ORCID Profile
0000-0002-2072-9056
Current Organisation
The University of Newcastle
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Publisher: Wiley
Date: 20-01-2014
DOI: 10.1111/DME.12347
Abstract: It is proposed that diabetic neuropathy may affect peripheral bone. Direct innervation of bone as well as neural control over its vascular supply and muscular influences may be affected by diabetes-induced peripheral neuropathies. Associated changes to bone may contribute to the occurrence of foot bone pathology in this population. This systematic review aims to examine the literature related to the effect of diabetic neuropathy on foot bones. Studies examining relationships between neuropathy and indicators of bone health (e.g. bone mineral density) in populations with diabetes were sought. Relevant publications were obtained from searches in MEDLINE, CINAHL and Embase in the period up to March 2013. Meta-analysis was performed using a random effects model in the statistical package Stata version 12.1. Ten studies met the inclusion criteria and were included in the narrative synthesis. All studies were cross-sectional or case-control in design. Four of the 10 included studies found results indicating poorer bone health in those with diabetes and neuropathy compared with those with diabetes without neuropathy. Seven of the 10 studies were able to be included in a meta-analysis. The mean pooled effect was -0.36 (95% CI -0.76 to 0.04 P = 0.08), indicating a non-significant trend towards poorer bone health in those with diabetic neuropathy. We did not find a significant relationship between presence of neuropathy in those with diabetes and poorer peripheral bone health. However, methodological limitations of the included studies mean further research is required to investigate this theoretical relationship.
Publisher: BMJ
Date: 07-2016
Publisher: Springer Science and Business Media LLC
Date: 13-02-2019
Publisher: MDPI AG
Date: 31-07-2021
Abstract: Pneumoconiosis, or occupational lung disease, is one of the world’s most prevalent work-related diseases. Silicosis, a type of pneumoconiosis, is caused by inhaling respirable crystalline silica (RCS) dust. Although silicosis can be fatal, it is completely preventable. Hundreds of thousands of workers globally are at risk of being exposed to RCS at the workplace from various activities in many industries. Currently, in Australia and internationally, there are a range of methods used for the respiratory surveillance of workers exposed to RCS. These methods include health and exposure questionnaires, spirometry, chest X-rays, and HRCT. However, these methods predominantly do not detect the disease until it has significantly progressed. For this reason, there is a growing body of research investigating early detection methods for silicosis, particularly biomarkers. This literature review summarises the research to date on early detection methods for silicosis and makes recommendations for future work in this area. Findings from this review conclude that there is a critical need for an early detection method for silicosis, however, further laboratory- and field-based research is required.
Publisher: Elsevier BV
Date: 08-2016
DOI: 10.1016/J.JDIACOMP.2016.04.013
Abstract: Neuropathies are common complications of diabetes and are proposed to influence peripheral bone, principally via an altered vascular supply. This study aimed to determine the relationship between subtypes of neuropathy and vascular reactivity on foot bone density in people with diabetes. A case-control observational design was utilised with two groups: those with diabetic peripheral large fibre neuropathy (n=23) and a control group with diabetes but without neuropathy (n=23). Bone density in 12 foot bones was determined with computed tomography scanning. Additionally, post-occlusive reactive hyperemia, presence of small fibre neuropathy and heart rate variability were determined. T-tests and hierarchical regression were used to examine the relationships among the variables. No difference in foot bone density was found between those with and those without large fibre neuropathy. Furthermore, no association between heart rate variability or reactive hyperemia and bone density was found. Small fibre neuropathy was associated with increased cuboid trabecular bone density (p=0.006) with its presence predictive of 14% of the variance. This study found no clear association between presence of diabetic neuropathies and foot bone density. Furthermore, vascular reactivity appears to have no impact on bone density.
Publisher: Springer Science and Business Media LLC
Date: 03-03-2017
Publisher: Informa UK Limited
Date: 13-11-0021
Publisher: Elsevier BV
Date: 05-2018
DOI: 10.1016/J.APERGO.2018.01.013
Abstract: This cross-sectional study investigated musculoskeletal discomfort and computer use in university staff, through the use of online questionnaires. Results showed a high prevalence of staff reported musculoskeletal discomfort during the preceding year (80%), with neck (60%), shoulder (53%) and lower back discomfort (47%) being the most common. Most believed discomfort was caused by work, although neck discomfort was significantly less in those reporting excellent mental health (OR 0.44, p < 0.01). Computer navigation was performed primarily by mouse (77%) however, using a touch pad increased the odds (OR 1.17, p < 0.01) of wrist discomfort and the belief it was caused by work (OR 1.19, p < 0.01). Few staff attended ergonomic training (16%) or requested workstation assessments (26%). However, high rates of staff reporting musculoskeletal discomfort sought professional treatment (range: 35.2% wrist/hand to 65.0% shoulder). Strategies are needed to address uptake of preventive measures and reduce reliance on medical treatments following musculoskeletal discomfort in universities.
No related grants have been discovered for John Tessier.