ORCID Profile
0000-0003-4688-5222
Current Organisations
Washington University in St. Louis
,
University of Melbourne
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Publisher: Future Medicine Ltd
Date: 06-2020
Publisher: AME Publishing Company
Date: 03-2019
Publisher: Springer Science and Business Media LLC
Date: 26-05-2020
Publisher: Public Library of Science (PLoS)
Date: 12-09-2016
Publisher: AME Publishing Company
Date: 06-2019
Publisher: AME Publishing Company
Date: 04-2018
Publisher: AME Publishing Company
Date: 04-2019
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 08-2018
Publisher: SAGE Publications Ltd
Date: 2020
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 09-2020
Publisher: AME Publishing Company
Date: 12-2017
Publisher: American Society of Clinical Oncology (ASCO)
Date: 10-04-2017
Abstract: We investigated the correlation between the number of examined lymph nodes (ELNs) and correct staging and long-term survival in non–small-cell lung cancer (NSCLC) by using large databases and determined the minimal threshold for the ELN count. Data from a Chinese multi-institutional registry and the US SEER database on stage I to IIIA resected NSCLC (2001 to 2008) were analyzed for the relationship between the ELN count and stage migration and overall survival (OS) by using multivariable models. The series of the mean positive LNs, odds ratios (ORs), and hazard ratios (HRs) were fitted with a LOWESS smoother, and the structural break points were determined by Chow test. The selected cut point was validated with the SEER 2009 cohort. Although the distribution of ELN count differed between the Chinese registry (n = 5,706) and the SEER database (n = 38,806 median, 15 versus seven, respectively), both cohorts exhibited significantly proportional increases from N0 to N1 and N2 disease (SEER OR, 1.038 China OR, 1.012 both P .001) and serial improvements in OS (N0 disease: SEER HR, 0.986 China HR, 0.981 both P .001 N1 and N2 disease: SEER HR, 0.989 China HR, 0.984 both P .001) as the ELN count increased after controlling for confounders. Cut point analysis showed a threshold ELN count of 16 in patients with declared node-negative disease, which were examined in the derivation cohorts (SEER 2001 to 2008 HR, 0.830 China HR, 0.738) and validated in the SEER 2009 cohort (HR, 0.837). A greater number of ELNs is associated with more-accurate node staging and better long-term survival of resected NSCLC. We recommend 16 ELNs as the cut point for evaluating the quality of LN examination or prognostic stratification postoperatively for patients with declared node-negative disease.
Publisher: American Society of Clinical Oncology (ASCO)
Date: 04-10-2023
DOI: 10.1200/OP.23.00147
Publisher: SAGE Publications Ltd
Date: 2020
Publisher: AME Publishing Company
Date: 06-2018
Publisher: BMJ
Date: 10-04-2019
Abstract: An investigation of the risk of high blood pressure (HBP) associated with heavy alcohol consumption in adolescence and early adulthood is lacking. Therefore, we aimed to investigate the association between binge drinking from adolescence to early adulthood and the risk of HBP in early adulthood. We applied logistic regression to publicly available, population-representative data from waves I (1994-1995 ages 12-18) and IV (2007-2008 ages 24-32) of the National Longitudinal Study of Adolescent to Adult Health (n=5114) to determine whether past 12-month binge drinking in adolescence (wave I) and early adulthood (wave IV) was associated with HBP in early adulthood after adjusting for covariates, including smoking and body mass index. HBP was defined according to both the former and new classifications. HBP was significantly, positively associated with infrequent binge drinking (less than once a week) in adolescence based on the new classification (overall: OR 1.23, 95% CI 1.02 to 1.49 male: OR 1.35, 95% CI 1.00 to 1.81) and frequent binge drinking (heavy consumption) in adolescence based on the former classification (overall: OR= 1.64, 95% CI 1.22 to 2.22 male: OR= 1.79, 95% CI 1.23 to 2.60). The risk of HBP was high when participants engaged in frequent binge drinking in both adolescence and early adulthood, especially based on the former classification (overall: OR 2.43, 95% CI 1.13 to 5.20 female: OR 5.81, 95% CI 2.26 to 14.93). Binge drinking in adolescence may increase risk of HBP in early adulthood. This association is independent of other important risk factors for HPB, such as smoking and obesity.
Publisher: AME Publishing Company
Date: 11-2016
Publisher: Hindawi Limited
Date: 2015
DOI: 10.1155/2015/205054
Abstract: Despite advances in management over the last several decades, sepsis and acute respiratory distress syndrome (ARDS) still remain major clinical challenges and the leading causes of death for patients in intensive care units (ICUs) due to insufficient understanding of the pathophysiological mechanisms of these diseases. However, recent studies have shown that histones, also known as chromatin-basic structure proteins, could be released into the extracellular space during severe stress and physical challenges to the body (e.g., sepsis and ARDS). Due to their cytotoxic and proinflammatory effects, extracellular histones can lead to excessive and overwhelming cell damage and death, thus contributing to the pathogenesis of both sepsis and ARDS. In addition, antihistone-based treatments (e.g., neutralizing antibodies, activated protein C, and heparin) have shown protective effects and have significantly improved the outcomes of mice suffering from sepsis and ARDS. Here, we review researches related to the pathological role of histone in context of sepsis and ARDS and evaluate the potential value of histones as biomarkers and therapeutic targets of these diseases.
Publisher: Oxford University Press (OUP)
Date: 14-06-2016
DOI: 10.1093/EJCTS/EZW209
Abstract: At present, few data exist regarding the comparisons of perioperative outcomes and recurrence of spontaneous ventilation (SV) video-assisted thoracic surgery (VATS) bullectomy using total intravenous anaesthesia (TIVA) with local anaesthesia (LA) or thoracic epidural anaesthesia (TEA). We evaluated the feasibility and safety of TIVA with LA in the management of primary spontaneous pneumothorax (PSP). We conducted a single-institution retrospective analysis of patients undergoing VATS bullectomy between July 2011 and May 2015 240 patients were included for analysis. Preoperative, intraoperative and postoperative variables of patients undergoing VATS bullectomy using TIVA-TEA (n = 140) were compared with those using TIVA-LA (n = 100). Baseline demographics were similar between groups. No patients in either group required conversion to thoracotomy. Three patients (TIVA-TEA: 2 TIVA-LA: 1) required conversion to intubated general anaesthesia. Both groups had comparable surgical duration, estimated blood loss, peak EtCO SV-VATS bullectomy using TIVA with LA or TEA is technically feasible and safe. Both groups have comparable short-term outcomes and recurrence rates TIVA-LA seems a valid alternative to TIVA-TEA for the surgical management of PSP under SV.
Publisher: AME Publishing Company
Date: 12-2017
Publisher: AME Publishing Company
Date: 03-2018
Publisher: Springer Science and Business Media LLC
Date: 25-12-2019
DOI: 10.1038/S41586-019-1872-1
Abstract: Educational attainment is an important social determinant of maternal, newborn, and child health 1–3 . As a tool for promoting gender equity, it has gained increasing traction in popular media, international aid strategies, and global agenda-setting 4–6 . The global health agenda is increasingly focused on evidence of precision public health, which illustrates the subnational distribution of disease and illness 7,8 however, an agenda focused on future equity must integrate comparable evidence on the distribution of social determinants of health 9–11 . Here we expand on the available precision SDG evidence by estimating the subnational distribution of educational attainment, including the proportions of in iduals who have completed key levels of schooling, across all low- and middle-income countries from 2000 to 2017. Previous analyses have focused on geographical disparities in average attainment across Africa or for specific countries, but—to our knowledge—no analysis has examined the subnational proportions of in iduals who completed specific levels of education across all low- and middle-income countries 12–14 . By geolocating subnational data for more than 184 million person-years across 528 data sources, we precisely identify inequalities across geography as well as within populations.
Publisher: Impact Journals, LLC
Date: 22-02-2016
Publisher: Elsevier BV
Date: 10-2020
Publisher: AME Publishing Company
Date: 07-2020
DOI: 10.21037/TBCR-20-30
Publisher: AME Publishing Company
Date: 09-2019
Publisher: BMJ
Date: 09-2018
DOI: 10.1136/BMJOPEN-2017-017240
Abstract: Unbiased assessment of tumour response is crucial in randomised controlled trials (RCTs). Blinded independent central review is usually used as a supplemental or monitor to local assessment but is costly. The aim of this study is to investigate whether systematic bias existed in RCTs by comparing the treatment effects of efficacy endpoints between central and local assessments. Literature review, pooling analysis and correlation analysis. PubMed, from 1 January 2010 to 30 June 2017. Eligible articles are phase III RCTs comparing anticancer agents for advanced solid tumours. Additionally, the articles should report objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS) or time to progression (TTP) the treatment effect of these endpoints, OR or HR, should be based on central and local assessments. Of 76 included trials involving 45 688 patients, 17 (22%) trials reported their endpoints with statistically inconsistent inferences (p value lower/higher than the probability of type I error) between central and local assessments among them, 9 (53%) trials had statistically significant inference based on central assessment. Pooling analysis presented no systematic bias when comparing treatment effects of both assessments (ORR: OR=1.02 (95% CI 0.97 to 1.07), p=0.42, I 2 =0% DCR: OR=0.97 (95% CI 0.92 to 1.03), p=0.32, I 2 =0%) PFS: HR=1.01 (95% CI 0.99 to 1.02), p=0.32, I 2 =0% TTP: HR=1.04 (95% CI 0.95 to 1.14), p=0.37, I 2 =0%), regardless of funding source, mask, region, tumour type, study design, number of enrolled patients, response assessment criteria, primary endpoint and trials with statistically consistent/inconsistent inferences. Correlation analysis also presented no sign of systematic bias between central and local assessments (ORR, DCR, PFS: r .90, p .01 TTP: r=0.90, p=0.29). No systematic bias could be found between local and central assessments in phase III RCTs on solid tumours. However, statistically inconsistent inferences could be made in many trials between both assessments.
Publisher: AME Publishing Company
Date: 03-2016
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 05-2016
Location: China
Location: China
Location: United States of America
Location: China
No related grants have been discovered for Jianrong Zhang.