ORCID Profile
0000-0002-1749-2449
Current Organisations
Shanghai Ninth People's Hospital
,
University of Vermont
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Publisher: Wiley
Date: 04-08-2023
DOI: 10.1111/MEC.17093
Abstract: Manipulation of host phenotypes by parasites is hypothesized to be an adaptive strategy enhancing parasite transmission across hosts and generations. Characterizing the molecular mechanisms of manipulation is important to advance our understanding of host–parasite coevolution. The trematode ( Levinseniella byrdi ) is known to alter the colour and behaviour of its hipod host ( Orchestia grillus ) presumably increasing predation of hipods which enhances trematode transmission through its life cycle. We s led 24 infected and 24 uninfected hipods from a salt marsh in Massachusetts to perform differential gene expression analysis. In addition, we constructed novel genomic tools for O. grillus including a de novo genome and transcriptome. We discovered that trematode infection results in upregulation of hipod transcripts associated with pigmentation and detection of external stimuli, and downregulation of multiple hipod transcripts implicated in invertebrate immune responses, such as vacuolar ATPase genes. We hypothesize that suppression of immune genes and the altered expression of genes associated with coloration and behaviour may allow the trematode to persist in the hipod and engage in further biochemical manipulation that promotes transmission. The genomic tools and transcriptomic analyses reported provide new opportunities to discover how parasites alter erse pathways underlying host phenotypic changes in natural populations.
Publisher: Oxford University Press (OUP)
Date: 08-09-2020
Abstract: Acorn barnacle adults experience environmental heterogeneity at various spatial scales of their circumboreal habitat, raising the question of how adaptation to high environmental variability is maintained in the face of strong juvenile dispersal and mortality. Here, we show that 4% of genes in the barnacle genome experience balancing selection across the entire range of the species. Many of these genes harbor mutations maintained across 2 My of evolution between the Pacific and Atlantic oceans. These genes are involved in ion regulation, pain reception, and heat tolerance, functions which are essential in highly variable ecosystems. The data also reveal complex population structure within and between basins, driven by the trans-Arctic interchange and the last glaciation. Divergence between Atlantic and Pacific populations is high, foreshadowing the onset of allopatric speciation, and suggesting that balancing selection is strong enough to maintain functional variation for millions of years in the face of complex demography.
Publisher: Informa UK Limited
Date: 04-2020
DOI: 10.2147/IJN.S238005
No related grants have been discovered for Long-Po Zheng.