ORCID Profile
0000-0002-1126-4971
Current Organisations
University of Wollongong
,
Organisation
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Peter MacCallum Cancer Centre
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Organometallic Chemistry | Physical Organic Chemistry | Organic Chemistry | Catalysis and Mechanisms of Reactions | Organic Chemical Synthesis | Physical Chemistry (Incl. Structural)
Publisher: American Chemical Society (ACS)
Date: 16-06-2023
Publisher: American Chemical Society (ACS)
Date: 02-11-2010
DOI: 10.1021/IC1020912
Abstract: Ligand effects in bimetallic high oxidation state systems containing a X-Pd-Pd-Y framework have been explored with density functional theory (DFT). The ligand X has a strong effect on the dissociation reaction of Y to form [X-Pd-Pd](+) + Y(-). In the model system examined where Y is a weak σ-donor ligand and a good leaving group, we find that dissociation of Y is facilitated by greater σ-donor character of X relative to Y. We find that there is a linear correlation of the Pd-Y and Pd-Pd bond lengths with Pd-Y bond dissociation energy, and with the σ-donating ability of X. These results can be explained by the observation that the Pd d(z(2)) population in the PdY fragment increases as the donor ability of X increases. In these systems, the Pd(III)-Pd(III) arrangement is favored when X is a weak σ-donor ligand, while the Pd(IV)-Pd(II) arrangement is favored when X is a strong σ-donor ligand. Finally, we demonstrate that ligand exchange to form a bimetallic cationic species in which each Pd is six-coordinate should be feasible in a high polarity solvent.
Publisher: Wiley
Date: 21-12-2019
Publisher: Springer Science and Business Media LLC
Date: 06-05-2020
Publisher: Wiley
Date: 26-07-2022
Publisher: Oxford University Press (OUP)
Date: 07-2006
DOI: 10.1093/NAR/GKL196
Publisher: Elsevier
Date: 2017
Publisher: Georg Thieme Verlag KG
Date: 18-01-2017
Publisher: Springer Science and Business Media LLC
Date: 09-03-2018
Publisher: Research Square Platform LLC
Date: 30-01-2023
DOI: 10.21203/RS.3.RS-2487314/V1
Abstract: Background: Genetic counselling aims to identify, and address, patient needs while facilitating informed decision-making about genetic testing and promoting empowerment and adaptation to genetic information. Increasing demand for cancer genetic testing and genetic counsellor workforce capacity limitations may impact the quality of genetic counselling provided. The use of a validated genetic-specific screening tool, the Genetic Psychosocial Risk Instrument (GPRI), may facilitate patient-centred genetic counselling. The aim of this study is to assess the effectiveness and implementation of using the GPRI in improving patient outcomes after genetic counselling and testing for an inherited cancer predisposition. Methods: The PersOnalising gEneTIc Counselling (POETIC) trial is a hybrid type 2 effectiveness-implementation trial using a randomised control trial to assess the effectiveness of the GPRI in improving patient empowerment (primary outcome), while also assessing implementation from the perspective of clinicians and the healthcare service. Patients referred for a cancer risk assessment to the conjoint clinical genetics service of two metropolitan hospitals in Victoria, Australia, who meet the eligibility criteria and consent to POETIC will be randomised to the usual care or intervention group. Those in the intervention group will complete the GPRI prior to their appointment with the screening results available for the clinicians’ use during the appointment. Appointment audio recordings, clinician reported information about the appointment, patient-reported outcome measures, and clinical data will be used to examine the effectiveness of using the GPRI. Appointment audio recordings, health economic information, and structured interviews will be used to examine the implementation of the GPRI. Discussion: The POETIC trial takes a pragmatic approach by deploying the GPRI as an intervention in the routine clinical practice of a cancer-specific clinical genetics service that is staffed by a multidisciplinary team of genetics and oncology clinicians. Therefore, the effectiveness and implementation evidence generated from this real-world health service setting aims to optimise the relevance of the outcomes of this trial to the practice of genetic counselling while enhancing the operationalisation of the screening tool in routine practice. Trial registration: Australian New Zealand Clinical Trials Registry registration number 12621001582842p. Date of registration: 19 th November 2021.
Publisher: Informa UK Limited
Date: 25-05-2021
Publisher: Elsevier
Date: 2022
Publisher: Royal Society of Chemistry (RSC)
Date: 2011
DOI: 10.1039/C0OB01046D
Abstract: TiCl(4) and TiBr(4) rapidly transform cyclopropenylmethyl acetates to (E)-halodienes via ring-opening to allyl-vinyl cations. DFT calculations suggest that the regioselectivity of the halogenation of this cationic intermediate by [TiX(4)OAc](-) is under thermodynamic control, while the stereoselectivity is governed by kinetics.
Publisher: Wiley
Date: 22-10-2015
Publisher: Cold Spring Harbor Laboratory
Date: 17-02-2023
DOI: 10.1101/2023.02.16.23286057
Abstract: Polygenic risk scores (PRS) for breast and ovarian cancer risk are increasingly available to the public through clinical research and commercial genetic testing companies. Healthcare providers frequently report limited knowledge and confidence using PRS, representing a significant barrier to evaluation and uptake of this technology. We aimed to develop and evaluate the impact of a novel online educational program on genetic healthcare providers (GHP) attitudes, confidence and knowledge using PRS for breast and ovarian cancer risk. The educational program was informed by adult learning theory and the Kolb experiential learning model. The program was comprised of two phases: i) an online module covering the theoretical aspects of PRS and ii) a facilitated virtual workshop with pre-recorded role plays and case discussions. A pre-and post-education survey was administered to evaluate the impact of the educational program on GHP attitudes, confidence, knowledge, and preparedness for using PRS. Eligible participants were GHP working in one of 12 familial cancer in Australia registered to recruit patients for a breast and ovarian cancer PRS clinical trial and completed the education program. 124 GHP completed the PRS education, of whom 80 (64%) and 67 (41%) completed the pre- and post-evaluation survey, respectively. Pre-education, GHP reported limited experience, confidence and preparedness using PRS. GHP frequently recognized potential benefits to PRS, most commonly that this information could improve access to tailored screening (rated as beneficial/very beneficial by 92% of GHP pre-education). Completion of the education program was associated with significantly improved attitudes (p= .001), confidence (p= .001), knowledge of (p= .001) and preparedness (p= .001) using PRS. Most GHP indicated the education program entirely met their learning needs (73%) and felt the content was entirely relevant to their clinical practice (88%). GHP identified further PRS implementation issues including limited funding models, ersity issues, need for clinical guidelines and ongoing updates given the rapid pace of PRS research. Delivery of a novel education program can improve GHP attitudes, confidence, knowledge, and preparedness using PRS. Careful consideration of healthcare providers’ learning needs is required to support PRS research and clinical translation.
Publisher: American Society of Clinical Oncology (ASCO)
Date: 20-03-2016
Publisher: Elsevier
Date: 2016
Publisher: Elsevier BV
Date: 11-2007
Abstract: With the completion of sequencing projects for several parasite genomes, efforts are ongoing to make sense of this mass of information in terms of the gene products encoded and their interactions in the growth, development and survival of parasites. The emerging science of systems biology aims to explain the complex relationship between genotype and phenotype by using network models. One area in which this approach has been particularly successful is in the modeling of metabolism. With an accurate picture of the set of metabolic reactions encoded in a genome, it is now possible to identify enzymes or transporters that might be viable targets for new drugs. Because these predictions greatly depend on the quality and completeness of the genome annotation, there are substantial efforts in the scientific community to increase the numbers of metabolic enzymes identified. In this review, we discuss the opportunities for using metabolic reconstruction and analysis tools in parasitology research, and their applications to protozoan parasites.
Publisher: Springer Science and Business Media LLC
Date: 18-08-2018
Publisher: Wiley
Date: 08-12-2023
DOI: 10.1002/JGC4.1659
Abstract: Genetic counseling plays a critical role in supporting in iduals and their families' adaption to psychiatric conditions, addressing the multifactorial nature of these conditions in a personally meaningful and empowering way. Yet data related to the practice and attitudes of Australian genetic counselors about psychiatric genetic counseling (PGC) is limited. This survey investigated the practice of Australian genetic counselors, and their attitudes toward PGC. Genetic counselors ( N = 393) were invited to participate in an anonymous online survey between March and May 2022. Forty‐four genetic counselors (response rate = 11%) from Australia and New Zealand responded. No respondents practice in psychiatric genetics as their speciality area most respondents do not see any patients where the primary indication is a personal and/or family history of psychiatric disorders (91%). Greater than half of respondents (56%) believed there was sufficient evidence to support PGC, and 64% enquire about personal and/or family history of psychiatric disorders, but only 25% provide genetic counseling on this topic. Most respondents do not feel confident providing risk assessments for psychiatric disorders (72%), while the majority expressed interest in attending specialist training (95%), and in incorporating PGC into future practice (77%). Australian genetic counselors would benefit from psychiatric genetic education and training, and establishment of specialized PGC services would address this gap in patient care, while providing opportunities for genetic counselors to gain skills and experience in PGC.
Publisher: Wiley
Date: 17-11-2021
DOI: 10.1002/JGC4.1532
Abstract: Increasing demand for clinical genetic services may impact the resources and quality of genetic counseling, potentially impacting patient outcomes. Using a psychosocial screening tool may aid the provision of genetic counseling by reliably identifying patients’ psychosocial needs. The Genetic Psychosocial Risk Instrument (GPRI) is a validated genetic‐specific screening tool designed to identify psychological risk factors that predict distress in patients having genetic testing. This questionnaire‐based study investigated the perceived acceptability, feasibility, and usefulness of the GPRI in patients and clinicians in routine clinical genetic practice. From December 2018 to January 2019, 154 patients attending an Australian clinical genetic service were invited to complete a paper‐based survey that included the GPRI. The GPRI was scored and provided to the clinician for use in the appointment. In February 2019, clinicians completed an anonymous online survey regarding acceptability, feasibility, and usefulness of the GPRI. Descriptive statistics, chi‐squared, t tests, and regression analyses were used to analyze the patient data, and descriptive statistics were employed for clinician surveys. A total of 145 patients participated (94% response rate). The average GPRI score was 46.3 (95% CI 43.6—49.0) with 41% of patients meeting the 50‐point threshold indicating high risk for psychological distress. The GPRI was highly acceptable to patients, regardless of their level of psychosocial risk. Fourteen clinicians participated (54% response rate): 85% found the GPRI not too time consuming, and 86% believed it improved patient care by identifying patient needs. All were willing to use the GPRI routinely. The use of the GPRI is highly acceptable to patients and clinicians in this setting, assisting in identifying patients at risk for distress, prompting clinicians to address concerns, provide psychosocial support, and consider ongoing referral. As 41% of patients’ scores indicated a high risk of distress, the GPRI is an important tool for potentially enhancing overall patient outcomes.
Publisher: Elsevier
Date: 2021
Publisher: Elsevier BV
Date: 03-2008
Publisher: American Chemical Society (ACS)
Date: 14-06-2011
DOI: 10.1021/IC102323S
Abstract: Reductive elimination of C-Cl and C-C bonds from binuclear organopalladium complexes containing Pd-Pd bonds with overall formal oxidation state +III are explored by density functional theory for dichloromethane and acetonitrile solvent environments. An X-ray crystallographically authenticated neutral complex, [(L-C,N)ClPd(μ-O(2)CMe)](2) (L = benzo[h]quinolinyl) (I), is examined for C-Cl coupling, and the proposed cation, [(L-C,N)PhPd(1)(μ-O(2)CMe)(2)Pd(2)(L-C,N)](+) (II), examined for C-C coupling together with (L-C,N)PhPd(1)(μ-O(2)CMe)(2)Pd(2)Cl(L-C,N) (III) as a neutral analogue of II. In both polar and nonpolar solvents, reaction from III via chloride dissociation from Pd(2) to form II is predicted to be favored. Cation II undergoes Ph-C coupling at Pd(1) with concomitant Pd(1)-Pd(2) lengthening and shortening of the Pd(1)-O bond trans to the carbon atom of L natural bond orbital analysis indicates that reductive coupling from II involves depopulation of the d(x(2)-y(2)) orbital of Pd(1) and population of the d(z(2)) orbitals of Pd(1) and Pd(2) as the Pd-Pd bond lengthens. Calculations for the symmetrical dichloro complex I indicate that a similar dissociative pathway for C-Cl coupling is competitive with a direct (nondissociative) pathway in acetonitrile, but the direct pathway is favored in dichloromethane. In contrast to the dissociative mechanism, direct coupling for I involves population of the d(x(2)-y(2)) orbital of Pd(1) with Pd(1)-O(1) lengthening, significantly less population occurs for the d(z(2)) orbital of Pd(1) than for the dissociative pathway, and d(z(2)) at Pd(2) is only marginally populated resulting in an intermediate that is formally a Pd(1)(I)-Pd(2)(III) species, (L-Cl-N,Cl)Pd(1)(μ-O(2)CMe)Pd(2)Cl(O(2)CMe)(L-C,N) that releases chloride from Pd(2) with loss of Pd(I)-Pd(III) bonding to form a Pd(II) species. A similar process is formulated for the less competitive direct pathway for C-C coupling from III, in this case involving decreased population of the d(z(2)) orbital of Pd(2) and strengthening of the Pd(I)-Pd(III) interaction in the analogous intermediate with η(2)-coordination at Pd(1) by L-Ph-N, C(1)-C(2).
Publisher: Wiley
Date: 08-2006
Publisher: Wiley
Date: 29-11-2005
Publisher: Wiley
Date: 16-01-2019
Publisher: American Chemical Society (ACS)
Date: 12-11-2021
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6OB90061E
Abstract: Correction for ‘Oxidative ring-opening of ferrocenylcyclopropylamines to N -ferrocenylmethyl β-hydroxyamides’ by Yi Sing Gee et al. , Org. Biomol. Chem. , 2016, 14 , 2498–2503.
Publisher: Springer Science and Business Media LLC
Date: 08-01-2018
Publisher: Wiley
Date: 19-07-2005
Publisher: American Chemical Society (ACS)
Date: 03-06-2021
Publisher: IGI Global
Date: 07-2016
Abstract: The aim of this study was to gather university student perspectives on a new type of assessment task requesting them to create “blended media”. Blended media is a new form of student-generated multimedia whereby students devise a narration or voiceover to explain a science concept complemented by any combination of visuals such as video, animation or still images that are original or created by others to enhance the explanation. In the assessment task all the students successfully made a blended media product in their own time using their own technology and only requiring one session of media instruction. Surprisingly, the three case students who volunteered to be interviewed stated that they had never made a media product for a science assignment before and enjoyed creating this new form of assignment because they found it engaging and interesting. It also required them to represent content in new ways. Blended media is an innovative way for students to make digital media that engages them with content and as an assessment task could be used in any subject.
Publisher: Wiley
Date: 09-07-2021
DOI: 10.1002/JGC4.1307
Publisher: AMPCo
Date: 06-2011
DOI: 10.5694/J.1326-5377.2011.TB03117.X
Abstract: To determine the prevalence of patient-initiated aggression toward general practitioners in Australia. A cross-sectional national survey, conducted during February-May 2010, of 3090 GPs in 19 Divisions of General Practice, purposively s led to represent urban, rural and remote areas. Proportion of GPs experiencing patient-initiated aggression. Eight-hundred and four GPs returned completed surveys (response rate, 26.3%). In the previous 12 months, 58% of GPs had experienced verbal abuse and 18% had experienced property damage or theft. Very few GPs had experienced physical abuse (6%), stalking (4%), sexual harassment (6%) or sexual assault (0.1%). After controlling for other demographic variables, GPs with fewer years of experience (P = 0.003), or who worked full-time or in larger practices (both P = 0.03) experienced significantly more verbal abuse than their counterparts, and GPs who worked full-time (P = 0.004) or in metropolitan areas (P = 0.01) experienced significantly more property damage or theft. Female GPs experienced significantly more sexual harassment than male GPs (P < 0.001). This is the first national evidence of the prevalence of patient aggression toward GPs in Australia, which could inform the development of policies and guidelines that aim to reduce the prevalence of patient aggression toward GPs.
Publisher: Elsevier BV
Date: 08-2023
Publisher: Elsevier BV
Date: 04-2005
Publisher: Wiley
Date: 22-09-2016
Publisher: American Chemical Society (ACS)
Date: 27-04-2021
Publisher: Wiley
Date: 17-01-2019
Abstract: A synthesis of unconjugated (E)-enediynes from allenyl amino alcohols is reported and their gold-catalyzed cascade cycloaromatization to a broad range of enantioenriched substituted isoindolinones has been developed. Experimental and computational studies support the reaction proceeding via a dual-gold σ,π-activation mode, involving a key gold-vinylidene- and allenyl-gold-containing intermediate.
Publisher: Elsevier
Date: 2012
Publisher: Wiley
Date: 27-06-2011
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C4OB01786B
Abstract: The palladium( ii )-catalysed addition of arylboronic acids to vinylaziridines has been developed. This reaction proceeds via an insertion/ring-opening process to provide ( E )-allylsulfonamides. This stereoselectivity is complimentary to existing methods that typically proceed via an S N 2′ mechanism to yield ( Z )-allylic systems.
Publisher: Elsevier BV
Date: 11-2023
Publisher: Walter de Gruyter GmbH
Date: 2006
Abstract: An efficient synthesis of α-aminoallenylstannane from propargyloxazolidinone has been developed. It undergoes reaction with aldehydes to give homopropargylic alcohols with high syn selectivity. Epoxides undergo a similar reaction preceded by rearrangement to the aldehyde. These alcohols were used in the synthesis of β-amino acids, azasugars, and deoxyaminohexoses. Imines underwent reaction with this stannane to give 1,2-diamines. The related propargylborane reacts with aldehydes to produce allenyl carbinols. The Co 2 (CO) 6 complexes of propargyloxazolidinones were developed as an α-aminopropargyl cation equivalent.
Publisher: Royal Society of Chemistry (RSC)
Date: 1973
DOI: 10.1039/P29730001402
Publisher: Wiley
Date: 17-08-2023
Abstract: The crotylation reactions of chiral α‐F, α‐OBz and α‐OH aldehydes under Petasis‐borono‐Mannich conditions using ( E )‐ or ( Z )‐crotylboronates and primary amines resulted in γ‐addition products in high dr and high er. α‐F and α‐OBz aldehydes gave 1,2‐ anti ‐2,3‐ syn and 1,2‐ anti ‐2,3‐ anti , products, respectively while an α‐OH aldehyde gave 1,2‐ syn ‐2,3‐ syn products. The stereochemical outcomes of reactions of the former aldehydes can be explained using a six‐membered ring transition state (TS) model in which a Cornforth‐like conformation around the imine intermediate is favoured resulting in 1,2‐ anti products. The 2,3‐stereochemical outcome is dependent upon the geometry of the crotylboronate. These TS models were also supported by DFT calculations. The stereochemical outcomes of reactions employing an α‐OH aldehyde can be rationalised as occurring via an open‐TS involving H‐bonding in the imine intermediate between the α‐OH group and the imine N atom. Representative products were converted to highly functionalized 1,2,3,6‐tetrahydropyridines and 3 H ‐oxazolo[3,4‐ a ]pyridine‐3‐ones which will be valuable scaffolds in synthesis.
Publisher: American Chemical Society (ACS)
Date: 27-01-2021
Publisher: Elsevier BV
Date: 08-2013
DOI: 10.1016/J.EJMECH.2013.05.007
Abstract: A whole organism high-throughput screen of approximately 87,000 compounds against Trypanosoma brucei brucei led to the recent discovery of several novel compound classes with low micromolar activity against this organism and without appreciable cytotoxicity to mammalian cells. Herein we report a structure-activity relationship (SAR) investigation around one of these hit classes, the 3-(oxazolo[4,5-b]pyridin-2-yl)anilides. Sharp SAR is revealed, with our most active compound (5) exhibiting an IC₅₀ of 91 nM against the human pathogenic strain T.b. rhodesiense and being more than 700 times less toxic towards the L6 mammalian cell line. Physicochemical properties are attractive for many compounds in this series. For the most potent representatives, we show that solubility and metabolic stability are key parameters to target during future optimisation.
Publisher: American Association for Cancer Research (AACR)
Date: 06-2019
DOI: 10.1158/1940-6207.CAPR-18-0443
Abstract: In idualized screening is our logical next step to improve population breast cancer screening in Australia. To explore breast screening participants' views of the current program in Victoria, Australia, examine their openness to change, and attitudes toward an in idualized screening model, this qualitative work was performed from a population-based breast screening cohort. This work was designed to inform the development of a decision aid to facilitate women's decisions about participating in in idualized screening, and to elicit Australian consumer perspectives on the international movement toward in idualized breast screening. A total of 52 women participated in one of four focus groups, and were experienced with screening with 90% of participants having had more than three mammograms. Focus group discussion was facilitated following three main themes: (i) experience of breast screening (ii) breast cancer risk perception, and (iii) views on in idualized screening. Participants had strong, positive, emotional ties to breast screening in its current structure but were supportive, with some reservations, of the idea of in idualized screening. There was good understanding about the factors contributing to personalized risk and a wide range of opinions about the inclusion of genetic testing with genetic testing being considered a foreign and evolving domain. In idualized breast screening that takes account of risk factors such as mammographic density, lifestyle, and genetic factors would be acceptable to a population of women who are invested in the current system. The communication and implementation of a new program would be critical to its acceptance and potential success. Reservations may be had in regards to uptake of genetic testing, motivations behind the change, and management of the women allocated to a lower risk category.
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0MD00277A
Abstract: African sleeping sickness is a potentially fatal neglected disease affecting sub-Saharan Africa.
Publisher: Wiley
Date: 28-03-2013
Publisher: American Chemical Society (ACS)
Date: 14-06-2017
Abstract: The simultaneous control of diastereoselectivity and regioselectivity in Zn-catalyzed allenylation reactions of N-protected l-α-amino aldehydes is reported. A reversal in diastereoselectivity could be realized by variation of the α-amino aldehyde protecting groups. A range of 1-allenyl-2-amino alcohols were obtained with excellent regioselectivity and converted to oxazolidinones and dihydrofurans. Many of which could be isolated as single diastereoisomers and without significant erosion of ee, making this a practical catalytic synthesis of highly functionalized heterocycles.
Publisher: Wiley
Date: 09-09-2014
Publisher: American Chemical Society (ACS)
Date: 15-11-2021
DOI: 10.26434/CHEMRXIV-2021-N9HRB
Abstract: Density functional theory (DFT) is used in this work to predict the mechanism for constructing congested quaternary-quaternary carbon(sp3)–carbon(sp3) bonds in a pentanidium catalyzed substitution reaction. Computational mechanistic studies were carried out to investigate the proposed SN2X manifold, which consists of two primary elementary steps: halogen atom transfer (XAT) and subsequent SN2. For the first calculated model on original experimental substrates, XAT reaction barriers were more kinetically competitive than an SN2 pathway and connects to thermodynamically stable intermediates. Extensive computational screening-modelling were then done on various substrate combinations designed to study steric influence and to understand the mechanistic rationale, and calculations reveal that sterically congested substrates prefer the SN2X manifold over SN2. Different halides as leaving groups were also screened and it was found that the reactivity increases in order of Br Cl F in agreement of the strength of C–X bonds. However, DFT modelling suggests that chlorides can be a viable substrate for the SN2X process which should be further explored experimentally. Finally, ONIOM calculations on the full catalyst model were carried out to rationalize the stereoselectivity which corroborates with experimental results.
Publisher: Royal Society of Chemistry (RSC)
Date: 2002
DOI: 10.1039/C5OB02577J
Abstract: The in situ reduction of ferrocenyl cyclopropylimines to the corresponding amines triggers a facile oxidative ring-opening to yield the formal four-electron oxidation products: N -ferrocenylmethyl β-hydroxyamides.
Publisher: Elsevier
Date: 2014
Publisher: Springer Science and Business Media LLC
Date: 10-08-2019
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5MD00174A
Abstract: This review summarises recent developments in the search for novel organometallic drug compounds for the treatment of neglected tropical diseases.
Publisher: Wiley
Date: 11-12-2014
Publisher: Wiley
Date: 11-05-2010
DOI: 10.1002/AJMG.A.33385
Abstract: The communication of genetic information in families is an important process which can inform family members that they are at risk. However, evidence suggests that at-risk family members are often uninformed. Genetic health professionals have a role to assist consultands to communicate genetic information to their family members. Therefore, the aim of this study was to investigate genetic health professionals' practice with regard to the familial implications of a genetic diagnosis and subsequent family communication. An online survey resulted in 626 responses from genetic health professionals internationally. The results indicated that over 90% of genetic health professionals consistently counsel consultands about the familial implications of a genetic diagnosis during a consultation. Also there were no major differences in practice between clinical geneticists and genetic counselors. An average of 79% of genetic health professionals always send a summary letter to the consultand after a consultation. In contrast, 41% of genetic health professionals never write letters for at-risk family members. Other support is available to consultands after a consultation, but the availability of support relies on consultands and family members acting proactively and seeking out assistance from genetic health professionals for family communication. This may result in family members who are unaware that they are at risk of carrying and/or developing a genetic condition. This study is limited by the self-selection and self-reporting of the respondents' practice.
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7RA11711F
Abstract: A synthesis of thiourea-bridged mesoporous organosilica is reported.
Publisher: Elsevier
Date: 2013
Publisher: Elsevier
Date: 2011
Publisher: Springer Science and Business Media LLC
Date: 21-05-2008
Abstract: Genetic information may have health and reproductive implications for the proband and their family members. The responsibility for communicating this information within families generally lies with the proband or consultand. Previous research has explored the barriers and facilitators to communication, particularly in families affected with familial cancer syndromes. This study is an exploration of families' experiences, which aims to elucidate the process of communicating genetic information in families affected with non-cancer genetic conditions. The methodology involved 12 semi-structured interviews with probands, consultands and their family members. There were six different genetic conditions present in the families: adrenoleukodystrophy (n=3), cystic fibrosis (n=3), fragile X syndrome (n=1), haemochromatosis (n=1), balanced reciprocal chromosomal translocation (n=3) and Robertsonian chromosomal translocation (n=1). The results presented arise from two key themes, (1) the diagnosis and (2) post diagnosis. The interview data illustrate that the time of the diagnosis is a traumatic experience for families and that communication stimulated by this event revolves around informing family members about the diagnosis, but not warning them of their genetic risk. Post diagnosis, the collection of information about the genetic condition and continued communication to more distant family members, often using pre-existing family communication patterns, enables the continuation of communication about the genetic condition.
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1OB00836F
Abstract: By examining the various contributions to the conformational and stereogenic stability of medium-sized benzo-fused N-heterocyclic atropisomers, this review serves to aid the design, synthesis and study of these pharmaceutically relevant heterocycles.
Publisher: Wiley
Date: 27-02-2007
Publisher: Wiley
Date: 21-12-2019
Publisher: American Chemical Society (ACS)
Date: 04-01-2017
Publisher: American Chemical Society (ACS)
Date: 07-05-2015
Abstract: We report a highly efficient ring-opening reaction of vinylcyclopropanes by boronic acids in water, using palladium nanoparticles formed from Pd(OAc)2 under ligandless conditions. Unsubstituted vinylcyclopropanes provide linear addition products with high selectivity, while a switch in regioselectivity to branched products is observed for aryl-substituted vinylcyclopropanes.
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3OC90011H
Publisher: Elsevier
Date: 2021
Publisher: Wiley
Date: 22-11-2017
DOI: 10.1007/S10897-017-0162-Z
Abstract: Genome wide association studies have identified a number of common genetic variants - single nucleotide polymorphisms (SNPs) - that combine to increase breast cancer risk. SNP profiling may enhance the accuracy of risk assessment and provides a personalized risk estimate. SNP testing for breast cancer risks may supplement other genetic tests in the future, however, before it can be implemented in the clinic we need to know how it will be perceived and received. Semi-structured qualitative interviews were conducted with 39 women who had previously had a breast cancer diagnosis and undergone BRCA1/2 testing, participated in the Variants in Practice (ViP) study and received personalized risk (SNP) profiles. Interviews explored their understanding and experiences of receiving this SNP information. Women reported feeling positive about receiving their personalized risk profile, because it: provided an explanation for their previous diagnosis of cancer, vindicated previous risk management decisions and clarified their own and other family members' risks. A small group was initially shocked to learn of the increased risk of a second primary breast cancer. This study suggests that the provision of personalized risk information about breast cancer generated by SNP profiling is understood and well received. However, a model of genetic counseling that incorporates monogenic and polygenic genetic information will need to be developed prior to clinical implementation.
Publisher: Wiley
Date: 19-03-2015
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9SC03215K
Abstract: The first reported catalytic reactivity of 5-allenyloxazolidinones is the tightly controlled, ergent synthesis of chiral 1,3-dienes or 5-vinyloxazolidinones under Pd(0) catalysis.
Publisher: Royal Society of Chemistry (RSC)
Date: 1972
DOI: 10.1039/C39720000720
Publisher: Elsevier
Date: 2018
Publisher: American Chemical Society (ACS)
Date: 12-06-2019
DOI: 10.1021/ACS.ORGLETT.9B01580
Abstract: Aminobenzaldehydes bearing a pendant 3,5-dinitrophenyl group react thermally with N-substituted α-amino acids to form unprecedented benzoazepine-fused isoindolines. The reaction proceeds via a dearomatization/rearomatization sequence involving an intramolecular (3 + 2)-cycloaddition between the in situ formed azomethine ylide and the dinitroarene. Various glycine derivatives are tolerated as well as branched substrates based on cyclic, α-mono-, and α,α-disubstituted amino acids, giving single diastereomers in many cases. The method is scalable and gives products with a nitro group ready for further manipulation.
Publisher: Wiley
Date: 16-01-2014
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1SC03268B
Abstract: The Pd-catalysed asymmetric allylic alkylation (Pd-AAA) of prochiral enamide anions derived from 5 H -oxathiazole 2,2-dioxides has been developed.
Publisher: Elsevier
Date: 2020
Publisher: Elsevier BV
Date: 03-2014
DOI: 10.1038/GIM.2013.125
Abstract: Cystic fibrosis is the most common severe autosomal recessive disease, with a prevalence of 1 in 2,500-3,500 live births and a carrier frequency of 1 in 25 among Northern Europeans. Population-based carrier screening for cystic fibrosis has been possible since CFTR, the disease-causing gene, was identified in 1989. This review provides a systematic evaluation of the literature from the past 23 years on population-based carrier screening for cystic fibrosis, focusing on the following: uptake of testing how to offer screening attitudes, opinions, and knowledge factors influencing decision making and follow-up after screening. Recommendations are given for the implementation and evaluation of future carrier-screening programs.
Publisher: Elsevier BV
Date: 2012
DOI: 10.1038/GIM.2011.3
Abstract: The aim of this study was to investigate the uptake of genetic testing by at-risk family members for four genetic conditions: chromosomal translocations, fragile X syndrome, Huntington disease, and spinal muscular atrophy. A clinical audit was undertaken using genetics files from Genetic Health Services Victoria. Data were extracted from the files regarding the number of at-risk family members and the proportion tested. Information was also collected about whether discussion of at-risk family members and family communication during the genetic consultation was recorded. The proportion of at-risk family members who had genetic testing ranged from 11% to 18%. First-degree family members were most frequently tested and the proportion of testing decreased by degree of relatedness to the proband. Smaller families were significantly more likely to have genetic testing for all conditions except Huntington disease. Female at-risk family members were significantly more likely to have testing for fragile X syndrome. The majority of at-risk family members do not have genetic testing. Family communication is likely to influence the uptake of genetic testing by at-risk family members and therefore it is important that families are supported while communicating to ensure that at-risk family members are able to make informed decisions about genetic testing.
Publisher: Wiley
Date: 27-01-2022
Abstract: Diazo compounds have been largely used as carbene precursors for carbene transfer reactions in a variety of functionalization reactions. However, the ease of carbene generation from the corresponding diazo compounds depends upon the electron donating/withdrawing substituents either side of the diazo functionality. These groups strongly impact the ease of N 2 release. Recently, tris(pentafluorophenyl)borane [B(C 6 F 5 ) 3 ] has been shown to be an alternative transition metal‐free catalyst for carbene transfer reactions. Herein, a density functional theory (DFT) study on the generation of carbene species from α‐aryl α‐diazocarbonyl compounds using catalytic amounts of B(C 6 F 5 ) 3 is reported. The significant finding is that the efficiency of the catalyst depends directly on the nature of the substituents on both the aryl ring and the carbonyl group of the substrate. In some cases, the boron catalyst has negligible effect on the ease of the carbene formation, while in other cases there is a dramatic reduction in the activation energy of the reaction. This direct dependence is not commonly observed in catalysis and this finding opens the way for intelligent design of this and other similar catalytic reactions.
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0OB01568G
Abstract: Five-membered ring cyclic sulfamidate imines (5 H -1,2,3-oxathiazole 2,2-dioxides) have received increasing attention as useful precursors for the synthesis of many valuable heterocycles. This review highlights recent developments in this area.
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C6RP00244G
Abstract: Students can now digitally construct their own representations of scientific concepts using a variety of modes including writing, diagrams, 2-D and 3-D models, images or speech, all of which communicate meaning. In this study, final-year chemistry students studying a pharmacology subject created a “blended media” digital product as an assignment to summarize an independently prepared technical literature review on a current research topic in pharmacology for a non-expert audience. A blended media is a simplified way for students to combine a variety of modes to complement a narration to explain a concept to others. In this study, the students learned how to create a blended media during a one-hour workshop, and used the technique to create the representation as an assessment task. The research question that guided the study was, “What are the students’ perceptions of making a digital product such as blended media and how did these shape their multimodal awareness?” We draw from theoretical perspectives in multimodalities, representations and meaning making. Data included interviews at three points of the semester, the literature review and the digital media product. We present three case studies with volunteering students, who demonstrated a strong awareness of effective communications techniques as they attended to the audience. Making a blended media is a creative way for chemistry students to summarize complex scientific information and as a task may help to focus their multimodal awareness and developing communications skills.
Publisher: Springer Science and Business Media LLC
Date: 08-04-2019
Publisher: Springer Science and Business Media LLC
Date: 28-03-2007
Abstract: This article aims to review ethical and clinical guidelines and policies addressing the communication of genetic information in families. Websites of national and regional bioethics committees, national human genetics societies, international health organisations, genetic interest groups and legal recommendations committees were searched for guidelines and policies. The databases Medline, Web of Science and Google Scholar were also utilised to search for additional guidelines relating to the communication of genetic information in families. The guidelines and policies included in this review are limited to those available in English. The search resulted in guidelines from 18 international, regional and national organisations from six countries pertaining to family communication of genetic information. The following ideals were common in their guidelines: (1) in iduals have a moral obligation to communicate genetic information to their family members (2) genetic health professionals should encourage in iduals to communicate this information to their family members and (3) genetic health professionals should support in iduals throughout the communication process. The difference between the organisations' guidelines was the inclusion of information about the role of the health professional in supporting clients during the process of communicating genetic information to their family members. Only two recommendations suggested that the health professional should support their clients by identifying at-risk family members, but more guidelines recommended that directive counselling should be undertaken to encourage clients to communicate genetic information to their family members. In conclusion, the guidelines provide an overview of the role that genetic health professionals may undertake however, there are gaps that need to be addressed.
Publisher: Wiley
Date: 25-07-2013
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9CC06241F
Abstract: Cyclopropenylmethyl sulfonamides with tethered heteroaromatics can undergo ergent gold-catalysed cyclisation reactions based on the nature of the aromatic tether.
Publisher: Wiley
Date: 23-04-2015
Publisher: Wiley
Date: 23-06-2009
Publisher: American Chemical Society (ACS)
Date: 04-12-2017
Abstract: A trans-diastereoselective Pd-catalyzed dearomative [3 + 2] cycloaddition between vinylcyclopropane dicarboxylates and 3-nitroindoles has been developed. The reaction provides densely functionalized cyclopenta[b]indolines with versatile vinyl and nitro-groups. The addition of a halide additive was found to be critical for the diastereoselectivity of the reaction, which is proposed to be a result of a rapid π-σ-π interconversion between the intermediates allowing for Curtin-Hammett control. A switch in diastereoselectivity to afford products with the vinyl and nitro groups cis to each other is observed with a 4-substituted 3-nitroindole.
Publisher: American Chemical Society (ACS)
Date: 13-09-2013
DOI: 10.1021/JO401544E
Abstract: DFT calculations have been carried out in order to rationalize and predict the ring-opening regioselectivity of substituted cyclopropenes in the presence of gold(I) catalysts. It has been shown that the regioselectivity of these ring-opening processes is driven by the relative π-donor ability of the substituents on the cyclopropene double bond (C1 and C2). A stronger π-donor substituent at C2 favors Au(I)-induced polarization of the double bond toward C1, resulting in preferential breaking of the C1-C3 bond. An excellent correlation between ΔE(++) and the difference in the C1-C2 p(π) orbital population was observed for a broad range of substituents, providing a useful predictive model for gold-induced cyclopropene ring-opening. Furthermore, it was found that the stability of the resulting gold-stabilized allyl-cation intermediates do not follow the same trend as the ring-opening reaction energies. Generally, the more facile ring-opening process led to the less thermodynamically stable intermediate, which lacked stabilization of the carbocation by a π-donor in the α-position.
Publisher: Hindawi Limited
Date: 24-06-2019
DOI: 10.1111/ANE.13132
Abstract: Modifiable lifestyle factors are implicated in multiple sclerosis (MS) symptoms but their role in mood is unclear. This study aimed to investigate associations between lifestyle and depression and anxiety in Australian participants with MS. Self-reported data from the Australian Multiple Sclerosis Longitudinal Study included the Hospital Anxiety and Depression Scale (HADS) and lifestyle measurements from 1500 participants. SNAP score (range 0-5) was the sum of non-smoking, sufficient fruit/vegetable intake, non-hazardous alcohol consumption, sufficient physical activity and healthy BMI. Analyses by log-binomial and linear regression were adjusted for confounding. Symptoms of depression and anxiety were prevalent in 27% and 40%, respectively 20% had both. Mean SNAP score was 2.7/5 only 3% met all healthy lifestyle recommendations. Only 10% reported adequate fruit/vegetable intake, and 22% reported a combination of unhealthy BMI, inadequate physical activity and inadequate nutrition. A healthier SNAP score was associated with lower depression prevalence (adjusted prevalence ratio 0.83 [95% CI 0.75, 0.92] per unit increase) and depression severity (adjusted β-0.44 [95% CI -0.64, -0.24]), but not with anxiety. Modifiable lifestyle factors are associated with lower frequency and severity of depression, but not anxiety, in Australian people with multiple sclerosis. The associations between a healthier SNAP score and lower depression are likely bi-directional. SNAP risk factor prevalence and co-occurrence, especially inadequate nutrition and low physical activity, were high among Australians with MS.
Publisher: Georg Thieme Verlag KG
Date: 08-2006
Publisher: Wiley
Date: 11-10-2021
DOI: 10.1002/PON.5556
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C8CY02482K
Abstract: PR 3 AuOTf-Catalyzed hydrofunctionalisation of nonactivated alkenes using acetic acid and phenol was found to take place via a binuclear mechanism.
Publisher: Springer Science and Business Media LLC
Date: 08-08-2023
DOI: 10.1038/S41523-023-00569-4
Abstract: Internationally, population breast cancer screening is moving towards a risk-stratified approach and requires engagement and acceptance from current and future screening clients. A decision aid ( www.defineau.org ) was developed based on women’s views, values, and knowledge regarding risk-stratified breast cancer screening. This study aims to evaluate the impact of the decision aid on women’s knowledge, risk perception, acceptance of risk assessment and change of screening frequency, and decision-making. Here we report the results of a pre and post-survey in which women who are clients of BreastScreen Victoria were invited to complete an online questionnaire before and after viewing the decision aid. 3200 potential participants were invited, 242 responded with 127 participants completing both surveys. After reviewing the decision aid there was a significant change in knowledge, acceptance of risk-stratified breast cancer screening and of decreased frequency screening for lower risk. High levels of acceptance of risk stratification, genetic testing and broad support for tailored screening persisted pre and post review. The DEFINE decision aid has a positive impact on acceptance of lower frequency screening, a major barrier to the success of a risk-stratified program and may contribute to facilitating change to the population breast screening program in Australia.
Publisher: Wiley
Date: 03-02-2019
DOI: 10.1111/JNC.14655
Publisher: MDPI AG
Date: 07-07-2022
DOI: 10.3390/JPM12071112
Abstract: Background Research identifying and returning clinically actionable germline variants offer a new avenue of access to genetic information. The psychosocial and clinical outcomes for women who have received this ‘genome-first care’ delivering hereditary breast and ovarian cancer risk information outside of clinical genetics services are unknown. Methods: An exploratory sequential mixed-methods case-control study compared outcomes between women who did (cases group 1) and did not (controls group 2) receive clinically actionable genetic information from a research cohort in Victoria, Australia. Participants completed an online survey examining cancer risk perception and worry, and group 1 also completed distress and adaptation measures. Group 1 participants subsequently completed a semi structured interview. Results: Forty-five participants (group 1) and 96 (group 2) completed the online survey, and 31 group 1 participants were interviewed. There were no demographic differences between groups 1 and 2, although more of group 1 participants had children (p = 0.03). Group 1 reported significantly higher breast cancer risk perception (p 0.001) compared to group 2, and higher cancer worry than group 2 (p 0.001). Some group 1 participants described how receiving their genetic information heightened their cancer risk perception and exacerbated their cancer worry while waiting for risk-reducing surgery. Group 1 participants reported a MICRA mean score of 27.4 (SD 11.8, range 9–56 possible range 0–95), and an adaptation score of 2.9 (SD = 1.1). Conclusion: There were no adverse psychological outcomes amongst women who received clinically actionable germline information through a model of ‘genome-first’ care compared to those who did not. These findings support the return of clinically actionable research results to research participants.
Publisher: Springer Science and Business Media LLC
Date: 06-02-2014
Publisher: American Chemical Society (ACS)
Date: 19-06-2019
Publisher: Wiley
Date: 28-07-2011
Publisher: Mary Ann Liebert Inc
Date: 10-2018
Abstract: Li-Fraumeni syndrome (LFS), a multiorgan cancer predisposition caused by germline TP53 mutations, confers significant cancer risks for young people (15-39 years). Yet evidence of how in iduals experience this condition and the psychosocial implications are lacking. Therefore, this systematic review assessed the psychosocial implications of living with, or at risk of, an autosomal dominant condition as a young person, to draw evidence that may be analogous for young people with LFS. We conducted a systematic search for studies published in peer-reviewed journals using Medline, CINAHL, PsycINFO, and Embase databases. Findings were synthesized and are reported thematically. We screened 352 articles and identified 39 studies, representing the perspectives of 765 young people. Most studies addressed hereditary breast and ovarian cancer (n = 22) and used qualitative methodologies (n = 35). Only one LFS study was identified, highlighting the distinct lack of psychosocial research describing experiences of young people with LFS. Translatable evidence showed that familial factors strongly influenced young people's experiences of genetic testing and their mutation status. Major adverse reactions to genetic test results were rare, although young people with a gene mutation experienced various psychosocial concerns at key developmental milestones, including family planning, developing romantic relationships, and making risk management decisions. Young people undergoing genetic testing for inherited disease require in idualized support and recognition of previous lived experiences. We recommend that longitudinal care be made available to young people with inherited disease as they reach developmental milestones that intersect with risk management, risk perception, and family formation.
Publisher: University of Toronto Press Inc. (UTPress)
Date: 09-2017
DOI: 10.3138/IJCS.56.2017-0004
Abstract: In this article, I examine how a select group of English-Canadian social science, humanities, and law academics made significant contributions to Canadian foreign policy and diplomacy during the Second World War. Leaving the confines of their universities to work in wartime Ottawa through a formal secondment process, an influential and yet heretofore unrecognized group of seconded academics became key administrators and diplomats working on behalf of the Canadian state in the sphere of external affairs. Aiding a federal civil service short on administrative talent, seconded academics staffed crucially important posts in the Department of External Affairs, Department of Finance, Wartime Prices and Trade Board, and Wartime Information Board. Although permanent officials handled most issues regarded as first rank, the academics analyzed in this article did the heavy lifting in the committees and preparatory deskwork, making strong contributions to those issues of second rank, including the formulation and refinement of Canadian foreign policy. Academics also became both official and unofficial diplomats representing the nation in erse international fora. During the Second World War, the federal civil service did not have enough personnel to handle all the representational duties, and academics stepped in to fill an important void. Through their work in the international sphere, academics actively sought to forge a new Canadian identity and facilitate a process whereby Canada became less overtly British and more sovereign and independent.
Publisher: American Chemical Society (ACS)
Date: 10-04-2023
Publisher: Wiley
Date: 02-2022
Abstract: Thermally induced cycloisomerization reactions of 1,6‐allenynes gives α‐methylene‐γ‐lactams via intramolecular Alder‐ene reactions. The mechanism is supported by computational and deuterium labelling studies. This thermal, non‐radical method enables the discovery of a hitherto unknown route that proceeds via a ergent mechanism distinct from the previous [2+2] cycloisomerization manifold.
Publisher: American Chemical Society (ACS)
Date: 28-09-2010
DOI: 10.1021/OL101862U
Abstract: Cyclopropenylmethyl acetates have been shown to undergo rapid and stereoselective gold catalyzed rearrangement to Z-acetoxydienes in high yield. DFT calculations have shown that while several reaction pathways can be envisaged only a single, ring-opening one operates.
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0SC04390G
Abstract: Room temperature Rh-catalysed tetradehydro-Diels–Alder reaction via an unusual Rh-stabilised allene.
Publisher: American Chemical Society (ACS)
Date: 10-09-2005
DOI: 10.1021/JO051385C
Abstract: Propargylic boranes generated by lithiation of optically active N-propargyloxazolidinones undergo reaction with a range of aldehydes to produce gamma,gamma-disubstituted allenamides with good diastereoselectivity.
Publisher: Royal Society of Chemistry (RSC)
Date: 1973
DOI: 10.1039/P29730000223
Publisher: Wiley
Date: 12-12-2006
Publisher: Wiley
Date: 28-02-2006
Publisher: Royal Society of Chemistry (RSC)
Date: 2005
DOI: 10.1039/B504731E
Abstract: A novel route to the synthesis of 3-(tolylsulfonyl)-4,5-cis-disubstituted gamma-lactams using a diastereoselective palladium-catalysed intramolecular allylation of amino acid-derived allylic carbonates has been developed.
Publisher: American Chemical Society (ACS)
Date: 04-03-2022
Abstract: Density functional theory (DFT) is used in this work to predict the mechanism for constructing congested quaternary-quaternary carbon(sp
Publisher: Elsevier
Date: 2015
Publisher: American Chemical Society (ACS)
Date: 29-09-2006
DOI: 10.1021/JO061340R
Abstract: Chiral gamma-substituted allenamides have been shown to undergo efficient gold-catalyzed and N-iodosuccinimide-mediated cyclization to highly functionalized dihydrofurans. These reactions proceed rapidly and without loss of stereochemistry.
Publisher: Springer Science and Business Media LLC
Date: 17-10-2022
DOI: 10.1038/S41431-022-01200-Z
Abstract: Interventions to assist family communication about inherited cancer risk have the potential to improve family cancer outcomes. This review aimed to evaluate the efficacy of proband-mediated interventions employed within genetics clinics to increase disclosure of genetic risk to at-risk relatives. MEDLINE, Embase, CINAHL, PubMed and PsycINFO were searched for publications between 1990–2020. The quality of studies was assessed. From 5605 records reviewed, 9 studies (4 randomised control trials and 5 cohort studies) were included involving families with BRCA1, BRCA2 and Lynch syndrome. Intervention delivery modes included genetic counselling with additional telephone or in-person follow-up, letters, videos, and decision aids. The percentages of at-risk relatives informed by the proband about their risk ranged from 54.0% to 95.5% in the intervention or family-mediated comparison group. Of those who were informed, 24.4–60.0% contacted a genetics clinic and 22.8–76.2% had genetic testing after they were counselled at a genetics clinic . Significant differences between intervention and control group were reported on all three outcomes by one study, and with relatives contacting a genetics clinic by another study. The studies suggest but do not conclusively show, that tailored genetic counselling with additional follow-up can increase both the proportion of informed relatives and relatives who contact the genetics clinic. With the increase in germline testing, interventions are required to consider the family communication process and address post-disclosure variables (e.g., relative’s perceptions, emotional reactions) through engagement with probands and relatives to maximise the public health benefit of identifying inherited cancer risk in families.
Publisher: Georg Thieme Verlag KG
Date: 20-03-2020
Abstract: A diastereoselective palladium-catalyzed dearomative formal (4+2) cycloaddition between vinyl benzoxazinanones and 3-nitroindoles has been developed. This reaction provides a concise route to tetrahydro-5H-indolo[2,3-b]quinolines in excellent yield (up to 94%) and diastereoselectivity (up to :2), with versatile functional handles including vinyl, nitro, and free NH groups.
Publisher: Springer Science and Business Media LLC
Date: 19-09-2014
Publisher: American Chemical Society (ACS)
Date: 07-02-2012
DOI: 10.1021/OM2008106
Publisher: Springer Science and Business Media LLC
Date: 14-05-2015
DOI: 10.1038/EJHG.2014.86
Publisher: Research Square Platform LLC
Date: 30-11-2022
DOI: 10.21203/RS.3.RS-2258886/V1
Abstract: Background: Internationally, population breast cancer screening is moving towards a risk-stratified approach and requires engagement and acceptance from current and future screening clients. A decision aid (www.defineau.org) was developed based on women’s views, values, and knowledge regarding risk-stratified breast cancer screening. This study aims to evaluate the impact of the decision aid on women’s knowledge, risk perception, acceptance of risk assessment and change of screening frequency, and decision-making. Methods: Women who are clients of BreastScreen Victoria were invited to complete an online questionnaire before and after viewing the decision aid. Results: 3200 potential participants were invited, 242 responded with 127 participants completing both surveys. After reviewing the decision aid there was a significant change in knowledge, acceptance of risk stratified breast cancer screening and of decreased frequency screening for lower risk. High levels of acceptance of risk stratification, genetic testing and broad support for tailored screening persisted pre and post review. Conclusions: The DEFINE decision aid had a positive impact on accepting lower frequency screening, a major barrier to the success of a risk-stratified program and may contribute to facilitating change to the population breast screening program in Australia.
Publisher: American Chemical Society (ACS)
Date: 17-06-2022
Publisher: CSIRO Publishing
Date: 2018
DOI: 10.1071/CH18197
Abstract: Herein we report the formation of pyrrolines and tetrahydropyridines from the cyclisation reactions of β-amino allenes by both AuI and AgI catalysts in yields ranging from 5 to 70 %. AuI catalysts favour a 5-endo-dig cyclisation before rapid rearrangement to the 5-exo-dig product, while AgI favours a 6-endo-trig cyclisation. We also report the first known Ag2O catalysed cyclisation reaction of an allene which occurred in good yield (61 %).
Publisher: Informa UK Limited
Date: 12-08-2023
DOI: 10.1080/07347332.2022.2104676
Abstract: This study explored the experiences of young people with hereditary diffuse gastric cancer (HDGC), an inherited cancer predisposition syndrome, as they navigate becoming and being a parent. We used interpretive description and conducted semi-structured interviews with 13 young Australians (18-39 years) with a Participants' reproductive decisions centered on the perceived manageability of HDGC, namely via gastrectomy, and timing of their genetic testing. Participants yet to have children and those with challenging gastrectomy experiences favored using reproductive technologies to prevent passing on their PV. Parents who had children before genetic testing described complicated decisions about having more children. Gastrectomy was considered a parental responsibility but recovery diminished parenting abilities. Young people with HDGC face unique challenges navigating reproductive decision-making and parenting with gastrectomy. Findings lend credence to calls for longitudinal, developmentally sensitive genetic counseling services.
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D3SC01510F
Abstract: Formation of valuable spiroheterocycles with multiple contiguous stereogenic centres from palladium-catalysed enantioselective (3 + 2) cycloaddition reactions of sulfamidate-derived azadienes and vinylcyclopropanes.
Publisher: Future Medicine Ltd
Date: 2018
Abstract: Aim: To compare Australian and French perceptions of genetics and preferences regarding the return of incidental findings. Methods: Participants from the International Sarcoma Kindred Study received a survey at intake to cancer referral units. A total of 1442 Australian and 479 French in iduals affected by sarcoma and their unaffected family members responded to four hypothetical scenarios depicting hereditary conditions of varying treatability and severity. Results: Australians’ preference for the return of incidental findings was consistently higher than French for all scenarios. Country group differences were significant for two scenarios when in idual characteristics were controlled through multivariable analyses. Conclusion: Findings support the need for guidelines that are sensitive to sociocultural context and promote autonomous decision-making.
Publisher: Wiley
Date: 10-04-2019
DOI: 10.1002/JGC4.1110
Abstract: The practice of recontacting patients to provide new health information is becoming increasingly common in clinical genetics, despite the limited research to evidence the patient experience. We explored how men with Lynch Syndrome (LS) understand and experience being recontacted about a potential increased risk of prostate cancer. Sixteen men with LS (Meanage 51 years) were recruited from an Australian screening study to undergo a semi-structured interview. A modified grounded theory approach was used to guide data collection and thematic analysis. Qualitative coding was shared by the research team to triangulate analysis. The practice of recontact was viewed by participants as acceptable and was associated with minimal emotional distress. The majority of men understood that they may be above population risk of prostate cancer, although evidence was still emerging. Men reported high engagement with personal and familial health, including regular screening practices and familial risk communication. Findings suggest that men's carrier status and beliefs about the actionability of the new cancer risk information influence their response to recontact. Recontact practices that include the offer of risk management strategies may lead to improved patient outcomes (e.g., reduced cancer worry and increased health engagement), if perceived as valuable by recipients.
Publisher: Wiley
Date: 23-12-2019
DOI: 10.1002/JGC4.1199
Abstract: Li-Fraumeni syndrome (LFS), a rare cancer syndrome caused by pathogenic germline variants in TP53, has serious implications for adolescents and young adults (AYAs aged 15-39 years). The early-onset and multi-organ cancer risk associated with LFS means health professionals must concurrently contend with the developmental needs of in iduals who are diagnosed from a young age, and recent changes in practice due to advances in whole-body cancer surveillance. To help understand how current practice meets the developmental needs of AYAs with, or at risk of, LFS, we conducted a national online survey to explore the experiences of health professionals who care for this population in Australia and New Zealand. Forty-three respondents completed the survey (56% genetic counselors), one-third of whom had facilitated predictive TP53 testing for minors (n = 14/43, 33%). In hypothetical scenarios describing 15-year-olds eligible for predictive TP53 testing, respondents were more supportive of testing for emotionally mature compared to immature minors (p = .009) and more supportive of adolescent wishes compared to parental wishes for testing (p = .020) when families held discordant views on testing. Genetic health professionals were more likely than oncology health professionals to address psychological (p = .017) and information needs about reproductive options for LFS during consultations than to refer them on (p = .004). All respondents supported comprehensive risk management for LFS, but noted important medical, logistical, and psychosocial limitations for AYAs. This study offers valuable insight into developmentally appropriate practices of Australasian health professionals who care for AYAs with, or at risk of, LFS. These findings suggest they may foster the autonomy of minors undergoing predictive TP53 genetic testing and be supportive of new whole-body risk management guidelines.
Publisher: Royal Society of Chemistry (RSC)
Date: 2009
DOI: 10.1039/B815971H
Abstract: The highly regioselective, stereospecific ring-opening of trisubstituted N-tosylaziridines possessing vinyl and hydroxymethyl groups by sulfone- and sulfide-stablised carbanions is reported.
Publisher: CSIRO Publishing
Date: 2018
DOI: 10.1071/CH18196
Abstract: A study of the reactivity of a non-stabilised azomethine ylide, derived from N-(methoxymethyl)-N-(trimethylsilylmethyl)benzylamine, with nitro-substituted isatoic anhydrides was undertaken. N-Methyl-4-nitroisatoic anhydride underwent a 1,3-dipolar cycloaddition reaction exclusively at the isatoic anhydride C1-carbonyl group, followed by decarboxylative rearrangement to yield a benzo-1,3-diazepin-5-one derivative. In contrast, N-methyl-5-nitroisatoic anhydride underwent competing cycloaddition processes to the isatoic anhydride C1-carbonyl group and to the nitro-substituted aromatic ring. The dearomative addition reaction resulted in the formation of novel tetracyclic products.
Publisher: Springer Science and Business Media LLC
Date: 06-05-2021
Location: United Kingdom of Great Britain and Northern Ireland
Start Date: 2018
End Date: 12-2023
Amount: $357,072.00
Funder: Australian Research Council
View Funded ActivityStart Date: 06-2018
End Date: 06-2024
Amount: $381,855.00
Funder: Australian Research Council
View Funded Activity