ORCID Profile
0000-0001-5960-7702
Current Organisations
Western Sydney University - Campbelltown Campus
,
Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU)
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Publications
Identification of Specific Biomarkers and Pathways in the Treatment Response of Infliximab for Inflammatory Bowel Disease: In-Silico Analysis
Publisher: MDPI AG
Date: 02-03-2023
DOI: 10.3390/LIFE13030680
Abstract: Background: Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal tract. In biological therapy, infliximab became the first anti-tumor necrosis factor (TNF) agent approved for IBD. Despite this success, infliximab is expensive, often ineffective, and associated with adverse events. Prediction of infliximab resistance would improve overall potential outcomes. Therefore, there is a pressing need to widen the scope of investigating the role of genetics in IBD to their association with therapy response. Methods: In the current study, an in-silico analysis of publicly available IBD patient transcriptomics datasets from Gene Expression Omnibus (GEO) are used to identify subsets of differentially expressed genes (DEGs) involved in the pathogenesis of IBD and may serve as potential biomarkers for Infliximab response. Five datasets were found that met the inclusion criteria. The DEGs for datasets were identified using limma R packages through the GEOR2 tool. The probes’ annotated genes in each dataset intersected with DGEs from all other datasets. Enriched gene Ontology Clustering for the identified genes was performed using Metascape to explore the possible connections or interactions between the genes. Results: 174 DEGs between IBD and healthy controls were found from analyzing two datasets (GSE14580 and GSE73661), indicating a possible role in the pathogenesis of IBD. Of the 174 DEGs, five genes (SELE, TREM1, AQP9, FPR2, and HCAR3) were shared between all five datasets. Moreover, these five genes were identified as downregulated in the infliximab responder group compared to the non-responder group. Conclusions: We hypothesize that alteration in the expression of these genes leads to an impaired response to infliximab in IBD patients. Thus, these genes can serve as potential biomarkers for the early detection of compromised infliximab response in IBD patients.
Chronic treatment of (R)-α-lipoic acid reduces blood glucose and lipid levels in high-fat diet and low-dose streptozotocin-induced metabolic syndrome and type 2 diabetes in Sprague-Dawley rats
Publisher: Wiley
Date: 03-04-2017
DOI: 10.1002/PRP2.306
Anti-Inflammatory Effects of Bioactive Compounds from Seaweeds, Bryozoans, Jellyfish, Shellfish and Peanut Worms
Publisher: MDPI AG
Date: 30-09-2023
DOI: 10.3390/MD21100524
Chronic treatment of curcumin improves hepatic lipid metabolism and alleviates the renal damage in adenine-induced chronic kidney disease in Sprague-Dawley rats
Publisher: Springer Science and Business Media LLC
Date: 21-11-2019
DOI: 10.1186/S12882-019-1621-6
Abstract: Chronic kidney disease (CKD), including nephrotic syndrome, is a major cause of cardiovascular morbidity and mortality. The literature indicates that CKD is associated with profound lipid disorders due to the dysregulation of lipoprotein metabolism which progresses kidney disease. The objective of this study is to evaluate the protective effects of curcumin on dyslipidaemia associated with adenine-induced chronic kidney disease in rats. Male SD rats ( n = 29) were ided into 5 groups for 24 days: normal control ( n = 5, normal diet), CKD control ( n = 6, 0.75% w/w adenine-supplemented diet), CUR 50 ( n = 6, 50 mg/kg/day curcumin + 0.75% w/w adenine-supplemented diet), CUR 100 ( n = 6, 100 mg/kg/day curcumin + 0.75% w/w adenine-supplemented diet), and CUR 150 ( n = 6, 150 mg/kg/day curcumin + 0.75% w/w adenine-supplemented diet). The serum and tissue lipid profile, as well as the kidney function test, were measured using commercial diagnostic kits. The marked rise in total cholesterol, low-density lipoprotein (LDL) cholesterol, very low-density lipoprotein (VLDL) cholesterol, triglycerides and free fatty acids in serum, as well as hepatic cholesterol, triglyceride and free fatty acids of CKD control rats were significantly protected by curcumin co-treatment (at the dose of 50, 100 and 150 mg/kg). Furthermore, curcumin significantly increased the serum high-density lipoprotein (HDL) cholesterol compared to the CKD control rats but did not attenuate the CKD-induced weight retardation. Mathematical computational analysis revealed that curcumin significantly reduced indicators for the risk of atherosclerotic lesions (atherogenic index) and coronary atherogenesis (coronary risk index). In addition, curcumin improved kidney function as shown by the reduction in proteinuria and improvement in creatinine clearance. The results provide new scientific evidence for the use of curcumin in CKD-associated dyslipidaemia and substantiates the traditional use of curcumin in preventing kidney damage.
Evaluation of polyherbal formulation (SJT-HT-03) for antihypertensive activity in albino rats
Publisher: Medknow
Date: 2014
MicroRNAs as newer therapeutic targets: A big hope from a tiny player
Publisher: SAGE Publications
Date: 09-2012
(R)-α-Lipoic acid inhibits fructose-induced myoglobin fructation and the formation of advanced glycation end products (AGEs) in vitro
Publisher: Springer Science and Business Media LLC
Date: 15-01-2018
Diuretic and antiurolithiatic activities of an ethanolic extract of Acorus calamus L. rhizome in experimental animal models
Publisher: Elsevier BV
Date: 10-2016
Anti-Inflammatory Effects of Compounds from Echinoderms
Publisher: MDPI AG
Date: 03-11-2022
DOI: 10.3390/MD20110693
Abstract: Chronic inflammation can extensively burden a healthcare system. Several synthetic anti-inflammatory drugs are currently available in clinical practice, but each has its own side effect profile. The planet is gifted with vast and erse oceans, which provide a treasure of bioactive compounds, the chemical structures of which may provide valuable pharmaceutical agents. Marine organisms contain a variety of bioactive compounds, some of which have anti-inflammatory activity and have received considerable attention from the scientific community for the development of anti-inflammatory drugs. This review describes such bioactive compounds, as well as crude extracts (published during 2010–2022) from echinoderms: namely, sea cucumbers, sea urchins, and starfish. Moreover, we also include their chemical structures, evaluation models, and anti-inflammatory activities, including the molecular mechanism(s) of these compounds. This paper also highlights the potential applications of those marine-derived compounds in the pharmaceutical industry to develop leads for the clinical pipeline. In conclusion, this review can serve as a well-documented reference for the research progress on the development of potential anti-inflammatory drugs from echinoderms against various chronic inflammatory conditions.
Attenuation of Glucose-Induced Myoglobin Glycation and the Formation of Advanced Glycation End Products (AGEs) by (R)-α-Lipoic Acid In Vitro
Publisher: MDPI AG
Date: 08-02-2018
DOI: 10.3390/BIOM8010009
Atorvastatin Improves Hepatic Lipid Metabolism and Protects Renal Damage in Adenine-Induced Chronic Kidney Disease in Sprague-Dawley Rats
Publisher: Hindawi Limited
Date: 05-11-2019
DOI: 10.1155/2019/8714363
Abstract: Objective . Chronic kidney disease (CKD), including nephrotic syndrome, is a major cause of cardiovascular morbidity and mortality. The literature indicates that CKD is associated with profound lipid disorders largely due to the dysregulation of lipoprotein metabolism which further aggravates the progression of kidney disease. The present study sought to determine the efficacy of atorvastatin treatment on hepatic lipid metabolism and renal tissue damage in CKD rats. Methods . Serum, hepatic and faecal lipid contents and the expression and enzyme activity of molecules involved in cholesterol and triglyceride metabolism, along with kidney function, were determined in untreated adenine-induced CKD, atorvastatin-treated CKD (10 mg/kg/day oral for 24 days) and control rats. Key Findings . CKD resulted in metabolic dyslipidaemia, renal insufficiency, hepatic lipid accumulation, upregulation of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase, acyl-CoA cholesterol acyltransferase-2 (ACAT2) and the downregulation of LDL receptor protein, VLDL receptor, hepatic lipase, lipoprotein lipase (LPL), lecithin–cholesterol acyltransferase (LCAT) and scavenger receptor class B type 1 (SR-B1). CKD also resulted in increased enzymatic activity of HMG-CoA reductase and ACAT2 together with decreased enzyme activity of lipase and LCAT. Atorvastatin therapy attenuated dyslipidaemia, renal insufficiency, reduced hepatic lipids, HMG-CoA reductase and ACAT2 protein abundance and raised LDL receptor and lipase protein expression. Atorvastatin therapy decreased the enzymatic activity of HMG-CoA reductase and increased enzymatic activity of lipase and LCAT. Conclusions . Atorvastatin improved hepatic tissue lipid metabolism and renal function in adenine-induced CKD rats.
Preclinical Investigation of the Acute Effects of Trigonella foenum-graecum Seed Powder on Blood Glucose in Normal and Alloxan-Induced Diabetic Rabbits
Publisher: LIDSEN Publishing Inc
Date: 07-08-2020
The use and effectiveness of high-fidelity simulation in health professions education: current update
Publisher: SAGE Publications
Date: 02-06-2022
DOI: 10.1177/00375497221101066
Abstract: Over the past 10 years, there has been an increase in the use of high-fidelity simulation (HFS) as a tool to support and enhance learning in health profession programs. In this article, we review the utilization of HFS in biomedical (basic science) courses for health professions students, and we compare its effectiveness to traditional teaching methods. Studies exploring the impact of HFS on students and residents were included in the review. The use of HFS is more prevalent in advanced clinical settings such as in training residents and nurses than in teaching students in preclinical years. When compared to traditional teaching methods, HFS is noted to be superior in delivering core biomedical concepts to students and healthcare professionals. However, a few studies showed no significant differences between HFS and traditional teaching methods when assessing clinical management skills. Overall, HFS is a valuable teaching tool which enhances knowledge retention and clinical skill acquisition in medical education.
Related Organisations
Ludwig Boltzmann Institute For Lung Vascular Research
Location: Austria
Mohammed Bin Rashid University Of Medicine And Health Sciences (MBRU)
Location: United Arab Emirates
Related Funding Activities
No related grants have been discovered for Dr Hardik Ghelani.