ORCID Profile
0000-0001-5896-8178
Current Organisations
Royal Prince Alfred Hospital
,
Skin and Cancer Foundation Australia
,
University of New South Wales
,
University of Sydney
,
Westmead Hospital
,
Children's Hospital at Westmead
,
Liverpool Hospital
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Related Links
Publications
Assessment in the age of artificial intelligence
Publisher: Elsevier BV
Date: 2022
Lasers and laser-like devices: Part two
Publisher: Wiley
Date: 11-11-2013
DOI: 10.1111/AJD.12111
Abstract: Part two of this review series evaluates the use of lasers and laser-like devices in dermatology based on published evidence and the collective experience of the senior authors. Dermatologists can laser-treat a wide range of dermatoses, including vascular, pigmentary, textural, benign proliferative and premalignant conditions. Some of these conditions include vascular malformation, haemangioma, facial telangiectases, café-au-lait macules, naevi of Ota, lentigines, acne scarring, rhytides, rhinophyma and miscellaneous skin lesions. Photodynamic therapy with lasers and intense pulsed light is addressed, with particular reference to actinic keratosis and actinic cheilitis. A treatment algorithm for acne scarring based on scar morphology and severity is comprehensively outlined. Following from part one, the various devices are matched to the corresponding dermatological conditions with representative pictorial case vignettes illustrating likely clinical outcomes as well as limitations and potential complications of the various laser and light therapies.
Gut reaction: a congenital red nodule in the umbilicus of a 2‐year‐old child
Publisher: Oxford University Press (OUP)
Date: 16-08-2019
DOI: 10.1111/CED.14056
Urethral stricture caused by schistosomiasis in a renal transplant recipient
Publisher: Wiley
Date: 19-01-2012
Fashionable Pathology
Publisher: American Medical Association (AMA)
Date: 05-2015
Reliability of the autoimmune bullous disease quality of life (ABQOL) questionnaire in the USA
Publisher: Springer Science and Business Media LLC
Date: 21-03-2015
Isotretinoin on TikTok™: misinformation getting under our skin
Publisher: Oxford University Press (OUP)
Date: 23-07-2021
DOI: 10.1111/CED.14810
Utility of ultrasonography in hair‐thread tourniquet syndrome
Publisher: Wiley
Date: 16-01-2018
DOI: 10.1111/PDE.13400
Abstract: A 2-year-old girl presented with a 2-month history of an erythematous, indurated plaque with well-defined borders on the third toe of the right foot. Bedside high-resolution ultrasonography demonstrated a thickened epidermis overlying a hyperechoic focus within the dermis. Her clinical and sonographic presentation was in keeping with a foreign body causing hair-thread tourniquet syndrome. The foreign body was surgically extirpated without neurovascular sequelae. Ultrasonography expedited accurate diagnosis and is a promising adjunct to clinical evaluation for radiolucent foreign bodies.
Diffuse melanosis cutis: a systematic review of the literature.
Publisher: Elsevier BV
Date: 03-2013
DOI: 10.1016/J.JAAD.2012.08.018
Abstract: Diffuse melanosis cutis (DMC) is a rare presentation of metastatic melanoma characterized by a progressive blue-gray discoloration of the skin and mucous membranes. To foster a better understanding of the clinical presentation, histological findings, and pathophysiology underlying DMC. A systematic review of the literature was completed utilizing MEDLINE, CINAHL, Embase, and Google. Data were extracted using a protocol-driven spread sheet with all statistical analyses completed using SPSS. The review identified 68 original cases of DMC. The mean time from diagnosis of melanoma until development of DMC was 11.48 months (95% confidence interval [CI]: 0-48.16). The mean time to death following the onset of DMC was 4.43 months (95% CI: 0.00-11.11). Histological findings were relatively consistent demonstrating intracellular and extracellular melanin deposition in the dermis, with a pronounced perivascular distribution. The pathophysiological mechanisms underlying DMC could not be definitively elucidated however, it is hypothesized that the melanin precursors, melanin, and melanosomes liberated by cytolytic metastatic melanoma deposits are phagocytosed by dermal histiocytes, manifesting clinically as diffuse melanosis. The cross-sectional nature of case reports, paucity of cases of DMC, and heterogeneity in reporting limit any conclusions being drawn regarding the pathophysiology of DMC definitively. DMC heralds a poor prognosis for patients with metastatic melanoma and affected patients should be made aware of the implications of this condition on survival.
Dermatology training and practice in A ustralia
Publisher: Wiley
Date: 15-09-2014
DOI: 10.1111/IJD.12728
Abstract: Dermatology is a relatively young discipline in Australia compared to other specialities within the medical fraternity. From its humble beginnings, the profession has evolved significantly over the decades and is now represented by the Australasian College of Dermatologists which is charged with training the next generation of dermatologists and advocating for and advancing the profession. The authors reviewed and describe the history of dermatology training and practice in Australia. Despite the progress in education, there are only 415 dermatologists serving a population of 23.3 million (1 per 58 000) and yet it has the highest incidence and prevalence of skin cancer in the world. The scope of clinical practice is wide in Australia, with clinicians well versed in medical and procedural dermatology. It is hoped that Australian dermatology will continue to bolster the dermatology profession globally.
Comparison between Physical and Empirical Methods for Simulating Surface Brightness Temperature Time Series
Publisher: MDPI AG
Date: 14-07-2022
DOI: 10.3390/RS14143385
Abstract: Land surface temperature (LST) is a vital parameter in the surface energy budget and water cycle. One of the most important foundations for LST studies is a theory to understand how to model LST with various influencing factors, such as canopy structure, solar radiation, and atmospheric conditions. Both physical-based and empirical methods have been widely applied. However, few studies have compared these two categories of methods. In this paper, a physical-based method, soil canopy observation of photochemistry and energy fluxes (SCOPE), and two empirical methods, random forest (RF) and long short-term memory (LSTM), were selected as representatives for comparison. Based on a series of measurements from meteorological stations in the Heihe River Basin, these methods were evaluated in different dimensions, i.e., the difference within the same surface type, between different years, and between different climate types. The comparison results indicate a relatively stable performance of SCOPE with a root mean square error (RMSE) of approximately 2.0 K regardless of surface types and years but requires many inputs and a high computational cost. The empirical methods performed relatively well in dealing with cases either within the same surface type or changes in temporal scales in idually, with an RMSE of approximately 1.50 K, yet became less compatible in regard to different climate types. Although the overall accuracy is not as stable as that of the physical method, it has the advantages of fast calculation speed and little consideration of the internal structure of the model.
Treatment of erlotinib‐induced acneiform eruption with chromophore gel‐assisted phototherapy
Publisher: Wiley
Date: 06-01-2019
DOI: 10.1111/PHPP.12446
Diagnostic ultrasonography in a child with eosinophilic fasciitis
Publisher: Oxford University Press (OUP)
Date: 30-08-2018
DOI: 10.1111/CED.13714
Eruptive Multifocal Cutaneous Mucinous Cysts
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 2018
Reversible relapse of pemphigus foliaceus triggered by topical imiquimod suggests that Toll-like receptor 7 inhibitors may be useful treatments for pemphigus
Publisher: Oxford University Press (OUP)
Date: 2011
Treatment of pemphigus vulgaris and pemphigus foliaceus
Publisher: Informa UK Limited
Date: 10-2009
DOI: 10.1586/EDM.09.45
A diagnosis that will go down in history
Publisher: AMPCo
Date: 12-2014
DOI: 10.5694/MJA14.00786
A comparison of physical modalities in Galli–Galli disease: Erbium:YAG laser, Intense Pulsed Light and Electrofulguration
Publisher: Wiley
Date: 03-04-2019
DOI: 10.1111/AJD.13038
Clinical Features of Bullous Systemic Lupus Erythematosus
Publisher: Springer Berlin Heidelberg
Date: 2015
Circumcision in the Paediatric Patient: A Review of Indications, Technique and Complications
Publisher: Wiley
Date: 12-2018
DOI: 10.1111/JPC.14284
Estimation of Surface Upward Longwave Radiation Using a Direct Physical Algorithm
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 08-2017
The Sweetest Specialty
Publisher: American Medical Association (AMA)
Date: 12-2015
A comparison in real clinical practice of methyl aminolevulinate photodynamic therapy and surgery for small superficial basal cell carcinoma: 3-year recurrence rates and cosmetic outcomes
Publisher: Wiley
Date: 03-12-2010
Direct cost-analysis of mohs micrographic surgery and traditional excision for basal cell carcinoma at initial margin clearance
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 05-2016
Wikipedia use amongst medical students-New insights into the digital revolution
Publisher: Informa UK Limited
Date: 08-11-2013
A teenager with a black nodule on the buttock
Publisher: Wiley
Date: 02-2019
DOI: 10.1111/JPC.1_14302
Diffuse melanosis cutis in the setting of BRAFV600Emutant melanoma and treatment with targeted therapies
Publisher: Wiley
Date: 27-08-2015
DOI: 10.1111/AJD.12187
Abstract: Diffuse melanosis cutis (DMC) is a rare presentation of metastatic melanoma associated with a particularly guarded prognosis. We report a case of a 35-year-old man with BRAF(V600E) metastatic melanoma treated with dabrafenib (as well as ipilimumab and whole brain radiotherapy), who is alive, 25 months after the onset of his DMC. This is significantly longer than the reported mean survival of 4 months, highlighting the importance of BRAF mutation testing and the promising survival advantage of using targeted therapies compared with conventional chemotherapeutic regimens.
Quality-of-life measurement in blistering diseases.
Publisher: Elsevier BV
Date: 04-2012
DOI: 10.1016/J.DET.2011.11.008
Abstract: Both congenital and acquired bullous dermatoses have the potential to impose a significant burden of disease, and the impact exerted on the quality of life (QOL) of patients is often multifaceted. The qualitative and quantitative studies reviewing QOL in patients with bullous dermatoses have all reported a significant decrease in QOL scores compared with the greater population using a range of patient-based measures. Formal evaluation of QOL in the setting of bullous dermatoses facilitates the assessment of disease severity and mapping of disease trajectory and can capture outcomes of therapeutic intervention relevant to the patient.
Avoiding severe drug hypersensitivity reactions: a case for HLA genotyping for at‐risk patients
Publisher: Wiley
Date: 06-08-2023
DOI: 10.5694/MJA2.52065
The development and validation of the treatment of autoimmune bullous disease quality of life questionnaire, a tool to measure the quality of life impacts of treatments used in patients with autoimmune blistering disease.
Publisher: Oxford University Press (OUP)
Date: 31-10-2013
DOI: 10.1111/BJD.12623
Abstract: Treatments for autoimmune blistering diseases have significant risk of medical complications and quality of life impacts during treatment, and it is difficult to differentiate these impacts from disease burden or the effects of treatment. To develop a quality of life instrument specific to the effects of treatments used in patients with autoimmune bullous disease (AIBD). A comprehensive item generation process was used to build a 45-item pilot Autoimmune Bullous Disease Quality of Life (ABQOL) questionnaire, distributed to 70 patients with AIBD. Experts in bullous disease refined the pilot ABQOL, selecting only those questions pertaining to the treatment effects. This pilot Treatment of Autoimmune Bullous Disease Quality of Life (TABQOL) questionnaire was administered to 70 patients, before factor analysis was performed to yield the final questionnaire of 17 questions. Validity and reliability were evaluated across a range of indices. Face and content validity were established through a comprehensive patient interview process, expert review and summaries of treatments used. The questionnaire was found to have appropriate correlation with the Dermatology Life Quality Index (r = 0.64) and the level of treatments used (P < 0.01), and was found to be responsive to overall variations in treatment burden. The TABQOL was also found to be a reliable instrument as evaluated by internal consistency (Cronbach α = 0.892) and test-retest reliability (r = 0.99). We have shown that the TABQOL questionnaire is a valid and reliable instrument that may to be used to measure treatment burden in AIBD and serve as an end point in clinical trials.
Infant with hypopigmented streaks
Publisher: Wiley
Date: 09-2019
DOI: 10.1111/JPC.1_14548
Evolving role of Instagram in #medicine
Publisher: Wiley
Date: 10-2019
DOI: 10.1111/IMJ.14448
Abstract: Social media has become an integral part of daily life and its use is becoming increasingly intertwined with the healthcare sector. Instagram is a free photo and video sharing social media application that has been utilised extensively in visually rich fields within medicine. Herein, we discuss the advantages and disadvantages of its use in modern medicine.
Temperature-Based and Radiance-Based Validation of the Collection 6 MYD11 and MYD21 Land Surface Temperature Products Over Barren Surfaces in Northwestern China
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 02-2021
Sweet's syndrome following surgery: Cutaneous trauma as a possible aetiological co‐factor in neutrophilic dermatoses
Publisher: Wiley
Date: 11-03-2014
DOI: 10.1111/AJD.12142
Abstract: A 47-year-old man presented with an acute, cutaneous eruption of exquisitely painful papules at the operative site 4 weeks after a right tibial osteotomy. Initially this was managed as a postoperative wound infection however the exacerbation and spread of the cutaneous eruption prompted further investigation. Histopathology and clinical findings were consistent with the development of Sweet's syndrome and resolution was obtained after the initiation of dapsone. We propose that surgery may produce an acute inflammatory response in a similar manner to pathergy reactions, which play an aetiological role in other neutrophilic dermatoses, such as pyoderma gangrenosum. We conclude that there may be greater overlap between these neutrophilic dermatoses than previously appreciated.
Evidence of the high prevalence of neurological disorders in nonsyndromic X-linked recessive ichthyosis: a retrospective case series
Publisher: Oxford University Press (OUP)
Date: 11-09-2018
DOI: 10.1111/BJD.16826
Abstract: X-linked recessive ichthyosis (XLI) is a relatively common type of ichthyosis caused by a deficiency in the steroid sulfatase (STS) enzyme. It is the only type of ichthyosis that can be both syndromic and nonsyndromic. Typical clinical features include dark-brown scale of variable size favouring the extensor surfaces of the extremities. To characterize clinically nonsyndromic XLI, with a particular focus on extracutaneous manifestations. This was a multicentre retrospective review of clinical findings from a case series of patients with a clinical and genetic diagnosis of XLI. We identified 30 patients with XLI belonging to 25 different families carrying a deletion in the STS locus. All patients had dark scales of variable size on the extensor surfaces of the extremities. Lack of flexural involvement and pruritus were common but inconsistent findings, whereas palmoplantar hyperlinearity was absent in all but one patient. A history of orchiopexy was present in 10% and thus was more common than expected vs. the general population (3%). Neurological disorders including epilepsy (13%) and attention deficit hyperactivity disorder (ADHD 30%) were over-represented in patients with XLI. This was a retrospective study with a limited number of patients. In the absence of confirmatory genetic testing and family history of the disease, dark-brown scale of the extensor surfaces and the absence of palmoplantar hyperlinearity appear to be the most reliable clinical findings supporting a diagnosis of XLI. Dermatologists should be aware of the high prevalence of ADHD and epilepsy in patients with nonsyndromic XLI.
Social media for Australian doctors
Publisher: Wiley
Date: 11-2020
DOI: 10.1111/IMJ.15053
Cutaneous ultrasound and its utility in Pediatric Dermatology: Part II —Developmental anomalies and vascular lesions
Publisher: Wiley
Date: 19-11-2019
DOI: 10.1111/PDE.13897
Abstract: High‐frequency ultrasonography represents a promising tool for pediatric dermatologists. It is a noninvasive and harmless diagnostic technique that is especially appealing when working with children. It can be easily performed at the patient's bedside, avoiding diagnostic delays, sedation, or multiple visits. It represents a useful adjunct to clinical examination and aids our understanding of cutaneous pathology. In this second part, we describe the ultrasonographic findings of developmental anomalies and vascular lesions.
Hair Repigmentation With Anti–PD-1 and Anti–PD-L1 Immunotherapy: A Novel Hypothesis
Publisher: American Medical Association (AMA)
Date: 2018
Dermatology over the rainbow
Publisher: American Medical Association (AMA)
Date: 05-2015
Bullous Systemic Lupus Erythematosus
Publisher: Elsevier BV
Date: 10-2011
DOI: 10.1016/J.DET.2011.06.002
Abstract: Bullous systemic lupus erythematosus (BSLE) is a rare bullous dermatosis in patients with systemic lupus erythematosus. It is characterized by clinical and histologic features, resembling either bullous pemphigoid or dermatitis herpetiformis, and a heterogeneous immunologic profile, characterized by autoimmunity to components of type VII collagen, much like epidermolysis bullosa acquisita. As understanding of the pathology of this interesting dermatologic condition has evolved, so too have criteria and profiling of BSLE. The distinct clinical, histologic, and immunologic features of BSLE represent a unique bullous disease phenotype.
Stewart‐Bluefarb syndrome following traumatic arteriovenous malformation
Publisher: Wiley
Date: 13-03-2021
DOI: 10.1111/PDE.14580
Abstract: Stewart‐Bluefarb syndrome is a rare angioproliferative disorder that presents as violet plaques on the extremities, due to an underlying arteriovenous malformation (AVM). We report the case of a 12‐year‐old boy who developed a traumatic AVM in a bicycle accident and presented seven years later with exophytic, violet plaques. This is the first instance of a traumatic AVM preceding Stewart‐Bluefarb syndrome in a pediatric patient in the literature. Given the typically long period required to establish this diagnosis, it is crucial for clinicians to actively interrogate a history of preceding trauma in patients presenting with acroangiodermatitis.
Crazy in Love
Publisher: American Medical Association (AMA)
Date: 02-2016
A New Directional Canopy Emissivity Model Based on Spectral Invariants
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 12-2018
An Operational Split-Window Algorithm for Retrieving Land Surface Temperature from Geostationary Satellite Data: A Case Study on Himawari-8 AHI Data
Publisher: MDPI AG
Date: 13-08-2020
DOI: 10.3390/RS12162613
Abstract: An operational split-window (SW) algorithm was developed to retrieve high-temporal-resolution land surface temperature (LST) from global geostationary (GEO) satellite data. First, the MODTRAN 5.2 and SeeBor V5.0 atmospheric profiles were used to establish a simulation database to derive the SW algorithm coefficients for GEO satellites. Then, the dynamic land surface emissivities (LSEs) in the two SW bands were estimated using the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) Global Emissivity Dataset (GED), fractional vegetation cover (FVC), and snow cover products. Here, the proposed SW algorithm was applied to Himawari-8 Advanced Himawari Imager (AHI) observations. LST estimates were retrieved in January, April, July, and October 2016, and three validation methods were used to evaluate the LST retrievals, including the temperature-based (T-based) method, radiance-based (R-based) method, and intercomparison method. The in situ night-time observations from two Heihe Watershed Allied Telemetry Experimental Research (HiWATER) sites and four Terrestrial Ecosystem Research Network (TERN) OzFlux sites were used in the T-based validation, where a mean bias of −0.70 K and a mean root-mean-square error (RMSE) of 2.29 K were achieved. In the R-based validation, the biases were 0.14 and −0.13 K and RMSEs were 0.83 and 0.86 K for the daytime and nighttime, respectively, over four forest sites, four desert sites, and two inland water sites. Additionally, the AHI LST estimates were compared with the Collection 6 MYD11_L2 and MYD21_L2 LST products over southeastern China and the Australian continent, and the results indicated that the AHI LST was more consistent with the MYD21 LST and was generally higher than the MYD11 LST. The pronounced discrepancy between the AHI and MYD11 LST could be mainly caused by the differences in the emissivities used. We conclude that the developed SW algorithm is of high accuracy and shows promise in producing LST data with global coverage using observations from a constellation of GEO satellites.
Objective Scoring Systems for Disease Activity in Autoimmune Bullous Disease
Publisher: Elsevier BV
Date: 07-2011
DOI: 10.1016/J.DET.2011.03.015
Abstract: Objectively evaluating disease activity in autoimmune bullous disease (AIBD) is important in terms of the clinical assessment of patients and as an outcome measure for clinical trials. Measures need to be general enough to capture the issues specific to each of the bullous dermatoses but specific enough to capture any changes to disease status for a patient. Different tools have been put forward over the last 15 years, but presently the Autoimmune Bullous Skin Disorder Intensity Score and Pemphigus Disease Area Index seem to be the most promising tools to assess disease activity in AIBD.
Clascoterone as a novel treatment for androgenetic alopecia
Publisher: Oxford University Press (OUP)
Date: 23-06-2020
DOI: 10.1111/CED.14292
A ‘spot’ diagnosis
Publisher: BMJ
Date: 26-04-2016
Corynebacterium minutissimum infection: erythrasma
Publisher: AMPCo
Date: 09-2017
DOI: 10.5694/MJA16.01081
Apple of the Dermatologist’s Eye
Publisher: American Medical Association (AMA)
Date: 12-2014
Mammalian meat allergy
Publisher: Wiley
Date: 04-09-2018
DOI: 10.1111/IJD.14208
Abstract: Mammalian meat allergy is an allergic reaction mediated by IgE antibodies directed against the mammalian oligosaccharide epitope galactose-α-1,3-galactose. Clinically, it is characterized by a range of symptoms including urticaria, angioedema, gastroenteritis, and anaphylaxis hours following ingestion of red meat. It is an emergent allergy in tick endemic areas across the world. As a recently described disease with a cutaneous presentation, dermatologists should be familiar with this entity and recognize it as a differential diagnosis for urticarial and anaphylaxis reactions.
Comparison of the MuSyQ and MODIS Collection 6 Land Surface Temperature Products Over Barren Surfaces in the Heihe River Basin, China
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 10-2019
Biologics for pediatric psoriasis: A systematic review and meta‐analysis
Publisher: Wiley
Date: 09-12-2022
DOI: 10.1111/PDE.14870
Abstract: Biologics represent a promising treatment for children with moderate‐to‐severe psoriasis. Randomized control trials (RCTs) have been published evaluating different biologics in children with psoriasis, but no summative review exists. To summarize data from existing RCTs to assess the efficacy and safety of biologics in the management of pediatric psoriasis. A systematic review and meta‐analysis of RCTs was performed from Medline, Embase, PubMed, the Cochrane Central Register of Controlled Trials, and the American College of Physicians Journal Club from inception to November 2020. Random‐effects models were used to estimate the pooled effect size. Five RCTs assessing adalimumab, etanercept, ixekizumab, secukinumab, and ustekinumab were included (768 patients). The odds ratio of achieving a 75% improvement in Psoriasis Area and Severity index score was 12.37 (95% CI: 6.23‐24.55) at initial follow‐up, defined as 12‐16 weeks of treatment. The odds ratio of any adverse event was 0.95 (95% CI: 0.51‐1.80) at initial follow‐up, in patients treated with biologics when compared to placebo or a non‐biologic agent. Limitations of this study include heterogeneity in both the study design and the biologics investigated between the RCTs included in the meta‐analysis. Biologic therapy for pediatric patients with moderate‐to‐severe psoriasis has high efficacy and a favorable side effect profile.
Cutaneous ultrasound and its utility in pediatric dermatology. Part I: Lumps, bumps, and inflammatory conditions
Publisher: Wiley
Date: 19-11-2019
DOI: 10.1111/PDE.14033
Abstract: High‐frequency ultrasonography represents a promising tool for pediatric dermatologists. It is a non‐invasive diagnostic technique that is particularly appealing when working with children. It can be easily performed at the patient's bedside, avoiding diagnostic delays, sedation, or multiple visits. It represents a useful adjunct to clinical examination and can enhance our understanding of cutaneous diseases. Patient cooperation and limited training and experience are the main challenges for cutaneous ultrasonography in pediatric dermatology. This review describes cutaneous ultrasonography and the nuances of its use in the pediatric setting, followed by the ultrasonographic findings of cutaneous lumps, bumps, and inflammatory dermatoses commonly encountered in pediatric patients.
An Operational Split-Window Algorithm for Generating Long-Term Land Surface Temperature Products From Chinese Fengyun-3 Series Satellite Data
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2023
Development of a quality-of-life instrument for autoimmune bullous disease: the Autoimmune Bullous Disease Quality of Life questionnaire.
Publisher: American Medical Association (AMA)
Date: 10-2013
DOI: 10.1001/JAMADERMATOL.2013.4972
Abstract: Quality-of-life (QOL) evaluation is an increasingly important outcome measure in dermatology, with disease-specific QOL instruments being the most sensitive to changes in disease status. To develop a QOL instrument specific to autoimmune bullous disease (AIBD). A comprehensive item generation process was used to build a 45-item pilot Autoimmune Bullous Disease Quality of Life (ABQOL) questionnaire, distributed to 70 patients with AIBD. Experts in bullous disease refined the pilot ABQOL before factor analysis was performed to yield the final ABQOL questionnaire of 17 questions. We evaluated validity and reliability across a range of indices. Australian dermatology outpatient clinics and private dermatology practices. PATIENTS AND EXPOSURE: Patients with a histological diagnosis of AIBD. The development of an AIBD-specific QOL instrument. Face and content validity were established through the comprehensive patient interview process and expert review. In terms of convergent validity, the ABQOL was found to have a moderate correlation with scores on the Dermatology Life Quality Index (R = 0.63) and the General Health subscale of the 36-Item Short Form Health Survey (R = 0.69 P = .009) and low correlation with the Pemphigus Disease Area Index (R = 0.42) and Autoimmune Bullous Disease Skin Disorder Intensity Score (R = 0.48). In terms of discriminant validity, the ABQOL was found to be more sensitive than the Dermatology Life Quality Index (P = .02). The ABQOL was also found to be a reliable instrument evaluated by internal consistency (Cronbach α coefficient, 0.84) and test-retest reliability (mean percentage variation, 0.92). The ABQOL has been shown to be a valid and reliable instrument that may serve as an end point in clinical trials. Future work should include incorporating patient weighting on questions to further increase content validity and translation of the measure to other languages. anzctr.org.au Identifier: ACTRN12612000750886.
Syphilitic Alopecia
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 07-2018
Diffuse melanosis cutis in the setting of BRAF<sup>V</sup><sup>600</sup><sup>E</sup> metastatic melanoma
Publisher: Wiley
Date: 26-09-2014
DOI: 10.1111/IJD.12614
Abstract: A 79-year-old Caucasian male presented with a 1-week history of diffuse progressive blue-gray discoloration of the skin subsequently found to due to diffuse melanosis cutis (DMC) in the setting of metastatic melanoma. Mutation testing demonstrated BRAF(V600E) mutation status, an unexpected finding given his age. He died two weeks after presentation. As our understanding of the molecular subtypes of melanoma increases, in the future it may be possible to predict which melanoma patients have a predilection to developing DMC. Mutation testing of DMC patients should be considered as BRAF inhibitors, and other novel targeted therapies may improve the bleak prognosis associated with this unusual presentation of metastatic melanoma.
Evaluation of Six High-Spatial Resolution Clear-Sky Surface Upward Longwave Radiation Estimation Methods with MODIS
Publisher: MDPI AG
Date: 05-06-2020
DOI: 10.3390/RS12111834
Abstract: Surface upward longwave radiation (SULR) is a critical component in the calculation of the Earth’s surface radiation budget. Multiple clear-sky SULR estimation methods have been developed for high-spatial resolution satellite observations. Here, we comprehensively evaluated six SULR estimation methods, including the temperature-emissivity physical methods with the input of the MYD11/MYD21 (TE-MYD11/TE-MYD21), the hybrid methods with top-of-atmosphere (TOA) linear/nonlinear/artificial neural network regressions (TOA-LIN/TOA-NLIN/TOA-ANN), and the hybrid method with bottom-of-atmosphere (BOA) linear regression (BOA-LIN). The recently released MYD21 product and the BOA-LIN—a newly developed method that considers the spatial heterogeneity of the atmosphere—is used initially to estimate SULR. In addition, the four hybrid methods were compared with simulated datasets. All the six methods were evaluated using the Moderate Resolution Imaging Spectroradiometer (MODIS) products and the Surface Radiation Budget Network (SURFRAD) in situ measurements. Simulation analysis shows that the BOA-LIN is the best one among four hybrid methods with accurate atmospheric profiles as input. Comparison of all the six methods shows that the TE-MYD21 performed the best, with a root mean square error (RMSE) and mean bias error (MBE) of 14.0 and −0.2 W/m2, respectively. The RMSE of BOA-LIN, TOA-NLIN, TOA-LIN, TOA-ANN, and TE-MYD11 are equal to 15.2, 16.1, 17.2, 21.2, and 18.5 W/m2, respectively. TE-MYD21 has a much better accuracy than the TE-MYD11 over barren surfaces (NDVI 0.3) and a similar accuracy over non-barren surfaces (NDVI ≥ 0.3). BOA-LIN is more stable over varying water vapor conditions, compared to other hybrid methods. We conclude that this study provides a valuable reference for choosing the suitable estimation method in the SULR product generation.
Management of adverse events related to new cancer immunotherapy (Immune checkpoint inhibitors)
Publisher: AMPCo
Date: 05-2017
DOI: 10.5694/MJA16.01357
Buzzwords in Dermatology
Publisher: American Medical Association (AMA)
Date: 08-2015
Atypical fibroxanthoma management: Recurrence, metastasis and disease-specific death
Publisher: Wiley
Date: 17-08-2018
DOI: 10.1111/AJD.12646
Abstract: Atypical fibroxanthoma (AFX) is a rare spindle cell neoplasm predominantly found on the head and neck of elderly in iduals with sun-damaged skin, with no evidence-based guidelines for their management. A systematic retrospective review of the literature focusing on treatment modality found a recurrence and metastasis rate of 8.0% (5.6% when adjusted for incomplete excisions) and 0.5% for local excision and 4.6% and 3.2% for Mohs micrographic surgery, respectively. Our results suggest that with clear surgical margins, AFX is unlikely to recur and metastases are rare, with significantly higher rates in the immunosuppressed population.
Treatment-specific utility weightings are needed for cost-utility analysis in metastatic melanoma
Publisher: Oxford University Press (OUP)
Date: 09-01-2016
DOI: 10.1111/BJD.14264
Quality of life in non-melanoma skin cancer
Publisher: Wiley
Date: 08-09-2015
DOI: 10.1111/AJD.12205
Abstract: Basal cell carcinoma and squamous cell carcinoma are the most common malignancies and are classified under the umbrella of non-melanoma skin cancer (NMSC). NMSC exerts a small but appreciable decrement in quality of life (QOL). The impact posed may arise from the tumour itself or as a result of treatment, and through symptoms, functional limitations, cosmetic burden and auxiliary considerations such as cost and disturbance to the activities of daily living. Researchers have evaluated this burden using a variety of outcome measures including generic, dermatology-specific and disease-specific instruments. The skin cancer index represents a promising disease-specific patient-reported outcome measure in this setting. To overcome some of the constraints inherent to disease-specific instruments, and to allow comparisons with other diseases, utility weightings have been developed. Utility weightings represent a cardinal measure for a specific health status and are established through methods such as the standard gamble, willingness-to-pay and time trade-off, and have also been employed to generate utility weightings for NMSC. Utilities are becoming increasingly important as a means of comparing health states across medicine and are of particular importance from a health-care policy perspective as they are used for resource allocation. The small but definite impact on the in idual's QOL posed by NMSC should be a clinical consideration for physicians and it should be recognised by researchers as a potential outcome measure.
Response of a tertiary dermatology department to COVID‐19
Publisher: Wiley
Date: 21-04-2020
DOI: 10.1111/AJD.13298
Extent Measures in Autoimmune Bullous Disease
Publisher: Springer Berlin Heidelberg
Date: 2015
Evaluation of Four Kernel-Driven Models in the Thermal Infrared Band
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 08-2019
The hungry caterpillar flap: A variant of the V-to-Y island pedicle flap
Publisher: Elsevier BV
Date: 12-2017
Sirolimus in blue rubber bleb naevus syndrome: A systematic review
Publisher: Wiley
Date: 18-12-2018
DOI: 10.1111/JPC.14345
Abstract: The aim of this study is to review sirolimus as a treatment for blue rubber bleb naevus syndrome (BRBNS). A literature search of Medline, Embase, CINAHL, SCOPUS and Google Scholar was conducted for publications reporting treatment of patients with BRBNS with sirolimus. Of 46 articles identified, 17 studies reporting 23 patients met inclusion criteria. Sirolimus was well tolerated in all but one patient who required treatment cessation 17/18 patients noted an improvement in gastrointestinal disease where this was reported 21/22 patients noted an improvement in cutaneous disease where this was reported. Based on these results, sirolimus may be considered a first-line treatment of BRBNS depending on patient morbidity.
Subacute cutaneous lupus erythematosus induced by nivolumab
Publisher: Wiley
Date: 20-07-2017
DOI: 10.1111/AJD.12681
LASER TREATMENT OF CAPILLARY MALFORMATIONS IN CHILDREN IS NOT COSMETIC THERAPY
Publisher: Wiley
Date: 06-2020
DOI: 10.1111/JPC.14949
Cortexolone 17α‐propionate for hidradenitis suppurativa
Publisher: Hindawi Limited
Date: 04-09-2020
DOI: 10.1111/DTH.14142
Pregnancy in a patient with Netherton syndrome
Publisher: Oxford University Press (OUP)
Date: 08-12-2017
DOI: 10.1111/CED.13300
Cutaneous metastasis in a patient with multiple malignancies
Publisher: Oxford University Press (OUP)
Date: 04-06-2018
DOI: 10.1111/CED.13662
Dupilumab‐associated ocular surface disease: An interdisciplinary decision framework for prescribers in the Australian setting
Publisher: Wiley
Date: 20-09-2022
DOI: 10.1111/AJD.13924
Abstract: Dupilumab‐associated ocular surface disease (DAOSD) is of particular relevance in patients with atopic dermatitis (AD). Guidance on DAOSD assessment and management in the Australian setting is needed to reduce its impact and minimise disruption to treatment. A systematic review of the literature was undertaken to identify data pertaining to the incidence, pathophysiology, risk factors and management of DAOSD. A critical review of this literature was used to inform a decision framework for dupilumab‐prescribers and develop a graded severity scoring tool to guide appropriate management options. DAOSD typically emerges within 4 months of commencing dupilumab and the occurrence of new events diminishes over time. The reported incidence varies widely depending on the nature and source of the data: 8.6–22.1% (clinical trials programme), 0.5–70% (real‐world data differences in study size, duration of follow‐up, ophthalmologist intervention, use of prophylaxis). Occurrence increases with AD severity and in patients with prior history of ocular disease pathophysiology is still to be fully characterised. Management options have evolved over time and include lubricants/artificial tears, corticosteroids, calcineurin inhibitors, antihistamines, anti‐inflammatory agents and antimicrobial agents. Current therapies aim to resolve symptoms or reduce severity to levels sufficiently tolerable to enable continuation of dupilumab therapy. Recommendations for DAOSD assessment and management include identification of high‐risk patients, vigilance for red flags (keratoconus, herpetic and bacterial keratitis), regular assessment of symptom severity (before and during dupilumab therapy), conservative management of mild DAOSD by the prescribing physician and ophthalmologist referral for collaborative care of moderate–severe DAOSD and high‐risk patients.
Quality of life in patients with bullous dermatoses
Publisher: Elsevier BV
Date: 2012
The need for longer time horizons for cost-utility evaluation in bullous pemphigoid
Publisher: Oxford University Press (OUP)
Date: 07-02-2018
DOI: 10.1111/BJD.16213
Related Organisations
Related Funding Activities
No related grants have been discovered for Deshan Sebaratnam.