ORCID Profile
0000-0002-7663-5382
Current Organisation
UNSW Sydney
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Publisher: Wiley
Date: 09-05-2019
Publisher: American Chemical Society (ACS)
Date: 10-03-2023
Publisher: American Chemical Society (ACS)
Date: 10-07-2019
Abstract: Understanding the nature of the drug-polymer interactions in micellar drug delivery systems and what happens with the drug and the polymer once the complex has formed is essential for the rational design of the polymeric matrices suitable for a particular drug. In this work, glycopolymeric vesicles-a block copolymer, poly(1-
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C8PY01565A
Abstract: Polyion complex (PIC) micelles are frequently used as a means to deliver biologics such as proteins.
Publisher: American Chemical Society (ACS)
Date: 10-01-2019
Publisher: American Chemical Society (ACS)
Date: 16-07-2018
Publisher: American Chemical Society (ACS)
Date: 18-05-2023
Publisher: Wiley
Date: 11-10-2023
Abstract: Polymeric micelles are widely used as multifunctional drug carriers of poorly water‐soluble drugs, but the role of drug loading content is often overlooked. The purpose of this study is to investigate the cellular uptake and penetration of polymeric micelles with different drug loading contents and their effects on biological activities. In this study, poly( N ‐(2‐hydroxypropyl) methacrylamide‐co‐methacrylic acid)‐ block ‐poly methyl methacrylate P(HPMA‐co‐MAA)‐ b ‐PMMA micelles are used as a nanocarrier for the encapsulation of the potent anticancer agent ellipticine (EPT). The micelles are loaded with various amounts of EPT and the physicochemical characteristics such as particle size, morphology, and zeta potential of blank and EPT loaded nanoparticles are studied. Moreover, fluorescent lifetime studies confirm that hydrophobic EPT is indeed in the PMMA micelle core. In vitro cytotoxicity tests using the glioma cell line U87MG reveal lower IC 50 values when the cells are incubated with micelle with high drug loading content. The higher toxicity in micelles with higher drug loading content is associated with higher cellular uptake, which is monitored using laser scanning confocal microscopy and flow cytometry. Moreover, higher activity of micelles with higher drug loading is also observed in U87MG multicellular tumor spheroids although the difference is not significant.
Publisher: American Chemical Society (ACS)
Date: 31-03-2021
Publisher: Springer Science and Business Media LLC
Date: 04-02-2019
DOI: 10.1038/S41467-019-08402-Y
Abstract: In nature, self-assembly processes based on hiphilic molecules play an integral part in the design of structures of higher order such as cells. Among them, hiphilic glycoproteins or glycolipids take on a pivotal role due to their bioactivity. Here we show that sugars, in particular, fructose, are capable of directing the self-assembly of highly insoluble curcumin resulting in the formation of well-defined capsules based on non-covalent forces. Simply by mixing an aqueous solution of fructose and curcumin in an open vessel leads to the generation of capsules with sizes ranging between 100 and 150 nm independent of the initial concentrations used. Our results demonstrate that hydrogen bonding displayed by fructose can induce the self-assembly of hydrophobic molecules such as curcumin into well-ordered structures, and serving as a simple and virtually instantaneous way of making nanoparticles from curcumin in water with the potential for template polymerization and nanocarriers.
Publisher: American Chemical Society (ACS)
Date: 09-10-2023
Publisher: Royal Society of Chemistry (RSC)
Date: 29-10-2014
DOI: 10.1039/C4CC08010F
Abstract: The fluorescence intensity of N,N-dimethyl-4-((2-methylquinolin-6-yl)ethynyl)aniline exhibits an unusual intensification with increasing temperature, by activating more vibrational bands and leading to stronger TICT emissions upon heating in dimethyl sulfoxide. Based on the different temperature dependence at various wavelengths, as shown in the TICT fluorescence spectrum, this dye can be employed to ratiometrically detect temperature.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5RA15384K
Abstract: Herein, we described a probe for H 2 S detection based on the reduction of azide to amine. This probe was highly sensitive and selective toward H 2 S and successfully applied for H 2 S fluorescent imaging in living cells.
Publisher: American Chemical Society (ACS)
Date: 18-05-2022
DOI: 10.1021/ACS.BIOMAC.2C00265
Abstract: The estrone ligand is used for modifying nanoparticle surfaces to improve their targeting effect on cancer cell lines. However, to date, there is no common agreement on the ideal linker length to be used for the optimum targeting performance. In this study, we aimed to investigate the impact of poly(poly ethylene glycol methyl ether methacrylate) (PPEGMEMA) linker length on the cellular uptake behavior of polymer-coated upconverting nanoparticles (UCNPs). Different
Publisher: American Chemical Society (ACS)
Date: 17-11-2022
DOI: 10.1021/ACS.BIOMAC.2C01125
Abstract: We introduce a pH-sensitive amide bond, inspired by citraconic anhydride, for the reversible conjugation of polymers to the lysine residues of proteins and antibodies. The pH sensitivity arises from a conformation lock at the end of the polymer, which we introduce by means of a Diels-Alder reaction, that positions a carboxylic acid close to the amide after conjugation occurs. The amide is stable over weeks at pH 7.4 but sensitive to hydrolysis at pH 5.5 and below, returning the amine to its original state. The pH sensitivity can be tuned by positioning secondary amide groups nearby. We use this approach to PEGylate an antibody to human serum albumin at high dilution and demonstrate successful recovery of the activity after hydrolysis at pH 5.5. These results offer a convenient and traceless approach to protein and antibody functionalization.
Publisher: American Chemical Society (ACS)
Date: 15-02-2019
DOI: 10.1021/ACS.BIOMAC.8B01707
Abstract: Drug delivery carriers are now widely established because they can increase the therapeutic efficiency of drugs. In general, the aim in this field is to create effective carriers that have large amounts of drugs loaded to minimize drug carrier material that needs to be disposed of. However, there has been little attention so far in the literature on the effect of the amount of loaded drugs on the biological activity. In this paper, we are trying to answer the question of how the drug-loading content will affect the in vitro activity. We use two methods to load paclitaxel (PTX) into micelles based on the glycopolymer, poly(1- O-methacryloyl-β-d-fructopyranose)- block-poly(methyl methacylate) (Poly(1- O-MAFru)
Publisher: Wiley
Date: 23-03-2021
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D2NR01795D
Abstract: MIxing of curcumin with a hydrophobic drug in the presence of fructose results in the self-assembly into dynamic non-covalent nanocapsules that can be stabilised by polydopamine coating.
Publisher: American Chemical Society (ACS)
Date: 14-12-2019
DOI: 10.1021/ACS.BIOMAC.8B01406
Abstract: Glycopolymer-coated nanoparticles have attracted significant interest over the past few years, because of their selective interaction with carbohydrate receptors found on the surface of cells. While the type of carbohydrate determines the strength of the ligand-receptor interaction, the presentation of the sugar can be highly influential as the carbohydrate needs to be accessible in order to display good binding. To shine more light on the relationship between nanoparticle structure and cell uptake, we have designed several micelles based on fructose containing block copolymers, which are selective to GLUT5 receptors found on breast cancer cell lines. The polymers were based on poly-d,l-lactide (PLA), poly(2-hydroxyethyl) acrylate (PHEA), and poly(1- O-acryloyl-β-d-fructopyranose) (P[1- O-AFru]). A set of six micelles was synthesized based on four fructose containing micelles (PLA
Publisher: American Chemical Society (ACS)
Date: 09-06-2020
Publisher: American Chemical Society (ACS)
Date: 26-06-2020
Publisher: American Chemical Society (ACS)
Date: 21-12-2018
DOI: 10.1021/ACSMACROLETT.8B00853
Abstract: We report on the synthesis of poly(2-methacryloyloxyethyl phosphorycholine-
No related grants have been discovered for Cheng Cao.