ORCID Profile
0000-0002-6831-9478
Current Organisations
University of Technology Sydney
,
The University of Texas MD Anderson Cancer Center
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In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Cellular Interactions (incl. Adhesion, Matrix, Cell Wall) | Atomic molecular and optical physics | Medical biotechnology diagnostics (incl. biosensors) | Quantum technologies | Biochemistry and Cell Biology | Biocatalysis and enzyme technology | Nonlinear Optics and Spectroscopy | Quantum physics | Nanofabrication growth and self assembly | Biological Physics | Astronomical instrumentation | Photonics optoelectronics and optical communications | Biological physics | Nonlinear optics and spectroscopy
Expanding Knowledge in the Physical Sciences | Expanding Knowledge in the Biological Sciences |
Publisher: The Optical Society
Date: 08-11-2012
DOI: 10.1364/OE.20.026434
Publisher: OSA
Date: 2013
Publisher: Optica Publishing Group
Date: 26-10-2020
DOI: 10.1364/BOE.404535
Abstract: Brillouin imaging (BI) has become a valuable tool for micromechanical material characterisation, thanks to extensive progress in instrumentation in the last few decades. This powerful technique is contactless and label-free, thus making it especially suitable for biomedical applications. Nonetheless, to fully harness the non-contact and non-destructive nature of BI, transformational changes in instrumentation are still needed to extend the technology’s utility into the domain of in vivo and in situ operation, which we foresee to be particularly crucial for wide spread usage of BI, e.g. in medical diagnostics and pathology screening. This work addresses this challenge by presenting the first demonstration of a fibre-optic Brillouin probe, capable of mapping the micromechanical properties of a tissue-mimicking phantom. This is achieved through combination of miniaturised optical design, advanced hollow-core fibre fabrication and high-resolution 3D printing. Our prototype probe is compact, background-free and possesses the highest collection efficiency to date, thus providing the foundation of a fibre-based Brillouin device for remote, in situ measurements in challenging and otherwise difficult-to-reach environments in biomedical, material science and industrial applications.
Publisher: Optica Publishing Group
Date: 16-03-2009
DOI: 10.1364/OE.17.005083
Abstract: We experimentally demonstrate all-optical self-switching based on sub nanosecond pulse propagation through an optimized fiber Bragg grating with a pi phase-jump. The jump acts as a cavity leading to an intensity enhancement by factor 19. At pulse peak powers of 1.5 kW we observe 4.2 dB nonlinear change in transmission. Experimental results are consistent with numerical simulations.
Publisher: The Optical Society
Date: 28-06-2013
DOI: 10.1364/OE.21.016191
Publisher: The Optical Society
Date: 17-10-2012
DOI: 10.1364/AO.51.007333
Publisher: OSA
Date: 2010
Publisher: OSA
Date: 2014
Publisher: Springer Science and Business Media LLC
Date: 04-03-2015
DOI: 10.1038/NCOMMS7396
Abstract: On-chip nonlinear optics is a thriving research field, which creates transformative opportunities for manipulating classical or quantum signals in small-footprint integrated devices. Since the length scales are short, nonlinear interactions need to be enhanced by exploiting materials with large nonlinearity in combination with high-Q resonators or slow-light structures. This, however, often results in simultaneous enhancement of competing nonlinear processes, which limit the efficiency and can cause signal distortion. Here, we exploit the frequency dependence of the optical density-of-states near the edge of a photonic bandgap to selectively enhance or inhibit nonlinear interactions on a chip. We demonstrate this concept for one of the strongest nonlinear effects, stimulated Brillouin scattering using a narrow-band one-dimensional photonic bandgap structure: a Bragg grating. The stimulated Brillouin scattering enhancement enables the generation of a 15-line Brillouin frequency comb. In the inhibition case, we achieve stimulated Brillouin scattering free operation at a power level twice the threshold.
Publisher: OSA
Date: 2013
Publisher: The Optical Society
Date: 12-11-2010
Publisher: World Scientific Pub Co Pte Lt
Date: 11-2017
DOI: 10.1142/S1793545817420020
Abstract: Brillouin imaging (BI) for micromechanical characterization of tissues and biomaterials is a fast-developing field of research with a strong potential for medical diagnosis of disease-modified tissues and cells. Although the principles of BI imply its compatibility with in vivo and in situ measurements, the integration of BI with a flexible catheter, capable of reaching the region of interest within the body, is yet to be reported. Here, for the first time, we experimentally investigate integration of the Brillouin spectroscope with standard optical fiber components to achieve a Brillouin endoscope. The performance of single-fiber and dual-fiber endoscopes are demonstrated and analyzed. We show that a major challenge in construction of Brillouin endoscopes is the strong backward Brillouin scattering in the optical fiber and we present a dual-fiber geometry as a possible solution. Measurements of Brillouin spectra in test liquids (water, ethanol and glycerol) are demonstrated using the dual-fiber endoscope and its performance is analyzed numerically with the help of a beam propagation model.
Publisher: OSA
Date: 2011
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8TC00875B
Abstract: The impact of A and X site substitution on acoustic phonon speeds in hybrid perovskites with ABX 3 stoichiometry is studied.
Publisher: AIP Publishing
Date: 10-11-2022
DOI: 10.1063/5.0095488
Abstract: The Year 2022 marks 100 years since Leon Brillouin predicted and theoretically described the interaction of optical waves with acoustic waves in a medium. Accordingly, this resonant multi-wave interaction is referred to as Brillouin scattering. Today, Brillouin scattering has found a multitude of applications, ranging from microscopy of biological tissue, remote sensing over many kilometers, and signal processing in compact photonic integrated circuits smaller than the size of a thumbnail. What allows Brillouin scattering to be harnessed over such different length scales and research domains are its unique underlying properties, namely, its narrow linewidth in the MHz range, a frequency shift in the GHz range, large frequency selective gain or loss, frequency tunability, and optical reconfigurability. Brillouin scattering is also a ubiquitous effect that can be observed in many different media, such as freely propagating in gases and liquids, as well as over long lengths of low-loss optical glass fibers or short semiconductor waveguides. A recent trend of Brillouin research focuses on micro-structured waveguides and integrated photonic platforms. The reduction in the size of waveguides allows tailoring the overlap between the optical and acoustic waves and promises many novel applications in a compact footprint. In this review article, we give an overview of the evolution and development of the field of Brillouin scattering over the last one hundred years toward current lines of active research. We provide the reader with a perspective of recent trends and challenges that demand further research efforts and give an outlook toward the future of this exciting and erse research field.
Publisher: Springer Science and Business Media LLC
Date: 07-03-2016
DOI: 10.1038/SREP22665
Abstract: Near-field imaging is a powerful tool to investigate the complex structure of light at the nanoscale. Recent advances in near-field imaging have indicated the possibility for the complete reconstruction of both electric and magnetic components of the evanescent field. Here we study the electro-magnetic field structure of surface plasmon polariton waves propagating along subwavelength gold nanowires by performing phase- and polarization-resolved near-field microscopy in collection mode. By applying the optical reciprocity theorem, we describe the signal collected by the probe as an overlap integral of the nanowire’s evanescent field and the probe’s response function. As a result, we find that the probe’s sensitivity to the magnetic field is approximately equal to its sensitivity to the electric field. Through rigorous modeling of the nanowire mode as well as the aperture probe response function, we obtain a good agreement between experimentally measured signals and a numerical model. Our findings provide a better understanding of aperture-based near-field imaging of the nanoscopic plasmonic and photonic structures and are helpful for the interpretation of future near-field experiments.
Publisher: The Optical Society
Date: 04-11-2014
Publisher: Elsevier BV
Date: 03-2022
Publisher: Cold Spring Harbor Laboratory
Date: 18-02-2021
DOI: 10.1101/2021.02.18.431535
Abstract: Three-dimensional (3D) bioprinting has revolutionised the field of biofabrication by delivering precise, cost-effective and a relatively simple way of engineering in vitro living systems in high volume for use in tissue regeneration, biological modelling, drug testing and cell-based diagnostics. The complexity of modern bioprinted systems requires quality control assessment to ensure the resulting product meets the desired criteria of structural design, micromechanical performance and long-term durability. Brillouin microscopy could be an excellent solution for micromechanical assessment of the bioprinted models during or post-fabrication since this technology is non-destructive, label-free and is capable of microscale 3D imaging. In this work, we demonstrate the application of Brillouin microscopy to 3D imaging of hydrogel microstructures created through drop-on-demand bioprinting. In addition, we show that this technology can resolve variations between mechanical properties of the gels with slightly different polymer fractions. This work confirms that Brillouin microscopy can be seen as a characterisation technology complementary to bioprinting, and in the future can be combined within the printer design to achieve simultaneous real-time fabrication and micromechanical characterisation of in vitro biological systems.
Publisher: OSA
Date: 2013
Publisher: OSA
Date: 2014
Publisher: The Optical Society
Date: 17-04-2019
Publisher: Optica Publishing Group
Date: 07-06-2010
Publisher: Elsevier BV
Date: 03-2022
Publisher: The Optical Society
Date: 24-09-2013
DOI: 10.1364/OL.38.003850
Publisher: The Optical Society
Date: 02-2015
Publisher: Institution of Engineering and Technology
Date: 2013
DOI: 10.1049/CP.2013.1410
Publisher: The Optical Society
Date: 20-11-2013
Publisher: SPIE
Date: 30-04-2010
DOI: 10.1117/12.853770
Publisher: Springer Science and Business Media LLC
Date: 31-07-2018
Publisher: OSA
Date: 2013
Publisher: Wiley
Date: 28-04-2022
Abstract: Hybrid halide perovskites have emerged as highly promising photovoltaic materials because of their exceptional optoelectronic properties, which are often optimized via compositional engineering like mixing halides. It is well established that hybrid perovskites undergo a series of structural phase transitions as temperature varies. In this work, the authors find that phase transitions are substantially suppressed in mixed‐halide hybrid perovskite single crystals of MAPbI 3‐x Br x (MA = CH 3 NH 3 + and x = 1 or 2) using a complementary suite of diffraction and spectroscopic techniques. Furthermore, as a general behavior, multiple crystallographic phases coexist in mixed‐halide perovskites over a wide temperature range, and a slightly distorted monoclinic phase, hitherto unreported for hybrid perovskites, is dominant at temperatures above 100 K. The anomalous structural evolution is correlated with the glassy behavior of organic cations and optical phonons in mixed‐halide perovskites. This work demonstrates the complex interplay between composition engineering and lattice dynamics in hybrid perovskites, shedding new light on their unique properties.
Publisher: The Optical Society
Date: 17-12-2014
DOI: 10.1364/OE.22.031884
Publisher: IOP Publishing
Date: 13-08-2021
Abstract: Current in vivo and in vitro models fail to accurately recapitulate the human heart microenvironment for biomedical applications. This study explores the use of cardiac spheroids (CSs) to biofabricate advanced in vitro models of the human heart. CSs were created from human cardiac myocytes, fibroblasts and endothelial cells (ECs), mixed within optimal alginate/gelatin hydrogels and then bioprinted on a microelectrode plate for drug testing. Bioprinted CSs maintained their structure and viability for at least 30 d after printing. Vascular endothelial growth factor (VEGF) promoted EC branching from CSs within hydrogels. Alginate/gelatin-based hydrogels enabled spheroids fusion, which was further facilitated by addition of VEGF. Bioprinted CSs contracted spontaneously and under stimulation, allowing to record contractile and electrical signals on the microelectrode plates for industrial applications. Taken together, our findings indicate that bioprinted CSs can be used to biofabricate human heart tissues for long term in vitro testing. This has the potential to be used to study biochemical, physiological and pharmacological features of human heart tissue.
Publisher: Elsevier
Date: 2022
Publisher: Cold Spring Harbor Laboratory
Date: 18-08-2021
DOI: 10.1101/2021.08.17.456575
Abstract: Biofabrication of artificial 3D in vitro neural cell models that closely mimic the central nervous system (CNS) is an emerging field of research with applications from fundamental biology to regenerative medicine, and far reaching benefits for the economy, healthcare and the ethical use of animals. The micromechanical properties of such models are an important factor dictating the success of modelling outcomes in relation to accurate reproduction of the processes in native tissues. Characterising the micromechanical properties of such models non-destructively and over a prolonged span of time, however, are key challenges. Brillouin microscopy (BM) could provide a solution to this problem since this technology is non-invasive, label-free and is capable of microscale 3D imaging. In this work, the viscoelasticity of 3D bioprinted neural cell models consisting of NG 108-15 neuronal cells and GelMA hydrogels of various concentrations were investigated using BM. We demonstrate changes in the micro- and macro-scale mechanical properties of these models over a 7 day period, in which the hydrogel component of the model are found to soften as the cells grow, multiply and form stiffer spheroid-type structures. These findings signify the necessity to resolve in microscopic detail the mechanics of in vitro 3D tissue models and suggest Brillouin microscopy to be a suitable technology to bridge this gap.
Publisher: Springer Science and Business Media LLC
Date: 24-09-2013
DOI: 10.1038/SREP02607
Publisher: OSA
Date: 2014
Publisher: IOP Publishing
Date: 16-03-2012
Publisher: IEEE
Date: 05-2013
Publisher: Springer Science and Business Media LLC
Date: 29-08-2022
DOI: 10.1038/S41598-022-18701-Y
Abstract: Zirconium fluoride (ZBLAN) glass, the standard material used in fiber-based mid-infrared photonics, has been re-designed to enable the fabrication of high index-contrast low-loss waveguides via femtosecond laser direct writing. We demonstrate that in contrast to pure ZBLAN, a positive index change of close to 10 −2 can be induced in hybrid zirconium/hafnium (Z/HBLAN) glasses during ultrafast laser inscription and show that this can be explained by an electron cloud distortion effect that is driven by the existence of two glass formers with contrasting polarizability. High numerical aperture (NA) type-I waveguides that support a well confined 3.1 μm wavelength mode with a mode-field diameter (MFD) as small as 12 μm have successfully been fabricated. These findings open the door for the fabrication of mid-infrared integrated photonic devices that can readily be pigtailed to existing ZBLAN fibers.
Publisher: OSA
Date: 2015
Publisher: The Optical Society
Date: 15-03-2011
DOI: 10.1364/OE.19.005868
Publisher: Springer Science and Business Media LLC
Date: 22-05-2014
DOI: 10.1038/SREP05032
Publisher: IOP Publishing
Date: 06-05-2016
Publisher: The Optical Society
Date: 19-08-2013
DOI: 10.1364/OL.38.003208
Publisher: IOP Publishing
Date: 02-12-2020
Publisher: OSA
Date: 2014
Publisher: Optica Publishing Group
Date: 2020
DOI: 10.1364/CLEOPR.2020.C9D_2
Abstract: We apply Brillouin microscopy to characterize micromechanical properties of 3D bioprinted hydrogel constructs. Non-contact and label-free mapping of constructs’ mechanical properties in situ provides invaluable insight into spatial distribution and swelling behavior of hydrogels.
Publisher: Elsevier
Date: 2022
Publisher: American Physical Society (APS)
Date: 13-09-2013
Publisher: The Optical Society
Date: 04-08-2014
DOI: 10.1364/OL.39.004651
Publisher: Wiley
Date: 28-08-2021
DOI: 10.1111/CODI.15868
Abstract: Perforations are a rare but serious complication of colorectal cancer. The current standard of treatment is emergent surgery followed by adjuvant chemotherapy. The concern with this approach is not only the uncertainty of achieving a R0 resection but also potential injury to adjacent vessels, nerves and ureters due to inflamed tissue planes. A subset of this patient population with a contained perforation who are clinically stable may have superior oncological outcomes with local sepsis control, neoadjuvant therapy followed by radical resection. The aim of this study is to report on the pre‐operative safety profile for neoadjuvant therapy in the setting of an abscess from colon cancer perforation and the short‐term oncological surgical quality outcomes. In this retrospective observational study, all consecutive perforated colon cancer receiving neoadjuvant therapy from Jan 2010 to Dec 2019 were included. There were 21 patients that met the inclusion criteria. The most common symptom at presentation was abdominal pain (71.4%) and most common site of perforation was sigmoid colon (61.9%). Local sepsis control was achieved with a combination of radiological or surgical drainage, erting ostomy and/or intravenous antibiotics. Thirteen patients had long‐course chemoradiation and eight patients had neoadjuvant chemotherapy. Of these, 13 (61.9%) had tumour regression, with one patient having a pathological complete response. All patients achieved a R0 resection. In a small subset of patients with colon cancer perforation, this study has demonstrated the potential safe usage of neoadjuvant therapy first before radical surgery to achieve a clear resection margin.
Publisher: Wiley
Date: 10-02-2014
Publisher: The Optical Society
Date: 03-10-2016
DOI: 10.1364/OL.41.004633
Publisher: AIP Publishing
Date: 12-2022
DOI: 10.1063/5.0119961
Abstract: The femtosecond laser direct write technique was used to fabricate mid-infrared compatible waveguide couplers into Suprasil 3001, a fused silica glass with an OH content of as low as ≤1 ppm. Smooth positive step-index change multi-scan waveguides were produced with a high index contrast of 1 × 10−2, measured directly using quadriwave lateral shearing interferometry. Waveguides were annealed at 400 °C for 15 h and found to be highly stable, with only & % reduction in positive index change. Brillouin microscopy and cathodoluminescence are introduced as novel tools that complement Raman mapping and electron microscopy for the investigation of the laser-induced structural changes within the glass matrix, and it was found that although a uniform step index profile is observed across the entire guiding region, different physical mechanisms underpin the index change in the upper and lower sections of the waveguide cross-section, respectively. Waveguides were optimized for mode-matching with optical fibers for the 3.2 μm wavelength range, and evanescent four-port directional couplers with coupling ratios ranging from 5:95 to 50:50 were designed and fabricated. This demonstration opens the door to the development of fully integrated and temperature-stable hybrid chip/fiber systems for the important mid-infrared spectral range.
Publisher: OSA
Date: 2016
Publisher: Elsevier BV
Date: 08-2021
Publisher: World Scientific Pub Co Pte Lt
Date: 03-2014
DOI: 10.1142/S0218863514500015
Abstract: In recent years, chalcogenide glasses have emerged as a material platform for nonlinear signal processing and mid-infrared photonics. In addition, high Brillouin gain of these soft glasses enable compact and highly efficient Brillouin lasers (BL). We review recent progress on chalcogenide BL, compare fiber and waveguide laser geometries, and discuss the potential of chalcogenide platform for compact and high-coherence light sources.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 03-2016
Publisher: The Optical Society
Date: 16-12-2011
Publisher: The Optical Society
Date: 14-12-2011
DOI: 10.1364/OL.36.004761
Publisher: OSA
Date: 2016
Publisher: SPIE
Date: 11-09-2013
DOI: 10.1117/12.2025231
Location: United States of America
Location: United Kingdom of Great Britain and Northern Ireland
Location: Russian Federation
Start Date: 2022
End Date: 2023
Funder: Defence Science and Technology Organisation
View Funded ActivityStart Date: 2019
End Date: 2021
Funder: Australian Research Council
View Funded ActivityStart Date: 2019
End Date: 06-2023
Amount: $335,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 2023
End Date: 12-2029
Amount: $34,948,820.00
Funder: Australian Research Council
View Funded ActivityStart Date: 12-2023
End Date: 12-2030
Amount: $35,000,000.00
Funder: Australian Research Council
View Funded Activity