ORCID Profile
0000-0002-7319-9570
Current Organisation
Zhejiang University
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Publisher: Wiley
Date: 21-06-2018
Publisher: American Chemical Society (ACS)
Date: 12-02-2020
Publisher: American Chemical Society (ACS)
Date: 03-01-2019
Publisher: Springer Science and Business Media LLC
Date: 10-11-2021
DOI: 10.1038/S41467-021-26417-2
Abstract: During the past two decades, aggregation-induced emission luminogens (AIEgens) have been intensively exploited for biological and biomedical applications. Although a series of investigations have been performed in non-primate animal models, there is few pilot studies in non-human primate animal models, strongly hindering the clinical translation of AIE luminogens (AIEgens). Herein, we present a systemic and multifaceted demonstration of an optical imaging-guided surgical operation via AIEgens from small animals (e.g., mice and rabbits) to rhesus macaque, the typical non-human primate animal model. Specifically, the folic conjugated-AIE luminogen (folic-AIEgen) generates strong and stable fluorescence for the detection and surgical excision of sentinel lymph nodes (SLNs). Moreover, with the superior tumor/normal tissue ratio and rapid tumor accumulation, folic-AIEgen successfully images and guides the precise resection of invisible cancerous metastases. Taken together, the presented strategies of folic-AIEgen based fluorescence intraoperative imaging and visualization-guided surgery show potential for clinical applications.
Publisher: Wiley
Date: 12-08-2020
Publisher: Elsevier BV
Date: 03-2020
Publisher: Wiley
Date: 18-01-2021
No related grants have been discovered for Min Zhou.