ORCID Profile
0000-0001-6055-9488
Current Organisation
University of Adelaide
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Publisher: Elsevier BV
Date: 09-2014
Publisher: Wiley
Date: 21-04-2011
Publisher: Springer Science and Business Media LLC
Date: 14-11-2017
Publisher: Elsevier BV
Date: 04-1998
DOI: 10.1016/S0168-1702(98)00017-3
Abstract: Field collected flies were screened for the presence of rabbit haemorrhagic disease virus (RHDV) by applying reverse transcriptase PCR (RT-PCR) in which primers specific to the capsid protein of the virus were used. The virus was detected in flies from locations where rabbit haemorrhagic disease (RHD) was reported and also soon after the release of RHDV in a 'clean' area. Oral and/or anal excretions of flies (flyspots) were found to contain viable virus and oral inoculation of rabbits revealed that a single flyspot was able to cause RHD. We conclude that flyspots are a major potential source of the virus for oral or conjunctival transmission of the virus to rabbits.
Publisher: Wiley
Date: 04-2009
Publisher: CSIRO Publishing
Date: 2010
DOI: 10.1071/WR09162
Abstract: Context. European rabbits are serious environmental and agricultural pests throughout their range in Australia. Rabbit haemorrhagic disease virus (RHDV) greatly reduced rabbit numbers in arid central Australia but had less impact in cooler, higher-rainfall areas. RHDV-like benign caliciviruses (bCVs) have been implicated in limiting the impact of RHDV in the higher-rainfall regions of Australia and also in Europe. Aims. Experimental releases of RHDV on bait were tested as a means of initiating disease outbreaks. Serological evidence of antibodies to bCVs was examined to determine whether they reduce mortality rates and/or spread of the released RHDV, and how that might influence the effectiveness of future RHDV releases for rabbit management. Methods. Four experimental releases were conducted in high-rainfall and coastal regions of southern Australia. Virus activity was implied from recapture rates and serological changes in marked rabbits, and genetic sequencing of virus recovered from dead rabbits. Changes in rabbit abundance were estimated from spotlight transect counts. Key results. Release of RHDV on bait produced disease outbreaks that challenged almost all animals within the general release area and spread up to 4 km beyond the release sites. Recapture rates were high in marked rabbits that possessed antibodies from previous exposure to RHDV and extremely low amongst rabbits that lacked any detectable antibodies. Rabbits carrying antibodies classified as being due to previous infection with bCVs had recapture rates that were dependent on circulating antibody titre and were ~55% of recapture rates in rabbits with clear antibodies to RHDV. Conclusions. This is the first quantified evidence that antibodies produced against bCVs provide significant protection against RHD outbreaks in field populations of rabbits. Implications. bCVs can greatly reduce the impact of RHDV on wild-rabbit populations in Australia and presumably elsewhere. RHDV can be effectively released on bait although further releases are likely to be of minor or inconsistent benefit for controlling rabbit numbers where bCVs are common.
Publisher: Wiley
Date: 14-08-2014
DOI: 10.1111/EVA.12195
Abstract: In Australia, the rabbit haemorrhagic disease virus ( RHDV ) has been used since 1996 to reduce numbers of introduced European rabbits ( O ryctolagus cuniculus ) which have a devastating impact on the native Australian environment. RHDV causes regular, short disease outbreaks, but little is known about how the virus persists and survives between epidemics. We examined the initial spread of RHDV to show that even upon its initial spread, the virus circulated continuously on a regional scale rather than persisting at a local population level and that Australian rabbit populations are highly interconnected by virus‐carrying flying vectors. Sequencing data obtained from a single rabbit population showed that the viruses that caused an epidemic each year seldom bore close genetic resemblance to those present in previous years. Together, these data suggest that RHDV survives in the Australian environment through its ability to spread amongst rabbit subpopulations. This is consistent with modelling results that indicated that in a large interconnected rabbit meta‐population, RHDV should maintain high virulence, cause short, strong disease outbreaks but show low persistence in any given subpopulation. This new epidemiological framework is important for understanding virus–host co‐evolution and future disease management options of pest species to secure Australia's remaining natural bio ersity.
Publisher: Informa UK Limited
Date: 03-2002
DOI: 10.1071/MU01028
Publisher: Wiley
Date: 17-02-2012
Publisher: Wiley
Date: 09-12-2014
DOI: 10.1111/MEC.12596
Publisher: Springer Science and Business Media LLC
Date: 22-03-2014
Publisher: CSIRO Publishing
Date: 2009
DOI: 10.1071/AM08108
Abstract: A population of European rabbits (Oryctolagus cuniculus) has been monitored since November 1996 through mark–recapture as part of a longitudinal epidemiological study into two Australian rabbit biocontrol agents, rabbit haemorrhagic disease (RHD) and myxomatosis. A female rabbit, first captured as a subadult in late November 1999, was recaptured 18 times before its final capture at the end of February 2007. The longevity of this rabbit, being from its calculated birth date to the date it was last captured, was 7.6 years. A review of the literature indicates this to be the longest lifespan recorded for a European rabbit in the wild.
Publisher: JMIR Publications Inc.
Date: 17-09-2021
Abstract: ementia is a global public health priority with an estimated prevalence of 150 million by 2050, nearly two-thirds of whom will live in the Asia-Pacific region. Dementia creates significant care needs for people with the disease, their families, and carers. iSupport is a self-help platform developed by the World Health Organization (WHO) to provide education, skills training, and support to dementia carers. It has been adapted in some contexts (Australia, India, the Netherlands, and Portugal). Carers using the existing adapted versions have identified the need to have a more user-friendly version that enables them to identify solutions for immediate problems quickly in real time. The iSupport virtual assistant (iSupport VA) is being developed to address this gap and will be evaluated in a randomized controlled trial (RCT). his paper reports the protocol of a pilot RCT evaluating the iSupport VA. even versions of iSupport VA will be evaluated in Australia, Indonesia, New Zealand, and Vietnam in a pilot RCT. Feasibility, acceptability, intention to use, and preliminary impact on carer-perceived stress of the iSupport VA intervention will be assessed. his study was funded by the e-ASIA Joint Research Program in November 2020. From January to July 2023, we will enroll 140 dementia carers (20 carers per iSupport VA version) for the pilot RCT. The study has been approved by the Human Research Committee, University of South Australia, Australia (203455). his protocol outlines how a technologically enhanced version of the WHO iSupport program—the iSupport VA—will be evaluated. The findings from this intervention study will provide evidence on the feasibility and acceptability of the iSupport VA intervention, which will be the basis for conducting a full RCT to assess the effectiveness of the iSupport VA. The study will be an important reference for countries planning to adapt and enhance the WHO iSupport program using digital health solutions. ustralian New Zealand Clinical Trials Registry ACTRN12621001452886 fum5tjz RR1-10.2196/33572
Publisher: Springer Science and Business Media LLC
Date: 15-06-2016
Publisher: CSIRO Publishing
Date: 2004
DOI: 10.1071/WR02027
Abstract: Replicated field trials were conducted to compare the efficacy of zinc phosphide, strychnine and chlorpyrifos for the control of house mice (Mus domesticus) infesting recently sown wheat crops in South Australia. Bait was prepared using whole-wheat grain or grain-based pellets and broadcast into the crops at 1 kg ha–1. Treatment with zinc phosphide reduced mouse numbers by 98%. Two treatments with strychnine baits, applied 11 days apart, also reduced mouse numbers by 98% with no evidence of bait aversion in mice that survived the initial treatment. On the basis of these and other published results, zinc phosphide is considered an effective alternative to strychnine for control of house mice in cereal crops. Chlorpyrifos baits reduced mouse numbers by less than 10%. The trial began too late in the growing season to prevent substantial mouse damage to seed grain and seedlings. The number of seedlings established at treatment time one month after sowing explained 84% of variation in crop yield. Mouse damage is estimated to have reduced yield by more than 0.5 t ha–1 or 15% of potential yield and cost the grower more than $30 000 in lost production from the 300-ha study area.
Publisher: Wiley
Date: 24-07-2017
DOI: 10.1111/MEC.14228
Abstract: Deciphering the genes involved in disease resistance is essential if we are to understand host-pathogen coevolutionary processes. The rabbit haemorrhagic disease virus (RHDV) was imported into Australia in 1995 as a biocontrol agent to manage one of the most successful and devastating invasive species, the European rabbit (Oryctolagus cuniculus). During the first outbreaks of the disease, RHDV caused mortality rates of up to 97%. Recently, however, increased genetic resistance to RHDV has been reported. Here, we have aimed to identify genomic differences between rabbits that survived a natural infection with RHDV and those that died in the field using a genomewide next-generation sequencing (NGS) approach. We detected 72 SNPs corresponding to 133 genes associated with survival of a RHD infection. Most of the identified genes have known functions in virus infections and replication, immune responses or apoptosis, or have previously been found to be regulated during RHD. Some of the genes identified in experimental studies, however, did not seem to play a role under natural selection regimes, highlighting the importance of field studies to complement the genomic background of wildlife diseases. Our study provides a set of candidate markers as a tool for the future scanning of wild rabbits for their resistance to RHDV. This is important both for wild rabbit populations in southern Europe where RHD is regarded as a serious problem decimating the prey of endangered predator species and for assessing the success of currently planned RHDV variant biocontrol releases in Australia.
Publisher: Oxford University Press (OUP)
Date: 06-01-2016
Abstract: Mitochondria are critical for life, yet their underlying evolutionary biology is poorly understood. In particular, little is known about interaction between two levels of evolution: between in iduals and within in iduals (competition between cells, mitochondria or mitochondrial DNA molecules). Rapid evolution is suspected to occur frequently in mitochondrial DNA, whose maternal inheritance predisposes advantageous mutations to sweep rapidly though populations. Rapid evolution is also predicted in response to changed selection regimes after species invasion or removal of pathogens or competitors. Here, using empirical and simulated data from a model invasive bird species, we provide the first demonstration of rapid selection on the mitochondrial genome within in iduals in the wild. Further, we show differences in mitochondrial DNA copy number associated with competing genetic variants, which may provide a mechanism for selection. We provide evidence for three rarely documented phenomena: selection associated with mitochondrial DNA abundance, selection on the mitochondrial control region, and contemporary selection during invasion.
Publisher: Wiley
Date: 03-2017
DOI: 10.1136/VR.104135
Publisher: JMIR Publications Inc.
Date: 16-11-2021
DOI: 10.2196/33572
Abstract: Dementia is a global public health priority with an estimated prevalence of 150 million by 2050, nearly two-thirds of whom will live in the Asia-Pacific region. Dementia creates significant care needs for people with the disease, their families, and carers. iSupport is a self-help platform developed by the World Health Organization (WHO) to provide education, skills training, and support to dementia carers. It has been adapted in some contexts (Australia, India, the Netherlands, and Portugal). Carers using the existing adapted versions have identified the need to have a more user-friendly version that enables them to identify solutions for immediate problems quickly in real time. The iSupport virtual assistant (iSupport VA) is being developed to address this gap and will be evaluated in a randomized controlled trial (RCT). This paper reports the protocol of a pilot RCT evaluating the iSupport VA. Seven versions of iSupport VA will be evaluated in Australia, Indonesia, New Zealand, and Vietnam in a pilot RCT. Feasibility, acceptability, intention to use, and preliminary impact on carer-perceived stress of the iSupport VA intervention will be assessed. This study was funded by the e-ASIA Joint Research Program in November 2020. From January to July 2023, we will enroll 140 dementia carers (20 carers per iSupport VA version) for the pilot RCT. The study has been approved by the Human Research Committee, University of South Australia, Australia (203455). This protocol outlines how a technologically enhanced version of the WHO iSupport program—the iSupport VA—will be evaluated. The findings from this intervention study will provide evidence on the feasibility and acceptability of the iSupport VA intervention, which will be the basis for conducting a full RCT to assess the effectiveness of the iSupport VA. The study will be an important reference for countries planning to adapt and enhance the WHO iSupport program using digital health solutions. Australian New Zealand Clinical Trials Registry ACTRN12621001452886 fum5tjz PRR1-10.2196/33572
Publisher: Wiley
Date: 31-01-2012
Publisher: Wiley
Date: 04-05-2016
DOI: 10.1002/JWMG.21093
Publisher: The Royal Society
Date: 02-2015
Abstract: Infectious diseases can exert a strong influence on the dynamics of host populations, but it remains unclear why such disease-mediated control only occurs under particular environmental conditions. We used 16 years of detailed field data on invasive European rabbits ( Oryctolagus cuniculus ) in Australia, linked to in idual-based stochastic models and Bayesian approximations, to test whether (i) mortality associated with rabbit haemorrhagic disease (RHD) is driven primarily by seasonal matches/mismatches between demographic rates and epidemiological dynamics and (ii) delayed infection (arising from insusceptibility and maternal antibodies in juveniles) are important factors in determining disease severity and local population persistence of rabbits. We found that both the timing of reproduction and exposure to viruses drove recurrent seasonal epidemics of RHD. Protection conferred by insusceptibility and maternal antibodies controlled seasonal disease outbreaks by delaying infection this could have also allowed escape from disease. The persistence of local populations was a stochastic outcome of recovery rates from both RHD and myxomatosis. If susceptibility to RHD is delayed, myxomatosis will have a pronounced effect on population extirpation when the two viruses coexist. This has important implications for wildlife management, because it is likely that such seasonal interplay and disease dynamics has a strong effect on long-term population viability for many species.
Publisher: CSIRO Publishing
Date: 2012
DOI: 10.1071/WR11115
Abstract: Context Worldwide, invasive fauna species present one of the most intractable problems for agriculture and natural systems. Our ability to improve control techniques to combat the global invasive species predicament is constrained within the bounds of both economic and ethical considerations. In south-eastern Australia, the common starling (Sturnus vulgaris) is an established invasive avian pest that is now making incursions into areas of Western Australia (WA) that are currently free of this species. The most cost-effective and widely implemented starling control tool is trapping with live-lure birds. In recent years, the use of live-lure birds has been questioned on both economic and ethical grounds, and consequently alternative lure methods need investigating. Aims To evaluate the effectiveness of different trap and lure combinations for the capture of starlings in western South Australia (SA). Methods Modified Australian Crow (MAC) traps, used traditionally in WA to trap starlings, and Myna traps, originally designed for trapping common mynas (Sturnus tristis), were set during the peaks in starling flocking activity (Austral summer, 2007) using three different lure types: (1) live lure (live starlings) (2) moving water and (3) acoustic lures. A trapping grid consisting of a single Myna trap with live lure and three MAC traps, each with one type of lure (live, water or acoustic) was established at five sites on the Eyre Peninsula in SA and monitored twice daily for 28 days. Key results Live lures were significantly more effective at attracting starlings into traps compared with both water and sound lures. We also trapped at an additional three sites and showed that Myna traps caught ~1.5 times more starlings than MAC traps when both traps were fitted with live-lure birds. Conclusions Neither moving water nor acoustic play-back lures proved suitable replacements for the use of live-lure birds to capture starlings. The efficacy of alternative lure types may depend on several factors and may include neophobic response(s) to novel signals and also the length of time that an invasive population has been established. Implications We recommend that use of live lures is continued in ongoing starling control programs, and that MAC traps currently in use be modified to capitalise on known starling behaviour. Further research and development of traps that do not contain live lures will improve the welfare of invasive species control programs.
Publisher: Springer Science and Business Media LLC
Date: 22-11-2016
DOI: 10.1038/BJC.2016.357
No related grants have been discovered for Ronald Sinclair.