ORCID Profile
0000-0002-4244-2056
Current Organisation
Deakin University - Geelong Campus at Waurn Ponds
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Research Topics
In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Top 5 Research Topics
ANZSRC Field of Research (FoR)
Materials Engineering | Composite and Hybrid Materials | Functional Materials | Polymers and Plastics | Metals and Alloy Materials | Theory and Design of Materials | Nanomaterials | Materials engineering | Automotive Engineering Materials | Manufacturing Processes and Technologies (excl. Textiles) | Reaction Kinetics and Dynamics | Textile Technology | Composite and hybrid materials |
ANZSRC Socio-Economic Objective (SEO)
Expanding Knowledge in Engineering | Expanding Knowledge in the Chemical Sciences | Natural Fibres, Yarns and Fabrics | Automotive Equipment | Structural Metal Products | Human Diagnostics | Synthetic Fibres, Yarns and Fabrics | Environmentally Sustainable Manufacturing not elsewhere classified | Manufacturing not elsewhere classified | Expanding Knowledge in Technology
Related Links
Publications
Synthesis and preliminary investigations into norbornane-based amphiphiles and their self-assembly
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3NJ00145H
Brønsted Acid-Mediated Radical Processes in Organic Synthesis
Publisher: CSIRO Publishing
Date: 2015
DOI: 10.1071/CH15389
Abstract: This highlight focuses on recent applications of Brønsted acid-mediated radical processes across a range of reaction manifolds, including transition metal-based catalysis, photochemistry, and polymer science. A brief overview of significant research developments in the area and a discussion of the key mechanistic features of notable transformations are provided.
Investigations into the Parallel Synthesis of Novel Pyrrole-Oxazole Analogues of the Insecticide Pirate
Publisher: Georg Thieme Verlag KG
Date: 06-2006
Fiber with Butterfly Wings: Creating Colored Carbon Fibers with Increased Strength, Adhesion, and Reversible Malleability
Publisher: American Chemical Society (ACS)
Date: 11-10-2019
Abstract: Colored and color-changing materials are central to perception and interaction in nature and have been exploited in an array of modern technologies such as sensors, visual displays, and smart materials. Attempts to introduce color into carbon fiber materials have been limited by deleterious impacts on fiber properties, and the extension of colored fibers toward "smart composites" remains in its infancy. We present carbon fibers incorporating structural color, similar to that observed on the surface of soap bubbles and various insects and birds, by modifying the fiber surface through in situ polymerization grafting. When dry, the treated fibers exhibit a striking blue color, but when exposed to a volatile solvent, a cascade of colors across the visible light region is observed as the film first swells and then shrinks as the solvent evaporates. The treated fibers not only possess a unique color and color-changing ability but also can be reversibly formed into complex shapes and bear significant loads even without being encased in a supporting polymer. The tensile strength of treated fibers shows a statistically significant increase (+12%), and evaluation of the fiber-to-matrix adhesion of these polymers to an epoxy resin shows more than 300% improvement over control fibers. This approach creates a new platform for the multifaceted advance of smart composites.
Mixed Surface Chemistry on Carbon Fibers to Promote Adhesion in Epoxy and PMMA Polymers
Publisher: American Chemical Society (ACS)
Date: 20-01-2022
Synergistic interfacial effects of ionic liquids as sizing agents and surface modified carbon fibers
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C7TA10516A
Abstract: This paper presents investigations into the use of ionic liquids as sizing agents for carbon fibers in epoxy matrices.
Using Nitroxides to Enhance Carbon Fiber Interfacial Adhesion and as an Anchor for “Graft to” Surface Modification Strategies
Publisher: Wiley
Date: 04-08-2023
Abstract: Nitroxide groups covalently grafted to carbon fibers are used as anchoring sites for TEMPO‐terminated polymers (poly‐ n ‐butylacrylate and polystyrene) in a “graft to” surface modification strategy. All surface‐modified fibers are evaluated for their physical properties, showing that several treatments have enhanced the tensile strength and Young's modulus compared to the control fibers. Up to an 18% increase in tensile strength and 12% in Young's modulus are observed. Similarly, the evaluation of interfacial shear strength in an epoxy polymer shows improvements of up to 144% relative to the control s le. Interestingly, the polymer‐grafted surfaces show smaller increases in interfacial shear strength compared to surfaces modified with a small molecule only. This counterintuitive result is attributed to the incompatibility, both chemical and physical, of the grafted polymers to the surrounding epoxy matrix. Molecular dynamics simulations of the interface suggest that the diminished increase in mechanical shear strength observed for the polymer grafted surfaces may be due to the lack of exposed chain ends, whereas the small molecule grafted interface exclusively presents chain ends to the resin interface, resulting in good improvements in mechanical properties.
Promoting Silk Fibroin Adhesion to Stainless Steel Surfaces by Interface Tailoring
Publisher: Wiley
Date: 30-11-2023
Abstract: Bonding dissimilar materials has been a persistent challenge for decades. This paper presents a method to modify a stainless steel surface (316 L), routinely used in medical applications to enable the significant adhesion of a biopolymer (silk fibroin). The metallic surface was first covalently grafting with polyacrylamide, to enable a hydrogen bonding compatible surface. The polymerisation was initiated via the irreversible electrochemical reduction of a 4‐nitrobenzene diazonium salt (20 mM), in the presence of an acrylamide monomer (1 M) at progressively faster scan rates (0.01 V/s to 1 V/s). Examination of the modified s les by FT‐IR was consistent with successful surface modification, via observations of the acrylamide carbonyl (1600–1650 cm −1 ) was observed, with more intense peaks correlating to slower scan rates. Similar observations were made with respect to increasing surface polarity, assessed by water contact angle. Reductions of ° were observed for the grafted surfaces, relative to the unmodified control materials, indicating a surface able to undergo significant hydrogen bonding. The adhesion of silk to the metallic surface was quantified using a lap shear test, effectively using silk fibroin as an adhesive. Adhesion improvements of 5–7‐fold, from 4.1 MPa to 29.3 MPa per gram of silk fibroin, were observed for the treated s les, highlighting the beneficial effect of this surface treatment. The methods developed in this work can be transferred to any metallic (or conductive) surface and can be tailored to complement any desired interface.
Determination of Citrus aurantium protoalkaloids using HPLC with acidic potassium permanganate chemiluminescence detection
Publisher: Elsevier BV
Date: 15-03-2010
DOI: 10.1016/J.TALANTA.2009.10.052
Abstract: Acidic potassium permanganate chemiluminescence was explored as a sensitive and selective mode of detection for phenolic phenethylamines (adrenergic amines) in consumer products containing Citrus aurantium extracts. Nine commercially available weight-loss products were analysed using rapid reversed-phase chromatography with a monolithic column (separation time of 4 min). The results were in good agreement with package labelling, with some notable exceptions. The products contained a wide concentration range of synephrine and total adrenergic amines, and the difference in consumer intake was even greater when the manufacturers' recommended daily consumption was considered. The quantity of the extract, often specified on the packaging as equivalent grams of dry C. aurantium fruit, was a poor indicator of the concentration of the active ingredients. Methionine, a thioether amino acid contained in some weight-loss products, was identified as a potential interferent for this mode of detection.
Sizing effects on the interfacial shear strength of a carbon fibre reinforced two-component thermoplastic polymer
Publisher: Elsevier BV
Date: 12-2019
Accessing highly-halogenated flavanones using protic ionic liquids and microwave irradiation
Publisher: Bentham Science Publishers Ltd.
Date: 2012
Imbuing carbon fibers with electrochemical storage properties without compromising fiber‐to‐matrix adhesion
Publisher: Wiley
Date: 27-12-2022
DOI: 10.1002/PC.27214
Abstract: The application of carbon fiber in structural batteries and capacitors may be advanced by increasing the surface functionality of these materials. Herein, we describe the electrochemical surface modification to attach ferrocene containing polymers to the carbon fiber surface. This was carried out using a ferrocene monomer in isolation, and as part of a blend in acrylamide. The ferrocene‐containing polymers significantly improve the interfacial shear strength (+180%) in an epoxy resin and improves the tensile strength of the fiber by more than 10%, compared to a control s le (modified fiber 3.81 ± 0.08 GPa pristine fiber 3.56 ± 0.09 GPa, respectively). These polymers also improve the specific capacitance of the fiber (1250 mF g −1 ) compared to pristine (113 mF g −1 ). An excellent retention of capacitance (80%) was also found for these modified materials via galvanostatic charge–discharge stability tests after 1000 charge–discharge cycles.
Examining the Role of Aryldiazonium Salts in Surface Electroinitiated Polymerization
Publisher: American Chemical Society (ACS)
Date: 13-04-2022
DOI: 10.1021/ACS.LANGMUIR.2C00396
Abstract: Historically, the irreversible reduction of aryldiazonium salts has provided a reliable method to modify surfaces, demonstrating a catalogue of suitable diazonium salts for targeted applications. This work expands the knowledge of diazonium salt chemistry to participate in surface electroinitiated emulsion polymerization (SEEP). The influence of concentration, electronic effects, and steric hindrance/regiochemistry of the diazonium salt initiator on the production of polymeric films is examined. The objective of this work is to determine if a polymer film can be tailored, controlling the thickness, density, and surface homogeneity using specific diazonium chemistry. The data presented herein demonstrate a significant difference in polymer films that can be achieved when selecting a variety of diazonium salts and vinylic monomers. A clear trend aligns with the electron-rich diazonium salt substitution providing the thickest films (up to 70.9 ± 17.8 nm) with increasing diazonium concentration and electron-withdrawing substitution achieving optimal homogeneity for the surface of the film at a 5 mM diazonium concentration.
3-Benzhydryl-1,3,4-thia-diazole-2(3H)-thione.
Publisher: International Union of Crystallography (IUCr)
Date: 10-08-2013
A study on acute toxicity and solvent capacity of solvate ionic liquids: In vivo using a zebrafish model (Danio rerio)
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6NJ00291A
Abstract: The in vivo toxicity of several solvate ionic liquids have been assessed using a zebrafish model.
Carbon fibre surface modification facilitated by silver-catalysed radical decarboxylation
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D3CC02482B
Abstract: A silver catalysed radical decarboxylation process was used to graft a copolymer (4 : 1 methylacrylate/acrylic acid) onto short carbon fibres.
Protic ionic liquids as recyclable solvents for the acid catalysed synthesis of diphenylmethyl thioethers
Publisher: Elsevier BV
Date: 07-2013
Increasing the resistivity and IFSS of unsized carbon fibre by covalent surface modification
Publisher: Elsevier BV
Date: 08-2018
Catalyst Luminescence Exploited as an Inherent In Situ Probe of Photoredox Catalysis
Publisher: Wiley
Date: 22-10-2020
Palladium catalyzed tandem alkenyl- and aryl-C-N bond formation: A cascade N-annulation route to 4-, 5-, 6- and 7-chloroindoles
Publisher: Elsevier BV
Date: 08-2010
2D graphene oxide and MXene nanosheets at carbon fiber surfaces
Publisher: Elsevier BV
Date: 2023
Investigation of the processability, thermal, mechanical and flame retardant properties of bisoxazoline composites
Publisher: Elsevier BV
Date: 03-2022
Direct asymmetric aldol reactions in water catalysed by a highly active C 2-symmetrical bisprolinamide organocatalyst
Publisher: Wiley
Date: 2012
Using surface grafted poly(acrylamide) to simultaneously enhance the tensile strength, tensile modulus, and interfacial adhesion of carbon fibres in epoxy composites
Publisher: Elsevier BV
Date: 2022
Structure inducing ionic liquids - Enhancement of alpha helicity in the Abeta(1-40) peptide from Alzheimer's disease
Publisher: Royal Society of Chemistry (RSC)
Date: 2011
DOI: 10.1039/C1CC10377F
Abstract: We have studied the impact of ionic liquid solvents on the structure of the Abeta(1-40) peptide from Alzheimer's disease and found that ionic liquid solvents were able to induce a conformational change in the structure of the Abeta(1-40) peptide. This conformational change impacts the self-assembly of the peptide into amyloid fibrils.
Synthesis of a Novel Pyrrole Oxazole Analogue of the Insecticide Pirate
Publisher: CSIRO Publishing
Date: 2004
DOI: 10.1071/CH03184
Abstract: The pyrrole oxazole 4 is a novel analogue of the broad-spectrum insecticide and miticide pirate 2. The expedient synthesis of pyrrole oxazole 4 in six steps from pyrrole is reported using a synthetic route that could have potential for the solution-phase combinatorial synthesis of analogues. Preliminary biological evaluation of the protected pyrrole oxazole 4 (LD50 1.13 μg mL–1) and the deprotected pyrrole oxazole 5 (LD50 1.06 μg mL–1) for potential cytotoxicity was carried out.
Rapid Cross-Linking of Epoxy Thermosets Induced by Solvate Ionic Liquids
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
A comparative assessment of α-lipoic acid N-phenylamides as non-steroidal androgen receptor antagonists both on and off gold nanoparticles.
Publisher: Elsevier BV
Date: 02-2012
DOI: 10.1016/J.BIOORG.2011.11.007
Abstract: A group of α-lipoic acid N-phenylamides were synthesized employing a variety of amide coupling protocols utilizing electron deficient anilines. These compounds were then assessed for their ability to block androgen-stimulated proliferation of a human prostate cancer cell line, LNCaP. These structurally simple compounds displayed anti-proliferative activities at, typically, 5-20 μM concentrations and were comparable to a commonly used anti-androgen Bicalutamide®. The inclusion of a disulfide (RS-SR) moiety, serving as an anchor to several metal nanoparticle systems (Au, Ag, Fe(2)O(3), etc.), does not impede any biological activity. Conjugation of these compounds to a gold nanoparticle surface resulted in a high degree of cellular toxicity, attributed to the absence of a biocompatible group such as PEG within the organic scaffold.
Rapid and efficient protic ionic liquid-mediated pinacol rearrangements under microwave irradiation
Publisher: Royal Society of Chemistry (RSC)
Date: 2011
DOI: 10.1039/C0GC00916D
A conceptual framework for the development of iridium(iii ) complex-based electrogenerated chemiluminescence labels
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9SC01391A
Abstract: A new strategy to create iridium( iii )-based ECL labels reveals limitations of conventional approaches.
Green chemiluminescence from a bis-cyclometalated iridium(III) complex with an ancillary bathophenanthroline disulfonate ligand
Publisher: Royal Society of Chemistry (RSC)
Date: 2011
DOI: 10.1039/C1AN15315C
Abstract: The reaction of a fluorinated iridium complex with cerium(IV) and organic reducing agents generates an intense emission with a significant hypsochromic shift compared to contemporary chemically-initiated luminescence from metal complexes.
Waste-derived carbon fiber membrane with hierarchical structures for enhanced oil-in-water emulsion separation: Performance and mechanisms
Publisher: Elsevier BV
Date: 07-2022
(±)-1-Hydroxy-6,6-dimethyl-1H,6H-naphtho[1,2-c]furan-3,9-trione
Publisher: International Union of Crystallography (IUCr)
Date: 17-03-2006
DOI: 10.1107/S1600536806009172
Abstract: The title compound, C 14 H 12 O 4 , crystallizes as discrete molecular species which form hydroxy-to-ketone hydrogen-bonded dimers disposed about crystallographic centres of symmetry.
Evaluation of novel Hyphodermin derivatives as Glycogen Phosphorylase a inhibitors
Publisher: Elsevier BV
Date: 06-2008
DOI: 10.1016/J.BMC.2008.04.047
Abstract: The lipophilicity, permeability, solubility, polar surface area and 'rule-of-five' properties were assessed, using QikProp v2.5 (Schrödinger, Inc.) and ALOGPS 2.1 calculations, for 25 Hyphodermin derivatives. These compounds obeyed the 'rule-of-five', and the calculated physicochemical values were generally within desired limits. All compounds were tested against Glycogen Phosphorylase a (GPa). Four phenyl and benzyl substituted 2-oxo-hexahydro and tetrahydrobenzo[cd]indole carboxylic acids were identified as novel inhibitors of GPa with estimated IC(50) values in the range 0.8-1.3mM. Molecular modelling of these novel inhibitors was used to obtain the main structural features of this class of molecule for future structure-activity relationship studies.
Tension-induced toughening and conductivity enhancement in sequentially bridged MXene fibers
Publisher: IOP Publishing
Date: 12-09-2022
Abstract: Ti 3 C 2 T x MXene is a promising active material for developing fiber-based devices due to its exceptional electrical conductivity and electrochemical capacitance. However, fabricating robust fibers with high MXene content remains challenging due to shortcomings such as low interfacial adhesion between sheets and shrinkage-induced sheet disorientation during processing, leading to diminished physical and electrochemical properties. Here, we demonstrate the fabrication of tough, conductive, and electrochemically active fibers through a sequential bridging strategy involving calcium cation (Ca 2+ ) infiltration of cellulose nanocrystal (CNC)-bridged MXene, cross-linked and dried under tension. The resulting fibers exhibited a record toughness of ∼2.05 MJ m −3 and retained high volumetric capacitance (∼985 F cm −3 ), attributed to the synergistic CNC bridging, Ca 2+ cross-linking, and tension application during fiber drying. These fibers also surpass the conductivity of their unaligned pristine MXene counterpart (∼8347 S cm −1 vs ∼5078 S cm −1 ), ascribed to the tension-induced improvement in MXene alignment within these fibers, mitigating the undesirable effects of inserting an insulating CNC bridge. We anticipate that improving the toughness and conductivity of sequentially bridged MXene fibers will pave the way for the production of robust multifunctional MXene fibers, allowing their use in practical high-performance applications like wearable electronics and energy storage devices.
A redox-mediator pathway for enhanced multi-colour electrochemiluminescence in aqueous solution
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D1SC05609C
Abstract: A water-soluble Ir( iii ) complex is shown to enhance the ‘remote’ mechanism of the most widely used co-reactant ECL reaction of tris(2,2′-bipyridine)ruthenium( ii ) with tripropylamine.
Synthesis and evaluation of C8-substituted 4.5-spiro lactams as Glycogen Phosphorylase a inhibitors
Publisher: Elsevier BV
Date: 02-2013
Modification of Carbon Fibre Surfaces by Sulfur‐Fluoride Exchange Click Chemistry
Publisher: Wiley
Date: 11-10-2018
Abstract: Technologies that enable surface modification are in high demand and are critical for the implementation of new functional materials and devices. Here, we describe the first modification of a carbon surface (in this case carbon fiber) using the sulfur-fluoride exchange (SuFEx) reaction. The parent sulfur (VI) fluoride moiety can be installed directly to the surface via electrochemical deposition of the fluorosulfate phenyldiazonium tetrafluoroborate salt, or by 'SuFExing' a phenol on the carbon surface followed by treatment of the material with SO
Inducing liquid crystallinity in dilute MXene dispersions for facile processing of multifunctional fibers
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D1TA09547A
Abstract: The addition of CNCs into MXene dispersions enables LC-MXene phases at lower critical transition concentrations, allowing wet spinning of fibers using previously unspinnable concentrations of MXene.
Bioinspired Hard–Soft Interface Management for Superior Performance in Carbon Fibre Composites
Publisher: Springer Science and Business Media LLC
Date: 24-07-2023
DOI: 10.1007/S12221-023-00265-X
Abstract: Nature has evolved to create materials of unmatched performance governed by the interfacial interactions between hard and soft surfaces. Typically, in a carbon fibre composite, one polymer and one type of carbon fibre is used throughout a laminate. In this work, we use a carbon fibre surface modification approach to vary the fibre–matrix interface throughout the laminate to tailor the soft–hard interfaces. We demonstrate this effect using reclaimed carbon fibre materials in a thermoset polymer, then extend this concept to a thermoplastic polymer matrix–polypropylene. The thermoset specimens examined in this work consist of 5 carbon fibre plies, featuring 0, 1, 3 or 5 surface-modified layers located at the centre of the composite. The largest improvements in physical properties for these composites (yield strength, ultimate flexural strength, and tensile modulus) were found when only 1 modified layer of carbon fibre was placed directly within the centre of the composite. Subsequent investigations revealed that for a polypropylene matrix, where the surface chemistry is tailored specifically for polypropylene, improvements are also observed when mixed surface chemistries are used. This work shows that surface modification of reclaimed carbon fibres as non-woven mats can provide significant improvements in mechanical properties performance for structural composites when used in strategically advantageous locations throughout the composite.
General approach for electrochemical functionalization of glassy carbon surface by in situ generation of diazonium ion under acidic and non-acidic condition with a cascade protocol
Publisher: Elsevier BV
Date: 09-2014
Novel 1,4-substituted-1,2,3-triazoles as antitubercular agents.
Publisher: Wiley
Date: 18-03-2015
Abstract: Tuberculosis (TB) remains a pressing unmet medical need, particularly with the emergence of multidrug-resistant and extensively drug-resistant tuberculosis. Here, a series of 1,4-substituted-1,2,3-triazoles have been synthesized and evaluated as potential antitubercular agents. These compounds were assembled via click chemistry in high crude purity and in moderate to high yield. Of the compounds tested, 12 compounds showed promising antitubercular activity with six possessing minimum inhibitory concentration (MIC) values <10 μg mL(-1) , and total selectivity for Mycobacterium tuberculosis (Mtb) growth inhibition. A second set of 21 compounds bearing variations on ring C were synthesized and evaluated. This second library gave an additional six compounds displaying MIC values ≤10 μg mL(-1) and total selectivity for Mtb growth inhibition. These compounds serve as an excellent starting point for further development of antitubercular therapies.
Accelerated lithium-ion diffusion via a ligand ‘hopping’ mechanism in lithium enriched solvate ionic liquids
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D3CP04666D
Expanding the Scope of Surface Grafted Polymers Using Electroinitiated Polymerization
Publisher: American Chemical Society (ACS)
Date: 21-05-2020
Tough and Fatigue Resistant Cellulose Nanocrystal Stitched Ti3C2Tx MXene Films
Publisher: Wiley
Date: 21-04-2022
Abstract: Ti 3 C 2 T x MXene (or “MXene” for simplicity) has gained noteworthy attention for its metal‐like electrical conductivity and high electrochemical capacitance—a unique blend of properties attractive toward a wide range of applications such as energy storage, healthcare monitoring, and electromagnetic interference shielding. However, processing MXene architectures using conventional methods often deals with the presence of defects, voids, and isotropic flake arrangements, resulting in a trade‐off in properties. Here, a sequential bridging (SB) strategy is reported to fabricate dense, freestanding MXene films of interconnected flakes with minimal defects, significantly enhancing its mechanical properties, specifically tensile strength (≈285 MPa) and breaking energy (≈16.1 MJ m –3 ), while retaining substantial values of electrical conductivity (≈3050 S cm –1 ) and electrochemical capacitance (≈920 F cm –3 ). This SB method first involves forming a cellulose nanocrystal‐stitched MXene framework, followed by infiltration with structure‐densifying calcium cations (Ca 2+ ), resulting in tough and fatigue resistant films with anisotropic, evenly spaced, and strongly interconnected flakes — properties essential for developing high‐performance energy‐storage devices. It is anticipated that the knowledge gained in this work will be extended toward improving the robustness and retaining the electronic properties of 2D nanomaterial‐based macroarchitectures.
Investigating ionic effects applied to water based organocatalysed aldol reactions
Publisher: MDPI AG
Date: 07-12-2011
DOI: 10.3390/IJMS12129083
Electrochemical surface modification of carbon fibres by grafting of amine, carboxylic and lipophilic amide groups
Publisher: Elsevier BV
Date: 07-2017
The determination and characterisation of 2-naphthyloxycarbonyl chloride derivatised biogenic amines in pet foods
Publisher: Wiley
Date: 05-2012
Abstract: The need to monitor biogenic amines levels is essential for many areas of the food industry for two main reasons: the caustic nature and potential toxicity of these amines, and the potential to use amine levels as markers for freshness and quality in foodstuffs. Optimised analysis conditions used for the determination of biogenic amines derivatised with 2-napthyloxycarbonyl chloride has been applied to different pet food s les to assess the effectiveness of this method for complex s le matrices. Further to this, the use of high-resolution mass spectrometry has enabled the previously unconfirmed derivatised form of seven biogenic amines to be established. The derivatised forms identified include as mono substituted (tryptamine and histamine), bisubstituted (putrescine, cadaverine and tyramine), trisubstituted (spermidine) and tetrasubstituted (spermine). The methodology of biogenic amine determination was performed successfully to a range of pet food products highlighting the applicability to a variety of complex s le matrices.
A comparison of mechanical properties of recycled high‐density polyethylene/waste carbon fiber via injection molding and 3D printing
Publisher: Wiley
Date: 23-02-2022
DOI: 10.1002/PC.26550
Abstract: Recycled high‐density polyethylene (r‐HDPE) was combined with waste carbon fiber by loading 6 k, 12 k, and 24 k tows through an extruder to create thermoplastic/carbon pellets with fiber volume fractions of 11.2%, 18.9%, and 29.5%, respectively. Tensile and flexural coupons were subsequently produced via injection molding and novel 3D printing. The addition of carbon into r‐HDPE in all cases showed increased mechanical properties. Maximum increases were observed through the inclusion of 29.5% fiber volume fraction. Increases in tensile and flexural modulus of up to 2.9 GPa (+505.9%) and 5.8 GPa (+711.0%) respectively were observed for r‐HDPE/carbon fiber (CF) s les. Increases in tensile and flexural strengths of up to 57.9 MPa (+311.8%) and 47.7 MPa (+188.0%) respectively were observed for 29.5% r‐HDPE/CF s les. Some variance in mechanical performance between injection molded and 3D printed s les was observed indicating production methodology might influence final material performance.
Synthesis and preliminary investigations into novel 1,2,3-triazole-derived androgen receptor antagonists inspired by bicalutamide
Publisher: Elsevier BV
Date: 11-2014
DOI: 10.1016/J.BMCL.2014.09.036
Abstract: A versatile and high yielding synthesis of novel androgen receptor (AR) antagonists is presented. Using this methodology, six 1,4-substituted-1,2,3-triazole derived bicalutamide mimics were synthesised in five steps and in isolated overall yields from 41% to 85%. Evaluation of these compounds for their anti-proliferative properties against androgen dependent (LNCaP) and independent (PC-3) cells showed promising IC50 values of 34-45 μM and 29-151 μM, respectively. The data suggest that the latter compounds may be an excellent starting point for the development of prostate cancer therapeutics for both androgen dependent and independent forms of this disease. Docking of these compounds (each enantiomer) in silico into the T877A mutated androgen receptor, as possessed by LNCaP cells, was also undertaken.
A Novel Approach to the Functionalisation of Pristine Carbon Fibre Using Azomethine 1,3-Dipolar Cycloaddition
Publisher: CSIRO Publishing
Date: 2015
DOI: 10.1071/CH14254
Abstract: We demonstrate the utilisation of an azomethine 1,3-dipolar cycloaddition reaction with carbon fibre to graft complex molecules onto the fibre surface. In an effort to enhance the interfacial interaction of the fibre to the matrix, the functionalised fibres possessed a pendant amine that is able to interact with epoxy resins. Functionalisation was supported by X-ray photoelectron spectroscopy and the grafting process had no detrimental effects on tensile strength compared with the control (untreated) fibres. Also, microscopic roughness (as determined by atomic force microscopy) and fibre topography were unchanged after the described treatment process. This methodology complements existing methodology aimed at enhancing the surface of carbon fibres for advanced material applications while not compromising the desirable strength profile. Single-fibre fragmentation tests show a statistically significant decrease in fragment length compared with the control fibres in addition to transverse cracking within the curing resin, both of which indicate an enhanced interaction between fibre and resin.
Total Synthesis of (±)-Hyphodermins A and D
Publisher: American Chemical Society (ACS)
Date: 26-03-2008
DOI: 10.1021/JO800227P
Abstract: An efficient formal synthesis of (+/-)-hyphodermins A and D, metabolites of Hyphoderma radula, has been completed in 12 and 11 steps, respectively. The tricyclic carbon skeleton of enone 6 was rapidly assembled from diester 11 via an alpha brominationn-elimination sequence followed by anhydride formation. Regioselective reduction of the lactone group of enone 6 with LiAlH(t-BuO) 3 gave lactol 15. Lactol 15 was converted in two steps to (+/-)-hyphodermin D, without the need for complex protection-deprotection strategies. Lactol 15 was converted in three steps to (+/-)-hyphodermin A, via the key step of epoxidation of an enone in the presence of a THP lactol. A combination of NMR and ab initio studies suggests that the structures of hyphodermin C and D should be interchanged.
Ti3C2Tx MXene: from dispersions to multifunctional architectures for diverse applications
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1MH00968K
Abstract: This review article critically evaluates the erse strategies used in processing MXene into functional architectures, with an assessment of how processing variables influence properties and relevant device performance metrics.
Surface functionalization of unsized carbon fiber using nitrenes derived from organic azides
Publisher: Elsevier BV
Date: 04-2013
Ti3C2Tx MXene coated carbon fibre electrodes for high performance structural supercapacitors
Publisher: Elsevier BV
Date: 11-2023
A many-analysts approach to the relation between religiosity and well-being
Publisher: Informa UK Limited
Date: 06-07-2022
Facile and versatile solid state surface modification of silk fibroin membranes using click chemistry
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8TB02508H
Abstract: Reported is a fast and versatile protocol to surface modify pre-cast silk membranes targeting tyrosine residues.
Photocatalytic-triggered nanopores across multilayer graphene for high-permeation membranes
Publisher: Elsevier BV
Date: 09-2022
Improving mechanical and life cycle environmental performances of recycled CFRP automotive component by fibre architecture preservation
Publisher: Elsevier BV
Date: 12-2023
Simultaneously increasing the hydrophobicity and interfacial adhesion of carbon fibres: a simple pathway to install passive functionality into composites
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9TA02436K
Abstract: Hydrophobic carbon fibres were developed and show improved interfacial adhesion.
Effect of carbon fiber oxidization parameters and sizing deposition levels on the fiber-matrix interfacial shear strength
Publisher: Elsevier BV
Date: 11-2018
Cathodic electrogenerated chemiluminescence of tris(2,2′-bipyridine)ruthenium(ii) and peroxydisulfate at pure Ti3C2Tx MXene electrodes
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0CC02993A
Abstract: Two-dimensional transition metal carbide (Ti 3 C 2 T x MXene) film as a novel electrode material for electrogenerated chemiluminescence of tris(2,2′-bipyridine)ruthenium( ii ) and peroxydisulfate.
Methyl 3-[4-(4-nitrobenzyloxy)phenyl]propanoate
Publisher: International Union of Crystallography (IUCr)
Date: 02-06-2012
Carbon fibre surface chemistry and its role in fibre-to-matrix adhesion
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1TA07151C
Abstract: A key determinant for carbon fibre reinforced polymer (CFRP) performance is their fibre-matrix interactions at the interface and interphase. These allow for stress transfer from the relatively weak and ductile resin to the strong reinforcing fibres.
Front Cover: Modification of Carbon Fibre Surfaces by Sulfur‐Fluoride Exchange Click Chemistry (ChemPhysChem 23/2018)
Publisher: Wiley
Date: 05-12-2018
A novel approach to functionalise pristine unsized carbon fibre using in situ generated diazonium species to enhance interfacial shear strength
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C4TA04798B
Abstract: An in situ diazonium grafting methodology was used to decorate the surface of carbon fibres with pendant amines. This methodology was shown to greatly affect IFSS in single fibre composites.
Temperature-Responsive Self-Assemblies of ‘Kinked' Amphiphiles
Publisher: CSIRO Publishing
Date: 2013
DOI: 10.1071/CH13278
Abstract: The synthesis of novel norbornane-based hiphiles and the thermal response of their corresponding colloids is presented. It was found that the hydrodynamic diameter (DH) expansion or contraction of 1–4 in response to increasing temperature was governed by the length of the hydrophobic region possessed by the hiphile (a 12 or 16 carbon chain). These data were used as a starting point to extend into an active tumour targeting system whereby two hiphiles were modified to incorporate the oestrogen receptor antagonist Tamoxifen at the polar head group. This was achieved by a triazole moiety while both the C12 (18) or C16 (19) hydrophobic chains were incorporated as the hydrophobic region in an attempt to retain the response to thermal stimuli observed in our preliminary findings. These functionalised novel hiphiles possessed critical aggregation concentration values of 510 and 19 µM, while aqueous self-assemblies of 56 and 106 nm for 18 and 19 were observed. Imaging by cryogenic transmission electron microscopy showed 18 to possess liposomal morphology, while 19, bearing a C16 hydrophobic portion, formed non-defined amorphous aggregates. Finally, the response to temperature of these assemblies was investigated with only the C12 variant 18 displaying a temperature response in the 5–55°C thermal window investigated.
Synergistic effects within a C2-symmetric organocatalyst: the potential formation of a chiral catalytic pocket.
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3OB27250H
Abstract: This study describes the synthesis of five novel C2-symmetric organocatalysts that facilitate the on-water asymmetric aldol reaction at low catalyst loading (1 mol%) without the use of additives. Each catalyst is composed of two diprolinamide units joined by a symmetric alkyl bridging group allowing for systematic modulation of catalytic site proximity. Typically, catalysts in this manuscript which bear the catalytic units in close proximity gave the best reaction outcomes in terms of conversion (up to >99%), diastereomeric ratio (4/96, syn/anti) and enantiomeric excess (up to 97%). This effect has been attributed to the assembly of a chiral pocket, facilitated by hydrogen bonding at the oil-in-water interface.
Carbon fiber sizing agents based on renewable terpenes
Publisher: Elsevier BV
Date: 03-2022
Robust Biocompatible Fibers from Silk Fibroin Coated MXene Sheets
Publisher: Wiley
Date: 23-02-2023
Abstract: Conductive fibers are needed for the development of flexible electronic and biomedical devices. MXene fibers show great promise for use in such applications because of their high conductivity. Current literature on MXene fiber development highlights the need for improving their mechanical properties and investigation of biocompatibility. Here the use of silk fibroin biopolymer as a MXene formulation additive for the production of MXene fibers is studied. It is found that the favorable silk fibroin–MXene interactions resulted in improved durability, withstanding up to 1 h of high frequency sonication in buffered solutions. Furthermore, fibers with ≈5 wt% silk fibroin displays interesting properties including high conductivity (≈3700 S cm −1 ), high volumetric capacitance (≈910 F cm −3 ), and non‐cytotoxicity toward THP‐1 monocytic cells. The results presented here provide an important insight into potential use of MXene fibers in flexible electronics and biomedical applications.
Designing Carbon Fiber Composite Interfaces: Reactive Sizing Derived from Terpenes
Publisher: American Chemical Society (ACS)
Date: 07-02-2023
Reinterpreting the Fate of Iridium(III) Photocatalysts─Screening a Combinatorial Library to Explore Light-Driven Side-Reactions
Publisher: American Chemical Society (ACS)
Date: 15-06-2022
DOI: 10.1021/JACS.2C02011
Abstract: Photoredox catalysts are primarily selected based on ground and excited state properties, but their activity is also intrinsically tied to the nature of their reduced (or oxidized) intermediates. Catalyst reactivity often necessitates an inherent instability, thus these intermediates represent a mechanistic turning point that affords either product formation or side-reactions. In this work, we explore the scope of a previously demonstrated side-reaction that partially saturates one pyridine ring of the ancillary ligand in heteroleptic iridium(III) complexes. Using high-throughput synthesis and screening under photochemical conditions, we identified different chemical pathways, ultimately governed by ligand composition. The ancillary ligand was the key factor that determined photochemical stability. Following photoinitiated electron transfer from a sacrificial tertiary amine, the reduced intermediate of complexes containing 1,10-phenanthroline derivatives exhibited long-term stability. In contrast, complexes containing 2,2'-bipyridines were highly susceptible to hydrogen atom transfer and ancillary ligand modification. Detailed characterization of selected complexes before and after transformation showed differing effects on the ground and excited state reduction potentials dependent on the nature of the cyclometalating ligands and excited states. The implications of catalyst stability and reactivity in chemical synthesis was demonstrated in a model photoredox reaction.
Colour tuning and enhancement of gel-based electrochemiluminescence devices utilising Ru(ii ) and Ir(iii ) complexes
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9CC05031K
Abstract: Combining luminophores in ratios that compensate for energy transfer provides a range of new emission colours for gel-based electrochemiluminescence devices.
Carbon reinforced carbon fibers: Using surface modification as a route to enhanced physical performance
Publisher: Elsevier BV
Date: 02-2022
Ion-Tagged Prolinamide Organocatalysts for the Direct Aldol Reaction On-Water
Publisher: Springer Science and Business Media LLC
Date: 29-09-2016
Recent advances in the synthesis of diphenylmethyl ethers
Publisher: Informa UK Limited
Date: 03-09-2013
Data from an International Multi-Centre Study of Statistics and Mathematics Anxieties and Related Variables in University Students (the SMARVUS Dataset)
Publisher: Center for Open Science
Date: 10-10-2022
Abstract: This large, international dataset contains survey responses from N = 12,570 students from 100 universities in 35 countries, collected in 21 languages. We measured anxieties (statistics, mathematics, test, trait, social interaction, performance, creativity, intolerance of uncertainty, and fear of negative evaluation), self-efficacy, persistence, and the cognitive reflection test, and collected demographics, previous mathematics grades, self-reported and official statistics grades, and statistics module details. Data reuse potential is broad, including testing links between anxieties and statistics/mathematics education factors, and examining instruments’ psychometric properties across different languages and contexts. Data and metadata are stored on the Open Science Framework website (osf.io/mhg94/).
Rhodium(II) Azavinyl Carbenes and their Recent Application to Organic Synthesis
Publisher: CSIRO Publishing
Date: 2015
DOI: 10.1071/CH15363
Abstract: This highlight solely focusses on the synthetic applications of azavinyl rhodium(II) carbenes derived from N-sulfonyl triazoles. An overview of their use in intermolecular reactions to form a variety of heterocycles is examined, in addition to intramolecular annulations and rearrangements.
A comparison of compression molded and additively manufactured short carbon fiber reinforced polyamide‐6 samples and the effect of different infill printing patterns
Publisher: Wiley
Date: 02-07-2021
DOI: 10.1002/PC.26182
Abstract: Tensile s les were 3D printed using a commercially available 3D printing material, and the same material was pelletized and hot‐pressed. The s les had a 0°, ±45°, and a 90° filling orientation and their tensile modulus and tensile strength of the s les were determined and compared between fabrication methods. A tensile modulus of 7.56 ± 0.35 GPa (0°), 5.10 ± 0.13 GPa (±45°), and 4.05 ± 0.13 GPa (90°) was found, and the same trend was found for the tensile strength, 92.0 ± 9.5 MPa (0°), 63.3 ± 8.3 MPa (±45°), and 58.7 ± 2.2 MPa (90°). The hot‐pressed s les possessed a tensile modulus of 8.13 ± 0.8 GPa and tensile strength of 98.3 ± 6.8 MPa, very similar to that of the 0° printed s les. These results could be attributed to the printing mechanism and poor adhesion between each deposited composite layer was observed, contributing to the depressed properties. Thermogravimetric analysis was conducted and the carbon fiber content per weight of the commercially sourced printing material was determined to be 13.9%, and the length of the filaments showed that more than 50% of all measured fragments were between 50 and 150 μm.
Tailoring the fibre-to-matrix interface using click chemistry on carbon fibre surfaces
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7TA00922D
Abstract: A convenient and effective strategy to control the surface chemistry of carbon fibres is presented, comprising electro-chemical reduction of aryl diazonium salts onto the surface, followed by ‘click chemistry’ to tether the desired surface characteristic of choice.
Chemiluminescence detection of amino acids and related compounds using acidic potassium permanganate, manganese(IV) or tris(2,2′-bipyridine) ruthenium(III)
Publisher: Elsevier BV
Date: 09-2012
DOI: 10.1016/J.TALANTA.2012.06.022
Abstract: We have explored the chemiluminescence response of amino acids and related compounds (including the tripeptide glutathione, and disulfides: cystine, homocystine and glutathione disulfide) with several new adaptations of the permanganate and tris(2,2'-bipyridine)ruthenium(III) ([Ru(bipy)(3)](3+)) reagents and a recently developed colloidal manganese(IV) system. The selectivity of the permanganate reagent can be directed towards tyrosine or thiol compounds like cysteine, homocysteine and glutathione by manipulating reaction conditions (providing limits of detection of 4 nM tyrosine and 5 nM glutathione). Colloidal Mn(IV) produced measureable responses with all analytes, but was most suitable for tryptophan, tyrosine, thiols and disulfides, including α-lipoic acid and dihydrolipoic acid, for which the limits of detection were 30 nM and 20 nM, respectively. A stabilised form of [Ru(bipy)(3)](3+), prepared by oxidising [Ru(bipy)(3)](ClO(4))(2) in acetonitrile, exhibited similar selectivity to that of the conventional aqueous reagent. The [Ru(bipy)(3)](3+) reagent was effective for the detection of secondary amino acids such as proline and hydroxyproline, as well as the disulfide, homocystine.
A systematic study of carbon fibre surface grafting via in situ diazonium generation for improved interfacial shear strength in epoxy matrix composites
Publisher: Elsevier BV
Date: 10-2015
Size‐Controlled Nanosculpture of Cylindrical Pores across Multilayer Graphene via Photocatalytic Perforation
Publisher: Wiley
Date: 31-01-2022
Abstract: One of the bottlenecks in realizing the potential of nanoporous graphene assemblies is the difficulty of engineering narrow pores and high surface density distributions, with a nanometer resolution across multilayer graphene assemblies using scalable approaches. Here, the authors develop a photocatalyzed perforation protocol to incorporate nanopores across modified graphene assemblies via localizing the oxidation during the photo‐excitation process between photo‐initiators and graphitic assemblies under the ultraviolet–visible stimuli. Nanopores are engineered across the graphene nanostructures with a pore size range varying from 20 to 100 nm depending on the irradiation duration, as well as tunable densities of 10 1 –10 3 pores/ µ m 2 on the same order of the loaded nanocatalysts to the graphene surfaces. By fine‐tuning the graphene chemistry and the physical dimension of photo‐initiators, as well as their concentrations across graphitic planes used during the perforation, the diameter, and the density distributions of generated nanopores across graphene, can be rationally confined, avoiding merging between pores during the nanopore formation. These porosity parameters engineered across graphene nanosieves are in the same order obtained by other nanolithographic techniques. Plus, this sustainable route may boost the potential of porous graphene assemblies in energy‐efficient nanotechnologies based on separation and catalytic processes.
Rapid synthesis of cyclobutene diesters using a microwave-accelerated ruthenium-catalysed [2+2] cycloaddition
Publisher: Elsevier BV
Date: 11-2010
Direct polymer grafting to surfaces and its application to interface tailoring in composites
Publisher: Elsevier BV
Date: 05-2023
Rapid formation of diphenylmethyl ethers and thioethers using microwave irradiation and protic ionic liquids
Publisher: Elsevier BV
Date: 04-2012
Modification of Carbon Fibre Surfaces by Sulfur‐Fluoride Exchange Click Chemistry
Publisher: Wiley
Date: 05-12-2018
Designing carbon fiber composite interfaces using a ‘graft-to’ approach: Surface grafting density versus interphase penetration
Publisher: Elsevier BV
Date: 05-2019
Efficient Formal Synthesis of (±)-Hyphodermin B
Publisher: American Chemical Society (ACS)
Date: 11-02-2006
DOI: 10.1021/JO052485L
Abstract: An efficient formal synthesis of hyphodermin B 1, a metabolite of Hyphoderma radula, has been completed in 15% overall yield. The tricyclic carbon skeleton 3 was rapidly assembled from a novel vinyl enone via a Diels-Alder reaction, followed by dehydrogenation and anhydride formation. Selective reduction of anhydride 3 with LiAlH(t-BuO)3 gave hyphodermin B 1 in 99% yield. The structure of hyphodermin B 1 was confirmed by X-ray crystallographic analysis. The anhydride 3, bearing a gamma-carbonyl group, displayed unexpected reactivity with the anhydride carbonyl closest to the gamma-ketone being the most electrophilic site. This was confirmed by HF/6-31G calculations. In the presence of base, 3 underwent a rearrangement to the novel lactone 16.
Carbonisation of a polymer made from sulfur and canola oil
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1CC01555A
Abstract: A polymer made from sulfur and canola oil can be used as an oil spill sorbent and then repurposed into a sulfur-rich graphitic carbon for mercury removal from water.
Polymerically-enhanced nonwoven recycled carbon fibres used as capacitor electrodes
Publisher: Elsevier BV
Date: 10-2023
Carbon Fiber Surface Functional Landscapes: Nanoscale Topography and Property Distribution
Publisher: American Chemical Society (ACS)
Date: 11-01-2022
Abstract: The ultimate properties of carbon fibers and their composites are largely dictated by the surface topography of the fibers and the interface characteristics, which are primarily influenced by the surface distribution of chemical functionalities and their interactions with the matrix resin. Nevertheless, nanoscale insights on the carbon fiber surface in relationship with its chemical modification are still rarely addressed. Here, we demonstrate a critical insight on the nanoscale surface topography characterization of modified novel carbon fibers using high-resolution atomic force microscopy at multiple length scales. We compare the nanoscale surface characteristics relevant to their role in controlling interfacial interactions for carbon fibers manufactured at two different tensions and two distinct chemically functionalized coatings. We used surface dimple (also known as nanopores) profiling, microroughness analysis, power spectral density analysis, and adhesion and electrostatic potential mapping to reveal the fine details of surface characteristics at different length scales. This analysis demonstrates that the carbon fibers processed at lower tension possess a higher fractal dimension with a more corrugated surface and higher surface roughness, which leads to increased surface adhesion and energy dissipation across nano- and microscales. Furthermore, electrochemical surface modification with amine- and fluoro-functional groups significantly masks the microroughness inherent to these fibers. This results in increased fractal dimension and decreased energy dissipation and adhesion due to the high chemical reactivity in the areas of asperities and surface defects combined with a significant increase in the surface potential, as revealed by Kelvin probe mapping. These local surface properties of carbon fibers are crucial for designing next-generation fiber composites with predictable interfacial strength and the overall mechanical performance by considering the fiber surface topography for proper control of interphase formation.
Domino heck-aza-michael reactions: efficient access to 1-substituted tetrahydro-β-carbolines
Publisher: American Chemical Society (ACS)
Date: 04-02-2010
DOI: 10.1021/JO902652H
Abstract: A simple and efficient palladium-catalyzed domino reaction for the synthesis of a series of C1-substituted tetrahydro-beta-carbolines is described. This domino process involves a Heck reaction at the indole 2-position of a halogenated tryptamine precursor, followed by intramolecular aza-Michael addition.
DryLab® optimised two-dimensional high performance liquid chromatography for differentiation of ephedrine and pseudoephedrine based methamphetamine samples
Publisher: Elsevier BV
Date: 11-2014
DOI: 10.1016/J.FORSCIINT.2014.09.018
Abstract: In-silico optimised two-dimensional high performance liquid chromatographic (2D-HPLC) separations of a model meth hetamine seizure s le are described, where an excellent match between simulated and real separations was observed. Targeted separation of model compounds was completed with significantly reduced method development time. This separation was completed in the heart-cutting mode of 2D-HPLC where C18 columns were used in both dimensions taking advantage of the selectivity difference of methanol and acetonitrile as the mobile phases. This method development protocol is most significant when optimising the separation of chemically similar chemical compounds as it eliminates potentially hours of trial and error injections to identify the optimised experimental conditions. After only four screening injections the gradient profile for both 2D-HPLC dimensions could be optimised via simulations, ensuring the baseline resolution of diastereomers (ephedrine and pseudoephedrine) in 9.7 min. Depending on which diastereomer is present the potential synthetic pathway can be categorized.
Photoredox catalysis of intramolecular cyclizations with a reusable silica-bound ruthenium complex
Publisher: Wiley
Date: 07-05-2015
Synthesis of α-aminophosphonates using solvate ionic liquids
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7RA04407K
Abstract: A range of α-aminophosphonates were accessed in high yields and very rapidly, using solvate ionic liquids as the reaction media.
A Snapshot of Ionic-Liquid-Tagged Proline-Based Organocatalysts
Publisher: CSIRO Publishing
Date: 2013
DOI: 10.1071/CH13218
Abstract: This highlight focuses on the developments in ionic-liquid (IL)-tagged proline-based organocatalysts. An overview of catalyst structure and application to asymmetric transformations is provided, and a representative synthesis of an IL-tagged organocatalyst is also discussed.
Preliminary investigations into triazole derived androgen receptor antagonists
Publisher: Elsevier BV
Date: 05-2014
DOI: 10.1016/J.BMC.2014.03.018
Abstract: A range of 1,4-substituted-1,2,3-N-phenyltriazoles were synthesized and evaluated as non-steroidal androgen receptor (AR) antagonists. The motivation for this study was to replace the N-phenyl amide portion of small molecule antiandrogens with a 1,2,3-triazole and determine effects, if any, on biological activity. The synthetic methodology presented herein is robust, high yielding and extremely rapid. Using this methodology a series of 17 N-aryl triazoles were synthesized from commercially available starting materials in less than 3h. After preliminary biological screening at 20 and 40 μM, the most promising three compounds were found to display IC50 values of 40-50 μM against androgen dependent (LNCaP) cells and serve as a starting point for further structure-activity investigations. All compounds in this work were the focus of an in silico study to dock the compounds into the human androgen receptor ligand binding domain (hARLBD) and compare their predicted binding affinity with known antiandrogens. A comparison of receptor-ligand interactions for the wild type and T877A mutant AR revealed two novel polar interactions. One with Q738 of the wild type site and the second with the mutated A877 residue.
Developing an anion host for lipid A binding and antibacterial activity
Publisher: Royal Society of Chemistry (RSC)
Date: 2010
DOI: 10.1039/B925135A
Abstract: New structural hiphiles 2a and 2b bind the diphosphate lipid A anion and show potential as lead compounds for the development of novel antibacterial agents.
1-[4-Chloro-3-(trifluoromethyl)phenyl]-4-phenyl-1H-1,2,3-triazole
Publisher: International Union of Crystallography (IUCr)
Date: 20-10-2012
Design Rules for Enhanced Interfacial Shear Response in Functionalized Carbon Fiber Epoxy Composites
Publisher: American Chemical Society (ACS)
Date: 27-03-2017
Abstract: Carbon-fiber reinforced composites are ideal light-weighting candidates to replace traditional engineering materials. The mechanical performance of these composites results from a complex interplay of influences operating over several length and time scales. The mechanical performance may therefore be limited by many factors, one of which being the modest interfacial adhesion between the carbon fiber and the polymer. Chemical modification of the fiber, via surface grafting of molecules, is one possible strategy to enhance interactions across the fiber-polymer interface. To achieve systematic improvements in these modified materials, the ability to manipulate and monitor the molecular structure of the polymer interphase and the surface grafted molecules in the composite is essential, but challenging to accomplish from a purely experimental perspective. Alternatively, molecular simulations can bridge this knowledge gap by providing molecular-scale insights into the optimal design of these surface-grafted molecules to deliver superior mechanical properties. Here we use molecular dynamics simulations to predict the interfacial shear response of a typical epoxy/carbon-fiber composite for both pristine fiber and a range of surface graftings. We allow for the dynamic curing of the epoxy in the presence of the functionalized surface, including cross-link formation between the grafted molecules and the polymer matrix. Our predictions agree with recently reported experimental data for these systems and reveal the molecular-scale origins of the enhanced interfacial shear response arising from functionalization. In addition to the presence of interfacial covalent bonds, we find that the interfacial structural complexity, resulting from the presence of the grafted molecules, and a concomitant spatial homogeneity of the interphase polymer density are beneficial factors in conferring high interfacial shear stress. Our approach paves the way for computational screening processes to design, test, and rapidly identify viable surface modifications in silico, which would enable rapid systematic progress in optimizing the match between the carbon fiber treatment and the desired thermoset polymer matrix.
A comparison of interfacial testing methods and sensitivities to carbon fiber surface treatment conditions
Publisher: Elsevier BV
Date: 03-2019
Applications of nano-porous graphene materials - critical review on performance and challenges
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9MH01570A
Abstract: A critical review on the potential of nano-porous graphene materials, their key structural and physicochemical properties for applications in the areas of separation and sensing and energy storage.
Related Organisations
Deakin University - Geelong Campus At Waurn Ponds
Location: Australia
University Of Oxford
Location: United Kingdom of Great Britain and Northern Ireland
Related Funding Activities
Infrared And Raman Microspectroscopic Equipment For Biomolecular And Nanostructural Analysis
Start Date: 2012
End Date: 2012
Funder: Australian Research Council
View Funded ActivityBioinspired Interfaces For Improved Carbon Fibre Composite Performance
Start Date: 2014
End Date: 2016
Funder: Australian Research Council
View Funded ActivityARC Research Hub For A World-class Future Fibre Industry
Start Date: 2014
End Date: 2018
Funder: Australian Research Council
View Funded ActivityARC Training Centre In Lightweight Automotive Structures
Start Date: 2016
End Date: 2020
Funder: Australian Research Council
View Funded ActivityMid-Career Industry Fellowships - Grant ID: IM230100048
Start Date: 03-2024
End Date: 03-2028
Amount: $1,052,296.00
Funder: Australian Research Council
View Funded ActivityLinkage Infrastructure, Equipment And Facilities - Grant ID: LE120100166
Start Date: 06-2012
End Date: 12-2013
Amount: $240,000.00
Funder: Australian Research Council
View Funded ActivityIndustrial Transformation Research Hubs - Grant ID: IH210100023
Start Date: 09-2022
End Date: 09-2027
Amount: $5,000,000.00
Funder: Australian Research Council
View Funded ActivityDiscovery Projects - Grant ID: DP180100094
Start Date: 2018
End Date: 12-2022
Amount: $211,526.00
Funder: Australian Research Council
View Funded ActivityDiscovery Projects - Grant ID: DP220100130
Start Date: 10-2022
End Date: 12-2024
Amount: $317,442.00
Funder: Australian Research Council
View Funded ActivityDiscovery Projects - Grant ID: DP140100165
Start Date: 05-2014
End Date: 06-2018
Amount: $390,000.00
Funder: Australian Research Council
View Funded ActivityIndustrial Transformation Research Hubs - Grant ID: IH140100018
Start Date: 05-2016
End Date: 05-2021
Amount: $4,711,583.00
Funder: Australian Research Council
View Funded ActivityIndustrial Transformation Training Centres - Grant ID: IC160100032
Start Date: 06-2017
End Date: 06-2023
Amount: $3,024,379.00
Funder: Australian Research Council
View Funded Activity