ORCID Profile
0000-0002-8339-0336
Current Organisations
Jashore University of Science and Technology
,
Cornell University
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Publisher: Wiley
Date: 28-11-2022
DOI: 10.1111/VCP.13181
Abstract: Liver analyte measurement is important in the evaluation of sick animals. Liver injury in horses is recognized by increased glutamate dehydrogenase (GLDH), sorbitol dehydrogenase (SDH), and aspartate aminotransferase (AST) activities, whereas biliary pathology is identified by increased alkaline phosphatase and γ‐glutamyl transferase (GGT) activities or bilirubin concentrations. We have observed high GLDH, but not SDH, activities in neonatal foals admitted for conditions other than liver disease. Only one previous study have evaluated GLDH activity over time in healthy neonatal foals however, SDH activity was not measured. We aimed to evaluate changes in liver analytes in neonatal foals over time. We measured serum liver analytes (GLDH, SDH, GGT, AST, total, direct, and indirect bilirubin) and creatine kinase activity of 11 clinically healthy foals before and at various times after suckling until 46 days of age. Analytes were also measured in colostrum and mare serum. Median GLDH activities increased after birth to peak at 3‐4 days of age (106 U/L, reference interval, 0‐8 U/L). Median SDH activities had a lower peak at 3‐4 days (15 U/L, reference interval, 0‐11 U/L) and were frequently discordant with GLDH. There was no association between foal and mare serum or colostral enzyme activities. AST activity plateaued at 5‐6 days, whereas GGT activity and total and indirect bilirubin concentrations peaked at 14 and 3‐4 days of age, respectively. Transient increases in GLDH, SDH, and GGT activities and total and indirect bilirubin concentrations occur in clinically healthy neonatal foals and do not necessarily indicate relevant liver disease.
Publisher: Wiley
Date: 08-03-2021
DOI: 10.1111/VCP.12952
Publisher: MDPI AG
Date: 12-03-2022
Abstract: Oligo(L-lactic acid) (OLLA) was synthesized by ring opening polymerization of L-lactides using stannous octoate (0.03 wt% of lactide). While this served as the initiator, L-lactic acids were the co-initiators at 140 °C for 10 h, wherein L-lactic acids were prepared by hydrolytic degradation of L-lactides at 100 °C for 1 h. The molecular weight or degree of polymerization was controlled with monomer/co-initiator ratio (mol/mol). α-cellulose and microcrystalline cellulose (MCC) were extracted from jute fiber by subsequent treatment with sodium chlorite (Na2ClO2), NaOH and H2SO4. Grafting of OLLA onto α-cellulose and MCC in toluene was carried out using para-toluene sulphonic acid as a catalyst and potassium persulphate (KPS) as an initiator at 130 °C under 380 mm (Hg) pressure for 3, 6, 9, 12, 15, and 18 h. New properties of α-cellulose and MCC were observed due to the successful grafting onto α-cellulose and MCC. Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscope (SEM) were conducted in order to confirm grafting of OLLA onto cellulose and MCC. The FTIR analysis results showed there are some new characteristic absorption peaks appeared (1728 to 1732 cm−1) in the spectrum, which confirmed the grafting of OLLA onto α-cellulose and MCC was successful. SEM images of α-cellulose and MCC before and after grafting revealed significant changes in surface morphology. Grafting of MCC could be more effective for further application in comparison to α-cellulose.
Publisher: Wiley
Date: 04-04-2020
DOI: 10.1111/VCP.12843
Publisher: Wiley
Date: 03-2021
DOI: 10.1111/VCP.12981
Publisher: Wiley
Date: 08-03-2021
DOI: 10.1111/EVJ.13435
Abstract: High‐serum γ‐Glutamyl Transferase (GGT) activity has been associated with and thought to be a marker of maladaptation to training and possibly poor performance in racehorses, but the cause is unknown. To investigate possible metabolic and infectious causes for the high GGT syndrome. Pilot case‐control study and nested case‐control study. The case‐control study in 2017 included 16 horses (8 cases and 8 controls with median [range] serum GGT 82 [74‐148] and 22 [19‐28] IU/L, respectively) from the same stable. In 2018, similar testing was performed in a nested case‐control study that identified 27 case (serum GGT 50 ≥ IU/L)‐control pairs from three stables for further testing. Serum liver chemistries, selenium measurements, viral PCR and metabolomics were performed. No differences were found in frequency of detection of viral RNA/DNA or copy numbers for equine hepacivirus (EqHV) and parvovirus‐hepatitis (EqPV‐H) between cases and controls. Mild increases in hepatocellular injury and cholestatic markers in case vs control horses suggested a degree of liver disease in a subset of cases. Metabolomic and in idual bile acid testing showed differences in cases compared with controls, including increased abundance of pyroglutamic acid and taurine‐conjugated bile acids, and reduced abundance of Vitamin B6. Selenium concentrations, although within or above the reference intervals, were also lower in case horses in both studies. Observational study design did not allow us to make causal inferences. We conclude that high GGT syndrome is likely a complex metabolic disorder and that viral hepatitis was not identified as a cause for this syndrome in this cohort of racehorses. Our results support a contribution of oxidative stress and cholestasis in its pathophysiology.
Publisher: Wiley
Date: 24-06-2023
DOI: 10.1111/VCP.13152
Abstract: A 16‐year‐old female spayed domestic shorthaired cat was examined for lameness and a mass on the fourth digit of the right hindlimb. Cytologic examination of an aspirate of the mass revealed large discrete cells admixed with low numbers of well‐granulated mast cells. The discrete cells contained single to many variably sized light pink to purple granules in their cytoplasm and had pleomorphic nuclei, with intranuclear cytoplasmic inclusions. Karyomegalic, binucleated and multinucleated cells were seen. Histologic examination of formalin‐fixed sections of the excised mass showed a mildly infiltrative, unencapsulated, multinodular dermal mass that extended into the subcutis and consisted of similar discrete cells. On immunohistochemical staining, the tumor cells expressed ionized calcium‐binding adapter molecule 1 (Iba1) and CD18. The tumor cells did not express CD3, CD20, CD117, pancytokeratin (AE1/AE3), melanoma antigen (Melan‐A), multiple myeloma oncogene‐1 (MUM1), melanoma‐associated antigen (PNL‐2), and S‐100. Low numbers of tumor cells expressed CD204 and protein gene product 9.5 (PGP9.5). Granules were variably positive for Periodic‐acid Schiff (PAS) and Alcian blue. On transmission electron microscopy, the cells contained filopodia, abundant endoplasmic reticulum, and moderate numbers of low‐density membrane‐bound granules. This case documents a previously undescribed granular variant of a histiocytic tumor in a cat.
No related grants have been discovered for S. M. Nur Alam.