ORCID Profile
0000-0002-6021-1462
Current Organisations
Peking Union Medical College Hospital
,
China International Exchange and Promotive Association for Medical and Health Care
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Publications
Effects of infrapatellar fat pad preservation versus resection on clinical outcomes after total knee arthroplasty in patients with knee osteoarthritis (IPAKA): study protocol for a multicentre, random
Publisher: BMJ
Date: 10-2020
DOI: 10.1136/BMJOPEN-2020-043088
Abstract: The infrapatellar fat pad (IPFP) is commonly resected during total knee arthroplasty (TKA) for better exposure. However, our previous studies have suggested that IPFP size was protective against, while IPFP signal intensity alteration was detrimental on knee symptoms and structural abnormalities. We hypothesise that an IPFP with normal qualities, rather than abnormal qualities, should be preserved during TKA. The aim of this study is to compare, over a 1-year period, the postoperative clinical outcomes of IPFP preservation versus resection after TKA in patients with normal or abnormal IPFP signal intensity alteration on MRI. Three hundred and sixty people with end-stage knee osteoarthritis and on the waiting list for TKA will be recruited and identified as normal IPFP quality (signal intensity alteration score ≤1) or abnormal IPFP quality (signal intensity alteration score ≥2). Patients in each hospital will then be randomly allocated to IPFP resection group or preservation group. The primary outcomes are the summed score of self-reported Knee Injury and Osteoarthritis Outcome Score (KOOS), KOOS subscales assessing function in daily activities and function in sport and recreation. Secondary endpoints will be included: KOOS subscales (pain, symptoms and quality of life), Knee Society Score, 100 mm Visual Analogue Scale (VAS) Pain, timed up-and-go test, patellar tendon shortening, 100 mm VAS self-reported efficacy of reduced pain and increased quality of life, and Insall-Salvati index assessed on plain X-ray. Adverse events will be recorded. Intention-to-treat analyses will be used. The study is approved by the local Medical Ethics Committee (Zhujiang Hospital Ethics Committee, reference number 2017-GJGBK-001) and will be conducted according to the principle of the Declaration of Helsinki (64th, 2013) and the Good Clinical Practice standard, and in compliance with the Medical Research Involving Human Subjects Act . Data will be published in peer-reviewed journals and presented at conferences, both nationally and internationally. This trial was registered at Clinicaltrial.gov website on 19 October 2018 with identify number NCT03763448 .
A bioactive polymethylmethacrylate bone cement for prosthesis fixation in osteoporotic hip replacement surgery
Publisher: Elsevier BV
Date: 11-2021
TBX6 Null Variants and a Common Hypomorphic Allele in Congenital Scoliosis
Publisher: Massachusetts Medical Society
Date: 22-01-2015
TBX6-associated congenital scoliosis (TACS) as a clinically distinguishable subtype of congenital scoliosis: further evidence supporting the compound inheritance and TBX6 gene dosage model
Publisher: Elsevier BV
Date: 07-2019
Leptin Activates RhoA/ROCK Pathway to Induce Cytoskeleton Remodeling in Nucleus Pulposus Cells
Publisher: MDPI AG
Date: 16-01-2014
DOI: 10.3390/IJMS15011176
Related Organisations
China International Exchange And Promotive Association For Medical And Health Care
Location: China
Related Funding Activities
No related grants have been discovered for Xisheng Weng.