ORCID Profile
0000-0002-8456-5919
Current Organisations
University of Zambia
,
Spectra-Medics Pty Ltd
,
SpectraVET Inc
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Publisher: Mary Ann Liebert Inc
Date: 06-2023
Publisher: SPIE
Date: 10-02-2011
DOI: 10.1117/12.878827
Publisher: SPIE
Date: 12-02-2009
DOI: 10.1117/12.809563
Publisher: American Association for the Advancement of Science (AAAS)
Date: 24-05-2023
Abstract: Preterm birth (PTB) is the leading cause of death in children under five, yet comprehensive studies are hindered by its multiple complex etiologies. Epidemiological associations between PTB and maternal characteristics have been previously described. This work used multiomic profiling and multivariate modeling to investigate the biological signatures of these characteristics. Maternal covariates were collected during pregnancy from 13,841 pregnant women across five sites. Plasma s les from 231 participants were analyzed to generate proteomic, metabolomic, and lipidomic datasets. Machine learning models showed robust performance for the prediction of PTB (AUROC = 0.70), time-to-delivery ( r = 0.65), maternal age ( r = 0.59), gravidity ( r = 0.56), and BMI ( r = 0.81). Time-to-delivery biological correlates included fetal-associated proteins (e.g., ALPP, AFP, and PGF) and immune proteins (e.g., PD-L1, CCL28, and LIFR). Maternal age negatively correlated with collagen COL9A1, gravidity with endothelial NOS and inflammatory chemokine CXCL13, and BMI with leptin and structural protein FABP4. These results provide an integrated view of epidemiological factors associated with PTB and identify biological signatures of clinical covariates affecting this disease.
Publisher: Mary Ann Liebert Inc
Date: 12-2011
Abstract: Dose and beam parameters are critical for successful laser, LED, and other light therapy treatments however, in our experience, researchers frequently make critical errors and omissions when submitting papers for publication. Journals frequently publish studies with missing data, mathematical errors, and no reported verification of beam parameters. This makes reproducibility impossible, and further confounds an already complex subject. This article is intended to be a reference document for non-physicist researchers conducting low-level laser therapy (LLLT) laboratory studies and clinical trials to help them design and report the beam and dose aspects of their trials. It provides a checklist to help LLLT researchers understand and report all the necessary parameters for a repeatable scientific study. It includes the eight most important beam parameters to report, which are: wavelength, power, irradiation time, beam area at the skin or culture surface (this is not necessarily the same as the aperture size), pulse parameters, anatomical location, number of treatments, and interval between treatments. The three commonly used dose parameters are time, energy, and energy density. In addition, more thorough reporting would include coherence, application technique (contact, projection, scanning, pressure), beam profile, and spectral width, as these may also be considered important. Beam power often decreases as the device warms up and as the device ages therefore, this should be checked routinely during an experiment/trial. Measurements of beam area and beam power require special instruments and trained technicians to operate them. Power measurements should be taken before, after, and at frequent intervals during research trials. Reviewers should insist that the minimum eight most important beam parameters are included, and authors should take care to measure and record these accurately before, during, and after an experiment or clinical trial.
Publisher: Springer Science and Business Media LLC
Date: 14-10-2011
Publisher: CRC Press
Date: 22-10-2013
DOI: 10.1201/B15582-72
Publisher: Mary Ann Liebert Inc
Date: 03-2016
No related grants have been discovered for Peter Andrew Jenkins.