ORCID Profile
0000-0002-8389-8500
Current Organisation
Hong Kong University of Science and Technology
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Publisher: Wiley
Date: 22-08-2018
Abstract: Fluorescence-imaging-guided photodynamic therapy has emerged as a promising protocol for cancer theranostics. However, facile preparation of such a theranostic material for simultaneously achieving bright emission with long wavelength, high-performance reactive oxygen species (ROS) generation, and good targeting-specificity of cancer cells, is highly desirable but remains challenging. In this study, a novel type of far-red/near-infrared-emissive fluorescent molecules with aggregation-induced emission (AIE) characteristics is synthesized through a few steps reaction. These AIE luminogens (AIEgens) possess simple structures, excellent photostabilities, large Stokes shifts, bright emission, and good biocompatibilities. Meanwhile, their ROS generation is extremely efficient with up to 90.7% of ROS quantum yield, which is far superior to that of some popularly used photosensitizers. Importantly, these AIEgens are able to selectively target and ablate cancer cells over normal cells without the aid of any extra targeting ligands. Rather than using laser light, one of the presented AIEgens (MeTTPy) shows a remarkable tumor-targeting photodynamic therapeutic effect by using an ultralow-power l light (18 mW cm
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9TB02848J
Abstract: A lipid-droplet-specific AIEgen was used to evaluate the inhibitory efficacy of HIF-1-targeting drugs by assessing lipid-droplet levels.
Publisher: American Chemical Society (ACS)
Date: 28-12-2018
DOI: 10.1021/ACS.ANALCHEM.8B04736
Abstract: Facile, efficient, and mass production of aggregation-induced emission (AIE) luminogens (AIEgens) with excited-state intramolecular proton transfer (ESIPT) characteristics was achieved by a one-step condensation reaction of 2-(hydrazonomethyl)phenol with benzaldehydes. The function of as-prepared AIEgens could be tuned easily by varying the functional group being carried on the phenyl ring of benzaldehyde just like a Swiss knife handle. The suitable distance and angle of the intramolecular hydrogen bond in these AIEgens endowed them with ESIPT properties, intense solid-state luminescence, and large Stokes shifts (155-169 nm). These AIEgens could not only serve as biological probes showing specific targeting to lipid droplets, endoplasmic reticulum, and lysosomes, respectively, but also generate reactive oxygen species upon visible light irradiation to make them promise for photodynamic therapy.
Publisher: Elsevier BV
Date: 03-2022
Publisher: American Chemical Society (ACS)
Date: 20-07-2020
Publisher: Wiley
Date: 24-03-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9QM00242A
Abstract: Berberine chloride, an AIE-active natural product, can be utilized as a highly efficient theranostic agent for cancer and bacteria.
Publisher: Wiley
Date: 11-10-2017
Publisher: Wiley
Date: 20-03-2019
Abstract: The efficient utilization of energy dissipating from non-radiative excited-state decay of fluorophores was only rarely reported. Herein, we demonstrate how to boost the energy generation of non-radiative decay and use it for cancer theranostics. A novel compound (TFM) was synthesized which possesses a rotor-like twisted structure, strong absorption in the far red/near-infrared region, and it shows aggregation-induced emission (AIE). Molecular dynamics simulations reveal that the TFM aggregate is in an amorphous form consisting of disordered molecules in a loose packing state, which allows efficient intramolecular motions, and consequently elevates energy dissipation from the pathway of thermal deactivation. These intrinsic features enable TFM nanoparticles (NPs) to display a high photothermal conversion efficiency (51.2 %), an excellent photoacoustic (PA) effect, and effective reactive oxygen species (ROS) generation. In vivo evaluation shows that the TFM NPs are excellent candidates for PA imaging-guided phototherapy.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C7SC04963C
Abstract: The first water-soluble NIR AIEgen was synthesized and used for ultrafast wash-free cellular imaging and photodynamic cancer cell ablation.
Publisher: Wiley
Date: 20-03-2019
Publisher: American Chemical Society (ACS)
Date: 18-06-2020
Publisher: Wiley
Date: 29-11-2018
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C8SC05805A
Abstract: Facile synthesis and bio-applications of a series of AIEgens with widely tunable emissions ranging from violet to near-infrared are reported.
No related grants have been discovered for Mei Suet Lee.