ORCID Profile
0000-0003-3583-0584
Current Organisations
Hong Kong University of Science and Technology
,
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
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Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6PY00882H
Abstract: Protein–polymer conjugates are prepared via host–guest interactions and the effects of various parameters on protein activity are investigated.
Publisher: Wiley
Date: 06-04-2020
Publisher: American Chemical Society (ACS)
Date: 12-11-2019
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9TB02848J
Abstract: A lipid-droplet-specific AIEgen was used to evaluate the inhibitory efficacy of HIF-1-targeting drugs by assessing lipid-droplet levels.
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0SC00062K
Abstract: Fast surface immobilization of native bioconjugates through a spontaneous amino-yne click reaction is realized.
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7SC01054K
Abstract: For the first time, an AIEgen-conjugated monoclonal antibody is designed for “turn-on” and “wash-free” imaging of EGFR-overexpressed cancer cells.
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C4MH00081A
Abstract: Thermoresponsive poly(NIPAAm- co -Ada) surfaces integrated with host–guest interactions were used as a platform for fabricating reusable and tunable molecular recognition surfaces.
Publisher: American Chemical Society (ACS)
Date: 06-11-2013
DOI: 10.1021/LA4037748
Abstract: Surface-initiated SET-LRP was used to synthesize polymer brush containing N-isopropylacrylamide and adamantyl acrylate using Cu(I)Cl/Me6-TREN as precursor catalyst and isopropanol/H2O as solvent. Different reaction conditions were explored to investigate the influence of different parameters (reaction time, catalyst concentration, monomer concentration) on the polymerization. Copolymers with variable 1-adamantan-1-ylmethyl acrylate (Ada) content and comparable thickness were synthesized onto silicon surfaces. Furthermore, the hydrophilic and bioactive molecule β-cyclodextrin-(mannose)7 (CDm) was synthesized and complexed with adamantane via host-guest interaction. The effect of adamantane alone and the effect of CDm together with adamantane on the wettability and thermoresponsive property of surface were investigated in detail. Experimental and molecular structure analysis showed that Ada at certain content together with CDm has the greatest impact on surface wettability. When Ada content was high (20%), copolymer-CDm surfaces showed almost no CDm complexed with Ada as the result of steric hindrance.
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9SC06226B
Abstract: An AIE-active ratiometric probe for the first time achieved the long-term quantification of lysosomal pH during the medaka larva's caudal fin regeneration.
Publisher: Wiley
Date: 23-06-2014
Publisher: Wiley
Date: 02-11-2022
Abstract: Due to the fast dynamics and re‐equilibration of supramolecular self‐assembly, bottom‐up molecular strategies to fabricate well‐defined and controllable multiblock structures are rare. Herein, we propose a new concept for fabrication of fluorescent multiblock microcolumns containing 1 to 7 blocks via hierarchical supramolecular self‐assembly based on cucurbit[8]uril (CB[8]), NaBr and an AIEgen guest. Through the complexation between CB[8] and different numbers of AIEgen guests (2, 1, 0), the competitive displacement caused by the binding of the sodium cation to the CB[8] portal, and the reversible assembly of positively charged guests in salt solutions, one‐pot hierarchical supramolecular self‐assembly is realized. The molecular structure of each block is analyzed by single‐crystal X‐ray diffraction. The AIEgen enables the self‐assembly of multiblocks to be visualized, understood, and regulated.
Publisher: American Chemical Society (ACS)
Date: 22-08-2019
DOI: 10.1021/JACS.9B06196
Abstract: Acrylonitriles with aggregation-induced emission (AIE) characteristics have been found to show promising applications in two-photon biomedical imaging. Generally, elaborate synthetic efforts are required to achieve different acrylonitriles with distinct functionalities. In this work, we first reported the synthesis of two different group-functionalized AIE-active acrylonitriles (TPAT-AN-XF and 2TPAT-AN) obtained simply by mixing the same reactants at different temperatures using a facile and transition metal-free synthetic method. These two AIE luminogens (AIEgens) exhibit unique properties such as bright red emission in the solid state, large Stokes shift, and large two-photon absorption cross section. Water-soluble nanoparticles (NPs) of 2TPAT-AN were prepared by a nanoprecipitation method. In vitro imaging data show that 2TPAT-AN NPs can selectively stain lysosome in live cells. Besides one-photon imaging, remarkable two-photon imaging of live tumor tissues can be achieved with high resolution and deep tissue penetration. 2TPAT-AN NPs show high biocompatibility and are successfully utilized in in vivo long-term imaging of mouse tumors with a high signal-to-noise ratio. Thus, the present work is anticipated to shed light on the preparation of a library of AIE-active functionalized acrylonitriles with intriguing properties for biomedical applications.
Publisher: Wiley
Date: 02-11-2022
Abstract: Due to the fast dynamics and re‐equilibration of supramolecular self‐assembly, bottom‐up molecular strategies to fabricate well‐defined and controllable multiblock structures are rare. Herein, we propose a new concept for fabrication of fluorescent multiblock microcolumns containing 1 to 7 blocks via hierarchical supramolecular self‐assembly based on cucurbit[8]uril (CB[8]), NaBr and an AIEgen guest. Through the complexation between CB[8] and different numbers of AIEgen guests (2, 1, 0), the competitive displacement caused by the binding of the sodium cation to the CB[8] portal, and the reversible assembly of positively charged guests in salt solutions, one‐pot hierarchical supramolecular self‐assembly is realized. The molecular structure of each block is analyzed by single‐crystal X‐ray diffraction. The AIEgen enables the self‐assembly of multiblocks to be visualized, understood, and regulated.
Location: China
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Xiujuan Shi.