ORCID Profile
0000-0002-0851-6816
Current Organisations
University of Turku
,
Turku University Hospital
,
University of Technology Sydney
,
University of Sydney
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In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Agricultural Spatial Analysis and Modelling | Other Economics | Ecological Economics | Environmental Management
Ecosystem Assessment and Management of Farmland, Arable Cropland and Permanent Cropland Environments | Ecological Economics |
Publisher: Elsevier BV
Date: 11-2023
Publisher: Elsevier BV
Date: 08-2022
Publisher: American Association for the Advancement of Science (AAAS)
Date: 14-07-2023
Abstract: The progression of noninvasive ductal carcinoma in situ to invasive ductal carcinoma for patients with breast cancer results in a significantly poorer prognosis and is the precursor to metastatic disease. In this work, we have identified insulin-like growth factor–binding protein 2 (IGFBP2) as a potent adipocrine factor secreted by healthy breast adipocytes that acts as a barrier against invasive progression. In line with this role, adipocytes differentiated from patient-derived stromal cells were found to secrete IGFBP2, which significantly inhibited breast cancer invasion. This occurred through binding and sequestration of cancer-derived IGF-II. Moreover, depletion of IGF-II in invading cancer cells using small interfering RNAs or an IGF-II–neutralizing antibody ablated breast cancer invasion, highlighting the importance of IGF-II autocrine signaling for breast cancer invasive progression. Given the abundance of adipocytes in the healthy breast, this work exposes the important role they play in suppressing cancer progression and may help expound upon the link between increased mammary density and poorer prognosis.
Publisher: Elsevier BV
Date: 07-2020
Publisher: IGI Global
Date: 16-09-2022
DOI: 10.4018/JGIM.306245
Abstract: Recipient's absorptive capacity (ACAP) is a barrier to knowledge transfer in organizations. The technology readiness (TR) dimensions measure an in idual's technological beliefs and aligns with the in idual's ACAP. The purpose of this research is to study if technological beliefs have a causal effect onto in idual learning capability and behaviour. University's knowledge transfer makes them an ideal context for this research. Through surveying in iduals and conducting statistical analysis, the authors provide empirical evidence that there is a causal effect from the TR dimensions to in iduals ACAP and their technological learning behaviour at the in idual level. The findings could potentially help leverage technology to address said recipient's ACAP. It would also benefit the development of new technologies, in particular in e-learning and tailoring pedagogy.
Publisher: Elsevier
Date: 2022
Publisher: Informa UK Limited
Date: 20-07-2023
Publisher: Springer International Publishing
Date: 05-12-2018
Publisher: Elsevier BV
Date: 06-2022
Publisher: Elsevier BV
Date: 08-2022
Publisher: Informa UK Limited
Date: 13-08-2019
Publisher: Elsevier BV
Date: 07-2021
Publisher: Elsevier BV
Date: 06-2021
Publisher: Elsevier BV
Date: 06-2022
Publisher: Elsevier BV
Date: 2023
DOI: 10.2139/SSRN.4358507
Publisher: Elsevier BV
Date: 02-2021
Publisher: Elsevier BV
Date: 07-2023
Publisher: Elsevier BV
Date: 10-2023
Publisher: Elsevier BV
Date: 10-2022
Publisher: Elsevier BV
Date: 2023
DOI: 10.2139/SSRN.4421109
Publisher: Journal of Artificial Societies and Social Simulation
Date: 2021
DOI: 10.18564/JASSS.4573
Publisher: IEEE
Date: 14-12-2020
Publisher: Elsevier BV
Date: 10-2023
Publisher: Elsevier BV
Date: 07-2022
Publisher: Elsevier BV
Date: 12-2022
Publisher: Elsevier BV
Date: 08-2021
Publisher: Elsevier BV
Date: 2022
Publisher: Elsevier BV
Date: 08-2019
Location: Poland
Start Date: 09-2021
End Date: 09-2024
Amount: $323,091.00
Funder: Australian Research Council
View Funded Activity