the mean flow rate around the cylinder, the confinement of the near-wake flow by the plane wall and the characteristics of the shear layer formed above the moving wall directly below the cylinder. The first factor destabilizes the wake flow at a moderate $G^{\\ast }$ while the latter two factors stabilize the wake flow with decreasing $G^{\\ast }$ . In terms of 3D instability, the flow transition sequence of ‘2D steady $\\rightarrow$ 3D steady $\\rightarrow$ 3D unsteady’ for small gap ratios is analysed at $G^{\\ast }=0.2$ . It is found that the 3D steady and 3D unsteady flows are triggered by Mode C instability due to wall proximity. However, the Mode C structure is not sustained indefinitely, since interference with the shear layer leads to other 3D steady and unsteady flow structures.
Publisher: AIP Publishing
Date: 10-2018
DOI: 10.1063/1.5050439
Abstract: Two-dimensional (2D) and three-dimensional (3D) hydrodynamic characteristics of flow past a square cylinder are investigated using direct numerical simulations. The variations of the hydrodynamic forces and wake flow characteristics with the Reynolds number (Re) are examined for Re = 10–400 with a high resolution in Re. Distinct features in the variation trends of the hydrodynamic forces with Re are examined and explained. In addition, for the 3D flows up to Re = 400, three critical conditions are observed at Re of approximately 165.7, 210, and 330. At the onset of the secondary wake instability of Re = 165.7, a sudden increase or decrease in the 3D flow property with respect to its 2D counterpart is observed, which is due to the sudden increase in the flow three-dimensionality at the mode A instability that is subcritical in nature. The second critical condition is because for Re & 210, the mode B flow structure becomes increasingly disordered and the wake flow becomes increasingly turbulent such that the 3D flow property is increasingly deviated from its 2D counterpart. The third critical condition at Re ∼ 330 is related to the disappearance and reappearance of the recirculation regions on the upper and lower sides of the cylinder. While the first two critical conditions are also observed for flow past a circular cylinder, the third one is not since the geometry of a circular cylinder does not give rise to recirculation regions on the upper and lower sides of the cylinder.
Publisher: Cambridge University Press (CUP)
Date: 27-03-2019
DOI: 10.1017/JFM.2019.167
Abstract: Instabilities and flow characteristics in the far wake of a circular cylinder are examined through direct numerical simulations. The transitions to the two-layered and secondary vortex streets are quantified by a new method based on the time-averaged transverse velocity field. Two processes for the transition to the secondary vortex street are observed: (i) the merging of two same-sign vortices over a range of low Reynolds numbers ( $Re$ ) between 200 and 300, and (ii) the pairing of two opposite-sign vortices, followed by the merging of the paired vortices into subsequent vortices, over a range of $Re$ between 400 and 1000. Single vortices may be generated between the merging cycles due to mismatch of the vortices. The irregular merging process results in flow irregularity and an additional frequency signal $f_{2}$ (in addition to the primary vortex shedding frequency $f_{1}$ ) in the two-layered and secondary vortex streets. In particular, a gradual energy transfer from $f_{1}$ to $f_{2}$ with distance downstream is observed in the two-layered vortex street prior to the merging. The frequency spectra of $f_{2}$ are broad-band for $Re=200$ –300 but become increasingly sharp-peaked with increasing $Re$ because the vortex merging process becomes increasingly regular. The ratio of the sharp-peaked frequencies $f_{2}$ and $f_{1}$ is equal to the ratio of the numbers of vortices observed after and before the merging. The general conclusions drawn from a circular cylinder are expected to be applicable to other bluff bodies.
Publisher: Cambridge University Press (CUP)
Date: 14-05-2021
DOI: 10.1017/JFM.2021.354
Publisher: AIP Publishing
Date: 03-2021
DOI: 10.1063/5.0041168
Abstract: The benchmarking case of flow past a circular cylinder at the Reynolds number (Re) of 3900 is computed with two open-source codes, OpenFOAM and Nektar++, which are based on the conventional finite volume method (FVM) and the high-order spectral/hp element method, respectively. By using the Nektar++ model, mesh convergence for the case Re = 3900 is demonstrated (perhaps for the first time) through a systematic mesh dependence study, which includes separate examinations of the spanwise domain length (Lz/D), spanwise resolution, and the resolution in the plane perpendicular to the spanwise direction. The computational efficiencies for the Nektar++ and OpenFOAM approaches are then compared. This benchmarking study adds value to the broad Nektar++ and OpenFOAM communities and to the numerical modeling of bluff-body flows in general. Based on the Nektar++ approach, the computations are then generalized to a range of Re = 400–3900. It is found that Lz/D = 3 is adequate for Re = 2500–3900, while an increased Lz/D = 6 is recommended for Re = 400–2000. Based on the present high-fidelity numerical data, the physical mechanisms for the variations in the wake recirculation length and the hydrodynamic forces and pressure on the cylinder with Re are explored. In particular, the physics behind the inverse correlation between the root mean square lift coefficient (CL′) and the wake recirculation length, which includes a significant decrease in CL′ over Re = 270–1500, is highlighted.
Publisher: AIP Publishing
Date: 2020
DOI: 10.1063/1.5134850
Abstract: The evolution of Mode C wake characteristics with the Reynolds number (Re) for Re up to 400 is investigated numerically. The Mode C wake instability is generated by placing a small wire in the near wake of a main circular cylinder. This setup ensures that the wake is unstable to Mode C only (without potential mode interactions), as demonstrated by Floquet stability analysis. Based on three-dimensional direct numerical simulations, three evolution regimes are identified for the fully developed Mode C flow. In the uniform periodic regime (Re = 166.4–210), the Mode C structure is uniformly distributed along the spanwise direction. The flow structure is 2T-periodic (T being the vortex shedding period) but retains a spatiotemporal symmetry every 1T. In the nonuniform periodic regime (Re = 220–230), the slightly nonuniform Mode C structure remains 2T-periodic at Re = 220 but undergoes a period quadrupling to 4T-periodic at Re = 230 before transitioning to chaos. In the chaotic regime (Re ≥ 240), the flow loses periodicity and becomes increasingly chaotic with increasing Re. The progressive wake transition to chaos is found to originate from the instability in the braid shear layer region through the uneven growth in strength and the consequent nonuniformity of the Mode C streamwise vortices. The wake transitions to chaos through the routes of Mode C and Mode B (for an isolated circular/square cylinder) are compared.
Publisher: Elsevier BV
Date: 06-2017
Publisher: Cambridge University Press (CUP)
Date: 25-07-2016
DOI: 10.1017/JFM.2016.446
Abstract: This paper presents three-dimensional (3D) direct numerical simulations (DNS) of flow past a circular cylinder over a range of Reynolds number ( $Re$ ) up to 300. The gradual wake transition process from mode A* (i.e. mode A with large-scale vortex dislocations) to mode B is well captured over a range of $Re$ from 230 to 260. The mode swapping process is investigated in detail with the aid of numerical flow visualization. It is found that the mode B structures in the transition process are developed based on the streamwise vortices of mode A or A* which destabilize the braid shear layer region. For each case within the transition range, the transient mode swapping process consists of dislocation and non-dislocation cycles. With the increase of $Re$ , it becomes more difficult to trigger dislocations from the pure mode A structure and form a dislocation cycle, and each dislocation stage becomes shorter in duration, resulting in a continuous decrease in the probability of occurrence of mode A* and a continuous increase in the probability of occurrence of mode B. The occurrence of mode A* results in a relatively strong flow three-dimensionality. A critical condition is confirmed at approximately $Re=265{-}270$ , where the weakest flow three-dimensionality is observed, marking a transition from the disappearance of mode A* to the emergence of increasingly disordered mode B structures.
Publisher: Cambridge University Press (CUP)
Date: 31-03-2021
DOI: 10.1017/JFM.2021.195
Publisher: MDPI AG
Date: 17-08-2022
DOI: 10.3390/JMSE10081128
Abstract: The effects of yaw angle on wake characteristics of a stationary square cylinder were investigated in terms of the hydrodynamic forces, the vortex shedding frequency, and the vortical structures using direct numerical simulations (DNS) at a Reynolds number of 1000. In total, four yaw angles, namely, α = 0°, 15°, 30°, and 45°, were considered. The three-dimensional (3D) Navier–Stokes equations were solved directly using the finite volume method in OpenFOAM. It was found that the first-order statistics of the drag coefficient and the Strouhal number satisfied the independence principle (IP) closely. However, the second-order statistics of the drag and lift coefficients deviated apparently from the IP for α ≥ 25°. The iso-surfaces of the spanwise vorticity gradually disorganized and the magnitudes of the spanwise vorticity contour decreased as the yaw angle α was increased from 0° to 45°. By contrast, the streamwise vorticity iso-surfaces were found to become more organized and the magnitudes of the spanwise velocity contour became larger as a result of the increase in yaw angle, indicating the impairment of the quasi-two-dimensionality and the enhancement of the three-dimensionality of the wake flow. Extensive comparisons were also made with previous DNS results for a yawed circular cylinder, and both similarities and differences between these two kinds of cylinder wakes are discussed.
Publisher: Cambridge University Press (CUP)
Date: 16-01-2023
DOI: 10.1017/JFM.2022.939
Abstract: Large-eddy simulations of the unsteady flows around rectangular prisms with chord-to-depth ratios ( B / D ) ranging from 3 to 12 are carried out at a Reynolds number of 1000. A particular focus of the study is the physical mechanisms governing the global instability of the flow. The coherent structures and velocity spectra reveal that large-scale leading-edge vortices ( L vortices) are formed by the coalescence of Kelvin–Helmholtz rollers. Based on dynamic mode decomposition, the interactions between the L vortex and the trailing-edge vortex ( T vortex) at different B / D values are revealed. It is found that the phase difference between the L and T vortices is the critical factor promoting a stepwise increase in the Strouhal number with increasing B / D . According to the phase analysis, there are two types of pressure feedback-loop mechanisms maintaining the self-sustained oscillations. When B / D = 4–5, the feedback loop covers the separation region, and the global instability is controlled by the impinging shear-layer instability. When B / D = 3 and 6–12, the feedback loop covers the entire chord, and the global instability is controlled by the impinging leading-edge vortex shedding instability. Self-sustained oscillations of the shear layer still exist after a splitter plate is placed in the near wake, indicating that the T vortex shedding is not essential in triggering the global instability. Nevertheless, with the participation of the T vortex, the primary instability mode may be reselected due to the upper and lower limits of the shedding frequency imposed by the T vortex.
Publisher: Elsevier BV
Date: 2019
Publisher: American Society of Mechanical Engineers
Date: 21-06-2021
Abstract: Steady incoming flow past a circular cylinder has been a classical problem in fluid mechanics owing to its extensive practical applications in e.g. offshore engineering. In this study, large-eddy simulations are performed for flow past a circular cylinder at the Reynolds number (Re) of 3900. Particular focuses are on the comparisons of different numerical methods and computational domain patterns. The case Re = 3900 is computed with both OpenFOAM and Nektar++, which are based on the conventional finite volume method and the highorder spectral/hp element method, respectively. It is found that the computational cost for the Nektar++ model is only less than 10% of that for the OpenFOAM model. In addition, both circular and C-shaped domains are tested for the OpenFOAM and Nektar++ models. It is found that a circular domain is required for the OpenFOAM model to minimise the footprint of mesh non-orthogonality on the simulated flow, while the Nektar++ model does not have strict requirements for the orthogonality of the mesh. The present findings regarding the computational cost and the domain/mesh patterns are expected to be applicable to the numerical modelling of bluff-body flows in general. Based on Nektar++ and the circular domain, additional simulations are performed at Re = 1000 and 7000. For the three Re values investigated, the Strouhal number, hydrodynamic forces and the streamwise and spanwise vorticity fields are examined and compared.
Publisher: Elsevier BV
Date: 09-2018
Publisher: AIP Publishing
Date: 07-2023
DOI: 10.1063/5.0155066
Abstract: This paper presents a new flow control approach to suppress the vortex shedding in the wake of a circular cylinder through high-frequency oscillation. The circular cylinder is forced to oscillate in the streamwise direction at high-frequency and low litude, corresponding to a high Stokes number (β = 100–1000) and low Keulegan–Carpenter number (KC = 0.001–4). Two-dimensional (2-D) and three-dimensional (3-D) direct numerical simulations of an oscillating circular cylinder in steady current have been carried out in the parameter space of KC, Rec, and β. Our numerical results show that when the flow remains in the two-dimensional vortex shedding regime, the cylinder wake sequentially experiences transitions from the vortex shedding regime to the suppression of the vortex shedding regime and finally to the symmetry breaking regime, with increasing KC. Corresponding wake characteristics and variations of hydrodynamic forces over the three wake regimes are explored. Three quantities that represent shear-layer characteristics, including the length of separating shear layers, the circulation of shear layers and wake recirculation length, reach maxima at the onset of suppression. The physical mechanisms for the suppression of vortex shedding and occurrence of symmetry breaking are also explained. Once the flow becomes 3-D, vortex shedding from the cylinder cannot be suppressed, primarily because the outer shear layers induced by the steady approaching flow are enhanced in 3-D flows. The cylinder oscillation over the frequency range investigated in the present study delays wake transition to 3-D. The cylinder oscillation alters the 3-D vortical structure and its spanwise wavelength significantly.
Publisher: AIP Publishing
Date: 04-2020
DOI: 10.1063/5.0005757
Abstract: Flow (of a Newtonian and incompressible fluid) separation around a square cylinder for Reynolds numbers (Re) in the range of 10–400 is investigated through direct numerical simulations. In contrast to the general belief that for a square cylinder, the flow would always separate at the leading and/or trailing edges of the cylinder, this study shows that the flow (both time-averaged and instantaneous) may not separate at the sharp corners for a certain range of moderate Re values. Instead, separation emerges at approximately a quarter of the cylinder length downstream of the leading edge at critical Re values of 100.36 and 96 for the time-averaged and instantaneous flows, respectively. With the increase in Re, the time-averaged separation location gradually moves toward the leading edge, while its instantaneous variation range reduces. The evolution of the separation pattern with Re is categorized with a fine Re resolution of 1. A critical point is identified at Re = 156 (for the time-averaged flow), where a saddle point emerges away from the upper/lower surface of the cylinder to give rise to wake flow entrainment to the upper/lower side of the cylinder. The rate of the entrained flow is governed by the location of the saddle point. The flow three-dimensionality occurring at Re & 165.7 affects the location of the saddle point but has almost no influence on the location of the separation point. The corresponding physical mechanism is explained.
Publisher: Cambridge University Press (CUP)
Date: 02-08-2022
DOI: 10.1017/JFM.2022.587
Abstract: The turbulent kinetic energy and energy dissipation rate in the wake of a circular cylinder are examined at a Reynolds number of 1000. The turbulence characteristics are quantified using direct numerical simulation, which provides a comprehensive dataset that is almost impossible to acquire from physical experiments. The energy dissipation rate is decomposed into the components due to the mean flow, the coherent primary vortices and the remainder. It is found that the remainder component, which develops only in a three-dimensional turbulent wake and resides mainly in the regions of vortices, accounts for 95 % and 97 % of the total dissipation rate for 10 and 20 cylinder diameters downstream of the cylinder, respectively (while the remainder accounts for 62 % and 83 % of the total turbulent kinetic energy). Based on the remainder component, the validity of local isotropy, local axisymmetry, local homogeneity and homogeneity in the y – z plane for the turbulent dissipation in the wake is examined. The analysis reveals that the turbulent dissipation is largely locally homogeneous, but not locally isotropic or axisymmetric, even after the annihilation of the primary vortex street. In addition, the performances of the four corresponding surrogates to the true dissipation rate are evaluated. Owing to the general validity of local homogeneity, the surrogates of local homogeneity and homogeneity in the y – z plane perform well. Although local axisymmetry does not hold, the corresponding surrogate performs well, because errors from different terms largely cancel out. However, the surrogate of local isotropy generally underestimates the true dissipation rate.
Publisher: Elsevier BV
Date: 2014
Publisher: Elsevier BV
Date: 05-2018
Publisher: Cambridge University Press (CUP)
Date: 26-10-2017
DOI: 10.1017/JFM.2017.685
Abstract: The Strouhal–Reynolds number ( $St{-}Re$ ) relationship for flow past a circular cylinder in the low $Re$ range of $Re\\leqslant 1000$ is investigated through two- (2D) and three-dimensional (3D) direct numerical simulations (DNS). An improved method is proposed for the determination of the separating velocity and the wake width to allow for a better estimation of the wake Strouhal number $St^{\\ast }$ . For $Re$ in the extended laminar regime calculated by 2D DNS, the $St^{\\ast }$ values are found to be more uniform than the original $St$ for the 2D flow. It is also found that the $St^{\\ast }$ values for the 2D and 3D flows agree well in the laminar regime of $Re$ up to approximately 270. In addition, uniform $St^{\\ast }$ values are also obtained for different mode A and mode B flow structures triggered artificially by using different cylinder span lengths in DNS. It is demonstrated that the drop in $St$ (with respect to its 2D counterpart) with the development of different 3D wake structures is due to the decrease in the separating velocity and the increase in the wake width for a 3D flow, rather than the existence of a particular wake structure such as pure mode A or vortex dislocation. However, as the wake flow becomes increasingly turbulent with further increase in $Re$ , the $St^{\\ast }$ value for the 3D flow increases gradually and deviates from its 2D counterpart, since for turbulent 3D flows the vortex shedding frequency scales on a length smaller than the wake width.
Publisher: Cambridge University Press (CUP)
Date: 05-04-2017
DOI: 10.1017/JFM.2017.146
Abstract: Three-dimensional (3D) wake transition for a circular cylinder placed near to a moving wall is investigated using direct numerical simulation (DNS). The study covers a parameter space spanning a gap ratio $(G/D)\\geqslant 0.3$ and Reynolds number ( $Re$ ) up to 325. The wake transition regimes in the parameter space are mapped out. It is found that vortex dislocation associated with Mode A is completely suppressed at $G/D$ smaller than approximately 1.0. The suppression of vortex dislocation is believed to be due to the confinement of the Mode A streamwise vortices by the plane wall, which suppresses the excess growth and local dislocation of any Mode A vortex loop. Detailed wake transition is examined at $G/D=0.4$ , where the wake transition sequence is ‘two-dimensional (2D) $\\rightarrow$ ordered Mode A $\\rightarrow$ mode swapping (without dislocations) $\\rightarrow$ Mode B’. Relatively strong three-dimensionality is found at $Re=160{-}220$ as the wake is dominated by large-scale structure of ordered Mode A, and also at $Re\\geqslant 285$ , where Mode B becomes increasingly disordered. A local reduction in three-dimensionality is observed at $Re=225{-}275$ , where the wake is dominated by finer-scale structure of a mixture of ordered Modes A and B. Corresponding variations in the vortex shedding frequency and hydrodynamic forces are also investigated.
Publisher: Springer Science and Business Media LLC
Date: 25-01-2019
DOI: 10.1038/S41467-018-08054-4
Abstract: Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer ( r g = 0.57, p = 4.6 × 10 −8 ), breast and ovarian cancer ( r g = 0.24, p = 7 × 10 −5 ), breast and lung cancer ( r g = 0.18, p =1.5 × 10 −6 ) and breast and colorectal cancer ( r g = 0.15, p = 1.1 × 10 −4 ). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.
Publisher: Elsevier BV
Date: 2013
Start Date: 2019
End Date: 2021
Funder: Australian Research Council
View Funded ActivityStart Date: 01-2019
End Date: 01-2022
Amount: $314,574.00
Funder: Australian Research Council
View Funded Activity