ORCID Profile
0000-0003-1387-9379
Current Organisations
Kumamoto University
,
University of Western Australia
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In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Archaeology | Aboriginal and Torres Strait Islander Archaeology | Archaeological Science | Cultural Studies | Postcolonial And Global Cultural Studies | Aboriginal Cultural Studies | Tourism Not Elsewhere Classified | Aboriginal Studies | Palaeoecology | Other History And Archaeology | Heritage and Cultural Conservation | Archaeology Of Hunter-Gatherer Societies (Incl. Pleistocene | Historical Archaeology (incl. Industrial Archaeology) | Historical Archaeology (Incl. Industrial Archaeology)
Understanding Australia's Past | Aboriginal and Torres Strait Islander heritage | Climate change | Land and water management | Social Impacts of Climate Change and Variability | Studies in human society |
Publisher: Public Library of Science (PLoS)
Date: 20-10-2023
Publisher: Elsevier BV
Date: 11-2021
DOI: 10.1093/JN/NXAB311
Abstract: Severely energy-restricted diets that utilize meal-replacement products are the most effective dietary treatment for obesity. However, there are concerns they may fail to educate in iduals on how to adopt a healthy food-based diet after weight loss. The aim of this research was to compare changes in diet quality following total meal replacement compared with food-based weight-loss diets. In this secondary analysis of a randomized controlled trial, 79 postmenopausal women aged 45-65 y, with a BMI (in kg/m2) of 30-40, were randomly assigned to either a total meal-replacement diet (energy intake restricted by 65-75% relative to requirements) for 16 wks, followed by a food-based diet (energy intake restricted by 25-35% relative to requirements) until 52 wks, or the food-based diet for the entire 52-wk period. Diet quality was scored at baseline and 52 wks using the Healthy Eating Index for Australian Adults, with score changes compared between groups using an independent t test. Diet quality improved from baseline in both groups, but less so in the total meal-replacement group, with a mean (SD) increase of 3.6 (10.8) points compared with 11.8 (13.9) points in the food-based group, resulting in a mean between-group difference of -8.2 (P = 0.004 95% CI: -13.8, -2.7) points. This improvement in diet quality within both groups was mostly driven by a reduction in the intake of discretionary foods. Intake remained below the recommendations at 52 wks for 4 of the 5 food groups in both dietary interventions. In postmenopausal women with obesity, weight-loss interventions that involve either a total meal-replacement diet or a food-based diet both improve diet quality, however, not sufficiently to meet recommendations. This highlights the importance of addressing diet quality as a part of all dietary weight-loss interventions. This trial is registered with the Australia and New Zealand Clinical Trials Registry as 12612000651886.
Publisher: Elsevier
Date: 2008
Publisher: Informa UK Limited
Date: 02-01-2016
Publisher: Informa UK Limited
Date: 20-04-2022
Publisher: Wiley
Date: 30-01-2023
DOI: 10.1002/ART.42307
Abstract: To define the association between change in body mass index (BMI) and the incidence and progression of the structural defects of knee osteoarthritis as assessed by radiography. Radiographic analyses of knees at baseline and at 4–5 years of follow‐up were obtained from the following 3 independent cohort studies: the Osteoarthritis Initiative (OAI) study, the Multicenter Osteoarthritis Study (MOST), and the Cohort Hip and Cohort Knee (CHECK) study. Logistic regression analyses using generalized estimating equations, with clustering of both knees within in iduals, were used to investigate the association between change in BMI from baseline to 4–5 years of follow‐up and the incidence and progression of knee osteoarthritis. A total of 9,683 knees (from 5,774 participants) in an “incidence cohort” and 6,075 knees (from 3,988 participants) in a “progression cohort” were investigated. Change in BMI was positively associated with both the incidence and progression of the structural defects of knee osteoarthritis. The adjusted odds ratio (OR) for osteoarthritis incidence was 1.05 (95% confidence interval [95% CI] 1.02–1.09), and the adjusted OR for osteoarthritis progression was 1.05 (95% CI 1.01–1.09). Change in BMI was also positively associated with degeneration (i.e., narrowing) of the joint space and with degeneration of the femoral and tibial surfaces (as indicated by osteophytes) on the medial but not on the lateral side of the knee. A decrease in BMI was independently associated with lower odds of incidence and progression of the structural defects of knee osteoarthritis and could be a component in preventing the onset or worsening of knee osteoarthritis.
Publisher: Elsevier BV
Date: 07-2018
Publisher: Elsevier BV
Date: 11-2017
Publisher: Springer Science and Business Media LLC
Date: 26-04-2023
DOI: 10.1186/S12874-023-01926-4
Abstract: Rheumatology researchers often categorize continuous predictor variables. We aimed to show how this practice may alter results from observational studies in rheumatology. We conducted and compared the results of two analyses of the association between our predictor variable (percentage change in body mass index [BMI] from baseline to four years) and two outcome variable domains of structure and pain in knee and hip osteoarthritis. These two outcome variable domains covered 26 different outcomes for knee and hip combined. In the first analysis (categorical analysis), percentage change in BMI was categorized as ≥ 5% decrease in BMI, 5% change in BMI, and ≥ 5% increase in BMI, while in the second analysis (continuous analysis), it was left as a continuous variable. In both analyses (categorical and continuous), we used generalized estimating equations with a logistic link function to investigate the association between the percentage change in BMI and the outcomes. For eight of the 26 investigated outcomes (31%), the results from the categorical analyses were different from the results from the continuous analyses. These differences were of three types: 1) for six of these eight outcomes, while the continuous analyses revealed associations in both directions (i.e., a decrease in BMI had one effect, while an increase in BMI had the opposite effect), the categorical analyses showed associations only in one direction of BMI change, not both 2) for another one of these eight outcomes, the categorical analyses suggested an association with change in BMI, while this association was not shown in the continuous analyses (this is potentially a false positive association) 3) for the last of the eight outcomes, the continuous analyses suggested an association of change in BMI, while this association was not shown in the categorical analyses (this is potentially a false negative association). Categorization of continuous predictor variables alters the results of analyses and could lead to different conclusions therefore, researchers in rheumatology should avoid it.
Publisher: Springer Science and Business Media LLC
Date: 11-10-2019
Publisher: Cambridge University Press (CUP)
Date: 06-2013
DOI: 10.1017/S0003598X00049115
Abstract: Enhanced by recent survey, the authors define new kinds of rock art along the Lennard and Fitzroy rivers in Western Australia—black pigment and scratch-work images featuring anthropomorphic figures with elaborate head-dresses. These are shown to belong to the Contact period and represent the response of Indigenous artists to European land-taking by recalling and restating traditional themes from earlier times.
Publisher: Elsevier BV
Date: 02-2013
Publisher: Wiley
Date: 05-01-2023
DOI: 10.1002/OSP4.654
Abstract: Very low energy diets (VLEDs) effectively induce substantial weight loss in people with obesity, yet they are rarely used as a first line treatment. There is a belief that such diets do not teach the lifestyle behavior changes needed for long‐term weight maintenance. However, little is known about the lived experiences of people who have lost weight on a VLED in the long term. This study aimed to explore the behaviors and experiences of postmenopausal women who had followed a 4‐month VLED (using total meal replacement products [MRPs]), followed by a food‐based, moderately energy‐restricted diet for an additional 8 months, as part of the TEMPO Diet Trial. Qualitative in‐depth semi‐structured interviews were conducted with 15 participants at 12 or 24 months (i.e., at 8 or 20 months post diet completion). Transcribed interviews were analyzed thematically using an inductive approach. Undertaking a VLED was reported by participants to confer advantages in weight maintenance that previous weight loss attempts had not been able to do for them. Firstly, the rapid and significant weight loss, in conjunction with ease of use, was motivational and helped instill confidence in the participants. Secondly, the cessation of a normal diet during the VLED was reported by participants to break weight gain‐inducing habits, allowing them to abandon unhelpful habits and to introduce in their place more appropriate attitudes toward weight maintenance. Lastly, the new identity, helpful habits and increased self‐efficacy around weight loss supported participants during weight maintenance. Additionally, participants reported that ongoing occasional use of MRPs provided a useful and easy new strategy for countering weight regain and supporting their weight maintenance regimen. Among the participants in this qualitative study, most of whom had maintained a loss of over 10% of their baseline body weight at the time of interview, using a VLED in the context of a clinical weight loss trial conferred confidence, motivation and skills for weight maintenance. These findings indicate that VLEDs with clinical support could be successfully leveraged to set up behaviors that will support weight maintenance in the long term.
Publisher: Springer Science and Business Media LLC
Date: 29-12-2022
Publisher: SAGE Publications
Date: 10-2006
Abstract: A ision of labour between sexes/genders in which, although there is some overlap, men hunt large game and women collect smaller game, shellfish and most plant foods, is a characteristic of all documented hunter-gatherer societies. We argue that there is no biological reason for this behaviour and that it must be a social construct. These gender roles became part of the structure of societies at the same time as other forms of symbolic behaviour associated with anatomically modern humans ( Homo sapiens sapiens). Established gender roles were important for the first colonizers of a new continent, Australia, because it allowed the colonizers to tackle a completely new environment.
Publisher: Wiley
Date: 23-08-2022
DOI: 10.1111/OBR.13465
Abstract: This systematic review with meta‐analyses assessed the effects of total diet replacement (TDR) programs on mental well‐being in clinical trial participants with a body mass index greater than or equal to 25 kg/m 2 . TDR programs involve replacing all dietary requirements with nutritionally replete formula foods and are generally administered to induce rapid weight loss. To date, it is largely unclear what effects TDR programs may have on mental well‐being, particularly in the long‐term. To address this, we screened 25,976 references across six databases and extracted 35 publications. These 35 publications provided sufficient data to evaluate the effects of TDR programs on depression, anxiety, stress, positive affect, negative affect, vitality, role‐emotional, social functioning, mental health, mental composite summary score, self‐esteem, and general psychological health in 24 meta‐analyses. Due to the lack of research comparing TDR programs to comparator groups, 22 of our 24 meta‐analyses explored change in these mental well‐being sub‐domains over time in TDR programs without comparators. Specifically, we assessed the change from pre‐diet (before the TDR program) to either post‐diet (up to and including two months after the TDR program) and/or follow‐up (more than two months after the TDR program). For depression and anxiety, we were also able to assess the change from pre‐diet to mid‐diet (which fell within two weeks of the diet half‐way point). The remaining two meta‐analyses assessed the difference in depression scores between a TDR group and a food‐based comparator group from pre‐diet to post‐diet and from pre‐diet to follow‐up. Across all meta‐analyses, our results found no marked adverse effects of TDR programs on any mental well‐being sub‐domain. In fact, clear improvements were observed for depression, anxiety, stress, vitality, role‐emotional, and social functioning at post‐diet. Interestingly, the improvements for depression, vitality and role‐emotional were maintained at follow‐up. All improvements were observed in meta‐analyses without comparators. While the two comparator‐based meta‐analyses showed no difference between TDR programs and food‐based diets in depression symptoms, there was low statistical power. For all meta‐analyses containing three or more independent s les, we constructed prediction intervals to determine the range within which the mean of the true effects may fall for future populations. While these prediction intervals varied between sub‐domains, we found that mean depression scores are only likely to increase (i.e., depression will worsen) in less than 3% of future TDR interventions which meet our inclusion/exclusion criteria. Taken together, we concluded that for adults with a body mass index greater than or equal to 25 kg/m 2 , TDR programs are unlikely to lead to marked adverse effects on mental well‐being. These findings do not support the exclusion of participants from trials or interventions involving TDR programs based on concerns that these programs may adversely affect mental well‐being. In fact, by excluding these participants, they may be prevented from improving their metabolic health and mental well‐being.
Publisher: Springer Science and Business Media LLC
Date: 19-07-2018
DOI: 10.1038/S41598-018-28324-X
Abstract: The dingo is the only placental land mammal aside from murids and bats to have made the water crossings to reach Australia prior to European arrival. It is thought that they arrived as a commensal animal with people, some time in the mid Holocene. However, the timing of their arrival is still a subject of major debate with published age estimates varying widely. This is largely because the age estimates for dingo arrival are based on archaeological deposit dates and genetic ergence estimates, rather than on the dingo bones themselves. Currently, estimates vary from between 5000–4000 years ago, for finds from archaeological contexts, and as much as 18,000 based on DNA age estimates. The timing of dingo arrival is important as post arrival they transformed Indigenous societies across mainland Australia and have been implicated in the extinction of a number of animals including the Tasmanian tiger. Here we present the results of direct dating of dingo bones from their oldest known archaeological context, Madura Cave on the Nullarbor Plain. These dates demonstrate that dingoes were in southern Australia by between 3348 and 3081 years ago. We suggest that following their introduction the dingo may have spread extremely rapidly throughout mainland Australia.
Publisher: Wiley
Date: 06-2013
DOI: 10.1111/PED.12079
Abstract: This study was conducted to clarify whether respiratory stimulants used to treat apnea of prematurity (AOP) attenuate or aggravate hypoxia-induced neuronal damage. A human neuroblastoma cell line, SH-SY5Y cells, and hippoc al slice cultures from rat pups were exposed to hypoxia to induce cell injury. The effects of respiratory stimulants on cell injury were evaluated. Theophylline and doxapram did not have any effects against cell injury induced by hypoxia in SH-SY5Y cells and hippoc al slice cultures of rat pups, while caffeine protected these cells and the slice cultures from hypoxia. The protective effects of caffeine in SH-SY5Y cells disappeared with co-treatment by the adenosine A2A receptor agonist, CGS21680, and were mimicked by the adenosine A2A R antagonist, SCH58261. Meanwhile, co-treatment with phosphatidylinositol 3-kinase/AKT pathway inhibitors did not affect the protective effects of caffeine. Hydroxy radical scavenging activity of caffeine were not observed at the concentrations that produced cytoprotective activity, and radical scavengers did not have any effects on the cell injury induced by hypoxia in SH-SY5Y cells. Caffeine significantly attenuated cell injury induced by hypoxia in SH-SY5Y cells and hippoc al slice cultures of rat pups, at least partly through A2A R antagonism. Caffeine can protect neuronal cells from injury induced by hypoxemia, and may be a beneficial treatment for AOP with neuroprotective potential.
Publisher: Springer Science and Business Media LLC
Date: 24-05-2022
DOI: 10.1186/S12888-022-04005-Y
Abstract: Bulimia nervosa (BN) and binge eating disorder (BED) are eating disorders (EDs) characterized by recurrent binge eating. They are associated with medical complications, impaired adaptive function and often a high BMI, for which a multidisciplinary treatment approach may be needed. This study explored the efficacy of a novel intervention integrating Cognitive Behavioural Therapy- Enhanced (CBT-E) and weight management for people with recurrent binge eating episodes and high BMI with respect to physical, psychopathological and quality of life outcomes. Ninety-eight adults diagnosed with BN, BED, or Other Specified/Unspecified Feeding or Eating Disorder (OSFED/UFED) and BMI ≥ 27 to kg/m 2 were randomized to a multidisciplinary approach, the Healthy APproach to weIght management and Food in Eating Disorders (HAPIFED) or to CBT-E. Metabolic parameters, health-related quality of life, general psychological and ED symptoms and ED diagnostic status outcomes are reported. Data were analyzed with mixed effects models adopting multiple imputed datasets where data were missing. Both HAPIFED and CBT-E showed statistical significance for the time effect, with reduction in stress ( p 0.001), improvement in mental health-related quality of life ( p = 0.032), reduction in binge eating severity ( p 0.001), and also in global ED symptoms scores ( p 0.001), with the significant changes found at end of treatment and sustained at 12-month follow-up. However, no statistical significance was found for differences between the interventions in any of the outcomes measured. Despite a high BMI, most participants ( 75%) had blood test results for glucose, insulin, triglycerides and cholesterol within the normal range, and 52% were within the normal range for the physical component of quality of life at baseline with no change during the trial period. Integrating weight and ED management resulted in comparable outcomes to ED therapy alone. Although adding weight management to an ED intervention had no adverse effects on psychological outcomes, it also had no beneficial effect on metabolic outcomes. Therefore, more intense weight management strategies may be required where indicated to improve metabolic outcomes. Safety will need to be concurrently investigated. US National Institutes of Health clinical trial registration number NCT02464345 , date of registration 08/06/2015. Changes to the present paper from the published protocol paper (Trials 18:578, 2015) and as reported in the Trial registration (clinicaltrials.gov) are reported in Supplementary File 1.
Publisher: Elsevier BV
Date: 06-2009
Publisher: Springer Science and Business Media LLC
Date: 15-05-2021
DOI: 10.1038/S41366-021-00832-3
Abstract: This study aims to investigate the association between weight change and total knee or hip replacement (TKR or THR) for OA among middle-aged and older adults with overweight or obesity. Weight data were collected in 2006–2009 and in 2010 from the 45 and Up Study—a population-based cohort aged ≥45 years in New South Wales, Australia. Participants were included if they had a baseline body mass index (BMI) ≥ 25 kg/m 2 and no history of TKR or THR. Weight change was categorised into four groups: .5% loss –7.5% loss stable (≤5% change) and % gain. Hospital admission data were linked to identify TKR and THR for OA, and multivariable Cox regression was used to assess risk of TKR and THR. Of 23,916 participants, 2139 lost .5% weight, 1655 lost 5–7.5% weight, and 4430 gained % weight. Over 5.2 years, 1009 (4.2%) underwent TKR and 483 (2.0%) THR. Compared to weight-stable, weight loss of .5% was associated with reduced risk of TKR after adjusting for age, sex, BMI, socioeconomic and lifestyle factors (hazard ratio 0.69, 95%CI 0.54–0.87), but had no association with THR. Weight loss of 5–7.5% was not associated with altered risk of either TKR or THR. Weight gain was associated with increased risk of THR after adjusting for confounders, but not TKR. This study suggests that a weight loss target .5% is required to reduce the risk of TKR in adults with overweight or obesity. Weight gain should be avoided as it increases the risk of THR.
Publisher: Informa UK Limited
Date: 04-05-2017
Publisher: Wiley
Date: 06-08-2019
DOI: 10.1002/ARCO.5166
Publisher: SAGE Publications
Date: 27-04-2020
Abstract: Carpenter’s Gap 1 is a large rockshelter located within the Kimberley region of northwestern Australia. The site provides valuable archives of late Quaternary palaeoecological information within an area known for a lack of deposits preserving long-term continuous botanical records. Previous studies of the macrobotanic, phytolith and wood charcoal records from Carpenter’s Gap 1 are in general agreement about changes in broad vegetation patterns over time but differ in the time scales used, in the representation of some species, and in the interpretation of changes – particularly on the degree to which the variations in the record represent cultural activities. An examination of palynology (the transport, deposition and preservation of pollen within the rockshelter environment) provides more detail to the vegetation patterns identified in these previous studies. In addition, because the pollen most likely reflects the vegetation of the site’s surrounds over time rather than plants introduced into the shelter by people, interpretation can be more confidently linked to environmental change, and by inference climatic conditions. The pollen data reveal pre-glacial mixed wooded vegetation. From the beginning of the Holocene, tree loss occurred in a transition from monsoonal forest to thicket and eucalypt forest to woodland. Vegetation transition around the mid Holocene suggests a shift in climate, becoming drier and more variable towards and into the late Holocene. The role of fire in the establishment of vegetation communities remains under investigation.
Publisher: Frontiers Media SA
Date: 23-07-2021
Publisher: MDPI AG
Date: 10-01-2022
Abstract: Severely energy-restricted diets (SERDs) are an effective treatment for obesity, however, adherence to such diets is often perceived as poor by healthcare professionals. This investigation evaluated adherence to a 12-week SERD in participants with class II and III obesity. Reported food consumption was compared against in idualised SERD prescriptions. Body weight measures were obtained at baseline, 12 and 52 weeks. The data were analysed in three groups (i) the entire cohort (n = 26), (ii) completers (n = 13) and (iii) non-completers (n = 13). SERD prescription elements included (i) the number of meal replacement products (ii) total protein (iii) total energy intake (iv) level of dietary energy restriction (v) vegetable serves (vi) water serves, and (vii) how much physical activity was performed. A generalised repeated-measures mixed-effects model was used to investigate if adherence to the program elements in idually, or collectively, influenced weight loss. Completers had an average (± SD) of 4549 ± 748 kJ energy intake per day, resulting in a mean energy restriction of 62% compared to the 69% prescribed, indicating a degree of non-adherence. The percent weight changes for completers and non-completers were −7.8 ± 4.7% and −1.6 ± 2.6% at 12 weeks, and −12.2 ± 12.1% and −1.8 ± 3.2% at 52 weeks, respectively. Complete dietary adherence to a SERD may not be necessary to achieve a clinically relevant weight loss of 12% at 52 weeks, if energy is restricted by at least 62% (~4600 kJ per day) relative to requirements.
Publisher: Frontiers Media SA
Date: 06-2021
Abstract: Background: Previous studies have shown an increase in hunger during weight-loss maintenance (WLM) after diet-induced weight loss. Whether a combination of a higher protein, lower glycemic index (GI) diet and physical activity (PA) can counteract this change remains unclear. Aim: To compare the long-term effects of two diets [high protein (HP)-low GI vs. moderate protein (MP)-moderate GI] and two PA programs [high intensity (HI) vs. moderate intensity (MI)] on subjective appetite sensations during WLM after ≥8% weight loss (WL). Methods: Data derived from the 3-years PREVIEW randomized intervention study. An 8-weeks WL phase using a low-energy diet was followed by a 148-weeks randomized WLM phase. For the WLM phase, participants were assigned to one of the four groups: HP-MI, HP-HI, MP-MI, and MP-HI. Available data from 2,223 participants with overweight or obesity (68% women BMI ≥ 25 kg/m 2 ). Appetite sensations including satiety, hunger, desire to eat, and desire to eat something sweet during the two phases (at 0, 8 weeks and 26, 52, 104, and 156 weeks) were assessed based on the recall of feelings during the previous week using visual analogue scales. Differences in changes in appetite sensations from baseline between the groups were determined using linear mixed models with repeated measures. Results: There was no significant diet × PA interaction. From 52 weeks onwards, decreases in hunger were significantly greater in HP-low GI than MP-moderate GI ( P time × diet = 0.018, P dietgroup = 0.021). Although there was no difference in weight regain between the diet groups ( P time × diet = 0.630), hunger and satiety ratings correlated with changes in body weight at most timepoints. There were no significant differences in appetite sensations between the two PA groups. Decreases in hunger ratings were greater at 52 and 104 weeks in HP-HI vs. MP-HI, and greater at 104 and 156 weeks in HP-HI vs. MP-MI. Conclusions: This is the first long-term, large-scale randomized intervention to report that a HP-low GI diet was superior in preventing an increase in hunger, but not weight regain, during 3-years WLM compared with a MP-moderate GI diet. Similarly, HP-HI outperformed MP-HI in suppressing hunger. The role of exercise intensity requires further investigation. Clinical Trial Registration: www.ClinicalTrials.gov , identifier: NCT01777893.
Publisher: Elsevier BV
Date: 12-2012
DOI: 10.1016/J.LFS.2012.09.018
Abstract: Acetaminophen is a safe antipyretic and analgesic drug within the clinically recommended dosage range, but overdose can cause fatal liver and or kidney damage. Most of the nonsteroidal anti-inflammatory drugs (NSAIDs) exert their analgesic effect via inhibition of cyclooxygenase, which also results in a reduction of renal blood flow. Therefore, the use of NSAIDs in pain treatment for chronic kidney disease (CKD) patients is of particular concern. Acetaminophen lacks the anti-inflammatory and anti-coagulatory properties of the NSAIDs. In this study, we investigate whether acetaminophen has an impact on the progression of renal failure. Acetaminophen (150mg/kg/day or 750mg/kg/day) or indomethacin (5mg/kg/day) was orally administered to adenine-induced chronic renal failure model rats for 4weeks. The plasma concentrations of acetaminophen and its metabolites were measured during the treatment period renal function and oxidative stress in the rats were also monitored. Indomethacin significantly decreased the survival rate of renal failure model rats. In contrast, both low (150mg/kg) and high (750mg/kg) doses of acetaminophen improved the survival rate. The progression of renal failure was attenuated by acetaminophen (750mg/kg) after administration for 2weeks. The metabolites of acetaminophen were found to accumulate in plasma. Plasma glutathione concentration had significantly recovered after acetaminophen administration. Acetaminophen has no effect on the progression of renal damage in adenine-induced renal failure model rats. This result is in part due to acetaminophen's antioxidant activity. These results suggest that acetaminophen is a suitable analgesic agent for treating CKD patients.
Publisher: Informa UK Limited
Date: 06-2014
Publisher: Wiley
Date: 05-09-2014
DOI: 10.1002/ARCO.5040
Publisher: Cambridge University Press (CUP)
Date: 15-02-2023
DOI: 10.1017/S0954422423000045
Abstract: The cornerstone of obesity treatment is behavioural weight management, resulting in significant improvements in cardio-metabolic and psychosocial health. However, there is ongoing concern that dietary interventions used for weight management may precipitate the development of eating disorders. Systematic reviews demonstrate that, while for most participants medically supervised obesity treatment improves risk scores related to eating disorders, a subset of people who undergo obesity treatment may have poor outcomes for eating disorders. This review summarises the background and rationale for the formation of the Eating Disorders In weight-related Therapy (EDIT) Collaboration. The EDIT Collaboration will explore the complex risk factor interactions that precede changes to eating disorder risk following weight management. In this review, we also outline the programme of work and design of studies for the EDIT Collaboration, including expected knowledge gains. The EDIT studies explore risk factors and the interactions between them using in idual-level data from international weight management trials. Combining all available data on eating disorder risk from weight management trials will allow sufficient s le size to interrogate our hypothesis: that in iduals undertaking weight management interventions will vary in their eating disorder risk profile, on the basis of personal characteristics and intervention strategies available to them. The collaboration includes the integration of health consumers in project development and translation. An important knowledge gain from this project is a comprehensive understanding of the impact of weight management interventions on eating disorder risk.
Publisher: Informa UK Limited
Date: 03-05-2016
Publisher: Informa UK Limited
Date: 12-2010
Publisher: Springer Science and Business Media LLC
Date: 07-12-2022
DOI: 10.1007/S10761-022-00678-Z
Abstract: This paper discusses the Australian boab tree and its potential for research as living historical archaeology. Boab trees play an important role in the economy, culture, and cosmology of Indigenous people in northwest Australia and continue to hold a powerful presence in the Kimberley region today. Working with Nyikina and Mangala Traditional Owners we have undertaken to document ex les of this iconic tree and its cultural and historical associations, particularly in the form of carvings and inscriptions embedded in the bark. Focusing on four in idual trees located in the Kimberley region of northwest Australia, we propose that the modification of boab trees, as a practice undertaken by both Indigenous and non-Indigenous people, offers important insights into the everyday lives and historic events that shaped this cultural landscape.
Publisher: Elsevier BV
Date: 06-2016
Publisher: Springer Science and Business Media LLC
Date: 12-2014
DOI: 10.1186/S12913-014-0615-0
Abstract: The aims of this study were to evaluate the current awareness of and implementation by pharmacists in Japan of adjustment of drug dosage according to renal function (ADDR) in patients with chronic kidney disease (CKD) and to clarify the factors influencing implementation of ADDR by community pharmacists. We conducted a web-based questionnaire of Japanese community and hospital pharmacists. Responders were compared by characteristics, rate of implementation of ADDR, experience with adverse drug events, pharmacist awareness of implementation of ADDR, and obstacles to ADDR implementation experienced by pharmacists. Additionally, the factors influencing the implementation of ADDR by community pharmacists were investigated by logistic regression analysis. Fewer community pharmacists had implemented ADDR than hospital pharmacists. The community pharmacists had less experience with adverse drug events caused by an inappropriate dosage than the hospital pharmacists, while the hospital pharmacists had encountered more severe adverse drug events than the community pharmacists. The community pharmacists had less awareness of ADDR implementation, and believed that problems in implementing ADDR were caused by a lack of information on the renal function of patients. In the logistic regression analysis, the factors influencing implementation of ADDR were “Routinely receiving prescriptions from nephrologists”, “Experience with adverse drug events caused by inappropriate dosage for CKD patients”, and “Awareness of the need for pharmacists to check the dosage of renally excreted drugs” they did not include “Lack of information on patient renal function”. This study indicates that fewer Japanese community pharmacists than hospital pharmacists implement ADDR and that implementation of ADDR by community pharmacists is hindered by their limited awareness of the importance of patient renal function. We advocate that many countermeasures be introduced to prevent CKD patients from experiencing adverse drug events caused by inappropriate dosage. Such countermeasures would include a training program to educate pharmacists about the impact of impaired renal function on dosage of drugs that are excreted by the kidneys.
Publisher: Pharmaceutical Society of Japan
Date: 2012
DOI: 10.1248/BPB.35.606
Abstract: This study examined the cytoprotective and anti-oxidative properties of phosphoenolpyruvic acid (PEP), a glycolysis metabolite with a high-energy phosphate group. PEP (0.1-10 mM) significantly attenuated the decrease in cell viability induced by hydrogen peroxide (H(2)O(2)) in HeLa cells in a dose-dependent manner. PEP also inhibited the decrease in calcein-acetomethoxy-stained cells and the increase in propidium iodide-stained cells that were induced by H(2)O(2). The H(2)O(2)-stimulated increase in intracellular reactive oxygen species was significantly reduced by PEP. PEP also demonstrated scavenging potential against hydroxyl radicals, as assessed by the electron paramagnetic resonance method. In addition, PEP demonstrated scavenging potential against the 1,1-diphenyl-2-picrylhydrazyl radical, a representative artificial radical, although the potential is very weak. PEP (10 mM) slightly inhibited the decrease in cellular ATP content induced by H(2)O(2), but did not show any effects at low doses (0.1, 1 mM). PEP (0.1-10 mM) also attenuated the cell injury but not the decrease in intracellular ATP content, induced by 2-deoxy-D-glucose, a glycolysis inhibitor. These results indicate that PEP exerts cytoprotective effects and has anti-oxidative potential, although the precise cytoprotective mechanisms are not fully elucidated. We suggest that PEP is a functional carbohydrate metabolite with cytoprotective and anti-oxidative activity, and is potentially useful as a therapeutic agent against diseases that involve the oxidative stress.
Publisher: Wiley
Date: 25-03-2021
DOI: 10.1002/OA.2981
Abstract: Here, we describe eight bone artifacts recovered from Pleistocene and Holocene contexts at Riwi, a cave site located in Mimbi country of the south‐central Kimberley. These artifacts reflect a range of activities occurring at the site—including the manufacture of plant‐fiber items, the processing of spinifex resin, and fish or bird hunting. As the oldest four artifacts were found within the Pleistocene deposit and therefore date to older than 35,000 cal. BP, these tools represent some of the most ancient bone technologies thus far identified in northern Australia. Such rare finds are helping to rewrite stories surrounding the innovation and use of osseous technologies on the Australian continent.
Publisher: Elsevier BV
Date: 02-2018
Publisher: MDPI AG
Date: 21-02-2022
DOI: 10.3390/HEALTHCARE10020404
Abstract: Introduction: Overweight and obesity are the leading contributors to non-fatal burden of disease in Australia. Very low energy diets (VLEDs) comprising of meal replacement products (MRP) effectively induce substantial weight loss in people with obesity, yet they are rarely used as a first line treatment. Dietitians in private practice are perfectly placed to administer treatments for obesity however, little is known about the preferred interventions used or their attitudes to incorporating VLEDs and MRPs into their treatments for overweight and obesity. Methods: This study used descriptive qualitative methods to explore accredited practicing dietitians’ (APDs’) perspectives and practices regarding obesity and obesity interventions, including the use of VLEDs and MRPs. Qualitative in-depth semi-structured interviews were conducted with 20 dietitians who had experience in private practice and in treating obesity. Transcribed interviews were analysed thematically using the technique of template analysis. Results: In the context within which dietitians’ practice was found to be a barrier to using evidence-based practice (EBP) for obesity treatment, four overarching themes were found. These were: (1) patient-centred care is the dietitians’ preferred intervention model (2) VLEDs promote weight loss in specific situations (3) systemic barriers constrain effective dietetic practice and equitable access to all, and (4) successful outcomes are predicated on working outside of systemic barriers. Conclusion: Dietitians in private practice are well placed and able to provide life-enhancing and evidence-based treatments for overweight and obesity and associated chronic disease in the community. However, systemic barriers need to be addressed to provide equitable access to effective care irrespective of socio-economic status.
Publisher: Elsevier BV
Date: 06-2016
Publisher: Antiquity Publications
Date: 11-10-2022
Abstract: Found only in a restricted area of north-west Australia, the Australian boab ( Adansonia gregorii ) is recognisable by its massive, bottle-shaped trunk, and is an economically important species for Indigenous Australians, with the pith, seeds and young roots all eaten. Many of these trees are also culturally significant and are sometimes carved with images and symbols. The authors discuss the history of research into carved boabs in Australia, and present a recent survey to locate and record these trees in the remote Tanami Desert. Their results provide insight into the archaeological and anthropological significance of dendroglyphs in this region and add to a growing corpus of information on culturally modified trees globally.
Publisher: MDPI AG
Date: 03-04-2020
DOI: 10.3390/IJMS21072491
Abstract: Patients on dialysis are frequently administered high doses of potassium binders such as calcium polystyrene sulfonate (CPS) and sodium polystyrene sulfonate (SPS), which exacerbate constipation. Here, we compare the degree of constipation induced by CPS and SPS using a loperamide-induced constipation model to identify the safer potassium binder. Constipation model was created by twice-daily intraperitoneal administration (ip) of loperamide hydrochloride (Lop 1 mg/kg body weight) in rats for 3 days. Rats were assigned to a control group, Lop group, Lop + CPS group or Lop + SPS group, and a crossover comparative study was performed. Defecation status (number of feces, feces wet weight, fecal water content and gastrointestinal transit time (GTT)) was evaluated. In the Lop + CPS group, GTT was significantly longer, and fecal water content was reduced. In the Lop + SPS group—although the fecal water content and GTT were unaffected—the number of fecal pellets and the fecal wet weight improved. Thus, SPS was less likely to cause constipation exacerbation than CPS. Considering the high frequency of constipation in dialysis patients with hyperkalemia, preferentially administering SPS over CPS may prevent constipation exacerbation.
Publisher: MDPI AG
Date: 15-09-2021
DOI: 10.3390/NU13093200
Abstract: About half of Australian women have a body mass index in the overweight or obese range at the start of pregnancy, with serious consequences including preterm birth, gestational hypertension and diabetes, caesarean section, stillbirth, and childhood obesity. Trials to limit weight gain during pregnancy have had limited success and reducing weight before pregnancy has greater potential to improve outcomes. The PreBabe Pilot study was a randomised controlled pilot trial to assess the feasibility, acceptability and potential weight loss achieved using a commercial online partial meal replacement program, (MR) vs. telephone-based conventional dietary advice, (DA) for pre-conception weight-loss over a 10-week period. Women 18–40 years of age with a BMI ≥ 25 kg/m2 planning pregnancy within the next 6 to 12 months were included in the study. All participants had three clinic visits with a dietitian and one obstetric consultation. In total, 50 women were enrolled in the study between June 2018 and October 2019–26 in MR and 24 in DA. Study retention at the end of 10 week intervention 81% in the MR arm and 75% in the DA arm. In the-intention-to-treat analysis, women using meal replacements lost on average 5.4 ± 3.1% body weight compared to 2.3 ± 4.2% for women receiving conventional advice (p = 0.029). Over 80% of women in the MR arm rated the support received as excellent, compared to 39% in the DA arm (p 0.001). Women assigned to the MR intervention were more likely to achieve pregnancy within 12 months of the 10 week intervention (57% (12 of 21) women assigned to MR intervention vs. 22% (4 of 18) assigned to the DA group (p = 0.049) became pregnant). The findings suggest that a weight loss intervention using meal replacements in the preconception period was acceptable and may result in greater weight loss than conventional dietary advice alone.
Publisher: Wiley
Date: 19-06-2018
DOI: 10.1002/ARCO.5155
Publisher: Springer Science and Business Media LLC
Date: 11-05-2021
DOI: 10.1038/S41366-021-00839-W
Abstract: A systematic review with meta-analysis was conducted to synthesise evidence on the efficacy of dietary supplements containing isolated organic compounds for weight loss. Four electronic databases (Medline, Embase, Web of Science, Cinahl) were searched until December 2019. Sixty-seven randomised placebo-controlled trials of dietary supplements containing isolated organic compounds for weight loss were included. Meta-analyses were conducted for chitosan, glucomannan, conjugated linoleic acid and fructans, comparing mean weight difference post-intervention between participants receiving the dietary supplement or placebo. Statistically significant weight differences compared to placebo were observed for chitosan (-1.84 kg 95% confidence interval [CI] -2.79, -0.88 p < 0.01), glucomannan (-1.27 kg 95%CI -2.45, -0.09 p = 0.04), and conjugated linoleic acid (-1.08 kg 95%CI -1.61, -0.55 p < 0.01). None met our threshold for clinical significance (≥2.5 kg). There was no statistically significant effect on weight for fructans compared to placebo (p = 0.24). For dietary supplements with an inadequate number of trials for meta-analysis, a statistically and borderline clinically significant weight difference compared to placebo was found for modified cellulose, manno-oligosaccharides (in males), blood orange juice extract, and three multiple-ingredient dietary supplements. These were only reported in one trial of each. Thus, more evidence is needed before recommending them for weight loss. While some dietary supplements containing isolated organic compounds warrant further investigation to determine efficacy and safety, there is currently insufficient evidence to recommend any of these dietary supplements for weight loss.
Publisher: Elsevier BV
Date: 2017
Publisher: Informa UK Limited
Date: 12-2014
Publisher: Informa UK Limited
Date: 12-2014
Publisher: Pharmaceutical Society of Japan
Date: 2010
DOI: 10.1248/JHS.56.727
Publisher: Springer Science and Business Media LLC
Date: 11-01-2022
DOI: 10.1038/S41366-021-01046-3
Abstract: To describe the association between body weight change and the risk of knee replacement and hip replacement. Time-to-event survival analysis from a population-based cohort of participants who had or were at risk of clinically significant knee osteoarthritis at baseline. Data from the Osteoarthritis Initiative (OAI), which collected data from four clinical centres in the United States. A total of 8069 knees from 4081 participants, and 8076 hips from 4064 participants (59.3% female) aged 45-79 years, with mean ± SD body mass index (BMI) of 28.7 ± 4.8 kg/m Body weight change from baseline as a percentage of baseline at repeated follow-up visits over 8 years. Incidence of primary knee or hip replacement during 8-year follow-up. Body weight change had a small, positive, linear association with the risk of knee replacement (adjusted hazard ratio [HR] 1.02 95% confidence interval [CI] 1.00-1.04). Body weight change was also positively and linearly associated with the risk of hip replacement in hips that were persistently painful at baseline (adjusted HR 1.03 95% CI 1.01-1.05), but not in hips that were not persistently painful at baseline. There were no significant interactions between body weight change and baseline BMI in the association with knee or hip replacement. In people with or at risk of clinically significant knee osteoarthritis, every 1% weight loss was associated with a 2% reduced risk of knee replacement and - in those people who also had one or more persistently painful hips - a 3% reduced risk of hip replacement, regardless of baseline BMI. Public health strategies that incorporate weight loss interventions have the potential to reduce the burden of knee and hip replacement surgery.
Publisher: SAGE Publications
Date: 09-2020
Abstract: The Holocene is recognised as a period through which a number of climatic fluctuations and environmental stresses occur—associated with intensifying El Niño–Southern Oscillation (ENSO) climatic conditions from c. 5000 years—contemporaneous with technological and social changes in Australian Aboriginal lifeways. In the Kimberley region of northwest Western Australia, human responses to ENSO driven climate change are most evident archaeologically in technological transformations observed in lithic records, with little research on changes in plant use during this time. Using nine archaeological sites across the Kimberley, this paper synthesises previously published macrobotanical data (Carpenter’s Gap 1, Moonggaroonggoo, Mount Behn, and Riwi), reports unpublished data (Brooking Gorge 1, Djuru, and Wandjina rockshelter), and presents results of sites reanalysed for this study (Widgingarri Shelters 1 and 2) to develop a picture of localised and regional patterns of plant use during the Holocene. We conclude that food plants associated with monsoon rainforest environments dominate both mid- and late Holocene macrobotanical records and, although monsoon rainforest likely retreated to some extent because of decreased precipitation during the late Holocene, no human responses associated with ENSO driven climate change occurred in relation to human uses of plants.
Publisher: Wiley
Date: 05-01-2023
DOI: 10.1002/ACR.25021
Abstract: To define the association between change in body mass index (BMI) and the risk of knee and hip replacement. We used data from 3 independent cohort studies: the Osteoarthritis Initiative (OAI), the Multicenter Osteoarthritis Study (MOST), and the Cohort Hip and Cohort Knee (CHECK) study, which collected data from adults (45–79 years of age) with or at risk of clinically significant knee osteoarthritis. We conducted Cox proportional hazards regression analysis with clustering of both knees and hips per person to determine the association between change in BMI (our exposure of interest) and the incidence of primary knee and hip replacement over 7–10 years’ follow‐up. Change in BMI (in kg/m 2 ) was calculated between baseline and the last follow‐up visit before knee or hip replacement, or for knees and hips that were not replaced, the last follow‐up visit. A total of 16,362 knees from 8,181 participants, and 16,406 hips from 8,203 participants, were eligible for inclusion in our knee and hip analyses, respectively. Change in BMI was positively associated with the risk of knee replacement (adjusted hazard ratio [HR adj ] 1.03 [95% confidence interval (95% CI) 1.00–1.06]) but not hip replacement (HR adj 1.00 [95% CI 0.95–1.04]). The association between change in BMI and knee replacement was independent of participants’ BMI category at baseline (i.e., normal, overweight, or obese). Public health strategies incorporating weight loss interventions could reduce the burden of knee but not hip replacement surgery.
Publisher: John Wiley & Sons, Inc.
Date: 23-02-2018
Publisher: Public Library of Science (PLoS)
Date: 21-09-2016
Publisher: Oxford University Press (OUP)
Date: 16-11-2013
DOI: 10.1111/J.2042-7158.2012.01602.X
Abstract: The aim of this study was to examine the effect of phosphoenolpyruvate (PEP), a glycolytic intermediate, on organ damage during cold preservation of liver. An ex-vivo mouse liver cold-preservation model and an in-vitro liver injury model induced by hydrogen peroxide in HepG2 cells were leveraged. PEP attenuated the elevation of aminotransferases and lactate dehydrogenase leakage during organ preservation, histological changes and changes in oxidative stress parameters (measured as thiobarbituric acid reactive substance and glutathione content) induced by 72 h of cold preservation of the liver. The effects were comparable with the University of Wisconsin solution, a gold standard organ preservation agent. The decrease in ATP content in liver during the cold preservation was attenuated by PEP treatment. PEP prevented the cellular injury and increases in intracellular reactive oxygen species in HepG2 cells. In addition, PEP scavenged hydroxyl radicals, but had no effect on superoxide anion as evaluated by an electron paramagnetic resonance spin-trapping technique. PEP significantly attenuated the injury, oxidative stress and ATP depletion in liver during cold preservation. The antioxidative potential of PEP was confirmed by in-vitro examination. We suggest that PEP acts as a glycolytic intermediate and antioxidant, and is particularly useful as an organ preservation agent in clinical transplantation.
Publisher: Informa UK Limited
Date: 02-01-2019
Publisher: Elsevier BV
Date: 03-2023
Publisher: Informa UK Limited
Date: 09-2016
Publisher: Elsevier BV
Date: 02-2002
Publisher: Oxford University Press
Date: 10-02-2021
DOI: 10.1093/OXFORDHB/9780190095611.013.15
Abstract: The dingo, or native dog, arrived in Australia with people traveling on watercraft in the Late Holocene. By the time Europeans colonized the continent, dingoes were incorporated into the lives of Indigenous Australians, integrated into their kin systems and songlines, and used for a variety of purposes, including as companion animals, as guards, and as a biotechnology for hunting. Women, in particular, formed close bonds with dingoes, and they were widely used in women’s hunting. The incorporation of dingoes into Indigenous societies would therefore have had a significant impact on people’s lives. The greater contribution of meat to the diet would have allowed increased sedentism, improved fecundity, and therefore population growth. Such changes are hinted at in the archaeological record and indicate that more analysis of subsistence evidence could identify when and how the dingo–human relationship formed and how it varied in different environments across Australia.
Publisher: Informa UK Limited
Date: 12-2014
Publisher: Public Library of Science (PLoS)
Date: 17-06-2021
DOI: 10.1371/JOURNAL.PONE.0253127
Abstract: Meal replacement Severely Energy-Restricted Diets (SERDs) produce ≥ 10% loss of body mass when followed for 6 weeks or longer in people with class III obesity (BMI ≥ 40 kg/m 2 ). The efficacy of SERDs continues to be questioned by healthcare professionals, with concerns about poor dietary adherence. This study explored facilitators and barriers to dietary adherence and program attrition among people with class III obesity who had attempted or completed a SERD in a specialised weight loss clinic. Participants who commenced a SERD between January 2016 to May 2018 were invited to participate. Semi-structured in-depth interviews were conducted from September to October 2018 with 20 participants (12 women and 8 men). Weight change and recounted events were validated using the participants’ medical records. Data were analysed by thematic analysis using line-by-line inductive coding. The mean age ± SD of participants was 51.2 ± 11.3 years, with mean ± SD BMI at baseline 63.7 ± 12.6 kg/m 2 . Five themes emerged from participants’ recounts that were perceived to facilitate dietary adherence: (1.1) SERD program group counselling and psychoeducation sessions, (1.2) emotionally supportive clinical staff and social networks that accommodated and ch ioned change in dietary behaviours, (1.3) awareness of eating behaviours and the relationship between these and progression of disease, (1.4) a resilient mindset, and (1.5) dietary simplicity, planning and self-monitoring. There were five themes on factors perceived to be barriers to adherence, namely: (2.1) product unpalatability, (2.2) unrealistic weight loss expectations, (2.3) poor program accessibility, (2.4) unforeseeable circumstances and (2.5) externalised weight-related stigma. This study highlights opportunities where SERD programs can be optimised to facilitate dietary adherence and reduce barriers, thus potentially improving weight loss outcomes with such programs. Prior to the commencement of a SERD program, healthcare professionals facilitating such programs could benefit from reviewing participants to identify common barriers. This includes identifying the presence of product palatability issues, unrealistic weight loss expectations, socio-economic disadvantage, and behaviour impacting experiences of externalised weight-related stigma.
Start Date: 10-2010
End Date: 12-2017
Amount: $636,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 2004
End Date: 12-2006
Amount: $319,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 05-2021
End Date: 12-2024
Amount: $283,678.00
Funder: Australian Research Council
View Funded ActivityStart Date: 11-2004
End Date: 05-2005
Amount: $88,107.00
Funder: Australian Research Council
View Funded ActivityStart Date: 01-2021
End Date: 01-2025
Amount: $467,536.00
Funder: Australian Research Council
View Funded ActivityStart Date: 12-2006
End Date: 12-2015
Amount: $379,278.00
Funder: Australian Research Council
View Funded Activity