ORCID Profile
0000-0002-6280-0391
Current Organisation
University of Adelaide
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Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 09-2019
DOI: 10.1097/AJP.0000000000000735
Abstract: Inconsistent reporting of outcomes in clinical trials of treatments for Whiplash-associated Disorders (WAD) hinders effective data pooling and conclusions that can be drawn about the effectiveness of tested treatments. The aim of this study was to provide recommendations for core outcome domains that should be included in clinical trials of WAD. A 3-step process was used: (1) A list of potential core outcome domains were identified from the published literature. (2) Researchers, health care providers, patients, and insurance personnel participated and rated the importance of each domain via a 3-round Delphi survey. A priori criteria for consensus were established. (3) Experts comprising researchers, health care providers, and a consumer representative participated in a multidisciplinary consensus meeting that made final decisions on the recommended core outcome domains. The literature search identified 63 potential core domains. A total of 223 participants were invited to partake in the Delphi surveys, with 41.7% completing round 1, 45.3% round 2, and 51.4% round 3. Eleven core domains met the criteria for inclusion across the entire s le. After the expert consensus meeting, 6 core domains were recommended: Physical Functioning, Perceived Recovery, Work and Social Functioning, Psychological Functioning, Quality of Life, and Pain. A 3-step process was used to recommend core outcome domains for clinical trials in WAD. Six core domains were recommended: Physical Functioning, Perceived Recovery, Work and Social Functioning, Psychological Functioning, Quality of Life, and Pain. The next step is to determine the outcome measurement instruments for each of these domains.
Publisher: Wiley
Date: 29-03-2023
DOI: 10.1113/EP091065
Abstract: Exercise‐induced hypoalgesia (EIH) has been found to vary widely within in iduals with chronic neck pain (NP). Research has suggested that the presence of central sensitization within a subgroup of in iduals with chronic NP might be a mediating factor to explain the relationship between exercise and improvements in patient‐reported outcomes. Furthermore, recent work has found that lactate might play a role in the development and maintenance of chronic pain. The immediate effect of a single bout of physical exercise on central sensitization in in iduals with chronic NP and the relationship between lactate concentration, central sensitization and pain sensitivity are to be investigated. Eighty adult participants with chronic NP will be recruited for this randomized crossover trial. Outcome measures, including temporal summation, conditioned pain modulation, EIH and lactate concentration, will be assessed before and after low‐ and high‐intensity bicycling exercise. The outcomes of this study will provide new insights into the mechanistic effect of exercise on central sensitization in in iduals with chronic NP and have the potential to add important information to the current exercise prescription guidelines for in iduals with chronic NP. This study has been approved by the Human Research Ethics Committee, The University of Adelaide (H‐2022‐082) and registered in the Australian New Zealand Clinical Trials Registry (ACTRN12622000642785p).
Publisher: Elsevier BV
Date: 03-2021
Publisher: Informa UK Limited
Date: 09-2020
DOI: 10.2147/CIA.S270407
Publisher: Wiley
Date: 02-08-2022
DOI: 10.1111/PAPR.13150
Abstract: To evaluate the exercise‐induced hypoalgesic (EIH) effects of different types of physical exercise in in iduals with neck pain. Systematic review with meta‐analysis. An electronic search of six databases was completed to include studies assessing EIH effects on neck pain. Randomized controlled trials, controlled trials, and observational studies that assessed before and immediate after‐effects of a single session of physical exercise in people with neck pain were included. Two reviewers independently screened records, extracted outcomes, assessed the risk of bias, and rated the quality of evidence using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. EIH is characterized by increased pain threshold, pain tolerance, and/or decreased sensitivity to painful stimuli or unpleasantness, which may last up to 30 min after a single bout of exercise. EIH is usually measured with quantitative sensory testing (QST) and is mostly taken as the difference between pre‐ and postexercise pressure pain threshold (PPT). Data were pooled and analyzed using a fixed‐effect meta‐analysis. Eleven articles were included in this review nine with low risk of bias and two with some concerns about the risk of bias. Three studies with chronic whiplash‐associated disorders (WAD) were included in the meta‐analysis isometric exercise had a larger EIH effect at the local testing site compared with submaximal aerobic exercises (MD = −0.21, [95% CI = −0.43, 0.00], p = 0.05, I 2 = 92%), submaximal aerobic and isometric exercises had equal EIH effects at the remote testing site (MD = 0.01, [95% CI = −0.33, 0.35], p = 0.95, I 2 = 0%), and submaximal aerobic exercises exerted comparably larger EIH effect at the remote testing site than local testing site (MD = −0.01, [95% CI = −0.20, 0.18], p = 0.93, I 2 = 56%). The certainty of evidence (GRADE) for these analyses was low to very low. According to the descriptive analysis of the studies of chronic nonspecific neck pain, isometric and range of motion (ROM) exercises have shown EIH effects. Active stretching exercises have illustrated contradictory effects. Isometric and ROM exercises exerted hypoalgesia at local and remote sites. A larger EIH effect following submaximal aerobic exercises was exerted at the remote testing site compared with the local site.
Publisher: Oxford University Press (OUP)
Date: 28-09-2023
DOI: 10.1093/PM/PNAD134
Publisher: Springer Science and Business Media LLC
Date: 25-09-2020
DOI: 10.1186/S12891-020-03646-Y
Abstract: While there have been studies in Singapore on the prevalence and economic burden of osteoporotic hip fracture, there is a severe lack of reference data on bone mineral density and prevalence of osteoporosis. The purpose of this study is to establish the reference values for BMD and compare prevalence of osteoporotic conditions using other available reference values so as to better understand the status of bone health in Singaporean adults. We carried out a population-based cross-sectional study using dual-energy x-ray absorptiometry (Hologic Discovery Wi) to measure the bone mineral density of Singaporean adults aged ≥21 years. A total of 542 participants were recruited from the large north-eastern residential town of Yishun. We computed T- scores (denoted by T SG ) for each in idual in the study. Similar diagnoses were also done based on T-scores provided by the densitometer (T DXA ), NHANES database (T NHANES ), and China (T CHN ), and the differences in prevalence compared. We then compared the concordance between T SG and T DXA in the classification of osteoporosis. Osteoporosis was defined according to criteria by the World Health Organization (WHO). Peak lumbar spine BMD was 1.093 ± 0.168 g/cm 2 in women, and 1.041 ± 0.098 g/cm 2 for men. Peak whole-body BMD was 1.193 ± 0.93 g/cm 2 in women at, and 1.224 ± 0.112 g/cm 2 for men. Prevalence of osteoporosis based on lumbar spine was 9.3% in postmenopausal women, and 0.7% in men after 50 years of age. The percentage difference in prevalence range from 60.5–163.6%, when using reference values from T DXA , T NHANES , and T CHN . Comparing diagnosis using T DXA and T SG cut-off values, 28 versus 15 women were diagnosed as osteoporotic respectively. The kappa statistics was 0.81 for women and 0.85 for men. Conclusion: Our study shows that T-scores provided by DXA manufacturer over-diagnosed osteoporosis in Singaporeans, and the prevalence of osteoporotic conditions is not accurately represented. This over-diagnosis may result in unnecessary treatment in some in iduals.
Publisher: Research Square Platform LLC
Date: 19-08-2020
DOI: 10.21203/RS.3.RS-37206/V3
Abstract: Background While there have been studies in Singapore on the prevalence and economic burden of osteoporotic hip fracture, there is a severe lack of reference data on bone mineral density and prevalence of osteoporosis. The purpose of this study is to establish the reference values for BMD and compare prevalence of osteoporotic conditions using other available reference values so as to better understand the status of bone health in Singaporean adults. Methods We carried out a population-based cross-sectional study using dual-energy x-ray absorptiometry (Hologic Discovery Wi) to measure the bone mineral density of Singaporean adults aged [[EQUATION]] 21 years. 314 women and 223 men were recruited from the large north-eastern residential town of Yishun. We computed T-scores (denoted by T SG ) for each in idual in the study. Similar diagnoses were also done based on T-scores provided by the densitometer (T DXA ), NHANES database (T NHANES ), and China (T CHN ), and the differences in prevalence compared. We then compared the concordance between T SG and T DXA in the classification of osteoporosis. Osteoporosis was defined according to criteria by the World Health Organization (WHO). Results Peak lumbar spine BMD was 1.093±0.168g/cm 2 in women, and 1.041±0.098g/cm 2 for men. Peak whole-body BMD was 1.193±0.93g/cm 2 in women at, and 1.224±0.112g/cm 2 for men. Prevalence of osteoporosis based on lumbar spine was 9.3% in postmenopausal women, and 0.7% in men after 50 years of age. The percentage difference in prevalence range from 60.5 - 163.6%, when using reference values from T DXA , T NHANES , and T CHN . Comparing diagnosis using T DXA and T SG cut-off values, 28 versus 15 women were diagnosed as osteoporotic respectively. The kappa statistics was 0.81 for women and 0.85 for men. Conclusion Our study shows that T-scores provided by DXA manufacturer over-diagnosed osteoporosis in Singaporeans, and the prevalence of osteoporotic conditions is not accurately represented. This over-diagnosis may result in unnecessary treatment in some in iduals.
Publisher: Elsevier BV
Date: 04-2021
Publisher: Research Square Platform LLC
Date: 02-09-2020
DOI: 10.21203/RS.3.RS-37206/V4
Abstract: Background While there have been studies in Singapore on the prevalence and economic burden of osteoporotic hip fracture, there is a severe lack of reference data on bone mineral density and prevalence of osteoporosis. The purpose of this study is to establish the reference values for BMD and compare prevalence of osteoporotic conditions using other available reference values so as to better understand the status of bone health in Singaporean adults. Methods We carried out a population-based cross-sectional study using dual-energy x-ray absorptiometry (Hologic Discovery Wi) to measure the bone mineral density of Singaporean adults aged ≥ 21 years. A total of 542 participants were recruited from the large north-eastern residential town of Yishun. We computed T- scores (denoted by TSG) for each in idual in the study. Similar diagnoses were also done based on T-scores provided by the densitometer (TDXA), NHANES database (TNHANES), and China (TCHN), and the differences in prevalence compared. We then compared the concordance between TSG and TDXA in the classification of osteoporosis. Osteoporosis was defined according to criteria by the World Health Organization (WHO). Results Peak lumbar spine BMD was 1.093±0.168g/cm2 in women, and 1.041±0.098g/cm2 for men. Peak whole-body BMD was 1.193±0.93g/cm2 in women at, and 1.224±0.112g/cm2 for men. Prevalence of osteoporosis based on lumbar spine was 9.3% in postmenopausal women, and 0.7% in men after 50 years of age. The percentage difference in prevalence range from 60.5 - 163.6%, when using reference values from TDXA, TNHANES, and TCHN. Comparing diagnosis using TDXA and TSG cut-off values, 28 versus 15 women were diagnosed as osteoporotic respectively. The kappa statistics was 0.81 for women and 0.85 for men. Conclusion Our study shows that T-scores provided by DXA manufacturer over-diagnosed osteoporosis in Singaporeans, and the prevalence of osteoporotic conditions is not accurately represented. This over-diagnosis may result in unnecessary treatment in some in iduals.
Publisher: Research Square Platform LLC
Date: 23-06-2020
DOI: 10.21203/RS.3.RS-37206/V1
Abstract: Background : While there have been studies in Singapore on the prevalence and economic burden of osteoporotic hip fracture, there is a severe lack of reference data on bone mineral density and prevalence of osteoporosis. The purpose of this study is to establish the reference values for BMD and compare prevalence of osteoporotic conditions using other available reference values so as to better understand the status of bone health in Singaporean adults Methods : We carried out a population-based cross-sectional study using dual-energy x-ray absorptiometry (Hologic Discovery Wi) to measure the bone mineral density of Singaporean adults aged ³ 21 years. 314 women and 223 men were recruited from the large north-eastern residential town of Yishun. We computed T- scores (denoted by T SG ) for each in idual in the study. Similar diagnoses were also done based on T-scores provided by the densitometer (T DXA ), NHANES database (T NHANES ), and China (T CHN ), and the differences in prevalence compared. We then compared the concordance between T SG and T DXA in the classification of osteoporosis. Osteoporosis was defined according to criteria by the World Health Organization (WHO). Results: Peak lumbar spine BMD was 1.090±0.168g.cm -2 in women, and 1.041±0.098g.cm -2 for men. Peak whole body BMD was 1.193±0.93g.cm -2 in women at, and 1.224±0.112g.cm -2 for men. Prevalence of osteoporosis based on lumbar spine was 9.3% in women, and 0.7% in men. The percentage difference in prevalence range from 60.5 - 163.6%, when using reference values from T DXA , T NHANES , and T CHN . Among the 28 women who were diagnosed as osteoporotic by T DXA , 16.5% only had osteopenia according to T SG . The kappa statistics was 0.81 for women and 0.85 for men. Conclusion: Our study shows that T-scores provided by DXA manufacturer over-diagnosed osteoporosis in Singaporeans, and the prevalence of osteoporotic conditions is not accurately represented. This over-diagnosis may result in unnecessary treatment in some in iduals.
Publisher: Elsevier BV
Date: 09-2022
Publisher: Elsevier BV
Date: 08-2021
No related grants have been discovered for Kenneth Chen.