ORCID Profile
0000-0002-7479-3459
Current Organisation
University College London
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: Springer Science and Business Media LLC
Date: 18-09-2011
DOI: 10.1038/NG.940
Publisher: Elsevier BV
Date: 03-2013
Publisher: American Medical Association (AMA)
Date: 07-2014
Publisher: Cambridge University Press (CUP)
Date: 15-02-2013
DOI: 10.1017/S0033291713000196
Abstract: Schizophrenia is associated with lower pre-morbid intelligence (IQ) in addition to (pre-morbid) cognitive decline. Both schizophrenia and IQ are highly heritable traits. Therefore, we hypothesized that genetic variants associated with schizophrenia, including copy number variants (CNVs) and a polygenic schizophrenia (risk) score (PSS), may influence intelligence. IQ was estimated with the Wechsler Adult Intelligence Scale (WAIS). CNVs were determined from single nucleotide polymorphism (SNP) data using the QuantiSNP and PennCNV algorithms. For the PSS, odds ratios for genome-wide SNP data were calculated in a s le collected by the Psychiatric Genome-Wide Association Study (GWAS) Consortium (8690 schizophrenia patients and 11 831 controls). These were used to calculate in idual PSSs in our independent s le of 350 schizophrenia patients and 322 healthy controls. Although significantly more genes were disrupted by deletions in schizophrenia patients compared to controls ( p = 0.009), there was no effect of CNV measures on IQ. The PSS was associated with disease status ( R 2 = 0.055, p = 2.1 × 10 −7 ) and with IQ in the entire s le ( R 2 = 0.018, p = 0.0008) but the effect on IQ disappeared after correction for disease status. Our data suggest that rare and common schizophrenia-associated variants do not explain the variation in IQ in healthy subjects or in schizophrenia patients. Thus, reductions in IQ in schizophrenia patients may be secondary to other processes related to schizophrenia risk.
Publisher: Public Library of Science (PLoS)
Date: 12-04-2012
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Johan H Thygesen.