ORCID Profile
0000-0003-2538-6934
Current Organisation
University of Nottingham
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Publisher: Wiley
Date: 18-12-2022
Abstract: Wound healing is a complex biological process involving close crosstalk between various cell types. Dysregulation in any of these processes, such as in diabetic wounds, results in chronic nonhealing wounds. Fibroblasts are a critical cell type involved in the formation of granulation tissue, essential for effective wound healing. 315 different polymer surfaces are screened to identify candidates which actively drive fibroblasts toward either pro‐ or antiproliferative functional phenotypes. Fibroblast‐instructive chemistries are identified, which are synthesized into surfactants to fabricate easy to administer microparticles for direct application to diabetic wounds. The pro‐proliferative microfluidic derived particles are able to successfully promote neovascularization, granulation tissue formation, and wound closure after a single application to the wound bed. These active novel bio‐instructive microparticles show great potential as a route to reducing the burden of chronic wounds.
Publisher: American Chemical Society (ACS)
Date: 20-06-2019
Abstract: Surface-functionalized microparticles are relevant to fields spanning engineering and biomedicine, with uses ranging from cell culture to advanced cell delivery. Varying topographies of biomaterial surfaces are also being investigated as mediators of cell-material interactions and subsequent cell fate. To investigate competing or synergistic effects of chemistry and topography in three-dimensional cell cultures, methods are required to introduce these onto microparticles without modification of their underlying morphology or bulk properties. In this study, a new approach for surface functionalization of poly(lactic acid) (PLA) microparticles is reported that allows decoration of the outer shell of the polyesters with additional polymers via aqueous atom transfer radical polymerization routes. PLA microparticles with smooth or dimpled surfaces were functionalized with poly(poly(ethylene glycol) methacrylate) and poly[
Publisher: American Chemical Society (ACS)
Date: 31-08-2021
Abstract: We report the first successful combination of three distinct high-throughput techniques to deliver the accelerated design, synthesis, and property screening of a library of novel, bio-instructive, polymeric, comb-graft surfactants. These three-dimensional, surface-active materials were successfully used to control the surface properties of particles by forming a unimolecular deep layer on the surface of the particles via microfluidic processing. This strategy deliberately utilizes the surfactant to both create the stable particles and deliver a desired cell-instructive behavior. Therefore, these specifically designed, highly functional surfactants are critical to promoting a desired cell response. This library contained surfactants constructed from 20 molecularly distinct (meth)acrylic monomers, which had been pre-identified by HT screening to exhibit specific, varied, and desirable bacterial biofilm inhibitory responses. The surfactant's self-assembly properties in water were assessed by developing a novel, fully automated, HT method to determine the critical aggregation concentration. These values were used as the input data to a computational-based evaluation of the key molecular descriptors that dictated aggregation behavior. Thus, this combination of HT techniques facilitated the rapid design, generation, and evaluation of further novel, highly functional, cell-instructive surfaces by application of designed surfactants possessing complex molecular architectures.
Publisher: American Association for the Advancement of Science (AAAS)
Date: 05-06-2020
Abstract: Anti-attachment materials that are sprayable and 3D-printable passively prevent colonization by harmful fungi.
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9BM00667B
Abstract: Control in ROP allows polymers to be synthesized with a wide range of architectures and self-assembly properties.
Publisher: Wiley
Date: 03-10-2019
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Valentina Cuzzucoli Crucitti.