ORCID Profile
0000-0002-5971-3991
Current Organisations
RMIT University
,
Swinburne University of Technology
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Publisher: Elsevier BV
Date: 12-2012
Publisher: Wiley
Date: 02-2007
Abstract: The aim of this manuscript is to initiate a constructive discussion about the definition of clinical proteomics, study requirements, pitfalls and (potential) use. Furthermore, we hope to stimulate proposals for the optimal use of future opportunities and seek unification of the approaches in clinical proteomic studies. We have outlined our collective views about the basic principles that should be considered in clinical proteomic studies, including s le selection, choice of technology and appropriate quality control, and the need for collaborative interdisciplinary efforts involving clinicians and scientists. Furthermore, we propose guidelines for the critical aspects that should be included in published reports. Our hope is that, as a result of stimulating discussion, a consensus will be reached amongst the scientific community leading to guidelines for the studies, similar to those already published for mass spectrometric sequencing data. We contend that clinical proteomics is not just a collection of studies dealing with analysis of clinical s les. Rather, the essence of clinical proteomics should be to address clinically relevant questions and to improve the state-of-the-art, both in diagnosis and in therapy of diseases.
Publisher: Elsevier BV
Date: 06-2015
DOI: 10.1016/J.BIOMATERIALS.2015.02.066
Abstract: In this study, we describe a biodegradable vaccine depot which persists in vivo for at least 4-months, provides synergistic adjuvant effects and also allows dose sparing of both antigen and adjuvant. A single administration results in immediate release of a priming dose of vaccine, by a process of syneresis, which is then followed by release of remaining vaccine which maintains robust antibody levels that last for more than a year. The platform technology comprises two aqueous components one contains chitosan and hydroxyapatite, in which the vaccine is incorporated, and the other consists of a crosslinking agent, tripolyphosphate (TPP) and chondroitin sulphate. When co-injected into tissue, they spontaneously crosslink forming a firm yet compliant vaccine-containing depot. Whole body imaging of animals inoculated with the material show that the depot persists in situ for up to 19 weeks. Vaccination of mice with depot formulations containing ovalbumin (OVA) emulsified in Montanide ISA 61 adjuvant results in the induction of robust antibody responses using doses of adjuvant 40-fold less than those recommended by the manufacturer. Dose sparing effects were also apparent with antigen when delivered in the depot. Similar dose sparing effects were observed with Montanide ISA 50, complete and incomplete Freund's adjuvants but not with aluminium hydroxide nor Quil A. Antibody titres, induced by a single dose of antigen/adjuvant formulation incorporated in the depot, persisted at high levels for at least 55 weeks following a single dose of vaccine.
Publisher: Wiley
Date: 14-03-2015
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3RA41679H
Publisher: Elsevier BV
Date: 2012
DOI: 10.1016/J.BIOS.2011.10.051
Abstract: Bacterial meningitis is an infection of the thin membranes covering the brain and spinal cord by a number of microorganisms including Neisseria meningitidis, which can lead to permanent neurological damage in the event of late diagnosis. Given the quick onset and severity of the disease, there is a clear need for a rapid, sensitive and specific diagnostic technique. Here, we describe the development and evaluation of an acoustic wave sensor, the quartz crystal microbalance (QCM), as a rapid immunosensor employing antibodies against the cell surface outer membrane protein 85 (OMP85) of N. meningitidis as an immobilized selective layer. These antibodies were directionally orientated as receptors by thin film deposition of structured polyvinylidene fluoride and Protein A. The sensitivity of this QCM immunosensor was further increased by conjugation of the OMP85 antigen to 50 nm gold nanoparticles providing reproducible detection of the target down to 300 ng/mL. Subsequent treatment of the QCM surface with an acidic glycine solution regenerated the immunosensor allowing each crystal to be used several times.
Publisher: Public Library of Science (PLoS)
Date: 18-12-2017
Publisher: Springer Science and Business Media LLC
Date: 20-10-2013
Publisher: Walter de Gruyter GmbH
Date: 18-01-2023
Abstract: The magic angle of Twistronics has attracted a lot of attention because of its peculiar electrical characteristics. Moiré patterns formed by the superlattice of a twisted bilayer change overall physical properties. Circular dichroism can also be manipulated through the generated moiré pattern. Here, we report a polymer-based twisted bilayer meta-device fabricated by multilayer nanoimprint technology and study the magic angle of chirality. The superlattice of the bilayer meta-device creates moiré patterns and brings unique chiral optical responses. The bilayer nanoimprint technology is developed for metasurfaces with relative twist angles. Via the twist angle control, polymer materials with a low refractive index can manipulate the electric field of the light and reveal the chiral magic angle. Moreover, the shape of the meta-atoms plays a key role in chiral magic angle tuning. The chirality engineering by the reported nanoimprint technology and chiral meta-devices may contribute to applications in chiral imaging, biomedical sensing, lasing, and tunable optical devices.
Publisher: American Chemical Society (ACS)
Date: 26-08-2016
DOI: 10.1021/ACS.CHEMREV.6B00160
Abstract: This comprehensive review surveys developments over the past decade in the field of naphthalene diimides (NDIs). It explores their application toward: supramolecular chemistry sensors host-guest complexes for molecular switching devices, such as catenanes and rotaxanes ion-channels by ligand gating gelators for sensing aromatic systems catalysis through anion-π interactions and NDI intercalations with DNA for medicinal applications. We have also explored new designs, synthesis, and progress in the field of core-substituted naphthalene diimides (cNDIs), and their implications in areas such as artificial photosynthesis and solar cell technology. Also presented are some interesting synthetic routes and procedures that can be used toward further development of NDI-bearing compounds for future applications. Finally, we conclude with our views on NDI chemistry for future research endeavors, and we outline what we believe are the key obstacles that need to be overcome for NDIs to see real world applications.
Publisher: Springer Science and Business Media LLC
Date: 18-11-2015
DOI: 10.1038/SREP16817
Abstract: Titanium and its alloys remain the most popular choice as a medical implant material because of its desirable properties. The successful osseointegration of titanium implants is, however, adversely affected by the presence of bacterial biofilms that can form on the surface and hence methods for preventing the formation of surface biofilms have been the subject of intensive research over the past few years. In this study, we report the response of bacteria and primary human fibroblasts to the antibacterial nanoarrays fabricated on titanium surfaces using a simple hydrothermal etching process. These fabricated titanium surfaces were shown to possess selective bactericidal activity, eliminating almost 50% of Pseudomonas aeruginosa cells and about 20% of the Staphylococcus aureus cells coming into contact with the surface. These nano-patterned surfaces were also shown to enhance the aligned attachment behavior and proliferation of primary human fibroblasts over 10 days of growth. These antibacterial surfaces, which are capable of exhibiting differential responses to bacterial and eukaryotic cells, represent surfaces that have excellent prospects for biomedical applications.
Publisher: Wiley
Date: 23-05-2014
Abstract: Construction of thermodynamically stable nanostructures on the nano- to millimeter scales through noncovalent bonding plays an important role in material science. The self-assembly of tetra-alkylamino core-substituted naphthalene diimides (cNDIs) with variable alkyl chains (C8H17, C12H25, and C16H33) added on to the core leads to the formation of a variety of controlled morphologies and well-defined nanostructures. Such structures include nanorods, vesicular, belts, twisted ribbons, and donutlike morphologies (formed in CHCl3/MeOH and CHCl3/hexane mixtures) generated through solvophobic control. UV/Vis absorption and fluorescence spectroscopy demonstrate molecular aggregation in solution. Furthermore, SEM was employed to visualize the supramolecular self-assembled nanostructures. The growth of these structures is mainly due to packing of hydrophobic alkyl chains and π-π stacking of the cNDI core. The present study paves the way to rational and controlled designs of nanostructures made of optically active dyes (naphthalene diimide) this may open a new avenue towards tuning nanodimensional morphology.
Publisher: Wiley
Date: 20-02-2017
Abstract: The induction of chirality in supramolecular structures through hierarchical self-assembly of achiral compounds and the control of their handedness are closely related to the evolution of life and the chiral lification found in nature. Herein, it is shown that the combination of achiral tetraphenylethylene, an aggregation-induced emission (AIE)-active luminophore bearing four alkyl chains with an odd or even number of carbon atoms via an amide linkage in the molecular structure allows the induction and control of supramolecular chirality in well-defined helical superstructures by controlling the solvent composition and polarity. In particular, right-handed supramolecular structures were produced for an even number of carbon atoms in the alkyl chains, whereas an odd number led to the assembly of left-handed superstructures. The twisted superstructure was visualised by SEM, and circular dichroism was used to observe chirality in the assembly. These controlled assemblies of AIE-active molecules are of potential practical value, such as templates for helical crystallisation, catalysis and formation of chiral mechanochromic luminescent superstructures.
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C4TB00239C
Abstract: A mechano-responsive topology provides a highly active yet autogenous surface for erythrocyte lysis towards microfluidic haematology platforms.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5RA00777A
Abstract: A gold nanoparticle (Au NP) system based on interaction between cyclam and Au NPs resulted into well defined wheel like supramolecular nanostructures in the presence of Cd 2+ .
Publisher: American Chemical Society (ACS)
Date: 21-07-2015
Abstract: Pristine graphene, its derivatives, and composites have been widely reported to possess antibacterial properties. Most of the studies simulating the interaction between bacterial cell membranes and the surface of graphene have proposed that the graphene-induced bacterial cell death is caused either by (1) the insertion of blade-like graphene-based nanosheets or (2) the destructive extraction of lipid molecules by the presence of the lipophilic graphene. These simulation studies have, however, only take into account graphene-cell membrane interactions where the graphene is in a dispersed form. In this paper, we report the antimicrobial behavior of graphene sheet surfaces in an attempt to further advance the current knowledge pertaining to graphene cytotoxicity using both experimental and computer simulation approaches. Graphene nanofilms were fabricated to exhibit different edge lengths and different angles of orientation in the graphene sheets. These substrates were placed in contact with Pseudomonas aeruginosa and Staphylococcus aureus bacteria, where it was seen that these substrates exhibited variable bactericidal efficiency toward these two pathogenic bacteria. It was demonstrated that the density of the edges of the graphene was one of the principal parameters that contributed to the antibacterial behavior of the graphene nanosheet films. The study provides both experimental and theoretical evidence that the antibacterial behavior of graphene nanosheets arises from the formation of pores in the bacterial cell wall, causing a subsequent osmotic imbalance and cell death.
Publisher: American Chemical Society (ACS)
Date: 16-12-2011
DOI: 10.1021/MP200264M
Abstract: It has become increasingly recognized that polymer particle size can have a profound effect on the interactions of particle-based vaccines with antigen presenting cells (APCs) thereby influencing and modulating ensuing immune responses. With the aim of developing chitosan particle-based immunocontraceptive vaccines, we have compared the use of chitosan-based nanoparticles and chitosan-based microparticles as vaccine delivery vehicles for vaccine candidates based on luteinizing hormone-releasing hormone (LHRH). Particles, functionalized with chloroacetyl groups, which allows the covalent attachment of thiol-containing antigens, were able to adsorb ~60-70% of their weight of peptide-based antigen and 10-20% of their weight of protein-based antigen. Quantitation by amino acid analysis of antigen associated with particles demonstrated a correlation between associated antigen and the degree of chloracetylation of particles. Visualization of fluorescently labeled antigen-loaded particles by confocal microscopy indicated that the majority of antigen was localized at the particle surface with a smaller amount located in the interior. We also found that uptake of both fluoresceinated nanoparticles and microparticles by dendritic cells occurred in a manner dependent on particle concentration. Nanoparticles trafficked from the injection site to draining lymph nodes faster than microparticles high numbers of nanoparticle-bearing cells appeared in draining lymph nodes on day 3 and microparticles on day 4. This difference in trafficking rate did not, however, appear to have any significant impact on the ensuing immune response because inoculation with both peptide-conjugated and protein-conjugated particles induced high levels of LHRH-specific antibodies. In the case of protein-conjugated particles, the levels of antibodies elicited were similar to those elicited following inoculation with antigen emulsified with complete Freund's adjuvant. The approach to vaccine design that we have described here could represent another useful method for inducing immune responses against microbial, viral and tumorigenic protein antigens.
Publisher: Wiley
Date: 27-12-2012
DOI: 10.1002/POLB.23023
Publisher: Wiley
Date: 25-07-2023
Abstract: The polarization of light is a valuable information channel that has been studied extensively in optical devices. There has been limited progress in developing low‐refractive index contrast and large‐scale chiral meta‐devices that are easy to integrate and mass‐produce. In this image, a chiral imaging meta‐device with a large area and broadband chirality control is experimentally demonstrated. The centimeter‐scale Moiré meta‐device is achieved using nanoimprint technology. The Poynting vector and singularity features in the near field and chiral optical response in the far field are discussed. The proposed Moiré meta‐devices can achieve circular dichroism (CD) of more than 10%. Further chiral imaging harnessing CD mechanisms are demonstrated, which may lead to significant potential in various fields, including encryption and security, materials science, biochemistry, and medicine.
Publisher: Royal Society of Chemistry
Date: 2017
Publisher: Royal Society of Chemistry (RSC)
Date: 2012
DOI: 10.1039/C2JM32714G
Publisher: MDPI AG
Date: 29-08-2017
Publisher: Elsevier BV
Date: 09-2022
Publisher: MyJove Corporation
Date: 11-10-2016
DOI: 10.3791/54309
Publisher: American Chemical Society (ACS)
Date: 04-01-2016
DOI: 10.1021/ACS.LANGMUIR.5B04138
Abstract: Irrespective of the technology, we now rely on touch to interact with devices such as smart phones, tablet computers, and control panels. As a result, touch screen technologies are frequently in contact with body grease. Hence, surface deposition arises from localized inhomogeneous finger-derived contaminants adhering to a surface, impairing the visual/optical experience of the user. In this study, we examined the contamination itself in order to understand its static and dynamic behavior with respect to deposition and cleaning. A process for standardized deposition of fingerprints was developed. Artificial sebum was used in this process to enable reproducibility for quantitative analysis. Fingerprint contamination was shown to be hygroscopic and to possess temperature- and shear-dependent properties. These results have implications for the design of easily cleanable surfaces.
Publisher: Wiley
Date: 11-01-2016
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6RA06927D
Publisher: Springer Science and Business Media LLC
Date: 08-03-2016
DOI: 10.1038/SREP22928
Abstract: The discovery of photoswitchable azobenzene-systems that undergo trans- to- cis photoisomerisation was a milestone in supramolecular chemistry. Such photoswitches have possible applications in data storage, stimuli responsive delivery systems and molecular machines due to fast and selective switching. However, the light induced cis isomer of azobenzene is rather unstable and reverts thermally and photochemically to the thermodynamically stable trans configuration. We report, for the first time, controlled photoswitching of an azo-naphthalenediimide (azo-NDI) which can be achieved upon binding of fluoride ions through anion-π interaction. This NDI-F–NDI “sandwich” stabilises the cis configuration through the generation of an NDI •− radical anion and a dianionic, NDI 2− species that becomes unusually stable in the cis form. The sandwiched cis form reverts to the trans form only upon decomplexation of F − . A model pollutant was successfully degraded using the photogenerated NDI-F–NDI sandwich. This opens a wide range of applications in molecular and supramolecular nanotechnology.
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C4RA10511G
Abstract: A pyridyl functionalised tetraphenylethylene (Py-TPE) for ratiometric fluorescent detection of intracellular pH values is reported the Py-TPE fluorescent probe can be used for H + sensing in organic solvents (CHCl 3 , DMF and MeOH).
Publisher: Springer Science and Business Media LLC
Date: 23-10-2015
DOI: 10.1038/SREP15652
Abstract: The induction and development of chiral supramolecular structures from hierarchical self-assembly of achiral compounds is closely related to the evolution of life and the chiral lification found in nature. Here we show that the combination of achiral tetraphenylethene (TPE) an AIE-active luminophore bearing four long alkyl chains via amide linkage allows the entire process of induction and control of supramolecular chirality into well-defined uniform right-handed twisted superstructures via solvent composition and polarity, i.e. solvophobic effect. We showed that the degree of twist and the pitch of the ribbons can be controlled to one-handed helical structure via solvophobic effects. The twisted superstructure assembly was visualised by scanning electron microscope (SEM) and transmission electron microscopy (TEM), furthermore, circular dichroism (CD) confirms used to determine controlled right-handed assembly. This controlled assembly of an AIE-active molecule can be of practical value for ex le, as templates for helical crystallisation, catalysis and a chiral mechanochromic luminescent superstructure formation.
Publisher: American Chemical Society (ACS)
Date: 23-08-2017
DOI: 10.1021/ACS.JNATPROD.7B00435
Abstract: Three new meroterpenoids, hyrtiolacton A (1), nakijinol F (2), and nakijinol G (3), along with three known ones, nakijinol B (4), nakijinol E (5), and dactyloquinone A (6), were isolated and characterized from a Hyrtios sp. marine sponge collected from the South China Sea. The new structures were determined based on extensive analysis of HRESIMS and NMR data, and their absolute configurations were assigned by a combination of single-crystal X-ray diffraction and electronic circular dichroism analyses. Hyrtiolacton A (1) represents an unprecedented meroterpenoid featuring an unusual 2-pyrone attached to the sesquiterpene core, which is the first ex le of a pyrone-containing 4,9-friedodrimane-type sesquiterpene. These compounds were evaluated for their protein tyrosine phosphatase (PTP1B) inhibitory and cytotoxic activities. Nakijinol G (3) showed PTP1B inhibitory activity with an IC
Publisher: Springer Science and Business Media LLC
Date: 28-11-2017
DOI: 10.1038/S41598-017-15599-9
Abstract: A charge-transfer (CT) complex self-assembled from an electron acceptor (NDI-EA: naphthalene diimide with appended diamine) and an electron donor (DAN: phosphonic acid-appended dialkoxynapthalene) in aqueous medium. The aromatic core of the NDI and the structure of DAN1 were designed to optimize the dispersive interactions (π-π and van der Waals interactions) in the DAN1–NDI-EA self-assembly, while the amino groups of NDI also interact with the phosphonic acid of DAN1 via electrostatic forces. This arrangement prevented crystallization and favored the directional growth of 3D flower nanostructures. This molecular geometry that is necessary for charge transfer to occur was further evidenced by using a mismatching DAN2 structure. The flower-shaped assembly was visualized by scanning electron and transmission electron microscopy. The formation of the CT complex was determined by UV-vis and cyclic voltammetry and the photoinduced electron transfer to produce the radical ion pair was examined by femtosecond laser transient absorption spectroscopic measurements.
Publisher: American Chemical Society (ACS)
Date: 10-10-2016
DOI: 10.1021/ACS.LANGMUIR.6B02601
Abstract: The protein adsorption of two human plasma proteins-albumin (Alb) and fibronectin (Fn)-onto synthetic nanostructured bactericidal material-black silicon (bSi) surfaces (that contain an array of nanopillars) and silicon wafer (nonstructured) surfaces-was investigated. The adsorption behavior of Alb and Fn onto two types of substrata was studied using a combination of complementary analytical techniques. A two-step Alb adsorption mechanism onto the bSi surface has been proposed. At low bulk concentrations (below 40 μg/mL), the Alb preferentially adsorbed at the base of the nanopillars. At higher bulk concentrations, the Alb adsorbed on the top of the nanopillars. In the case of Fn, the protein preferentially adsorbed on the top of the nanopillars, irrespective of its bulk concentration.
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6CC04427A
Abstract: A controlled handed chiral supramolecular assembly of achiral porphyrins induced by chiral d - and l -arginine (Arg) in water.
Publisher: Springer Science and Business Media LLC
Date: 29-09-2015
DOI: 10.1038/SREP14609
Abstract: Diverse supramolecular assemblies ranging from nanometres to micrometers of small aromatic π-conjugated functional molecules have attracted enormous research interest in light of their applications in optoelectronics, chemosensors, nanotechnology, biotechnology and biomedicines. Here we study the mechanism of the formation of a flower-shaped supramolecular structure of phosphonic acid appended naphthalene diimide with melamine. The flower-shaped assembly formation was visualised by scanning electron microscope (SEM) and transmission electron microscopy (TEM) imaging, furthermore, XRD and DLS used to determined mode of aggregation. Characteristically, phosphonic acid-substituted at imide position of NDIs possess two important properties resulting in the formation of controlled flower-like nanostructures: (i) the aromatic core of the NDI which is designed to optimize the dispersive interactions (π-π stacking and van der Waals interactions) between the cores within a construct and (ii) phosphonic acid of NDI interact with malamine through molecular recognition i.e. strong hydrogen-bonding (H-bonding). We believe such arrangements prevent crystallization and favour the directional growth of flower-like nanostructure in 3D fashion. These works demonstrate that complex self-assembly can indeed be attained through hierarchical non-covalent interactions of two components. Furthermore, flower-like structures built from molecular recognition by these molecules indicate their potential in other fields if combined with other chemical entities.
Publisher: Elsevier BV
Date: 08-2013
Publisher: Wiley
Date: 23-11-2011
DOI: 10.1002/APP.33163
Publisher: Royal Society of Chemistry (RSC)
Date: 2012
DOI: 10.1039/C2JM34053D
Publisher: Wiley
Date: 15-09-2010
DOI: 10.1002/APP.31083
Publisher: Springer Science and Business Media LLC
Date: 08-2007
Publisher: Springer Science and Business Media LLC
Date: 23-02-2017
DOI: 10.1038/SREP42898
Abstract: The development of well-organized structures with high luminescent properties in the solid and aggregated states is of both scientific and technological interest due to their applications in nanotechnology. In this paper we described the synthesis of hiphilic and dumbbell shaped AIE-active tetraphenylethylene (TPE) derivatives and studied their self-assembly with solvophobic control. Interestingly, both TPE derivatives form a 3D flower-shape supramolecular structure from THF/water solutions at varying water fractions. SEM microscopy was used to visualise step-wise growth of flower-shape assembly. TPE derivatives also show good mechanochromic properties which can be observed in the process of grinding, fuming and heating. These TPE derivative self-assemblies are formed due to two main important properties: (i) the TPE-core along with alkyl chains, optimizing the dispersive interactions within a construct, and (ii) amide-linkage through molecular recognition. We believe such arrangements prevent crystallization and favour the directional growth of flower-shape nanostructures in a 3D fashion.
No related grants have been discovered for Mohammad Al Kobaisi.