ORCID Profile
0000-0002-3055-7841
Current Organisation
UNSW Sydney
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Publisher: American Chemical Society (ACS)
Date: 05-07-2021
Publisher: American Chemical Society (ACS)
Date: 02-01-2020
Publisher: American Chemical Society (ACS)
Date: 15-03-2018
DOI: 10.1021/ACSMACROLETT.8B00051
Abstract: A critical challenge in the application of functional cellulose fibrils is to perform efficient surface modification without disrupting the original properties. Three-component Passerini reaction (Passerini 3-CR) is regarded as an effective functionalization approach which can be carried out under mild and fast reaction condition. In this study, we investigated the application of Passerini 3-CR for the synthesis of thermoresponsive cellulose fibrils by covalently tethering poly(
Publisher: American Chemical Society (ACS)
Date: 25-10-2017
Publisher: American Chemical Society (ACS)
Date: 07-06-2022
Abstract: Laboratory models of the tumor microenvironment require control of mechanical and biochemical properties to ensure accurate mimicry of patient disease. In contrast to pure natural or synthetic materials, hybrid approaches that pair recombinant protein fragments with synthetic scaffolding show many advantages. Here we demonstrate production of a recombinant bacterial collagen-like protein (CLP) for thiol-ene pairing to norbornene functionalized hyaluronic acid (NorHA). The resultant hydrogel material shows an adjustable modulus with evidence for strain-stiffening behavior that resembles natural tumor matrices. Cysteine terminated peptide binding motifs are incorporated to adjust the cell-adhesion points. The modular hybrid gel shows good biocompatibility and was demonstrated to control cell adhesion, proliferation, and the invasive properties of MCF7 and MD-MBA-231 breast adenocarcinoma cells. The ease in which multiple structural and bioactive components can be integrated provides a robust framework to form models of the tumor microenvironment for fundamental studies and drug development.
Publisher: American Chemical Society (ACS)
Date: 02-06-2016
Publisher: Wiley
Date: 21-10-2015
DOI: 10.1002/POLA.27436
Publisher: American Chemical Society (ACS)
Date: 27-07-2022
Abstract: Understanding cellular uptake and particle trafficking within the cells is essential for targeted drug delivery applications. Existing studies reveal that the geometrical aspects of nanocarriers, for ex le, shape and size, determine their cell uptake and sub-cellular transport pathways. However, considerable efforts have been directed toward understanding the cell uptake mechanism and trafficking of spherical particles. Detailed analysis on the uptake mechanism and downstream intracellular processing of non-spherical particles remains elusive. Here, we used polymeric two-dimensional platelets based on poly(ε-caprolactone) (PCL) prepared by living crystallization-driven self-assembly as a platform to investigate the cell uptake and intracellular transport of non-spherical particles
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8TB00706C
Abstract: Internalization of rod-like micelles by breast cancer cells is significantly affected by the stiffness of nano-rods.
No related grants have been discovered for Sylvia Ganda.